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Research Article

Effect of L-Ascorbic Acid on the Climbing Ability and Protein Levels in the Brain of Drosophila Model of Parkinson's Disease

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Pages 704-709 | Received 01 May 2012, Published online: 08 Aug 2012

REFERENCES

  • Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L. Dopaminergic loss and inclusion body formation in alpha synuclein in mice: implication for neurogenerative disorders. Science. 2000;287:1265–9.
  • Vander Putten H, Wiederhold KH, Probst A, Barbieri S, Mistl C, Danner S, Haufmann S, Hofele K, Spooren WP, Ruegg M.A, Lin S, Caroni P, Sommer B, Tolnay M, Bilbe G. Neuropathology in mice expressing human alpha synuclein. J Neurosci. 2000;15:6021–9.
  • Dauer W, Przedborsk S. Parkinson disease: mechanisms and models. Neuron. 2003;39:889–909.
  • Feany MB, Bender WW. A Drosophila model of Parkinson's disease. Nature. 2000;404:394–8.
  • Pendleton RG, Parvez F, Sayed M, Hillman R. Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster. J Pharmacol Exp Ther. 2002;300:91–6.
  • Munoz-Soriano V, Paricio N. Drosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies. Parkinson's Dis. 2011;2011:1–14.
  • Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008;79:368–76.
  • Lees AJ, Hardy J, Revesz T. Parkinson's disease. Lancet. 2009;373:2055–66.
  • Naoi M, Maruyama W. Future of Neuroprotection in Parkinson's disease. Parkinson Relat Disord. 2001;8:139–45.
  • Lü JM, Nurko J, Weakley SM, Jiang J, Kouglas P, Lin PH, Yao Q, Chen C. Molecular mechanisms and clinical application of nordihydroguaiaretic acid (NDGA) and its derivatives: an update. Med Sci Monit. 2010;16:RA93–100.
  • Ono K, Yamada M. Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha synuclein fibrils in vitro. J Neurochem. 2006;97:105–15.
  • Pal R, Miranda M, Narayan M. Nitrosative stress induced Parkinsonian Lewy like aggregates prevented through polyphenolic phytochemical analog intervention. Biochem Biophys Res Commun. 2011;404:324–29.
  • Zhang Y, Dawson VL, Dawson TM. Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol Dis. 2000;7:240–50.
  • Butterfield DA, Kanski J. Brain protein oxidation in age related neurodegenerative disorders that are associated with aggregated proteins. Mech Age Dev. 2001;15:1945–62.
  • Giasson BI, Ischiropoulos H, Lee VM, Trojanowski JQ. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's disease. Free Radic Biol Med. 2002;32:1264–75.
  • Cookson MR. The biochemistry of Parkinson's disease. Ann Rev Biochem. 2005;74:29–52.
  • Abbott RA, Cox M, Markus H, Temkins A. Diet, body size and micronutrient status in Parkinson's disease. Eur J Clin Nutr. 1992;46:879–84.
  • Siddique YH, Ara G, Beg T, Afzal M, Faisal M. Protective role of Plumbago zeylanica extract against toxic effects of ethinylestradiol in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9 and cultured human peripheral blood lymphocytes. Altern Med Stud. 2011;107: 26–9.
  • Bradford MM. Rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye-binding. Ann Biochem. 1976;72:248–54.
  • Noor R, Mittal S, Iqbal J. Superoxide dismutase: applications and relevance to human diseases. Med Sci Monit. 2002;8:RA210–5.
  • Fahn S. The endogenous toxin hypothesis of the etiology of Parkinson's disease and a pilot trial of high dosage antioxidants in an attempt to slow the progression of the illness. Ann New York Acad Sci. 1989;570:186–96.
  • Sinonian NA, Coyle JT. Oxidative stress in neurodegenerative diseases. Ann Rev Pharmacol Toxicol. 1996;36:83–106.
  • Pardo B, Mena MA, Fahn S, Yebenes JG. Ascorbic acid protects against levodopa induced neurotoxicity on a catecholamine rich human neuroblastoma cell line. Mov Disord. 1993;8:278–84.
  • Etminan M, Gill S, Samii A. Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta analysis. Lancet Neurol. 2005;4:362–65.
  • Fernandez-Calle P, Jinénez-Jiménez FJ, Molina JA, Cabrera-Valdivia F, Vazguez A, Urra DG, Bermejo F, Matallana MC, Codoceo R. Serum levels of ascorbic acid (vitamin C) in patients with Parkinson's disease. J Neurol Sci. 1993;18:25–8.
  • Mytilineous C, Walker RH, Jnobaptiste R, Obanow CW. Levodopa is toxic to dopamine neurons in an in vitro but not an in vivo model of oxidative stress. J Pharmacol Exp Ther. 2003;304:797–800.
  • Kostrzewa RM, Kostrzewa JP, Brus R. Neuroprotective and neurotoxic roles of levodopa (l-DOPA) in neurodegenerative disorders relating to Parkinson's disease. Amino Acids. 2002;23:57–63.
  • Mazzio EA, Close F, Solimanan KFA. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. Int J Mol Sci. 2011;12:506–69.
  • Amer DA, Irvine GB, El-Agnaf OM. Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders. Exp Brain Res. 2006;173:223–33.
  • Caruana M, Hogen T, Levin J, Hillmer A, Giese A, Vassallo N. Inhibition and disaggregation of α-synuclein oligomer by natural polyphenolic compounds. FEBS Lett. 2011;585:1113–20.
  • Siddique YH, Ara G, Jyoti S, Afzal M. Effect of capsacin on the climbing ability in Drosophila model of Parkinson's disease. Am J Drug Discov Dev. 2012;2:50–4.
  • Siddique YH, Ara G, Jyoti S, Afzal M. Protective effect of curcumin in transgenic Drosophila melanogaster model of Parkinson's disease in Drosophila melanogaster. Altern Med Stud. 2012;2e:7–9.
  • Siddique YH, Ara G, Jyoti S, Afzal M. The dietary supplementation of nordihydroguaiaretic acid (NDGA) delayed the loss of climbing ability in Drosophila model of Parkinson's disease. J Diet Suppl. 2012;9:1–8.
  • Siddique YH, Jyoti S, Naz F, Afzal M. Protective effect of apigenin in transgenic Drosophila melanogaster model of Parkinson's disease. Pharmacologyonline. 2011;3:790–5.
  • Padayatty SJ, Katz A, Wang Y, Eck P, Know O, Lee JH, Chen S, Corpe C, Dutta SK, Levine M. Vitamin C as an antioxidant; evaluation of its role in disease prevention. J Am Coll Nutr. 2003;22:18–35.
  • Meister A. Glutathione–ascorbic acid antioxidant system in animals. J Biol Chem. 1994;269:9397–400.
  • Wilson JX. Regulation of vitamin C transport. Ann Rev Mutat. 2005;25:105–25.
  • Auluck PK, Chan HYE, Trojanowski JQ, Lee VMY, Bonini NM. Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease. Science. 2002;295:865–8.
  • Jia H, Li X, Gao H, Feng Z, Li X, Zhao L, Jia X, Zhang H, Liu J. High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease. J Neurosci Res. 2008;86:2083–90.
  • Long J, Gao H, Sun L, Liu J, Zhao-Wilson X. Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends life-span in Drosophila Parkinson's disease model. Rejuvenation Res. 2009;12:321–31.
  • Festing MFW, Baumans V, Combes DR, Halder M, Hendricsen FM, Howard BR, Lowell DP, Moore GJ, Overend P, Wilson MS. Reducing the use of laboratory animals in biomedical research: problems and possible solutions. Altern Lab Anim. 1998;26:283–301.
  • Benford DJ, Hanley AB, Bottrill K, Oehlschlager S, Balls M, Branca F, Castengnaro JJ, Descotes J, Hemminiki K, Lindsay D, Schitter B. Biomarkers as predictive tools in toxicity testing. The report and recommendations of EVCAM workshop. Altern Lab Anim. 2000;28:119–31.
  • Avanesian A, Semmani S, Jafri M. Can Drosophila melanogaster represent a model system the detection of reproductive adverse drug reactions? Drug Discov Today. 2009;14:761–6.

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