529
Views
36
CrossRef citations to date
0
Altmetric
Research Article

Aβ-induced microglial cell activation is inhibited by baicalin through the JAK2/STAT3 signaling pathway

, , , , , & show all
Pages 609-620 | Received 02 May 2013, Accepted 08 Nov 2013, Published online: 12 Dec 2013

References

  • Goedert M, Spillantini MG. A century of Alzheimer's disease. Science 2006;14(5800):777–81.
  • Vehmas AK, Kawas CH, Stewart WF, Troncoso JC. Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease. Neurobiol Aging 2003;24(2):321–31.
  • Roberson ED, Mucke L. 100 years and counting: prospects for defeating Alzheimer's disease. Science 2006;314(5800):781–4.
  • Li L, Zeng YY, Huang XY, Effects of baicalin on in vitro proliferation and cell cycle of murine T-lymphocytes. Chin J Cell Mol Immunol 2009;25:75–8.
  • Zeng Y, Song C, Ding X, Baicalin reduces the severity of experimental autoimmune encephalomyelitis. Braz J Med Biol Res 2007;40(7):1003–16.
  • Liu LL, Gong LK, Wang H, Baicalin protects mouse from Concanavalin A-induced liver injury through inhibition of cytokine production and hepatocyte apoptosis. Liver Int 2007;27(4):582–91.
  • Liu LL, Gong Lk, Wang H, Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock. Biochem Pharmacol 2008;75:914-22.
  • Heo HJ, Kim DO, Choi SJ, Potent inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity. J Agric Food Chem 2004;52(13):4128–32.
  • Wang SY, Wang HH, Chi CW, Effects of baicalein on beta-amyloid peptide-(25-35)-induced amnesia in mice. Eur J Pharmacol 2004;506:55–61.
  • Cheng Y, He G, Mu X, Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile. Neurosci Lett 2008;441:16–20.
  • Jung JS, Kim DH, Kim HS. Ginsenoside Rh1 suppresses inducible nitric oxide synthase gene expression in IFN-gamma-stimulated microglia via modulation of JAK/STAT and ERK signaling pathways. Biochem Biophys Res Commun 2010;397(2):323–8.
  • Shuai K, Liu B. Regulation of JAK–STAT signalling in the immune system. Nat Rev Immun 2003;3(11):900–11.
  • Natarajan C, Sriram S, Muthian G, Bright JJ. Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microglia. Glia 2004;45(2):188–96.
  • Yang LL, Wang L, Ren XY, The JAK/STAT signaling pathway mediates β-amyloid protein-induced TNF-αaction of microglia in vitro. J Shandong Univ (Health Sci) 2011;48(7):33–6. (Chinese)
  • Song M, Xiong JX, Wang YY, VIP enhances phagocytosis of fibrillar beta-amyloid by microglia and attenuates amyloid deposition in the brain of APP/PS1 mice. PLoS One 2012;7(2):e29790.
  • Bertoli C, Skotheim JM, de Bruin RA. Control of cell cycle transcription during G1 and S phases. Nat Rev Mol Cell Biol 2013;14(8):518–28.
  • Monsonego A, Weiner HL. Immunotherapeutic approaches to Alzheimer's disease. Science 2003;302:834–8.
  • Michaud M, Balardy L, Moulis G, Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc 2013;14(12):877–82.
  • Shibata N, Ohnuma T, Takahashi T, Effect of IL-6 polymorphism on risk of Alzheimer disease: Genotype-Phenotype Association Study in Japanese Cases. Am J Med Genet 2002;114:436–9.
  • Cheranov SY, Jaggar JH. TNF-alpha dilates cerebral arteries via NAD(P) Hoxidase-dependent Ca2+ spark activation. Am J Physiol Cell Physiol 2006;290(4):C964–7.
  • Kim YJ, Hwang SY, Hwang JS, C6 glioma cell insoluble matrix components enhance interferon-gamma-stimulated inducible nitric-oxide synthase/nitric oxide production in BV2 microglial cells. J Biol Chem 2008;283(5):2526–33.
  • Kong LY, Abou-Ghazal MK, Wei J, A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells. Clin Cancer Res 2008;14(18):5759–68.
  • Suh HS, Kim MO, Lee SC. Inhibition of granulocyte-macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and phosphatidylinositol 3-kinase/Akt. J Immunol 2005;174(5):2712–9.
  • Satriotomo I, Bowen KK, Vemuganti R. JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia. J Neurochem 2006;98:1353–68.
  • Huang C, Ma R, Sun S, JAK2-STAT3 signaling pathway mediates thrombin-induced proinflammatory actions of microglia in vitro. J Neuroimmunol 2008;204(1–2): 118–25.
  • Nishiki S, Hato F, Kamata N, Selective activation of STAT3 in human monocytes stimulated by G-CSF: implication in inhibition of LPS-induced TNF-α production. Am J Physiol Cell Physiol 2004;286:C1302–11.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.