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Research Article

Association of sex hormones and glucose metabolism with the severity of multiple sclerosis

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Pages 797-804 | Received 26 May 2015, Accepted 02 Jul 2015, Published online: 25 Sep 2015

References

  • Stadelmann C. Multiple sclerosis as a neurodegenerative disease: pathology, mechanisms and therapeutic implications. Curr Opin Neurol 2011;24(3):224–9.
  • Dunn SE1, Lee H, Pavri FR, Zhang MA. Sex-based differences in multiple sclerosis (part I): biology of disease incidence. Curr Top Behav Neurosci 2015:1–28 [Epub ahead of print].
  • Simpson S Jr, Blizzard L, Otahal P, et al. Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis. J Neurol Neurosurg Psychiatry 2011;82(10):1132–4.
  • Compston A, Coles A. Multiple sclerosis. Lancet 2008;372(9648):1502–17.
  • Sundqvist E, Bäärnhielm M, Alfredsson L, et al. Confirmation of association between multiple sclerosis and CYP27B1. Eur J Hum Genet 2010;18(12):1349–52.
  • Confavreux C, Hutchinson M, Hours MM, et al. Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in multiple sclerosis group. N Engl J Med 1998;339(5):285–91.
  • Smith R, Studd JW. A pilot study of the effect upon multiple sclerosis of the menopause, hormone replacement therapy and the menstrual cycle. J R Soc Med 1992;85(10):612–3.
  • Palaszynski KM, Loo KK, Ashouri JF, et al. Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. J Neuroimmunol 2004;146(1–2):144–52.
  • Mähler A, Steiniger J, Bock M, et al. Is metabolic flexibility altered in multiple sclerosis patients? PLoS One 2012;7(8):e43675. Epub 2012 Aug 28.
  • Oliveira SR, Simão AN, Kallaur AP, et al. Disability in patients with multiple sclerosis: influence of insulin resistance, adiposity, and oxidative stress. Nutrition 2014;30(3):268–73.
  • McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50:121–7.
  • Tsivgoulis G, Triantafyllou N, Papageorgiou C, et al. Associations of the expanded disability status scale with anxiety and depression in multiple sclerosis outpatients. Acta Neurol Scand 2007;115:67–72.
  • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444–52.
  • Bove R, Musallam A, Healy BC, et al. No sex-specific difference in disease trajectory in multiple sclerosis patients before and after age 50. BMC Neurol 2013;13:73. doi: 10.1186/1471-2377-13-73
  • Neuteboom RF, Janssens AC, Siepman TA, et al. Pregnancy in multiple sclerosis: clinical and self-report scales. J Neurol 2012;259(2):311–7.
  • Finkelsztejn A, Brooks JB, Paschoal FM Jr, Fragoso YD. What can we really tell women with multiple sclerosis regarding pregnancy? A systematic review and meta-analysis of the literature. BJOG. 2011;118(7):790–7. Epub 2011 Mar 15.
  • Finkelsztejn A, Fragoso YD, Ferreira ML, et al. The Brazilian database on pregnancy in multiple sclerosis. Clin Neurol Neurosurg 2011;113(4):277–80.
  • Coyle PK. Pregnancy and multiple sclerosis. Neurol Clin 2012;30(3):877–88.
  • Spence RD, Hamby ME, Umeda E, et al. Neuroprotection mediated through estrogen receptor-alpha in astrocytes. Proc Natl Acad Sci USA 2011;108(21):8867–72.
  • Gold SM, Voskuhl RR. Estrogen and testosterone therapies in multiple sclerosis. Prog Brain Res 2009;175:239–251.
  • Voskuhl RR, Palaszynski K. Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. Neuroscientist 2001;7(3):258–70.
  • Spence RD, Voskuhl RR. Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration. Front Neuroendocrinol 2012;33(1):105–15.
  • Airas L, Saraste M, Rinta S, et al. Finnish multiple sclerosis and pregnancy study group. Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: relevance of natural killer cells. Clin Exp Immunol 2008;151(2):235–43.
  • Patas K, Engler JB, Friese MA, Gold SM. Pregnancy and multiple sclerosis: feto-maternal immune cross talk and its implications for disease activity. J Reprod Immunol 2013;97(1):140–6.
  • Holmqvist P, Wallberg M, Hammar M, et al. Symptoms of multiple sclerosis in women in relation to sex steroid exposure. Maturitas 2006;54(2):149–153.
  • Haghmorad D, Amini AA, Mahmoudi MB, et al. Pregnancy level of estrogen attenuates experimental autoimmune encephalomyelitis in both ovariectomized and pregnant C57BL/6 mice through expansion of Treg and Th2 cells. J Neuroimmunol 2014;277(1–2):85–95.
  • Lélu K, Delpy L, Robert V, et al. Endogenous estrogens, through estrogen receptor α, constrain autoimmune inflammation in female mice by limiting CD4+ T-cell homing into the CNS. Eur J Immunol 2010;40(12):3489–98.
  • Sicotte NL, Liva SM, Klutch R, et al. Treatment of multiple sclerosis with the pregnancy hormone estriol. Ann Neurol 2002;52(4):421–8.
  • Bove R, Chitnis T. Sexual disparities in the incidence and course of MS. Clin Immunol 2013;149(2):201–10.
  • Greer JM, McCombe PA. Role of gender in multiple sclerosis: clinical effects and potential molecular mechanisms. J Neuroimmunol 2011;234(1–2):7–18.
  • Tomassini V, Onesti E, Mainero C, et al. Sex hormones modulate brain damage in multiple sclerosis: MRI evidence. J Neurol Neurosurg Psychiatry 2005;76:272–5.
  • Taylor LC, Puranam K, Gilmore W, et al. 17beta-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss. Neurobiol Dis 2010;39(2):127–37.
  • Dalal M, Kim S, Voskuhl RR. Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response. J Immunol 1997;159:3–6.
  • Bove R, Chitnis T. The role of gender and sex hormones in determining the onset and outcome of multiple sclerosis. Mult Scler 2014;20(5):520–6.
  • Bebo BF, Jr., Zelinka-Vincent E, Adamus G, et al. Gonadal hormones influence the immune response to PLP 139–151 and the clinical course of relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol 1998;84:122–30.
  • Foster SC, Daniels C, Bourdette DN, Bebo BF, Jr. Dysregulation of the hypothalamic–pituitary–gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosis. J Neuroimmunol 2003;140:78–87.
  • Sicotte NL, Giesser BS, Tandon V, et al. Testosterone treatment in multiple sclerosis: a pilot study. Arch Neurol 2007; 64(5):683–8.
  • Kurth F, Luders E, Sicotte NL, et al. Neuroprotective effects of testosterone treatment in men with multiple sclerosis. Neuroimage Clin 2014;4:454–60.
  • Wens I, Dalgas U, Deckx N, et al. Does multiple sclerosis affect glucose tolerance? Mult Scler 2013;20(9):1273–6.
  • Mathur D, López-Rodas G, Casanova B, Marti MB. Perturbed glucose metabolism: insights into multiple sclerosis pathogenesis. Front Neurol 2014;5:1–7.
  • Meyer-Moock S, Feng YS, Maeurer M, et al. Systematic literature review and validity evaluation of the expanded disability status scale (EDSS) and the multiple sclerosis functional composite (MSFC) in patients with multiple sclerosis. BMC Neurol 2014;14:58. doi: 10.1186/1471-2377-14-58

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