Inhibition of Protein and Aminoacyl-tRNA Synthesis, and Binding and Transport Sites for Aromatic Amino Acids in the Brain in vitro with Aromatic Acids

References

• Agrawal H. C., Bone A. H., Davison A. N. Effect of phenylalanine on protein synthesis in the developing rat brain. Biochemical Journal 1970; 117: 325–331
   PubMedGoogle Scholar
• Andrews T. M., Tata J. R. Protein synthesis by membrane-bound and free ribosomes of secretory and nonsecretory tissues. Biochemical Journal 1971; 121: 683–694
   PubMedGoogle Scholar
• Antonas K. N., Coulson W. F. Brain uptake and protein incorporation of amino acids studied in rats subjected to prolonged hyperphenylalaninaemia. Journal of Neurochemistry 1975; 25: 309–314
   PubMedGoogle Scholar
• Aragón M. C., Giménez C., Valdivieso F. Inhibition by L-phenylalanine of tyrosine transport by synaptosomal plasma membrane vesicles: Implications in the pathogenesis of phenylketonuria. Journal of Neurochemistry 1982; 39: 1185–1187
   PubMedGoogle Scholar
• Barra H. S., Arce C. A., Rodriguez J. A., Caputto R. Incorporation of phenylalanine as a single unit into rat brain protein: Reciprocal inhibition by phenylalanine and tyrosine of their respective incorporations. Journal of Neurochemistry 1973; 21: 1241–1251
   PubMedGoogle Scholar
• Binek-Singer P., Johnson T. C. The effects of chronic hyperphenylalaninaemia on mouse brain protein synthesis can be prevented by other amino acids. Biochemical Journal 1982; 206: 407–414
   PubMedGoogle Scholar
• Blasberg R. G., Lajtha A. Substrate specificity of steady-state amino acid transport in mouse brain slices. Archives of Biochemistry 1965; 112: 361–377
   Web of Science ®Google Scholar
• Blau K. Phenylalanine hydroxylase deficiency: Biochemical, physiological, and clinical aspects of phenylketonuria and related phenylalaninaemias. Aromatic amino acid hydroxylases and mental disease, M. B. H. Youdim. John Wiley, New York 1979; 77–139
   Google Scholar
• Chou L., Lerner M. P., Johnson T. C. In vitro binding of phenylalanyl-tRNA to neonatal and adult mouse brain ribosomes. Journal of Neurochemistry 1971; 18: 2535–2544
   PubMedGoogle Scholar
• Edwards D. J., Blau K. Aromatic acids derived from phenylalanine in the tissues of rats with experimentally induced phenylketonuria-like characteristics. Biochemical Journal 1972; 130: 495–503
   PubMedGoogle Scholar
• Fangman W. L., Neidhardt F. C. Demonstration of altered aminoacyl ribonucleic acid synthetase in a mutant of. Escherichia coli. Journal of Biological Chemistry 1964; 239: 1839–1843
   PubMedGoogle Scholar
• Geison R. L., Siegel F. L. Tolerance of protein and lipid synthesis to mild hyperphenylalaninaemia in developing rat brain. Brain Research 1975; 92: 431–441
   PubMedGoogle Scholar
• Goldstein F. B. Biochemical studies on phenylketonuria. I. Experimental hyperphenylalanemia in the rat. Journal of Biological Chemistry 1961; 236: 2656–2661
   PubMedGoogle Scholar
• Guroff G., Lovenberg W. Metabolism of aromatic amino acids. Handbook of neurochemistry, A. Lajtha. Academic Press, New York 1972; vol. 5: 209–223
   Google Scholar
• Hughes J. V., Johnson T. C. The effects of hyperphenylalaninaemia on the concentrations of aminoacyl-transfer ribonucleic acid. in vivo. Biochemical Journal 1977; 162: 527–537
   PubMedGoogle Scholar
• Korpi E. R. Tryptophan and phenylalanine transport in rat cerebral cortex slices as influenced by sodium ions. Neurochemical Research 1980; 5: 415–431
   PubMedGoogle Scholar
• Lähdesmäki P., Hannus M.-L. Effect of aromatic acids on the influx of aromatic amino acids in rat brain slices. Experimental Brain Research 1977; 30: 539–548
   PubMed Web of Science ®Google Scholar
• Lähdesmäki P., Kumpulainen E., Raasakka O., Kyrki P. Interaction of taurine, GABA and glutamic acid with synaptic membranes. Journal of Neurochemistry 1977; 29: 819–826
   PubMed Web of Science ®Google Scholar
• Lähdesmäki P., Oja S. S. Effect of electrical stimulation on the influx and efflux of taurine in brain slices of newborn and adult rats. Experimental Brain Research 1972; 15: 430–438
   PubMedGoogle Scholar
• Lähdesmäki P., Oja S. S. Effect of aromatic acids on protein synthesis in subcellular preparations from the rat brain. Journal of Neurobiology 1975; 6: 313–320
   PubMedGoogle Scholar
• Lees G. J., Weiner N. Transaminations between amino acids and keto acids elevated in phenylketonuria and maple syrup urine disease. Journal of Neurochemistry 1973; 20: 389–403
   PubMedGoogle Scholar
• Levitan I. B., Mushynski W. E., Ramirez G. Highly purified synaptosomal membranes from rat brain. Preparation and characterization. Journal of Biological Chemistry 1972; 247: 5376–5381
   PubMed Web of Science ®Google Scholar
• Lindroos O. F. C., Oja S. S. Hyperphenylalaninaemia and the exchange of tyrosine in adult rat brain. Experimental Brain Research 1971; 14: 48–60
   PubMedGoogle Scholar
• Loo Y. H. Serotonin deficiency in experimental hyperphenylalaninemia. Journal of Neurochemistry 1974; 23: 139–147
   PubMedGoogle Scholar
• Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
   PubMed Web of Science ®Google Scholar
• MacInnes J. W., Schlesinger K. Effects of excess phenylalanine on in vitro and in vivo RNA and protein synthesis and polyribosome levels in brains of mice. Brain Research 1971; 29: 101–110
   PubMedGoogle Scholar
• Menkes J. H. Cerebral proteolipids in phenylketonuria. Neurology 1968; 18: 1003–1011
   PubMedGoogle Scholar
• Neame K. D. Phenylalanine as inhibitor of transport of amino-acids in brain. Nature 1961; 192: 173–174
   PubMedGoogle Scholar
• Oja S. S. Incorporation of phenylalanine, tyrosine and tryptophan into protein of homogenates from developing rat brain: Kinetics of incorporation and reciprocal inhibiton. Journal of Neurochemistry 1972; 19: 2057–2069
   PubMedGoogle Scholar
• Pajari M., Oja S. S. Mutual inhibition of incorporation into protein of valine, leucine and isoleucine in brain homogenates of developing rats. Acta Universitatis Ouluensis 1980; A97: 17–24
   Google Scholar
• Patel M. S., Grover W. D., Auerbach V. H. Pyruvate metabolism by homogenates of human brain: Effects of phenylpyruvate and implications for the etiology of the mental retardation in phenylketonuria. Journal of Neurochemistry 1973; 20: 289–296
   PubMedGoogle Scholar
• Peterson N. A., McKean C. M. The effects of individual amino acids on the incorporation of labelled amino acids into proteins by brain homogenates. Journal of Neurochemistry 1969; 16: 1211–1217
   PubMedGoogle Scholar
• Peterson N. A., Raghupathy E., McKean C. M. Inhibition by homogentisic acid of polypeptide synthesis in rat liver and brain ribosomal systems. Biochimica et Biophysica Acta 1971; 228: 268–281
   PubMedGoogle Scholar
• Ragnotti G. A rapid method for the determination of ribonucleic acid in subcellular fractions. Biochemical Journal 1971; 125: 1057–1058
   PubMedGoogle Scholar
• Roscoe J. P., Eaton M. D., Choy G. C. Inhibition of protein synthesis in Krebs 2 ascites cells and cell-free systems by phenylalanine and its effect on leucine and lysine in the amino acid pool. Biochemical Journal 1968; 109: 507–515
   PubMed Web of Science ®Google Scholar
• Vahvelainen M.-L., Oja S. S. The uptake and incorporation into proteinof [3H] tyrosine by slices prepared from developing rat brain cortex. Brain Research 1969; 13: 227–233
   PubMedGoogle Scholar
• Vahvelainen M.-L., Oja S. S. Kinetics of influx of phenylalanine, tyrosine, tryptophan, histidine and leucine into slices of brain cortex from adult and 7-day-old rats. Brain Research 1972; 40: 477–488
   PubMedGoogle Scholar
• Vahvelainen M.-L., Oja S. S. Kinetic analysis of phenylalanine-induced inhibition in the saturable influx of tyrosine, tryptophan, leucine and histidine into brain cortex slices from adult and 7-day-old rats. Journal of Neurochemistry 1975; 24: 885–892
   PubMedGoogle Scholar
• Whittaker V. P., Michaelson I. A., Kirkland R. J. A. The separation of synaptic vesicles from nerve ending particles (“synaptosomes”). Biochemical Journal 1964; 90: 293–303
   PubMed Web of Science ®Google Scholar
• Winkler K., Heller-Schöch G., Neth R. Mutual inhibition of amino acid incorporation by amino acids in cell suspensions and cell-free systems. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 1972; 353: 787–792
   PubMedGoogle Scholar