Neurochemical Aspects of Depression: The Past and the Future?

References

• Aghajanian G. K. Central noradrenergic neurons: A locus for the functional interplay between alpha-2 adrenoceptors and opiate receptors. Journal of Clinical Psychiatry 1982; 43: 20–24
   PubMed Web of Science ®Google Scholar
• Agnoli A., Andreoli V., Casacchia M., Cerbo R. Effect of S-adenosyl-L-methionine (SAMe) upon depressive symptoms. Journal of Psychiatric Research 1976; 13: 43–54
   PubMed Web of Science ®Google Scholar
• Akiskal H. S., McKinney W. T., Jr. Depressive Disorders: Toward a unified hypothesis. Science 1973; 182: 20–29
   PubMed Web of Science ®Google Scholar
• Albouz S., Hauw J. J., Berwald-Netter Y., Boutry J. M., Bourdon R., Baumann N. Tricyclic antidepressants induce sphingomyleinase deficiency in fibroblast and neuroblastoma cell cultures. Biomedicine 1981; 35: 218–220
   PubMedGoogle Scholar
• Altman N., Sachar E. J., Gruen P. H., Halpern F. S., Eto S. Reduced plasma LH concentration in postmenopausal depressed women. Psychosomatic Medicine 1975; 37: 274–276
   PubMed Web of Science ®Google Scholar
• Anden N. E., Grabowska M., Strombom U. Different alpha- adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents. Naunyn-Schmiedeberg's Archives for Pharmacology 1976; 292: 43–52
   PubMed Web of Science ®Google Scholar
• Antelman S. M., Chiodo L. A. Dopamine autoreceptor subsensitivity. A mechanism common to the treatment of depression and induction of amphetamine psychosis ?. Biological Psychiatry 1981; 16: 717–727
   PubMed Web of Science ®Google Scholar
• Asberg M., Thoren P., Traskman L. Serotonin depression: A biochemical subgroup within the affective disorders?. Science 1976; 191: 478–480
   PubMed Web of Science ®Google Scholar
• Axelrod J. Pre- and postsynaptic regulation of catecholamine neurotransmitters. Advances in pharmacology and therapeutics, P. Simon. Pergamon Press, New York 1979; 2: 249–262
   Google Scholar
• Ayd F. A preliminary report on Marsilid. American Journal of Psychiatry 1957; 114: 459
   PubMed Web of Science ®Google Scholar
• Baer L., Durell J., Bunney W. E., Levy B. S., Gardon P. V. Sodium-22 retention and 17-hydroxycorticosteroid excretion in affective disorders. A preliminary report. Journal of Psychiatric Research 1969; 6: 289–297
   PubMed Web of Science ®Google Scholar
• Baldessarini R. J. Biogenic amine hypothesis in affective disorders. The nature and treatment of depression, F. F. Flack, S. C. Draghi. John Wiley & Sons, New York 1975; 347–385
   Google Scholar
• Banerjee S. P., Kung L. S., Figgi S. J., Chanda S. K. Development of β-adrenergic receptor subsensitivity by antidepressants. Nature 1977; 268: 455–456
   PubMed Web of Science ®Google Scholar
• Baraldi M., Poggioli R., Santi M., Vergoni A. V., Bertolini A. Antidepressants and opiate interactions: Pharmacological and biochemical evidences. Pharmacological Research Communications 1983; 15: 843–857
   PubMedGoogle Scholar
• Barchas J. D., Akil H., Elliott G. R., Holman R. B., Watson S. J. Behavioral neurochemistry: Neuroregulators and behavioral states. Science 1978; 200: 964–973
   PubMed Web of Science ®Google Scholar
• Bergstrom D. A., Kellar K. J. Adrenergic and serotonergic receptor binding in rat brain after chronic desmethylimipramine treatment. Journal of Pharmacology and Experimental Therapeutics 1979; 209: 256–261
   PubMed Web of Science ®Google Scholar
• Biegon A., Samuel D. The in vivo distribution of an antidepressant drug (DMI) in male and female rats. Psychopharmacology 1979; 65: 259–263
   PubMed Web of Science ®Google Scholar
• Biegon A., Samuel D. Interaction of tricyclic antidepressants with opiate receptors. Biochemical Pharmacology 1980; 29: 460–462
   PubMed Web of Science ®Google Scholar
• Billingsley M. L., Velletri P. A., Roth R. H., DeLorenzo R. J. Carboxylmethylation of calmodulin inhibits phosphorylation in rat membranes and cytosol. Journal of Biological Chemistry 1983; 258: 5352–5357
   PubMed Web of Science ®Google Scholar
• Bloom F. E., Baetge G., Deyo S., Ettenberg A., Koda L., Magistretti P. J., Shoemaker W. J., Staunton D. A. Chemical and physiological aspects of the actions of lithium and antidepressant drugs. Neuropharmacology 1983; 22: 359–365
   PubMed Web of Science ®Google Scholar
• Bonnet K. A. Adaptive alterations in receptor mediated processes and their implications for some mental disorders. Modulators, mediators and specifiers in brain function, Y. H. Ehrlich, J. Volavka, L. G. Davis, E. G. Brunngraber. Plenum Press, New York 1979; 247–256
   Google Scholar
• Borbe H. O., Zube I. The detection of specific (3H)-imipramine binding in bovine retina. Brain Research 1983; 264: 178–180
   PubMed Web of Science ®Google Scholar
• Briley M. S., Langer S. Z., Raisman R., Sechter D., Zarifian E. Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients. Science 1980; 209: 303–305
   PubMed Web of Science ®Google Scholar
• Briley M., Langer S. Z., Sette M. Allosteric interaction between the 3H-imipramine binding site and the serotonin uptake mechanism. British Journal of Pharmacology 1981; 74: 817P–818P
   Web of Science ®Google Scholar
• Brodie B. B., Pletscher A., Shore P. A. Evidence that serotonin has a role in brain function. Science 1955; 122: 968
   PubMed Web of Science ®Google Scholar
• Brodie B. B., Pletscher A., Shore P. A. Possible role of serotonin in brain function and in reserpine action. Journal of Pharmacology and Experimental Therapeutics 1956; 116: 9, (Abst.)
   Web of Science ®Google Scholar
• Brodie B. B., Spector S., Shore P. A. Interaction of drugs with norepinephrine in the brain. Pharmacological Reviews 1959a; 11: 548–564
   PubMed Web of Science ®Google Scholar
• Brodie B. B., Spector S., Shore P. A. Interaction of monoamine oxidase inhibitors with physiological and biochemical mechanisms in brain. Annals of the New York Academy of Science 1959b; 80: 609–614
   PubMed Web of Science ®Google Scholar
• Brown G. L., Ebert M. H., Goyer P. F., Jimerson D. C, Klein W. J., Bunney W. E., Goodwin F. K. Aggression, suicide and serotonin: Relationships to CSF amine metabolites. American Journal of Psychiatry 1982; 139: 741–746
   PubMed Web of Science ®Google Scholar
• Brunello N., Barbaccia M. L., Chuang D.-M., Costa E. Down- regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: Permissive role of serotonergic axons. Neuropharmacology 1982; 21: 1145–1149
   PubMed Web of Science ®Google Scholar
• Buchsbaum M. S., Haler R. J., Murphy D. L. Suicide attempts, platelet monoamine oxidase and the average evoked response. Acta Psychiatric Scandinavica 1977; 56: 69–79
   PubMed Web of Science ®Google Scholar
• Bunney B. S., De Riemer S. Effect of clonidine on dopaminergic neuron activity in the substantia nigra: Possible indirect mediation of noradrenergic regulation of the serotonergic raphe system. Gilles de la Tourette syndrome, A. J. Friedhoff, T. N. Chase. Raven Press, New York 1982; 99–104
   Google Scholar
• Bunney W. E., Jr, Davis J. M. Norepinephrine in depressive reactions: A review. Journal of Psychiatry 1965; 13: 285–305
   Google Scholar
• Bunney W. E., Jr., Garland B. L. Selected aspects of amine and receptor hypothesis of affective illness. Journal of Clinical Psychopharmacology 1981; 1: 3–11, (Supplement)
   Google Scholar
• Burt D. R., Creese I., Snyder S. H. Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain. Science 1977; 196: 326–328
   PubMed Web of Science ®Google Scholar
• Cade J. F. J. Lithium salts in the treatment of psychotic excitement. Medical Journal of Australia 1949; 2: 349–352
   PubMed Web of Science ®Google Scholar
• Cannon W. B., Rosenbleuth A. The supersensitivity of denervated structures. Mac-Millan, New York 1949
   Google Scholar
• Carlsson A., Lindquist M., Magnusson T. 3, 4-Dihydroxyphenylalanine and 5-hydroxytryp-tophan as reserpine antagonists. Nature 1957; 180: 1200
   PubMed Web of Science ®Google Scholar
• Carman J. S., Wyatt R. J. Calcium: Bivalent cation in the bivalent psychosis. Biological Psychiatry 1979a; 14: 295–336
   PubMed Web of Science ®Google Scholar
• Carman J. S., Wyatt R. J. Calcium: Pace setting the periodic psychoses. American Journal of Psychiatry 1979b; 3: 1035–1039
   Google Scholar
• Carpenter W. T., Bunney W. E. Behavioral effects of Cortisol in man. Seminars in Psychiatry 1971; 3: 421–434
   PubMedGoogle Scholar
• Carroll B. J., Curtis G. C., Mendels J. Neuroendocrine regulation in depression: I Limbic system-adrenocortical dysfunction. Archives of General Psychiatry 1976; 33: 1039–1044
   PubMed Web of Science ®Google Scholar
• Carroll B. J. Psychiatric disorders and steroids. Neuro-regulators and psychiatric disorders, E. Usdin, D. A. Hamburg, J. D. Barchas. Oxford University Press, New York 1977; 276–283
   Google Scholar
• Cerletti U., Bini L. L'elettroshock. Archives of General Neurology and Psychiatry and Psychoanalysis 1938; 19: 226
   Google Scholar
• Chan-Palay V. Gamma-aminobutyric acid pathways in the cerebellum studied by retrograde and anterograde transport of glutamic acid decarboxylase (GAD) antibody after in vivo injections. Progress in Brain Research 1982; 55: 51–76
   PubMed Web of Science ®Google Scholar
• Chamey D. S., Heninger G. R., Sternberg D. E., Redmond D. E., Leckman J. F., Maas J. W., Roth R. H. Presynaptic adrenergic receptor sensitivity in depression. Archives of General Psychiatry 1981a; 38: 1334–1340
   PubMedGoogle Scholar
• Chamey D. S., Menkes D. B., Heninger G. R. Receptor sensitivity and mechanism of action of antidepressant treatment. Archives of General Psychiatry 1981b; 38: 1160–1180
   PubMed Web of Science ®Google Scholar
• Chamey D. S., Heninger G. R., Sternberg D. E. Serotonin function and mechanism of action of antidepressant treatment. Archives of General Psychiatry 1984; 41: 359–365
   PubMed Web of Science ®Google Scholar
• Chauhan V. P., Kalra V. K. Effect of phospholipid methylation on calcium transport and (Ca++ + Mg++)-ATPase activity in kidney cortex basolateral membranes. Biochimica et Biophysica Acta 1983; 727: 185–195
   PubMedGoogle Scholar
• Chin J. H., Goldstein D. B. Electron paramagnetic resonance studies of ethanol on membrane fluidity. Advances in Experimental Medicine and Biology 1977; 85: 111–122
   Google Scholar
• Chin J. H., Parsons L. M., Goldstein D. B. Increased cholesterol content of erythrocyte and brain membranes in ethanol-tolerant mice. Biochimica et Biophysica Acta 1978; 513: 358–363
   PubMed Web of Science ®Google Scholar
• Chiodo L. A., Antelman S. M. Repeated tricyclics induce a progressive dopamine autoreceptor sub-sensitivity independent of daily drug treatment. Nature 1980a; 287: 451–454
   PubMed Web of Science ®Google Scholar
• Chiodo L. A., Antelman S. M. Electroconvulsive shock: Progressive dopamine autoreceptor subsensitivity independent of repeated treatment. Science 1980b; 210: 799–801
   PubMed Web of Science ®Google Scholar
• Cimino M., Vantini G., Algeri S., Curatola G., Pezzoli C., Stramentinoli G. Age-related modification of dopaminergic and β-adrenergic receptor system: Restoration to normal activity by modifying membrane fluidity with S-adenosyl methionine. Life Sciences 1984; 34: 2029–2039
   PubMed Web of Science ®Google Scholar
• Clements-Jewery S. The development of cortical β-adrenoceptor subsensitivity in the rat by chronic treatment with trazodone, doxepin and mianserin. Neuropharmacology 1978; 17: 779–781
   PubMed Web of Science ®Google Scholar
• Cohen M. R., Pickar D., Extein I., Gold M. S., Sweeney D. R. Plasma Cortisol and β-endorphin immunoreactivity in nonmajor and major depression. American Journal of Psychiatry 1984; 141: 628–632
   PubMed Web of Science ®Google Scholar
• Cohen R. M., Campell I. C, Dauphin M., Tallman J. F., Murphy D. L. Changes in α- and β-receptor densities in rat brain as a result of treatment with monoamine oxidase inhibiting antidepressants. Neuropharmacology 1982a; 21: 293–298
   PubMed Web of Science ®Google Scholar
• Cohen R. M., Ebstein R. P., Daly J. W., Murphy D. L. Chronic effects of a monoamine oxidase-inhibiting antidepressant: Decreases in functional α-adrenergic autoreceptors precede the decrease in norepinephrine-stimulated cyclic adenosine 3′:5′-monophosphate systems in rat brain. Journal of Neurosciences 1982b; 2: 1588–1595
   PubMed Web of Science ®Google Scholar
• Cohn C. K., Dunner D. L., Axelrod J. Reduced catechol-O-methyltransferase activity in red blood cells of depressed women with primary affective disorders. Science 1970; 170: 1323–1324
   PubMed Web of Science ®Google Scholar
• Consolo S., Ladinsky H., Forloni G. L., Grombi P. Modulation of the hippocampal β-adrenoceptor population by lesion of the serotonergic raphe-hippocampal pathway of rats. Life Sciences 1982; 30: 1113–1120
   PubMed Web of Science ®Google Scholar
• Coper H., Fahndrich E., Gelbert A., Helmchen H., Honecker H., Mulleroerlinghausen B., Pietzcker A. Depression and monoamine oxidase. Progress in Neuropsychopharmacology 1979; 3: 441–463
   PubMedGoogle Scholar
• Coppen A., Rama Rao V. A., Ruthven C. R. J., Goodwin B. L., Sandler M. Urinary 4-hydroxy-3-methoxyphenylglycol is not a predictor for clinical response to amitriptyline in depressive illness. Psychopharmacology 1979; 64: 95–97
   PubMed Web of Science ®Google Scholar
• Costa E. Perspectives in the molecular mechanisms of antidepressant action. Typical and atypical antidepressants: Molecular mechanisms, E. Costa, G. Racagni. Raven Press, New York, 21–26
   Google Scholar
• Creese I., Sibley I. Receptor adaptations to centrally acting drugs. Annual Review of Pharmacology and Toxicology 1981; 21: 357–391
   PubMed Web of Science ®Google Scholar
• Crews F. T., Paul S. M., Goodwin F. K. Acceleration of β-receptor desensitization in combined administration of antidepressants and phenoxybenzamine. Nature 1981; 290: 787–789
   PubMed Web of Science ®Google Scholar
• Daiguji M., Meltzer H. Y., Tong C, U'Prichard D. C, Young M., Kravitz H. α2-Adrenergic receptors in platelet membranes of depressed patients: No change in number or 3H-yohimbine affinity. Life Sciences 1981; 29: 2059–2064
   PubMed Web of Science ®Google Scholar
• Davidson J. R. T., McLeod M. N., Turnbull C. D., White H. L., Feuer E. J. Catechol-O-methyltransferase activity and classification of depression. Biological Psychiatry 1979; 14: 937–942
   PubMed Web of Science ®Google Scholar
• Davidson J. R. T., McLeod M. N., Turnbull C. D., White H. L., Feuer E. J. Platelet monoamine oxidase activity and the classification of depression. Archives of General Psychiatry 1980; 37: 771–773
   PubMed Web of Science ®Google Scholar
• Deguchi T., Axelrod J. Superinduction of serotonin N-acetyl-transferase and supersensitivity of adenyl cyclase to catecholamines in denervated pineal gland. Molecular Pharmacology 1973; 9: 612–618
   PubMed Web of Science ®Google Scholar
• Delay J., Laine B., Buisson J. F. Note concernant Taction de 1 'isonicotinylhydrazide dans le traitement des etats depressifs. Annals of Medicine and Psychology 1952; 110: 689
   PubMedGoogle Scholar
• De Montigney C., Aghajanian G. K. Tricyclic antidepressants: Long-term treatment increases responsivity of rat forebrain neurons to serotonin. Science 1978; 202: 1303–1306
   PubMed Web of Science ®Google Scholar
• Depue R. A., Monroe S. M., Shcckman S. L. The psychobiology of human disease: Implications for conceptualizing the depressive disorders. The psychobiology of the depressive disorders: Implications for the effects of stress, R. A. Depue. Academic Press, New York 1979; 3–20
   Google Scholar
• Dumbrille-Ross A., Tang S., Seeman P. High affinity binding of [3H]mianserin to rat cerebral cortex. European Journal of Pharmacology 1980; 68: 395–396
   PubMed Web of Science ®Google Scholar
• Dunner D. L., Cohn C. K., Gershon E. S., Goodwin F. K. Differential catechol-0-methyltransferase activity in unipolar and bipolar illnesses. Archives of General Psychiatry 1971; 25: 348–353
   PubMed Web of Science ®Google Scholar
• Ebstein R., Belmaker R. H., Benbenisty D., Rimon R. Electrophoretic pattern of red blood cell catechol-O-methyltransferase in schizophrenic and manic-depressive illness. Biological Psychiatry 1976; 11: 613–623
   PubMed Web of Science ®Google Scholar
• Eccles J. C. Conduction and synaptic transmission in the nervous system. Annual Review of Physiology 1948; 10: 93–116
   PubMed Web of Science ®Google Scholar
• Ellis E. F., Rosenblum W. I., Birkle D. L., Wright K. F., Traweek D. L., Saady J. J., Choi S. C. The effect of tranylcypromine on levels of 6-keto-PGFi and other prostaglandins in brain and mesentery of the mouse. Artery 1982; 10: 454–464
   PubMedGoogle Scholar
• Enna S. J., Gallagher J. P. Biochemical and electrophysiological characteristics of mammalian GABA receptor. International Reviews of Neurobiology 1983; 24: 181–212
   PubMed Web of Science ®Google Scholar
• Enna S. J., Mann E., Kendal D., Stancel G. M. Effect of chronic antidepressant administration on brain neurotransmitter receptor binding. Antidepressants: Neurochemical, behavioral and clinical perspectives, S. J. Enna, J. B. Malick, E. Richelson. Raven Press, New York 1981; 91–103
   Google Scholar
• Fawcett J. Depression at the biochemical level. Psychiatric Annals 1980; 10: 362–368
   Google Scholar
• Flynn D. D., Kloog Y., Potter L. T., Axelrod J. Enzymatic methylation of the membrane-bound nicotinic acetylcholine receptor. Journal of Biological Chemistry 1982; 257: 9513–9517
   PubMed Web of Science ®Google Scholar
• Friedhoff A. J. Receptor sensitivity modification (RSM)–a new paradigm for the potential treatment of some hormonal and transmitter disturbances. Comprehensive Psychiatry 1977; 18: 309–317
   PubMed Web of Science ®Google Scholar
• Friedman E., Dallob A. Enhanced serotonin receptor activity after chronic treatment with imipramine or amitriptyline. Communications in Psychopharmacology 1979; 3: 89–92
   PubMedGoogle Scholar
• Fries E. D. Mental depression in hypertensive patients treated for long periods with large doses of reserpine. New England Journal of Medicine 1954; 251: 1006–1008
   PubMed Web of Science ®Google Scholar
• Fuxe K., Ogren S.-O., Agnati L. F., Benfenati F., Fredholm B., Andersson K., Zini I., Eneroth P. Chronic antidepressant treatment and central 5-HT synapses. Neuropharmacology 1983; 22: 389–400
   PubMed Web of Science ®Google Scholar
• Gallager D. W., Bunney W. E., Jr. Failure of chronic lithium treatment to block tricyclic anti-depressants-induced 5-HT supersensitivity. Naunyn-Schmiedeberg's Archives for Pharmacology 1979; 307: 129–133
   PubMed Web of Science ®Google Scholar
• Garcia-Sevilla J. A., Zis A., Hollingworth P. J., Greden J. F., Smith C. B. Platelet α2-adrenergic receptors in major depressive disorders. Archives of General Psychiatry 1981; 38: 1327–1333
   PubMedGoogle Scholar
• Gershon E. S. The search for genetic markers in affective disorders. Psychopharmacology: A generation of progress, M. A. Lipton, A. DiMascia, K. F. Killam. Raven Press, New York 1978; 1197–1212
   Google Scholar
• Gershon E. S., Jonas W. Z. Erythrocyte soluble catechol-O-methyltransferase activity in primary affective disorders. Archives of General Psychiatry 1975; 32: 1351–1356
   PubMed Web of Science ®Google Scholar
• Gershon E. S., Bunney W. E., Jr., Leckman J., Van Eerdewegh M., DeBauche B. The inheritance of affective disorders: A review of data and of hypotheses. Behavioral Genetics 1976; 6: 227–261
   PubMed Web of Science ®Google Scholar
• Gershon E. S., Beimaker R. H., Ebstein R., Jonas W. Z. Plasma MAO-activity unrelated to genetic vulnerability to primary affective illness. Archives ofGeneral Psychiatry 1977; 34: 731–734
   PubMed Web of Science ®Google Scholar
• Gold P. W., Ballenger J. C, Weingartner H., Goodwin F. K., Post R. M. Effects of 1-desamo-8-D-arginine vasopressin on behavior and cognition in primary affective disorder. Lancet 1979; 2: 992–994
   PubMed Web of Science ®Google Scholar
• Goodwin F. K., Bunney W. E., Jr. Depressions following reserpine: A re-evaluation. Seminars in Psychiatry 1971; 3: 435–446
   PubMedGoogle Scholar
• Goodwin F. K., Post R. M., Sack R. L. Clinical evidence for neurochemical adaptation to psychotropic drugs. Neurobiological mechanisms of adaptation and behavior, A. J. Mandell. Raven Press, New York 1975; 33–45
   Google Scholar
• Green A. R., Sant K., Bowdler J. M., Cowen P. J. Further evidence for a relationship between changes in GABA concentration in rat brain and enhanced monoamine-mediated behavioral responses following repeated electroconvulsive shock. Neuropharmacology 1982; 21: 981–984
   PubMed Web of Science ®Google Scholar
• Green J. P., Maayani S. Tricyclic antidepressant drugs block histamine Ha receptors in brain. Nature 1977; 269: 163–165
   PubMed Web of Science ®Google Scholar
• Gross G., Brodde O. E., Schumann H. J. Decreased number of adrenoceptors in cerebral cortex of hypothyroid rats. European Journal of Pharmacology 1980; 61: 191–194
   PubMed Web of Science ®Google Scholar
• Heron D., Hershkowitz M., Shinitzky M., Samuel D. The lipid fluidity of synaptic membranes and the binding of serotonin and opiate ligands. Neurotransmitters and their receptors, Y. Dudai, U. Littauer, I. Silman, V. I. Teichberg, Z. Vogel. John Wiley, New York 1980a; 125
   Google Scholar
• Heron D. S., Shinitzky M., Hershkowitz M., Sammuel D. Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes. Proceedings of the National Academy of Sciences U.S.A. 1980b; 77: 7463–7467
   PubMed Web of Science ®Google Scholar
• Heron D., Israel M., Hershkowitz M., Sammuel D. Lipid induced modulation of opiate receptors in mouse brain membranes. European Journal of Pharmacology 1981; 72: 361–364
   PubMed Web of Science ®Google Scholar
• Heron D. S., Shinitzky M., Zamir N., Samuel D. Adaptive modulations of brain membrane lipid fluidity in drug addiction and denervation supersensitivity. Biochemical Pharmacology 1982a; 31: 2435–2438
   PubMed Web of Science ®Google Scholar
• Heron D. S., Shinitzky M., Samuel D. Alleviation of drug withdrawal symptoms by treatment with a potent mixture of natural lipids. European Journal of Pharmacology 1982b; 83: 253–261
   PubMed Web of Science ®Google Scholar
• Hershkowitz M., Heron D. S., Samuel D., Shinitzky M. The modulation of protein phosphorylation and receptor binding in synaptic membranes by changes in lipid fluidity: Implications for aging. Progress in Brain Research 1982; 56: 419–434
   PubMed Web of Science ®Google Scholar
• Hirata F., Axelrod J. Phospholipid methylation and the transmission of biological signals through membranes. Science 1980; 209: 1082–1090
   PubMed Web of Science ®Google Scholar
• Hokin-Neaverson M., Spiegel D. A., Lewis W. C. Deficiency of erythrocyte sodium pump activity in bipolar manic-depressive psychosis. Life Sciences 1974; 15: 1739–1748
   PubMed Web of Science ®Google Scholar
• Holmes R. P., Mahfauz M., Travis B. D., Yoss N. L., Keenan M. J. The effect of membrane lipid composition on the permeability of membranes to Ca2+. Annals of the New York Academy of Science 1983; 414: 44–50
   PubMed Web of Science ®Google Scholar
• Honegger U. E-, Roscher A. A., Wiesmann U. N. Evidence for lysosomotropic action of des-ipramine in cultured human fibroblasts. Journal of Pharmacology and Experimental Therapeutics 1983; 225: 436–441
   PubMed Web of Science ®Google Scholar
• Hornykiewicz O. Brain catecholamines in schizophrenia–a good case for noradrenaline. Nature 1982; 299: 484–486
   PubMed Web of Science ®Google Scholar
• Houslay M. D., Stanley K. K. Dynamics of biological membranes: Influence of synthesis, structure and function. Wiley, New York 1982
   Google Scholar
• Houslay M. D., Gordon L. M. The activity of adenylate cyclase is regulated by the nature of its lipid environment. Current Topics in Membrane Transport 1983; 18: 179–231
   Web of Science ®Google Scholar
• Hughes J. Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine. Brain Research 1975; 88: 295–308
   PubMed Web of Science ®Google Scholar
• Hughes J., Smith T. W., Kosterlitz H. W., Fothergill L., Morgan B. A., Morris H. R. Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 1975a; 258: 577–579
   PubMed Web of Science ®Google Scholar
• Hughes J., Smith T., Morgan B., Fothergill L. Purification and properties of enkephalin–the possible endogenous ligand for the morphine receptor. Life Sciences 1975b; 16: 1753–1758
   PubMed Web of Science ®Google Scholar
• Hullin R. P. Biochemistry of affective disorders. Journal of International Medical Research 1977; 5: 140–145
   PubMed Web of Science ®Google Scholar
• Jahr C. E., Nicoll R. A. Noradrenergic modulation of dendrodendritic inhibition in the olfactory bulb. Nature 1982; 297: 227–229
   PubMed Web of Science ®Google Scholar
• Janowsky A., Steranka L. R., Gillespie D. D., Sulser F. Role of neuronal signal input in the down-regulation of central noradrenergic receptor function by antidepressant drugs. Journal of Neurochemistry 1982; 39: 290–292
   PubMed Web of Science ®Google Scholar
• Jimmerson D. C, Post R. M., Stoddard F. R., Gillin J. C, Bunney W. E., Jr. Preliminary trial of the noradrenergic agonist clonidine in psychiatric patients. Biological Psychiatry 1980; 15: 45–57
   PubMed Web of Science ®Google Scholar
• Johnson D. A., Cooke R., Loh H. H. Effect of opiate agonists and antagonists on lipid fluidity. Molecular Pharmacology 1979a; 16: 154–162
   PubMed Web of Science ®Google Scholar
• Johnson D. A., Lee N. M., Cooke R. Adaptation to ethanol- induced fluidization of brain lipid bilayers. Drug and Alcohol Dependence 1979b; 4: 197–202
   PubMed Web of Science ®Google Scholar
• Johnson R. W., Reisine T., Spotnitz S., Wiech N., Ursillo R., Yamamura H. I. Effects of desipramine and yohimbine on α2 and α1 adrenoreceptor sensitivity. European Journal of Pharmacology 1980; 67: 123–127
   PubMed Web of Science ®Google Scholar
• Kafka M. S., Wirz-Justice A., Naber D., Wehr T. A. Orcadian acetylcholine receptor rhythm in rat brain and its modification by imipramine. Neuropharmacology 1981; 20: 421–425
   PubMed Web of Science ®Google Scholar
• Kandei E. R., Schwartz J. H. Molecular biology of learning: Modulation of transmitter release. Science 1982; 218: 433–443
   PubMed Web of Science ®Google Scholar
• Kanno K., Sasaki Y. Interaction of psychotropic drugs with phospholipids. Biochemical Pharmacology 1982; 31: 2977–2981
   PubMed Web of Science ®Google Scholar
• Kanof P. D., Greengard P. Brain histamine receptor as targets for antidepressant drugs. Nature 1978; 272: 329–333
   PubMed Web of Science ®Google Scholar
• Karliner J. S., Motulsky H. J., Insel P. A. Apparent “down- regulation” of human platelet alpha2-adrenergic receptors is due to retained agonist. Molecular Pharmacology 1982; 21: 36–43
   PubMed Web of Science ®Google Scholar
• Katz B., Thesleff S. A study of desensitization produced by acetylcholine at the motor endpiate. Journal of Physiology (London) 1957; 138: 63–80
   PubMed Web of Science ®Google Scholar
• Kellar K. J., Cascio C. S., Bergstrom D. A., Butler J. A., Iadarola P. Electroconvulsive shock and reserpine: Effects on β-adrenergic receptors in rat brain. Journal of Neurochemistry 1981; 37: 830–836
   PubMed Web of Science ®Google Scholar
• Kimelberg H. K. The influence of membrane fluidity on the activity of membrane-bound enzymes. Dynamic aspects of cell surface organization, G. Poste, G. L. Nicolson. Elsevier, Amsterdam 1977; 205–293
   Google Scholar
• Kinnier W. J., Chuang D.-M., Gwynn G., Costa E. Characteristics and regulation of high affinity [3H]imipramine binding to rat hippocampal membranes. Neuropharmacology 1981; 20: 411–419
   PubMed Web of Science ®Google Scholar
• Kline N. S. Present status of psychopharmacological research hearings before the subcommittee on appropriations. U.S. Government Printing Office, Washington, D.C. 1957, US Senate, 85 Congress First Session on H. R. 6287
   Google Scholar
• Koide T., Matsushita H. An enhanced sensitivity of muscarinic cholinergic receptor associated with dopaminergic receptor subsensitivity after chronic antidepressant treatment. Life Sciences 1981; 28: 1139–1145
   PubMed Web of Science ®Google Scholar
• Koss M. C., Christensen H. D. Evidence for central post-synaptic action of clonidine. Naunyn-Schmiedeberg's Archives for Pharmacology 1979; 307: 45–50
   PubMed Web of Science ®Google Scholar
• Kufferle B., Grunberger J. Early clinical double-blind study with S-adenosyl-L-methionine: A new potential antidepressant. Typical and atypical antidepressants: Clinical practice, E. Costa, G. Racagni. Raven Press, New York 1982; 175–180
   Google Scholar
• Kuhn R. The treatment of depressive states with G-22355 (Imipramine Hydrochloride). American Journal of Psychiatry 1958; 115: 459–464
   PubMed Web of Science ®Google Scholar
• Langer S. Z., Briley M. S., Raisman R., Henery J. F., Morselli P. L. Specific 3H-imipramine binding in human platelets: Influence of sex and age. Naunyn-Schmiedeberg's Archives for Pharmacology 1980; 313: 189–194
   PubMed Web of Science ®Google Scholar
• Langer S. Z., Raisman R. Binding of [3H]imipramine and [3H] desipramine as biochemical tools for studies in depression. Neuropharmacology 1983; 22: 407–413
   PubMed Web of Science ®Google Scholar
• Leckman J. E., Gershon E. S., Nichols A. S., Murphy D. L. Reduced MAO-activity in first degree relatives of individuals with bipolar affective disorders. Archives of General Psychiatry 1977; 34: 601–606
   PubMed Web of Science ®Google Scholar
• LeFur G., Phan T., Burgevin M. C, Flamier A., Mitrani N., Marquis F., Lozefczak F., Uzan A. A subacute treatment with 1- methionine induces an increase in the number of 3H-spiperone binding sites in the striatum of the rat. Life Sciences 1983; 32: 2321–2328
   PubMed Web of Science ®Google Scholar
• Littleton I. M. Cell-membrane lipids in ethanol-tolerance and -dependence. Biochemistry Society Transactions 1983; 11: 61–62
   PubMed Web of Science ®Google Scholar
• Long J. B., Youngblood W. Y., Kizer J. S. Regional differences in the response of serotonergic neurons in rat CNS to drugs. European Journal of Pharmacology 1983; 88: 89–97
   PubMed Web of Science ®Google Scholar
• Loomer H. P., Saunders J. C., Kline N. S. A clinical and pharmacodynamic evaluation of iproniazid as a psychic energizer. American Psychiatric Association Psychiatric Research Reports 1957; 8: 129
   PubMedGoogle Scholar
• Maas J. W., Hattox S. E., Green N. M., Landis D. H. 3-Methoxy- 4-hydroxyphenethyleneglygol production by human brain in vivo. Science 1979; 205: 1025–1027
   PubMed Web of Science ®Google Scholar
• Maeda K., Kato U., Ohgo S., Chihara K. Growth hormone and prolactin release after injection of TRH in patients with depression. Journal of Clinical Endocrinology and Metabolism 1975; 40: 501–505
   PubMed Web of Science ®Google Scholar
• Maggi A., U'Prichard D. C., Enna S. I. Differential effects of antidepressant treatment on brain monoaminergic receptors. European Journal of Pharmacology 1980; 61: 91–98
   PubMed Web of Science ®Google Scholar
• Maley B., Elde R. The ultrastructural localization of serotonin immunoreativity within the nucleus of the solitary tract of the cat. Journal of Neuroscience 1982; 2: 1499–1506
   PubMed Web of Science ®Google Scholar
• Mandell A. J., Knapp S. A neurobiological model for the symmetrical prophylactic action of lithium in bipolar affective disorder. Pharmakopsychiatria 1976; 9: 116–126
   Google Scholar
• Mann E., Enna S. J. Neurochemical and behavioral correlates of antidepressant drug action. Life Sciences 1982; 30: 1653–1661
   PubMed Web of Science ®Google Scholar
• Maura G., Gemignani A., Raiteri M. Noradrenaline inhibits central serotonin release through alpha2-adrenoceptors located on serotonergic nerve terminals. Naunyn-Schmiedeberg's Archives for Pharmacology 1982; 320: 272–274
   PubMed Web of Science ®Google Scholar
• McGeer P. L., McGeer E. G. Chemistry of mood and emotion. Annual Review of Psychology 1980; 31: 273–307
   PubMed Web of Science ®Google Scholar
• McNamara J. O. Selective alterations of regional /3-adrenergic receptor binding in the kindling model of epilepsy. Experimental Neurology 1978; 61: 582–591
   PubMed Web of Science ®Google Scholar
• Mendels J., Frazer A. Alternations in cell membrane activity in depression. American Journal of Psychiatry 1974; 131: 1240–1246
   PubMed Web of Science ®Google Scholar
• Menkes D. B., Aghajanian G. K., Gallager D. W. Chronic antidepressant treatment enhancesagonist affinity of brain α1 adrenoceptors. European Journal of Pharmacology 1983; 87: 35–41
   PubMed Web of Science ®Google Scholar
• Meyerson L. R., Wennogie L. P., Abel M. S., Coupet J., Lippa A. S., Rauh C. E., Beer B. Human brain receptor alterations in suicide victims. Pharmacology Biochemistry and Behavior 1982; 17: 159–163
   PubMed Web of Science ®Google Scholar
• Mishra R., Janowsky A., Sulser F. Action of mianserin and zimelidine on the norepinephrine receptor coupled adenylate cyclase system in brain: Subsensitivity without reduction in β-adrenergic receptor binding. Neuropharmacology 1980; 19: 983–987
   PubMed Web of Science ®Google Scholar
• Mogilnicka E., Arbilla S., Depoortere H., Langer S. Z. Rapid- eye-movement sleep deprivation decreases the density of 3H-dihydroalprenolol and 3H-imipramine binding sites in the rat cerebral cortex. European Journal of Pharmacology 1980; 65: 289–292
   PubMed Web of Science ®Google Scholar
• Mohler H., Okada T. Benzodiazepine receptor: Demonstration in the central nervous system. Science 1977; 198: 849–851
   PubMed Web of Science ®Google Scholar
• Moore R. Y., Bloom F. E. Central catecholamine neuron systems: Anatomy and physiology of the norepinephrine and epinephrine systems. Annual Review of Neuroscience 1979; 2: 113–168
   PubMed Web of Science ®Google Scholar
• Muller J. C, Pryor W. W., Gibbons J. E., Orgain E. S. Depressions and anxiety during Rauwolfia therapy. Journal of the American Medical Association 1955; 159: 836–840
   PubMed Web of Science ®Google Scholar
• Murphy D. L., Belmaker R., Wyatt R. J. Monoamine oxidase in schizophrenia and other behavioral disorders. Journal of Psychiatry Research 1974; 11: 221–247
   PubMed Web of Science ®Google Scholar
• Naber D., Wirz-Justice A., Kafka M. S., Wehr T. A. Dopamine receptor binding in rat striatum : Ultradian rhythm and its modification by chronic imipramine. Psychopharmacology 1980; 68: 1–5
   PubMed Web of Science ®Google Scholar
• Naylor G. J., Smith A. H. Defective genetic control of sodium- pump density in manic depressive psychosis. Psychological Medicine 1981; 11: 257–263
   PubMed Web of Science ®Google Scholar
• Nies A., Robinson D. S., Ravaris C. L., Davis J. M. Amines and monoamine oxidase in relation to aging and depression. Psychosomatic Medicine 1971; 33: 470, (Abstract).
   Web of Science ®Google Scholar
• O'Brien R. A., Spirit N. M., Horst W. D. Antidepressant receptor binding in brain. Society of Neuroscience 1978, Abstract 136.6
   Google Scholar
• Olpe H.-R. Differential effects of clomipramine and clorgyline on the sensitivity of cortical neurons to serotonin: Effect of chronic treatment. European Journal of Pharmacology 1981; 69: 375–377
   PubMed Web of Science ®Google Scholar
• Palkovits M., Raisman R., Briley M., Langer S. Z. Regional distribution of [3H]imipramine binding in rat brain. Brain Research 1981; 210: 493–498
   PubMed Web of Science ®Google Scholar
• Pare C. M. B., Sandler M. J. A clinical and biochemical study of a trial of iproniazid in the treatment of depression. Journal of Neurology, Neurosurgery and Psychiatry 1959; 22: 247–251
   PubMed Web of Science ®Google Scholar
• Passarelli F., de Carolis Scotti A. Effects of chronic treatment with imipramine on the behavioral and electroencephalographic modifications induced by clonidine in the rat. Neuropharmacology 1982; 21: 591–593
   PubMed Web of Science ®Google Scholar
• Paul S. M., Rehavi M., Skolnik P., Ballenger J. C., Goodwin F. K. Depressed patients have decreased binding of tritiated imipramine to platelet serotonin “transporter”. Archives of General Psychiatry 1981; 38: 315–317
   Web of Science ®Google Scholar
• Peroutka S. J., Snyder S. H. Multiple serotonin receptors: Differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol. Molecular Pharmacology 1979; 16: 687–699
   PubMed Web of Science ®Google Scholar
• Peroutka S. J., Snyder S. H. Long-term antidepressant treatment lowers spiroperidol-labeled serotonin receptors. Science 1980a; 21: 88–90
   Google Scholar
• Peroutka S. J., Snyder S. H. Regulation of serotonin (5-HT2) receptors labeled with [3H]spiroperidol by chronic treatment with the antidepressant amitriptyline. Journal of Pharmacology and Experimental Therapeutics 1980b; 215: 582–587
   PubMed Web of Science ®Google Scholar
• Peroutka S. J., Snyder S. H. [3H]mianserin: Differential labeling of serotonina and histamine1 receptors in rat brain. Journal of Pharmacology and Experimental Therapeutics 1981; 216: 142–148
   PubMed Web of Science ®Google Scholar
• Peroutka S. J., Lebovitz R. M., Snyder S. H. Two distinct central serotonin receptors with different physiological functions. Science 1981; 212: 827–829
   PubMed Web of Science ®Google Scholar
• Perry E. K., Marshall E. F., Blessed G., Tomlinson B. E., Perry R. H. Decreased imipramine binding in the brains of patients with depressive illness. British Journal of Psychiatry 1983; 142: 188–192
   PubMed Web of Science ®Google Scholar
• Pert C. B., Snyder S. H. Opiate receptor: Demonstration in nervous tissue. Science 1973; 179: 1011–1014
   PubMed Web of Science ®Google Scholar
• Pilc A., Vetulani J. Attenuation by chronic imipramine treatment of [3H]clonidine binding to cortical membranes and of clonidine-induced hypothermia: The influence of central chemo-sympathectomy. Brain Research 1982; 238: 499–504
   PubMed Web of Science ®Google Scholar
• Plenge P., Mellerup E. T. 3H-imipramine high affinity binding sites in rat brains: Effects of imipramine and lithium. Psychopharmacology 1982; 77: 94–97
   PubMed Web of Science ®Google Scholar
• Post R. M., Kotin J., Goodwin F. K. The effects of cocaine on depressed patients. American Journal of Psychiatry 1974; 131: 511–517
   PubMed Web of Science ®Google Scholar
• van Praag H. M. The significance of biochemical factors in the diagnosis of depressions: I Biochemical variables. Comprehensive Psychiatry 1982; 23: 124–135
   PubMed Web of Science ®Google Scholar
• van Praag H. M., de Haan S. Depression vulnerability and 5-hydroxytryptophan prophylaxis. Psychiatric Research 1980; 3: 75–83
   PubMed Web of Science ®Google Scholar
• van Praag H. M., Korf J. Endogenous depressions with and without disturbances in 5-hydroxy-tryptamine metabolism: A biochemical classification. Psychopharmacology 1971; 19: 148–152
   PubMedGoogle Scholar
• Racagni G., Mocchetti I., Caldfrini G., Battistella A., Brunello N. Temporal sequence of changes in central noradrenergic system of rat after prolonged antidepressant treatment: Receptor densitization and neurotransmitter interactions. Neuropharmacology 1983; 22: 415–424
   PubMedGoogle Scholar
• Rainbow T. C, Biegon A., McEwen B. S. Autoradiographic localization of imipramine binding in rat brain. European Journal of Pharmacology 1982; 77: 363–364
   PubMed Web of Science ®Google Scholar
• Raisman R., Briley M., Langer S. Z. Specific tricyclic antidepressant binding sites in rat brain. Nature 1979a; 281: 148–150
   PubMed Web of Science ®Google Scholar
• Raisman R., Briley M., Langer S. Z. High-affinity 3H- imipramine binding in rat cerebral cortex. European Journal of Pharmacology 1979b; 54: 307–308
   PubMed Web of Science ®Google Scholar
• Raisman R., Briley M. S., Langer S. Z. Specific tricyclic antidepressant binding sites in rat brain characterized by high affinity 3H-imipramine binding. European Journal of Pharmacology 1980; 61: 373–380
   PubMed Web of Science ®Google Scholar
• Raisman R., Briley M. S., Langer S. Z., Sechter D., Zarifian E. High affinity 3H-imipramine binding in platelets from healthy volunteers and untreated and treated depressed patients. Psychopharmacology 1981; 75: 368–371
   PubMed Web of Science ®Google Scholar
• Raisman R., Briley M. S., Bouchani F., Sechter D., Zarifian E., Langer S. Z. 3H-imipramine binding and serotonin uptake in platelets from untreated depressed patients and control volunteers. Psychopharmacology 1982; 77: 332–335
   PubMed Web of Science ®Google Scholar
• Raiteri M., Maura G., Versace P. Functional evidence for two steroechemically different alpha-2 adrenoceptors regulating central norepinephrine and serotonin release. Journal of Pharmacology and Experimental Therapeutics 1982; 224: 679–684
   Web of Science ®Google Scholar
• Ramsey T. A., Frazer A., Mendels J. Plasma and erythrocyte cations in affective illness. Neuro-psychobiology 1979; 5: 1–10
   Google Scholar
• Rehavi M., Sokolovsky M. Multiple binding sites of tricyclic antidepressant drugs to mammalian brain receptors. Brain Research 1978; 149: 525–529
   PubMed Web of Science ®Google Scholar
• Rehavi M., Ramot O., Yavetz B., Sokolovsky M. Amitriptyline: Long-term treatment elevates a-adrenergic and muscarinic receptor binding in mouse brain. Brain Research 1980; 194: 443–453
   PubMed Web of Science ®Google Scholar
• Reid R. L., Yen S. S. Premenstrual syndrome. American Journal of Obstetrics and Gynecology 1980; 139: 85–104
   Web of Science ®Google Scholar
• Reinhard J. F., Roth R. H. Noradrenergic modulation of serotonin synthesis and metabolism: 1. Inhibition by clonidine in vivo. Journal of Pharmacology and Experimental Therapeutics 1982; 221: 541–546
   PubMed Web of Science ®Google Scholar
• Reisine T., Soubrie P. Loss of rat cerebral cortical opiate receptors following chronic desipramine treatment. European Journal of Pharmacology 1982; 77: 39–44
   PubMed Web of Science ®Google Scholar
• Richardson J. S., Cowan N., Hartman R., Jacobowitz D. M. On the behavioral and neurochemical actions of 6-hydroxydopa and 5, 6-dihydroxytryptamine in rats. Research Communications in Chemical Pathology and Pharmacology 1974; 8: 29–45
   PubMedGoogle Scholar
• Richelson E. Tricyclic antidepressants block histamine Hi receptors of mouse neuroblastoma cells. Nature 1978; 274: 176
   PubMed Web of Science ®Google Scholar
• Risch S. C, Kalin N. H., Murphy D. L. Pharmacological challenge strategies: Implications for neurochemical mechanisms in affective disorders and treatment approaches. Journal of Clinical Psychopharmacology 1981; 1: 238–243
   PubMed Web of Science ®Google Scholar
• Ritzmann R. F., Springer A. Age differences in brain sensitivity and tolerance to ethanol in mice. Age 1980; 3: 15
   Google Scholar
• Rosenblatt J. E., Pert C. B., Tallman J. F., Pert A., Bunney W. E., Jr. The effect of imipramine and lithium on a- and /8-receptor binding in rat brain. Brain Research 1979; 160: 186–191
   PubMed Web of Science ®Google Scholar
• Rubinow D. R., Post R. M., Gold P. W. Cortisol hypersecretion and cognitive impairment in depression. Archives of General Psychiatry 1984; 41: 279–283
   PubMed Web of Science ®Google Scholar
• Sachar E. J., Baron M. The biology of affective disorders. Annual Review of Neuroscience 1979; 2: 505–518
   PubMed Web of Science ®Google Scholar
• Savage D. D., Frazer A., Mendels J. Differential effects of monoamine oxidase inhibitors and serotonin reuptake inhibitors on 3H-serotonin receptor binding in rat brain. European Journal of Pharmacology 1979; 58: 87–88
   PubMed Web of Science ®Google Scholar
• Savage D. D., Mendels J., Frazer A. Decrease in [3H]-serotonin binding in rat brain produced by the repeated administration of either monoamine oxidase inhibitors or centrally acting serotonin agonists. Neuropharmacology 1980; 19: 1063–1070
   PubMed Web of Science ®Google Scholar
• Schildkraut J. J. Catecholamine hypothesis of affective disorders: Review of supporting evidence. American Journal of Psychiatry 1965; 122: 509–522
   PubMed Web of Science ®Google Scholar
• Schildkraut J. J., Kety S. S. Biogenic amines and emotions. Science 1967; 156: 21–30
   PubMed Web of Science ®Google Scholar
• Schildkraut J. J., Orsulak P. J., Schatzberg A. F., Gudeman J. E., Cole J. O., Rohde W. A., LaBrie R. A. Towards a biochemical classification of depressive disorders. I: Difference in urinary MHPG and other catecholamine metabolites in clinically defined subtypes of depression. Archives of General Psychiatry 1978; 35: 1427–1433
   PubMed Web of Science ®Google Scholar
• Schottstaedt W. W., Grace W. J., Wolff H. G. Life situations, behavior attitudes, emotions and renal excretion of fluid and electrolytes. IV: Situations associated with retention of water, sodium and potassium. Journal of Psychosomatic Research 1956; 1: 287–291
   PubMed Web of Science ®Google Scholar
• Scott J. A., Crews F. T. Rapid decrease in rat brain beta adrenergic receptor binding during combined antidepressant a2 antagonist treatment. Journal of Pharmacology and Experimental Therapeutics 1983; 224: 640–646
   PubMed Web of Science ®Google Scholar
• Sedvall G., Fryo B., Gullberg B. Relationships in healthy volunteers between concentration of monoamine metabolites in cerebrospinal fluid and family history of psychiatric morbidity. British Journal of Psychiatry 1980; 136: 366–374
   PubMed Web of Science ®Google Scholar
• Segal D. S., Kuczenski R., Mandell A. Theoretical implications of drug-induced adaptive regulation for a biogenic amine hypothesis of affective disorder. Biological Psychiatry 1974; 9: 147–159
   PubMed Web of Science ®Google Scholar
• Segal M. Serotonergic innervation of the locus coeruleus from the dorsal raphe and its action of responses to noxious stimuli. Journal of Physiology (London) 1979; 286: 401–415
   PubMed Web of Science ®Google Scholar
• Segal M. Regional differences in neuronal response to 5-HT: Intracellular studies in hippocampal slices. Journal of Physiology (Paris') 1981a; 77: 373–375
   PubMedGoogle Scholar
• Segal M. The action of serotonin in the rat hippocampus. Serotonin: Current aspects of neurochemistry and function, B. Haber, S. Gabay, M. R. Issidorides, S. G.A. Alivisatos. Plenum Press, New York 1981b; 375–390
   Google Scholar
• Segawa T., Mituta T., Nomura Y. Modifications of central 5-hydroxytryptamine binding sites in synaptic membranes from rat brain after long-term administration of tricyclic antidepressants. European Journal of Pharmacology 1979; 58: 75–83
   PubMed Web of Science ®Google Scholar
• Serra G., Argiolas F., Fadda F., Gessa G. L. Hyposensitivity of dopamine “autoreceptors” induced by chronic administration of tricyclic antidepressants. Pharmacological Research Communications 1980; 12: 619–624
   PubMedGoogle Scholar
• Sette M., Raisman R., Briley M, Langer S. Z. Localization of tricyclic antidepressant binding sites on serotonin nerve terminals. Journal of Neurochemistry 1981; 37: 40–42
   PubMed Web of Science ®Google Scholar
• Sgaragli G. P., Corte L. D., Gremigni D. Chlorimipramine-induced phospholipidosis: Biochemical and pharmacokinetic observations in the rat. Pharmacological Research Communications 1983; 15: 231–246
   PubMedGoogle Scholar
• Shinitzky M., Barenholz Y. Fluidity parameters of lipid regions determined by fluorescence polarization. Biochimica et Biophysica Acta 1978; 515: 367–394
   PubMed Web of Science ®Google Scholar
• Shopsin B., Wilk S., Gershon S., RofTman M., Goldstein M. Collaborative psychopharma-cologic studies exploring catecholamine metabolism in psychiatric disorders. Frontiers in catecholamine research, E. Usdin, S. Snyder. Pergamon Press, New York 1974; 1173–1179
   Google Scholar
• Shore P. A., Brodie B. B. Influence of various drugs on serotonin and norepinephrine in the brain. Psychotropic drugs, S. Garattini, U. Ghetti. Elsevier, Amsterdam 1957; 423–427
   Google Scholar
• Shore P. A., Silver S. L., Brodie B. B. Interaction of reserpine, serotonin and lysergic acid diethylamide in brain. Science 1955; 122: 284–285
   PubMed Web of Science ®Google Scholar
• Siever L. J., Cohen R. M., Murphy D. L. Antidepressants and α2 adrenergic autoreceptor desensitization. American Journal of Psychiatry 1981; 138: 681–682
   PubMed Web of Science ®Google Scholar
• Siever L. J., Uhde T. W. New studies and perspectives on the noradrenergic receptor system in depression: Effects of the α2-adrenergic agonist clonidine. Biological Psychiatry 1984; 19: 131–156
   PubMed Web of Science ®Google Scholar
• Silverman J. S., Silverman J. A., Eardley D. A. Do maladaptive attitudes cause depression?. Archives of General Psychiatry 1984; 41: 28–30
   PubMed Web of Science ®Google Scholar
• Simon E. J., Hiller J. M., Edeiman I. Stereospecific binding of the potent narcotic analgesic [3H]etorphine to rat-brain homogenate. Proceedings of the National Academy of Science U.S.A. 1973; 70: 1947–1949
   PubMed Web of Science ®Google Scholar
• Sjoerdsma A., Smith T. E., Stevenson T. D., Udenfriend S. Metabolism of 5-hydroxytryptamine (serotonin) by monoamine oxidase. Proceedings of the Society of Experimental Biology and Medicine 1955; 89: 36–38
   PubMed Web of Science ®Google Scholar
• Smith C. B., Garcia-Sevilla J. A., Hollingsworth P. J. α2-adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant treatment. Brain Research 1981; 210: 413–418
   PubMed Web of Science ®Google Scholar
• Snyder S. H. Receptors, neurotransmitters and drug responses. New England Journal of Medicine 1979; 300: 465–472
   PubMed Web of Science ®Google Scholar
• Spyraki C., Fibiger H. C. Functional evidence of subsensitivity of noradrenergic α2 receptors after chronic despiramine treatment. Life Sciences 1980; 27: 1863–1867
   PubMed Web of Science ®Google Scholar
• Squires R. F., Braestrup C. Benzodiazepine receptors in rat brain. Nature 1977; 266: 732–734
   PubMed Web of Science ®Google Scholar
• Stanbury J. B., Wyngaarden J. B., Fredrickson D. S. The metabolic basis of inherited disease. McGraw-Hill, New York 1978
   Google Scholar
• Stanley M., Virgilio J., Gershon S. Tritiated imipramine binding sites are decreased in frontal cortex of suicides. Science 1982; 216: 1337–1339
   PubMed Web of Science ®Google Scholar
• Stone E. A., Piatt J. E. Brain adrenergic receptors and resistance to stress. Brain Research 1982; 237: 405–414
   PubMed Web of Science ®Google Scholar
• Stone T. W., Taylor D. A. Antidepressant drugs potentiate suppression by adenosine of neuronal firing in rat cerebral cortex. Neuroscience Letters 1979; 11: 93–97
   PubMed Web of Science ®Google Scholar
• Sulser F. New perspectives on the mode of action of antidepressant drugs. Trends in Pharmacological Sciences 1979; 1: 92–94
   Web of Science ®Google Scholar
• Sulser F., Janowsky A. J., Okada F., Manier D. H., Mobley P. L. Regulation of the recognition and action function of the norepinephrine (NE) receptor-coupled adenylate cyclase system in brain: Implications for the therapy of depression. Neuropharmacology 1983; 22: 425–431
   PubMed Web of Science ®Google Scholar
• Sulser F., Vetulani J. The noradrenergic cyclic AMP generating system in the limbic forebrain: A functional postsynaptic norepinephrine receptor system and its modification by drugs which either precipitate or alleviate depression. Models in psychiatry and neurology, E. Usdin, I. Hanin. Pergamon Press, New York 1977; 189–199
   Google Scholar
• Suranyi-Cadotte B. E., Wood P. L., Vasavan-Nair N. P., Schwartz G. Normalization of platelet 3[H] imipramine binding in depressed patients during remission. European Journal of Pharmacology 1982; 85: 357–358
   PubMed Web of Science ®Google Scholar
• Svensson J. H., Usdin R. Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: Receptor mediation. Science 1978; 202: 1089–1091
   PubMed Web of Science ®Google Scholar
• Tran V. T., Lebovitz R, Toll L., Snyder S. H. [3H]Doxepin interactions with histamine Hi-receptor and other sites in guinea pig and rat brain homogenates. European Journal of Pharmacology 1981; 70: 501–509
   PubMed Web of Science ®Google Scholar
• Traskman L., Asberg M., Bertilsson L. Monoamine metabolite in CSF and suicidal behavior. Archives of General Psychiatry 1981; 38: 631–636
   PubMed Web of Science ®Google Scholar
• U'Prichard D. C, Greenberg D. A., Sheehan P. P., Snyder S. H. Tricyclic antidepressants: Therapeutic properties and affinity for α-noradrenergic receptor binding sites in the brain. Science 1978; 199: 197–198
   PubMed Web of Science ®Google Scholar
• U'Prichard D. C, Bechtel W. D., Rouot B. M., Snyder S. H. Multiple apparent alpha noradrenergic receptor binding sites in rat brain: Effects of 6-hydroxydopamine. Molecular Pharmacology 1979; 16: 47–60
   PubMed Web of Science ®Google Scholar
• van Zwieten P. A., Timmermans P. B. The role of central a-adrenoreceptors in the mode of action of hypotensive drugs. Trends in Pharmacological Sciences 1979; 1: 39–44
   Web of Science ®Google Scholar
• Vetulani J., Suiser F. Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain. Nature 1975; 257: 495–496
   PubMed Web of Science ®Google Scholar
• Vetulani J., Stawarz R. J., Suiser F. Adaptive mechanism of the noradrenergic cyclic AMP generating system in limbic forebrain of the rat: Adaptation to persistent changes in the availability of norepinephrine. Journal of Neurochemistry 1976a; 27: 661–666
   PubMed Web of Science ®Google Scholar
• Vetulani J., Stawarz R. J., Dingell J. U., Suiser F. A possible mechanism of action of antidepressant treatments. Naunyn-Schmeideberg's Archives of Pharmacology 1976b; 293: 109–114
   PubMed Web of Science ®Google Scholar
• Wagner H. R., Davies J. N. Decreased β-adrenergic responses in the female rat brain are eliminated by ovariectomy: Correlation of 3[H]dihydroalprenoloI binding and catecholamine stimulated cyclic AMP levels. Brain Research 1980; 201: 235–239
   PubMed Web of Science ®Google Scholar
• Wang R. Y., Aghajanian G. K. Correlative firing patterns of serotonergic neurons in rat dorsal raphe nucleus. Journal of Neuroscience 1982; 2: 11–16
   PubMed Web of Science ®Google Scholar
• Weiner N. Multiple factors regulating the release of norepinephrine consequent to nerve stimulation. Federation Proceedings 1979; 38: 2193–2202
   PubMedGoogle Scholar
• Weissman M. M., Gershon E. S., Kidd K. K., Prusoff B. A., Leckman J. F., Dibble E., Hamovit J., Thompson W. D., Pauls D. L., Guroff J. J. Psychiatric disorders in the relatives of probands with affective disorders. Archives of General Psychiatry 1984; 41: 13–21
   PubMed Web of Science ®Google Scholar
• Williams M., Risley E. A., Robinson J. L. Chronic in vivo treatment with desmethylimipramine and mianserin does not alter adenosine A-1 radioligand binding in rat cortex. Neuroscience Letters 1983; 35: 47–51
   PubMed Web of Science ®Google Scholar
• Willner P. Dopamine and depression: A review of recent evidence. I. Empirical studies. Brain Research Reviews 1983a; 6: 211–224
   Google Scholar
• Willner P. Dopamine and depression: A review of recent evidence. II. Theoretical approaches. Brain Research Reviews 1983b; 6: 225–236
   Google Scholar
• Willner P. Dopamine and depression: A review of recent evidence. III. The effects of antidepressant treatments. Brain Research Reviews 1983c; 6: 237–246
   Google Scholar
• Winokur G. Genetic markers in depressive disorders. Progress in Neuro-Psychopharmacology 1979; 3: 625–630
   PubMedGoogle Scholar
• Wirz-Justice A., Krauchi K., Morimasa T., Willener R., Feer H. Orcadian rhythm of [3H] imipramine binding in the rat suprachiasmatic nuclei. European Journal of Pharmacology 1983; 87: 331–333
   PubMed Web of Science ®Google Scholar
• Wolf W. A., Kuhn D. M., Lovenberg W. Blood pressure responses to local application of serotonergic agents in the nucleus tractus solitarii. European Journal of Pharmacology 1981; 69: 291–299
   PubMed Web of Science ®Google Scholar
• Wong D. L., Zager E. L., Ciaranello R. D. Effects of hypophysectomy and dexamethasone administration on central and peripheral S-adenosylmethionine levels. Journal of Neuroscience 1982; 2: 758–764
   PubMed Web of Science ®Google Scholar
• Wood K., Coppen A. α2-adrenergic receptors in depression. Lancet 1982; 1: 1121–1122
   PubMedGoogle Scholar
• Woodward D. J., Moises H. C, Waterhouse B. D., Hoffer B. J., Freedman R. Modulatory actions of norepinephrine in the central nervous system. Federation Proceedings 1979; 38: 2109–2116
   PubMedGoogle Scholar
• Woolley D. W., Shaw E. Some neurophysiological aspects of serotonin. British Medical Journal 1954; 2: 122–126
   PubMed Web of Science ®Google Scholar
• Yasuhara H., Matsuo H., Sakamoto K., Ueda I. Mechanism of membrane stabilizing and lytic effects of tricyclic antidepressants. Japanese Journal of Pharmacology 1980; 30: 397–401
   PubMedGoogle Scholar
• Yoshioka T., Inoue H., Hotta Y. Defective phospholipid metabolism in the retinular cell membrane of norpA (no receptor potential) visual transduction mutants of Drosophila. Biochemical and Biophysical Research Communications 1983; 111: 567–573
   PubMed Web of Science ®Google Scholar
• Zeller E. M., Barsky J. In vivo inhibition of liver and brain monoamine oxidase by 1-isonicotinyl- 2-isopropyl hydrazine. Proceedings of the Society for Experimental Biology and Medicine 1952; 81: 459–461
   PubMed Web of Science ®Google Scholar
• Zimmer G., Gross W., Mehler U., Dorn-Zachertz D. Membrane action of tricyclic drugs. Arzneimittel-ForschunglDrug Research 1980; 30: 221–228
   PubMedGoogle Scholar
• Zis A. P., Goodwin F. K. Novel antidepressants and the biogenic amine hypothesis of depression. Archives of General Psychiatry 1979; 36: 1097–1107
   PubMed Web of Science ®Google Scholar