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Original Article

Identification of New Molecular Targets for Experimental Immunomodulation

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Pages 349-350 | Received 20 Nov 1989, Published online: 07 Jul 2009

References

  • Berrebi G., Takayama H., Sitkovsky M. The antigen-receptor requirement for conjugate formation and lethal hit triggering by cytotoxic T lymphocytes can be bypassed by protein kinase C activators and Ca ++-ionophores. Proceedings National Academy of Science USA 1987; 84: 1364–1368
  • Kincaid R., Takayama H., Billingsley M. L., Sitkovsky M. V. Differential expression of calmodulin-binding protein in B, T-lymphocyte and thymocytes. Nature 1987; 330: 176–178
  • Sitkovsky M. V. Mechanistic, functional and immunopharmacological implications of biochemical studies of antigen receptor-triggered cytolytic T-lymphocyte activation. Immunological Review 1988; 103: 127–160
  • Takayama H., Sitkovsky M. V. Potential use of cAMP-dependent protein kinase to block inhibition and modulate T-cell receptor triggered activation of cytotoxic T-lymphocytes. Journal of Pharmacological Sciences 1988; 78: 8–10
  • Takayama H., Sitkovsky M. Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes. Journal of Experimental Medicine 1987; 166: 725–743
  • Takayama H., Trenn G., Sitkovsky M. Locus of inhibitory action of cAMP-dependent protein kinase in the antigen receptor triggered cytotoxic T-lymphocyte activation pathway. Journal of Biological Chemistry 1988; 263: 2330–2336
  • Takayama H., Trenn G., Sitkovsky M. A novel cytotoxic T lymphocyte activation assay. Optimized conditions for antigen receptor triggered granule enzyme secretion. Journal of Immunological Methods 1987; 104: 183–190
  • Trenn G., Pettit R., Takayama H., Hu-Li J., Sitkovsky M. Immunomodulating properties of a novel series of protein kinase C activators: the bryostatins. Journal of Immunology 1988; 140: 433–449

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