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Original Article

Anti-Stress Role of the Melatonin-Immuno-Opioid Network: Evidence for a Physiological Mechanism Involving T Cell-Derived, Immuno-Reactive β-Endorphin and Met-Enkephalin Binding to Thymic Opioid Receptors

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Pages 289-298 | Received 19 Feb 1991, Published online: 07 Jul 2009

References

  • Barath P., Csaba G. Histological changes in the lung, thymus and adrenal, one and a half year after pinealectomy. Acta Biochimica et Biophysica Academiae Scientiarum Hungaricae 1974; 25: 123–125
  • Becker J., Veit G., Handgretinger R., Attanasio A., Bruchett G., Trenner I., Niethammer D., Gupta D. Circadian variations in the immunomodulatory role of the pineal gland. Neu-roendocrinology Letters 1988; 10: 65–80
  • Besedovsky H. O., Del Rey A. E., Sorkin E. Immuneneuroendocrine interactions. Journal of Immunology 1985; 135: 750s–755s
  • Blalock J. E. The immune system as a sensory organ. Journal of Immunology 1984; 132: 1067–1070
  • Blask D. E. The pineal: an oncostatic gland?. The pineal gland, R. J. Reiter. Raven Press, New York 1984; 253–285
  • Csaba G., Barath P. Morphological changes in thymus and the thyroid gland after postnatal estirpation of pineal body. Endocrinologia Experimentalis 1975; 9: 59–64
  • Del Gobbo V., Libri V., Villani N., Calio R., Nistico G. Pinealectomy inhibits interleukin-2 production and natural killer activity in mice. International Journal of Immunopharmacology 1989; 11: 567–577
  • Hansonn I., Holmdahl R., Mattsson R. Constant darkness enhances autoimmunity to type II collagen and exaggerates development of collagen induced arthritis in DBA/1 mice. Journal of Neuroimmunology 1990; 27: 79–84
  • Lissoni P., Morabito F., Esposti G., Ripamonti G., Fraschini F. A study of the thymus-pineal axis: interactions between thymic hormones and melatonin secretion. Acta Medica Auxo-logica 1988; 20: 35–40
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–270
  • Maestroni G. J. M., Conti A., Pierpaoli W. Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody production and antagonizes the immunosuppressive effect of corticosterone. Journal of Neuroimmunology 1986; 13: 19–30
  • Maestroni G. J. M., Conti A., Pierpaoli W. Role of the pineal gland in immunity. II Melatonin enhances the antibody response via an opiatergic mechanism. Clinical Experimental Immunology 1987a; 68: 384–391
  • Maestroni G. J. M., Conti A., Pierpaoli W. The pineal gland and the circadian, opiatergic immunoregulatory role of melatonin. Annals of the NY Academy of Sciences 1987b; 496: 61–11
  • Maestroni G. J. M., Conti A. Role of the pineal gland in immunity. III Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism. Immunology 1988; 63: 465–469
  • Maestroni G. J. M., Conti A. Beta-endorphin and dynorphin mimic the circadian immu-noenhancing and anti-stress effects of melatonin. International Journal of Immunopharmacology 1989; 11: 333–340
  • Maestroni G. J. M., Conti A. The pineal neurohormone melatonin stimulates activated CD4+, Thy+ cells to release opioid agonist(s) with immunoenhancing and anti-stress properties. Journal of Neuroimmunology 1990; 28: 167–176
  • Ovadia H., Nitsan P., Abramsky O. Characterization of opiate binding sites on membranes of rat lymphocytes. Journal of Neuroimmunology 1989; 21: 93–102
  • The pineal gland, R. J. Reiter. Raven Press, New York 1984
  • Sibinga N. E. S., Goldstein A. Opioid peptides and opioid receptors in cell of the immune system. Annual Review of Immunology 1988; 6: 219–249
  • Silman R. E., Leone R. M., Hooper R. F. L., Preece M. A. Melatonin, the pineal gland and human puberty. Nature 1979; 282: 301–303
  • Melatonin in humans, R. J. Wurtmann, F. Waldhauser. Springer-Verlag, Wien 1986; 21, Journal of Neural Transmission, Suppl.

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