Resolution of Lhermitte's Sign in Multiple Sclerosis by Treatment with weak Electromagnetic Fields

References

• Acuna‐Castroviejo D., Rosenstein R. E., Romeo H. E., Cardinali D. P. Changes in gamma‐aminobu‐tyric acid high affinity binding to cerebral cortex membranes after pinealectomy or melatonin administration to rats. Neuroendocrinology 1986; 43: 24–31
   PubMed Web of Science ®Google Scholar
• Albert M. L. Treatment of pain in multiple sclerosis. New England Journal of Medicine 1969; 280: 1395
   PubMedGoogle Scholar
• Albertson T. E., Peterson S. L., Stark L. C., Lakin M. L., Winters W. D. The anticonvulsant properties of melatonin on kindled seizures in rats. Neuropharmacology 1981; 20: 61–66
   PubMed Web of Science ®Google Scholar
• Aldegunde M., Miguez I., Veira J. Effects of pinealectomy on regional brain serotonin metabolism. International Journal of Neuroscience 1985; 26: 9–13
   PubMed Web of Science ®Google Scholar
• Anton‐Tay F. Melatonin: effects on brain function. Advances in Biochemical Psychopharmacology 1974a; II: 315–324
   Google Scholar
• Anton‐Tay F. Melatonin: effects on brain function. Serotonin‐new vistas: biochemistry and behavioral and clinical studies, E. Costa, G. L. Gessa, M. Sandier. Raven Press, New York 1974b; 315–324
   Google Scholar
• Anton‐Tay F., Chou C., Anton S., Wurtman R. J. Brain serotonin concentration: elevation following intraperitoneal administration of melatonin. Science 1968; 162: 277–278
   PubMed Web of Science ®Google Scholar
• Anton‐Tay F., Diaz J. L., Femandez‐Guardiola A. On the effect of melatonin upon human brain. Its possible therapeutic implications. Life Sciences 1971; 10: 841–850
   Web of Science ®Google Scholar
• Axelrod J. The pineal gland: a neurochemical transducer. Chemical signals from nerves regulate synthesis of melatonin and convey information about internal clocks. Science 1974; 184: 1341–1348
   PubMed Web of Science ®Google Scholar
• Barasi S., Roberts M. H. T. The action of 5‐hydroxytryptamine antagonists and precursors on bulbospinal facilitation of spinal reflexes. Brain Research 1973; 52: 385–388
   PubMed Web of Science ®Google Scholar
• Bar‐Or A., Brown G. M. Pineal involvement in the diurnal rhythm of nociception in the rat. Life Sciences 1989; 44: 1067–1075
   PubMed Web of Science ®Google Scholar
• Basbaum A. I., Fields H. L. Endogenous pain control mechanisms: review and hypothesis. Annals of Neurology 1978; 4: 451–462
   PubMed Web of Science ®Google Scholar
• Bawin S. M., Adey W. R. Sensitivity of calcium binding in cerebral tissue to weak environmental electrical fields oscillating at low frequency. Proceedings of the National Academy of Sciences USA 1976; 73: 1999–2003
   PubMed Web of Science ®Google Scholar
• Bindoni M., Rizzo R. Hippocampal evoked potentials and convulsive activity after electrolytic lesions of the pineal body in chronic experiments in rabbits. Archives of Science and Biology 1965; 49: 223–233
   PubMedGoogle Scholar
• Blackman C. F. Stimulation of brain tissue in vitro by extremely low frequency, low intensity, sinusoidal electromagnetic fields. Electromagnetic fields and neurobehavioral function, M. E. O'Connor, R. H. Lovely. Alan R. Liss, New York 1988
   Google Scholar
• Blackman C. F., Shawnee B. G., Kinney L. S., Joines W. T., House D. E. Effects of ELF fields on calcium‐ion efflux from brain tissue in vitro. Radiation Research 1982; 92: 510–520
   PubMed Web of Science ®Google Scholar
• Bostock H. The pathophysiology of demyelination. Multiple sclerosis: current research and treatment, R. M. Herndon, F. J. Seil. Demos Publications, New York 1994; 89–112
   Google Scholar
• Charcot J. M. Lecons sur les maladies du systeme nerveux faites a la Salpetriere. Delahaye, Paris 1872; 239–240
   Google Scholar
• Claveria L. F., Curzon G., Harrison M. J. G., Kantamaneni B. D. Amine metabolites in the cerebrospinal fluid of patients with disseminated sclerosis. Journal of Neurology, Neurosurgery and Psychiatry 1974; 37: 715–718
   PubMed Web of Science ®Google Scholar
• Clifford D. B., Trotter J. L. Pain in multiple sclerosis. Archives of Neurology 1984; 41: 1270–1272
   PubMedGoogle Scholar
• Davidson D., Pullar I. A., Mawdsley C., Kinloch N., Yates M. Monoamine metabolites in cere‐brospinal fluid in multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry 1977; 40: 741–745
   PubMed Web of Science ®Google Scholar
• Demaine C., Semm P. The avian pineal gland as an independent magnetic sensor. Neuroscience Letters 1985; 62: 119–122
   PubMed Web of Science ®Google Scholar
• Ekbom K. A., Westerberg C. E., Osterman P. O. Focal sensory‐motor seizures of spinal origin. Lancet 1968; 1: 67
   PubMed Web of Science ®Google Scholar
• Erlich S. S., Apuzzo M. L. J. The pineal gland: anatomy, physiology, and clinical significance. Journal of Neurosurgery 1985; 63: 321–341
   PubMed Web of Science ®Google Scholar
• Fariello R. G., Bubenik G. A., Brown G. M., Grota L. J. Epileptogenic action of intraventricularly injected antimelatonin antibody. Neurology 1977; 27: 567–570
   PubMedGoogle Scholar
• Ffrench‐Constant C. Pathogenesis of multiple sclerosis. Lancet 1994; 343: 271–275
   PubMed Web of Science ®Google Scholar
• Fields H. L. Pain: II, new approaches to management. Annals of Neurology 1981; 9: 101–106
   PubMedGoogle Scholar
• Garelis E., Young S. N., Lal S., Sourkes T. L. Monoamine metabolites in lumbar CSF: the question of their origin in relation to clinical studies. Brain Research 1974; 79: 1–8
   PubMed Web of Science ®Google Scholar
• Guyton A. C. Basic neuroscience: anatomy, & physiology. W. B. Saunders Company, Philadelphia 1991; 127–137
   Google Scholar
• Jaffe R. A., Laszewski B. L., Carr D. B., Phillips R. D. Chronic exposure to a 60‐Hz electric field: effects on synaptic transmission and peripheral nerve function in the rat. Bioelectromagnetics 1980; I: 131–147
   Google Scholar
• Joffe R. T., Lippert G. P., Gray T. A. Mood disorder and multiple sclerosis. Archives of Neurology 1987; 44: 376–378
   PubMed Web of Science ®Google Scholar
• Johansson B., Roos B. E. 5‐hydroxyindoleacetic acid in cerebrospinal fluid of patients with neurological diseases. European Neurology 1974; II: 37–45
   Google Scholar
• Kassirer M. R., Osterberg D. H. Pain in chronic multiple sclerosis. Journal of Pain Symptom Management 1987; 2: 95–97
   PubMedGoogle Scholar
• Kavaliers M. Pineal mediation of the thermoregulatory and behavioral activating effects of beta‐endorphin. Peptides 1982; 3: 679–685
   PubMed Web of Science ®Google Scholar
• Kavaliers M., Hirst M., Teskey G. C. Ageing, opioid analgesia and the pineal gland. Life Sciences 1983; 32: 2279–2287
   PubMed Web of Science ®Google Scholar
• Kumar M. S. A., Chen C. L., Sharp D. C., Liu J. M., Kalra P. S., Kalra S. P. Diurnal fluctuations in methionine‐enkephalin levels in the hypothalamus and preoptic area of the male rat: effects of pinealectomy. Neuroendocrinology 1982; 35: 28–31
   PubMed Web of Science ®Google Scholar
• Lakin M. L., Miller C. H., Statt M. L., Winters W. D. Involvement of the pineal gland and melatonin in murine analgesia. Life Sciences 1981; 29: 2543–2551
   PubMed Web of Science ®Google Scholar
• Lance J. W. A concept of migraine and the search for the ideal headache drug. Headache 1990; 30(suppl I)17
   PubMedGoogle Scholar
• Lissoni P., Esposti D., Esposti G., Mauri R., Resentini M., Morabito F., Fumagali P., Santagostino A., Delitala G., Fraschini F. A clinical study on the relationship between the pineal gland and the opioid system. Journal of Neural Transmission 1986; 65: 63–73
   PubMed Web of Science ®Google Scholar
• Lowenstein P. R., Pereyra E. N., Solveyra C. G., Cardinal D. P. Effect of naloxone on the nocturnal rise of rat pineal melatonin content. European Journal of Pharmacology 1984; 98: 261–264
   PubMed Web of Science ®Google Scholar
• Luca N., Hategan D. Determination of serotonin content and ceruloplasmin activity of blood and CSF amino acid level in multiple sclerosis. Reveu Roumania Medica Neurologica Psychiatrica 1986; 24: 153–159
   Google Scholar
• Matthews W. B. Paroxysmal symptoms in multiple sclerosis. Journal of Neurology Neurosurgery and Psychiatry 1975; 38: 617–623
   PubMed Web of Science ®Google Scholar
• Monaco F., Fumero S., Mondino A., Mutani R. Plasma and cerebrospinal fluid tryptophan in multiple sclerosis and degenerative diseases. Journal of Neurology, Neurosurgery and Psychiatry 1979; 42: 640–641
   PubMed Web of Science ®Google Scholar
• Moulin D. E. Pain in multiple sclerosis. Neurologic Clinics 1989; 7: 321–331
   PubMed Web of Science ®Google Scholar
• Moulin D. E., Foley K. M., Ebers G. C. Pain syndromes in multiple sclerosis. Neurology 1988; 38: 1830–1834
   PubMed Web of Science ®Google Scholar
• Nir I., Behroozi K., Assael M., Ivriani I., Sulman F. G. Changes in the electrical activity of the brain following pinealectomy. Neuroendocrinology 1969; 4: 122–127
   PubMed Web of Science ®Google Scholar
• Nordin M., Nystrom B., Wallin U., Hagbarth K. E. Ectopic sensory discharges and paresthesia in patients with disorders of peripheral nerves, dorsal root and dorsal columns. Pain 1984; 20: 231–245
   PubMed Web of Science ®Google Scholar
• Olcese J., Reuss S., Semm P. Geomagnetic field detection in rodents. Life Sciences 1988; 42: 605–613
   PubMed Web of Science ®Google Scholar
• Ossenkopp K. P., Cain D. P. Inhibitory effects of acute exposure to low‐intensity 60‐Hz magnetic fields on electrically kindled seizures in rats. Brain Research 1988; 442: 255–260
   PubMed Web of Science ®Google Scholar
• Pazo J. H. Effects of melatonin on spontaneous and evoked neuronal activity in the mesencephalic retic‐ular formation. Brain Research Bulletin 1979; 4: 725–730
   PubMed Web of Science ®Google Scholar
• Pincus J. H., Lee S. Diphenylhydantoin and calcium. Archives of Neurology 1973; 29: 239–244
   PubMedGoogle Scholar
• Richardson B. P. Organization of serotonin neurones regulating central pain. Serotonin, CNS receptors and brain function, P. B. Bradley, S. L. Handley, S. J. Cooper, B. J. Key, N. M. Barnes, J. H. Coote. Pergamon Press, Oxford 1992; vol. 85: 335–347
   Google Scholar
• Romijn H. J. The pineal, a tranquillizing organ?. Life Sciences 1978; 23: 2257–2274
   PubMed Web of Science ®Google Scholar
• Rosen A. D., Lubowsky J. Magnetic fields influence on central nervous system function. Experimental Neurology 1987; 95: 679–687
   PubMed Web of Science ®Google Scholar
• Rosenstein R. E., Cardinali D. P. Melatonin increases in vivo GABA accumulation in rat hypothala‐mus, cerebellum, cerebral cortex and pineal gland. Brain Research 1986; 398: 403–406
   PubMed Web of Science ®Google Scholar
• Rudick R. A., Schiffer R. B., Herndon R. M. Drug treatment of multiple sclerosis. Seminars in Neurology 1987; 7: 150–159
   PubMed Web of Science ®Google Scholar
• Rudolph K., Wirz‐Justice A., Krauchi K., Feer H. Static magnetic fields decrease nocturnal pineal cAMP in the rat. Brain Research 1988; 446: 159–160
   PubMed Web of Science ®Google Scholar
• Sallanon M., Claustrat B., Touret M. Presence of melatonin in various cat brainstem nuclei determined by radioimmunoassay. Acta Endocrinologica 1982; 101: 161–165
   PubMedGoogle Scholar
• Sandyk R. The influence of the pineal gland on migraine and cluster headaches and effects of treatment with picotesla magnetic fields. International Journal of Neuroscience 1992; 67: 145–171
   PubMed Web of Science ®Google Scholar
• Sandyk R., Awerbuch G. I. Nocturnal plasma melatonin and alpha‐melanocyte stimulating hormone levels during exacerbation of multiple sclerosis. International Journal of Neuroscience 1992; 67: 173–186
   PubMed Web of Science ®Google Scholar
• Sandyk R., Derpapas K. Successful treatment of an acute exacerbation of multiple sclerosis by external magnetic fields. International Journal of Neuroscience 1993a; 70: 97–105
   PubMedGoogle Scholar
• Sandyk R., Awerbuch G. I. Nocturnal melatonin secretion in multiple sclerosis patients with affective disorders. International Journal of Neuroscience 1993a; 68: 227–240
   PubMed Web of Science ®Google Scholar
• Sandyk R., Awerbuch G. I. Nocturnal melatonin secretion in suicidal patients with multiple sclerosis. International Journal of Neuroscience 1993c; 71: 173–182
   PubMed Web of Science ®Google Scholar
• Schauf C. L., Davis F. A., Marder J. Effects of carbamazepine on the ionic conductances of Myxicola giant axons. Journal of Pharmacology and Experimental Therapeutics 1974; 189: 538–543
   PubMed Web of Science ®Google Scholar
• Schiffer R. B. The spectrum of depression in multiple sclerosis. An approach for clinical management. Archives of Neurology 1987; 44: 596–599
   PubMedGoogle Scholar
• Semm P. Neurobiological investigations on the magnetic sensitivity of the pineal gland in rodents and pigeons. Comparative Biochemistry and Physiology 1983; 76A: 683–689
   Web of Science ®Google Scholar
• Semm P. Pineal function in mammals and birds is altered by earth‐strength magnetic fields. Electromagnetic fields and circadian rhythmicity, M. C. Moore‐Ede, S. S. Campbell, R. J. Reiter. Birkhauser, Boston 1992; 53–62
   Google Scholar
• Shibasaki H., Kuroiwa Y. Painful tonic seizures in multiple sclerosis. Archives of Neurology 1974; 30: 47–51
   PubMedGoogle Scholar
• Silberstein S. D. Advances in undestanding the pathophysiology of headache. Neurology 1992; 42(suppl 2)6–10
   PubMedGoogle Scholar
• Sonninen V., Riekkinen P., Rinne U. K. Acid monoamine metabolites in cerebrospinal fluid in multiple sclerosis. Neurology 1973; 23: 760–763
   PubMed Web of Science ®Google Scholar
• Sperber D., Dransfield K., Maret G., Weisenseel M. H. Oriented growth of pollen tubes in strong magnetic field. Naturwissenschaften 1981; 68: 40–43
   Web of Science ®Google Scholar
• Stenager E., Knudsen L., Jensen K. Acute and chronic pain syndromes in multiple sclerosis. Acta Neuroogica Scandinavica 1991; 84: 197–200
   PubMed Web of Science ®Google Scholar
• Surridge D. An investigation into some psychiatric aspects of multiple sclerosis. British Journal of Psychiatry 1969; 115: 749–764
   PubMed Web of Science ®Google Scholar
• Tourtellotte W. W., Baumhefner R. W. Comprehensive management of multiple sclerosis. Multiple sclerosis, J. F. Hallpike, C. W. M. Adams, W. W. Tourtellotte. Williams, & Wilkins, Baltimore 1983; 513–578
   Google Scholar
• Twomey J. A., Espir L. E. Paroxysmal symptoms as the first manifestation of multiple sclerosis. Journal of Neurology Neurosurgery and Psychiatry 1980; 43: 296–304
   PubMed Web of Science ®Google Scholar
• Van Diemen H. A. M., Polman C. H., van Dongen M. M. M. M., Nauta J. J. P., Strijers R. L. M., van Loenen A. C., Bertelsmann F. W., Koetsier J. C. 4‐aminopyridine induces functional improvement in multiple sclerosis patients: a neuropsychiological study. Journal of the Neurological Sciences 1993; 116: 220–226
   PubMed Web of Science ®Google Scholar
• Vermote R., Ketelaer P., Carton H. Pain in multiple sclerosis patients. Clinical Neurology and Neurosurgery 1986; 88: 87–93
   PubMedGoogle Scholar
• Waxman S. G., Ritchie J. M. Hyperexcitability of pathologically myelinated axons and positive symptoms in multiple sclerosis. Demyelinating diseases: basic and clinical electrophysiology, G. Stephen, S. G. Waxman, J. M. Ritchie. Raven Press, New York 1981; 289–297
   Google Scholar
• Weil‐Fugazza J. Central metabolism and release of serotonin in pain and analgesia. Serotonin and pain, J. M. Beson. Elsevier Science Publishers, New York 1990; 221–238
   Google Scholar
• Welker H. A., Semm P., Willig R. P., Commentz J. C., Wiltschko W., Vollrath L. Effects of an artificial magnetic field on serotonin N‐acetyltransferase activity and melatonin content of the rat pineal gland. Experimental Bruin Research 1983; 50: 426–432
   PubMed Web of Science ®Google Scholar
• Wendel O. T., Waterbury L. D., Pearce L. A. Increase in monoamine concentration in rat brain following melatonin administration. Experientia 1974; 30: 1167–1168
   PubMedGoogle Scholar
• Wurtman R. J., Axelrod J., Kelly D. E. The pineal. Academic Press, New York 1968
   Google Scholar
• Yaari Y., Selzer M. E., Picus J. H. Phenytoin: mechanisms of its anticonvulsant action. Annals of Neurology 1986; 20: 171–184
   PubMed Web of Science ®Google Scholar
• Zeise M. L., Semm P. Melatonin lowers excitability of guinea pig hippocampal neurons in vitro. Journal of Comparative Physiology 1985; 157: 23–29
   PubMed Web of Science ®Google Scholar