Failure of Systemic N-Acetyl Cysteine to Protect the Rat Lung Against Bleomycin Toxicity

References

• Luna M, Bedrossian C, Lichtiger I, Salem PA. Interstitial pneumonitis associated with bleomycin therapy. Am J Clin Pathol 1972; 58: 501–10
   PubMed Web of Science ®Google Scholar
• Trush M A, Mimnaugh E G, Ginsburg E, Gram TE. Studies on the interaction of bleomycin A with rat lung microsomes II. Involvement of adventitious iron and reactive oxygen in bleomycin-mediated DNA chain breakage. J Pharmacol Exp Ther 1982; 221: 159–65
   Google Scholar
• Berend N. Low temperature inhibits bleomycin lung toxicity in the rat. Am Rev Respir Dis 1983; 128: 304–6
   PubMed Web of Science ®Google Scholar
• Berend N. Protective effect of hypoxia on bleomycin lung toxicity in the rat. Am Rev Respir Dis 1984; 130: 307–8
   Google Scholar
• Berend N. Inhibition of bleomycin lung toxicity by N-acetyl cysteine in the rat. Pathology 1985; 17: 108–10
   PubMed Web of Science ®Google Scholar
• Lazo J S, Humphreys CJ. Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity. Proc Natl Acad Sci 1983; 80: 3064–8
   PubMed Web of Science ®Google Scholar
• Umezawa H, Ishizuka M, Maeda K, Takeuchi T. Studies on bleomycin. Cancer 1967; 20: 891–5
   PubMed Web of Science ®Google Scholar
• Passero M A, Held J K, Shearer PN. Effects of bleomycin, O2concentration, and H2O2on peroxidation of arachidonic acid. Am Rev Respir Dis 1983; 127, 287, suppl
   Google Scholar
• Shen A S, Haslett C, Feldsein D, et al. Severity of acute bleomycin lung injury directly affects the amount of subsequent chronic inflammation and fibrosis. Am Rev Respir Dis 1986; 133: A144
   Google Scholar
• Thrall R S, McCormick J R, Jack R M, et al. Bleomycin-induced pulmonary fibrosis in the rat. Inhibition by indomethacin. Am J Pathol 1979; 95: 117–27
   PubMed Web of Science ®Google Scholar
• Riley D J, Kerr J S, Berg R A, et al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-L-proline. Am Rev Respir Dis 1981; 123: 388–93
   PubMed Web of Science ®Google Scholar
• Phan S H, Thrall R S, Williams C. Bleomycin-induced pulmonary fibrosis. Effects of steroid on lung collagen metabolism. Am Rev Respir Dis 1981; 124: 428–34
   PubMed Web of Science ®Google Scholar
• Fedullo A J, Karlinsky J B, Snider G L, Goldstein RH. Lung siatics and connective tissues after penicillarnine in bleomycin-treated hamsters. J Appl Physiol 1980; 49: 1083–90
   PubMed Web of Science ®Google Scholar
• Borek C, Troll W. Modifiers of free radicals inhibit in vitro the oncogenic actions of X-rays, bleomycin and the tumor promoter 12–0-tetradecanoylphorbol 13-acetate. Proc Natl Acad Sci 1983; 80: 1304–7
   PubMed Web of Science ®Google Scholar
• Tryka A F, Skornik W A, Godleski J J, Brain JD. Potentiation of bleomycin-induced lung injury by exposure to 70% oxygen. Morphologic assessment. Am Rev Respir Dis 1982; 126: 1074–9
   PubMed Web of Science ®Google Scholar
• Berend N. The effect of bleomycin and oxygen on rat lung. Pathology 1984; 16: 136–9
   PubMed Web of Science ®Google Scholar
• Doroshow J H, Locker G J, Ifrim I, Myers CE. Prevention of doxorubicin cardiac toxicity in the mouse by N-acetyl cysteine. J Clin Invest 1981; 68: 1053–64
   PubMed Web of Science ®Google Scholar
• Simon L M, Suttorp N. Lung cell oxidant injury: Decrease in polymorphonuclear leukocyte mediated cytotoxicity by N-acetyl cysteine. Am Rev Respir Dis 1983; 127 Suppl: 286. 19. Webb WR. Clinical evaluation of a new effective mycolytic agent (N-acetyl-L-cysteine). Am Rev Respir Dis 1962; 86: 115–6
   Google Scholar
• Prescott L F, Illingworth R N, Critchley J A, et al. Intravenous N-acetyl cysteine: The treatment of choice for paracetamol poisoning. Br Med J 1979; 2: 1097–100
   PubMed Web of Science ®Google Scholar
• Morgan L R, Holdiness M R, Gillen LE. N-acetylcysteine: Its bioavailability and interaction with ifosfamide metabolites. Sem. Oncol 1983; 10: 56–61
   Google Scholar
• Reeve J, Kuhlenkamp J, Kaplowitz N. Estimation of glutathione in rat liver by reverse-phase high-performance liquid chromatography: Separation from cysteine & γ-glutamylcysteine. J Chromatogr 1980; 194: 424–8
   PubMed Web of Science ®Google Scholar
• Frank H, Thiel D, Langer K. Determination of N-acetyl-L-cysteine in biological fluids. J Chromatogr 1984; 309: 261–7
   PubMed Web of Science ®Google Scholar
• Ward H E, Nicholson A, Berend N. Does systemic N-acetyl cysteine protect the lung from hyperoxic damage? (Abstract) Proc. III. World conference on clinical pharmacology and therapeutics., Stockholm July, 1986; 222
   Google Scholar
• Sugiura Y. Bleomycin-iron complexes. Electron spin resonance study, ligand effect and implication for action mechanism. J Am Chem Soc 1980; 102: 5208–15
   Web of Science ®Google Scholar