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ORIGINAL ARTICLE

Effect of N-acetylcysteine on the accuracy of the prothrombin time assay of plasma coagulation factor II+VII+X activity in subjects infused with the drug. Influence of time and temperature

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Pages 643-650 | Received 13 Mar 2009, Accepted 25 Mar 2009, Published online: 25 Nov 2009

References

  • Keays R, Harrison PM, Wendon JA, Forbes A, Gove C, Alexander GJ, Williams R. Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ. 1991; 303:1026–9.
  • Prescott LF, Illingworth RN, Critchley JA, Proudfoot AT. Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning. Br Med J. 1980; 280:46–7.
  • Smilkstein MJ, Bronstein AC, Linden C, Augenstein WL, Kulig KW, Rumack BH. Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med. 1991; 20:1058–63.
  • Dargan PI, Jones AL. Management of paracetamol poisoning. Trends Pharmacol Sci. 2003; 24:154–7.
  • Brok J, Buckley N, Gluud C. Interventions for paracetamol (acetaminophen) overdose. Cochrane Database Syst Rev. 2006; :–.CD003328
  • Walsh TS, Lee A. N-acetylcysteine administration in the critically ill. Intensive Care Med. 1999; 25:432–4.
  • Heller AR, Groth G, Heller SC, Breitkreutz R, Nebe T, Quintel M, Koch T. N-acetylcysteine reduces respiratory burst but augments neutrophil phagocytosis in intensive care unit patients. Crit Care Med. 2001; 29:272–6.
  • Sklar GE, Subramaniam M. Acetylcysteine treatment for non-acetaminophen-induced acute liver failure. Ann Pharmacother. 2004; 38:498–500.
  • Kanter MZ. Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning. Am J Health Syst Pharm. 2006; 63:1821–7.
  • TOXBASE, NPIS UK. Guidelines for the management of acute paracetamol overdose. 2007. http://www.toxbase.org
  • Harrison PM, O'Grady JG, Keays RT, Alexander GJ, Williams R. Serial prothrombin time as prognostic indicator in paracetamol induced fulminant hepatic failure. BMJ. 1990; 301:964–6.
  • Jepsen S, Hansen AB. The influence of N-acetylcysteine on the measurement of prothrombin time and activated partial thromboplastin time in healthy subjects. Scand J Clin Lab Invest. 1994; 54:543–7.
  • Knudsen TT, Thorsen S, Jensen SA, Dalhoff K, Schmidt LE, Becker U, Bendtsen F. Effect of intravenous N-acetylcysteine infusion on haemostatic parameters in healthy subjects. Gut. 2005; 54:515–21.
  • Koterba AP, Smolen S, Joseph A, Basista MH, Brecher AS. Coagulation protein function. II. Influence of thiols upon acetaldehyde effects. Alcohol. 1995; 12:49–57.
  • Schmidt LE, Knudsen TT, Dalhoff K, Bendtsen F. Effect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury. Lancet. 2002; 360:1151–2.
  • Thijssen HH, Soute BA, Vervoort LM, Claessens JG. Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle. Thromb Haemost. 2004; 92:797–802.
  • Jonsson M, Hillarp A, Svensson P. Comparison between CoaguChek S- and Owren-type prothrombin time assay for monitoring anticoagulant therapy. Thromb Res. 2004; 114:83–9.
  • Prescott LF, Donovan JW, Jarvie DR, Proudfoot AT. The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. Eur J Clin Pharmacol. 1989; 37:501–6.
  • Niemi TT, Munsterhjelm E, Pöyhiä R, Hynninen MS, Salmenperä MT. The effect of N-acetycysteine on blood coagulation and platelet function in patients undergoing open repair of abdominal aortic aneurysm. Blood Coagul Fibrinol. 2006; 17:29–34.
  • Palmer RN, Gralnick HR. Cold-induced contact surface activation of the prothrombin time in whole blood. Blood. 1982; 59:38–42.
  • Sanchez J, Elgue G, Larsson R, Nilsson B, Olsson P. Surface-adsorbed fibrinogen and fibrin may activate the contact activation system. Thromb Res. 2008; 122:257–63.
  • Kratz A, Stanganelli N, Van Cott EM. A comparison of glass and plastic blood collection tubes for routine and specialized coagulation assays: a comprehensive study. Arch Pathol Lab Med. 2006; 130:39–44.
  • Laragione T, Bonetto V, Casoni F, Massignan T, Bianchi G, Gianazza E, Ghezzi P. Redox regulation of surface protein thiols: identification of integrin alpha-4 as a molecular target by using redox proteomics. Proc Natl Acad Sci USA. 2003; 100:14737–41.
  • Harada D, Naito S, Otagiri M. Kinetic analysis of covalent binding between N-acetyl-L-cysteine and albumin through the formation of mixed disulfides in human and rat serum in vitro. Pharm Res. 2002; 19:1648–54.
  • Garant MJ, Kole S, Maksimova EM, Bernier M. Reversible change in thiol redox status of the insulin receptor alpha-subunit in intact cells. Biochemistry. 1999; 38:5896–904.
  • Kim KY, Rhim T, Choi I, Kim SS. N-acetylcysteine induces cell cycle arrest in hepatic stellate cells through its reducing activity. J Biol Chem. 2001; 276:40591–8.
  • Dymock IW, Tucker JS, Woolf IL, Poller L, Thomson JM. Coagulation studies as a prognostic index in acute liver failure. Br J Haematol. 1975; 29:385–95.
  • Lucena MI, Lopez-Torres E, Verge C, Andrade RJ, Puche MJ, Seoane J, dela Cuesta FS. The administration of N-acetylcysteine causes a decrease in prothrombin time in patients with paracetamol overdose but without evidence of liver impairment. Eur J Gastroenterol Hepatol. 2005; 17:59–63.

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