79
Views
4
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Effect of regional fat loss assessed by DXA on insulin resistance and dyslipidaemia in obese women

, &
Pages 229-236 | Received 31 Aug 2009, Accepted 18 Dec 2009, Published online: 12 Apr 2010

References

  • Björntorp P. Metabolic implications of body fat distribution. Diabetes Care 1991;14:1132–43.
  • Carey DG, Jenkins AB, Campbell LV, Freund J, Chrisholm DJ. Abdominal fat and insulin resistance in normal and overweight women. Diabetes 1996;45:633–8.
  • Despres J-P: Abdominal obesity as an important component of insulin resistance syndrome. Nutrition 1993;9:452–9.
  • Tankó LB, Bagger YZ, Alexandersen P, Larsen PJ, Christiansen C. Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women. Circulation 2003;107:1626–31.
  • Williams MJ, Hunter GR, Kekes-Szabo T, Snyder S, Treuth MS. Regional fat distribution in women and risk of cardiovascular disease. Am J Clin Nutr 1997;65: 855–60.
  • Van Pelt RE, Evans EM, Schechtman KB, Ehsani AA, Kohrt WM. Contribution of total and regional fat mass to risk for cardiovascular disease in older women. Am J Physiol Endocrinol Metab 2002;282:E1023–8.
  • Tatsukawa M, Kurokawa M, Tamari Y, Yoshimatsu H, Sakata T. Regional fat deposition in the legs is useful as a presumptive marker of antiatherogenesity in Japanese. Proc Soc Exp Bio Med. 2000;223:156–62.
  • Snijder MB, Dekker JM, Visser M, Bouter LM, Stehouwer CD, Yudkin JS, Heine RJ, Nijpels G, Seidell JC. Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels. Diabetes Care 2004; 27:372–7.
  • Goodpaster BH, Kelley DE, Wing RR, Meier A, Thaete L. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 1999;48:839–47.
  • Aasen G, Fagertun H, Halse J. Regional fat mass by DXA: High leg fat mass attenuates the relative risk of insulin resistance and dyslipidaemia in obese but not in overweight postmenopausal women. Scand J Clin Lab Invest 2008; 68:204–11.
  • Aasen. G, Fagertun H, Halse J. Leg Fat mass measured by dual X-ray absorptiometry (DXA) impacts insulin resistance differently in obese women versus men. Scand J Clin Lab Invest 2009;69:181–9.
  • Aasen G, Fagertun H, Halse J. Insulin resistance and dyslipidemia in obese pre- and postmenopausal women matched for leg/trunk fat mass ratio. Scand J Clin Lab Invest 2009;69:505–11.
  • Krebs JD, Evans S, Cooney L, Mishra GD, Fruhbeck G, Finer N, Jet SA. Changes in risk factors for cardiovascular disease with body loss in obese women. Diabetes Obes Metab 2002;4:379–87.
  • Rosenfalck AM, Hendel H, Rasmussen MH, Almdal T, Anderson T, Madsbad S. Minor long-term changes in weight have beneficial effect on sensitivity and beta-cell function in obese subjects. Diabetes Obes Metab 2002;4:19–28.
  • Cornier MA, Donahoo WT, Pereira R, Gurevich I, Westergren R, Enerback S, Eckel PJ, Goalstone ML, Hill JO, Eckel RH, Draznin B. Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women. Obes Res 2005;13:703–9.
  • McLaughlin T, Abbasi F, Carantoni M, Schaaf P, Reaven G. Differences in insulin resistance do not predict weight loss in response to hypocaloric diets in healthy obese women. J Clin Endocrinol Metab 1999;84:578–81.
  • De Luis DA, Aller R, Izaola O, Gonzales SM, Conde R. Differences in glycaemic status do not predict weight loss in response to hypocaloric diets in obese patients. Clin Nutr 2006;25:117–22.
  • Aasen G, Fagertun H, Halse J. Body composition analysis by dual X-ray absorptiometry : in vivo and in vitro comparison of three different fan-beam instruments. Scand J Clin Lab invest 2006;66:659–66.
  • Matthews DR, Hosker JP, Rudenski AS, Maylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412–9.
  • Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggianai F, Zenner MB, Monauni T, Muggero M. Homeostasis model assessment closely mirrors the glucose clamp technique in the J Clin Endocrinol Metab assessment of insulin sensitivity. Diabetes Care 2000;23:57–63.
  • Katz A, Nambi SS, Mather K, Baron AD, Follman DA, Sullivan G, Quon MJ. Quantitative insulin sensitivity check index: a simple accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000; 85:2402–10.
  • Yokoyama H, Emoto M, Fujiwara S, Motomyama K, Morioka T, Komatsu M, Tahara H, Shoji T, Nishizawa Y. Quantitative insulin sensitivity check index and the reciprocal index of homeostasis model assessment in normal weight range and moderately obese type 2 diabetic patients. Diabetes Care 2003;26:426–32.
  • Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Jarvinen HY, Van Haften T, Renn W, Gerich J. Use of the oral tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 2000;23:295–301.
  • Friedewald WR, Levy RI, Fredichson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin chem. 1972;18:499–502.
  • Wang J, Laferrere B, Thornton JB, Pierson RN Jr, Pi-Sunyer FX. Regional subcutaneous-fat loss induced by caloric restriction in obese women. Obes Res 2002;10:885–90.
  • Chaston TB, Dixon JB. Factors associated with per cent change in visceral versus subcutaneous abdominal fat tissue during weight loss: findings from a systematic review. Int J Obes (Lond) 2008;32:619–28.
  • Janiszewski PM, Kuk JL, Ross R. Is the reduction of lower-body subcutaneous adipose tissue associated with elevations in risk factors for diabetes and cardiovascular disease? Diabetologia 2008;52:1475–82.
  • Larson-Meyer DE, Heilbronn LK, Redman LM, Newcomer BR, Frisard MI, Anton S. Effect of caloric restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care 2006;29:1337–44.
  • Lundgren M, Svensson M, Lindmark S, Renstrøm F, Ruge T, Eriksson JW. Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’. Diabetologia 2007;50:625–33.
  • Weyer C, Foley JE, Bogardus C, Tataranni PA, Pratley RE. Enlarged abdominal subcutaneous adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia 2000;43:1498–1506.
  • Mundi MS, Karpyak MV, Koutsari C, Votruba SB, O'Brien PC, Jensen MD. Body Fat distribution, adipocyte size, and metabolic characteristics of nondiabetic adults. J Clin Endocrinol Metab 2010;95:67–73.
  • Kuk J, Kilpatrick K, Davidson LE, Hudson R, Ross R. Whole-body skeletal muscle mass is not related to glucose tolerance or insulin sensitivity in overweight and obese men and women. Appl Physiol Nutr Metab 2008;33:769–74.
  • Goldstein DJ. Beneficial effects of modest weight loss. Int J Obes Relat Metab Disord. 1992;16:397-415.
  • Busetto L. Visceral obesity and the metabolic syndrome: effects of weight loss. Nutr Metab Cardiovasc Dis 2001; 11:195–204.
  • Marcovic TP, Campbell LV, Balasubramanian S, Jenkins A, Fleury AC, Simons LA, Chrisholm DJ. Beneficial effect on average lipid levels from energy restriction and fat loss in obese individuals with or without type 2 diabetes. Diabetes Care 1998;21:695–700.
  • Muscelli E, Camastra S, Catalano C, , Q GalvanCiociaro D, Baldi S and Ferrannini E. Metabolic and cardiovascular assessment in moderate obesity: effect of weight loss. J Clin Endocrinol Metab 1997;82:2937–43.
  • Ditschuneit HH, Fletcher-Mors M, Johnson TD and Adler G. Metabolic and weight-loss effects of a long-term dietary intervention in obese patients. Am J Clin Nutr 1999; 69:198–204.
  • Okura T, Nakata Y, Yamabuki K, Tanaka K. Regional body composition changes exhibit opposing effects on coronary heart disease risk factors. Arterioscler Vasc Biol 2004; 24:923–9.
  • Nordmann AJ, Nordmann A, Briel M, Keller U, Yancy WS, Brehm BJ, Bucher HC. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors. A meta-analysis of randomized controlled trials. Arch Int Med 2006:166;285–93.
  • Joseph LJO, Trappe TA, Farrell PA, Campbell WW, Yaresheski KE, Lambert CP, Evans WJ. Short-term moderate weight loss and resistance training do not affect insulin-stimulated glucose disposal in postmenopausal women. Diabetes Care 2001;24:1863–9.
  • Salpeter SR, Walsh JM, Ormiston TM, Greyber E, Buckley NS, Salpeter EE. Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in post-menopausal women. Diabetes Obes Metab 2006;8:538–54.
  • Gaspard U. Hyperinsulinaemia, a key factor of the metabolic syndrome in postmenopausal women. Maturitas 2009;62: 362–5.
  • Demir B, Ozturkoglu E, Solaroglu A, Baskan B, Kandemir O, Karabulut E, Haberal A. The effects of estrogen therapy and estrogen combined with different androgenic progestins on carbohydrate and lipid metabolism in overweight-obese younger postmenopausal women. Gynecol Endocrinol 2008; 24:347–53.
  • Fernandes CE, Pompei LM, Machado RB, Ferreira JA, Melo NR, Peixoto S. Effects of oestradiol and norethisterone on lipids, insulin resistance and carotid flow. Maturitas 2008;59:249–58.
  • Hanley AJG, Williams K, Stern MP, Haffner SM. Homeostasis model assessment of insulin resistance of cardiovascular disease. The San Antonio Heart Study. Diabetes Care 2002;25:1177–84.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.