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ORIGINAL ARTICLE

Biodistribution of 99mTc-HYNIC-lactadherin in mice – a potential tracer for visualizing apoptosis in vivo

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Pages 209-216 | Received 07 Aug 2009, Accepted 30 Dec 2009, Published online: 09 Apr 2010

References

  • Fadeel B, Orrenius S. Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Intern Med 2005;258:479–517.
  • Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992;148:2207–16.
  • Concha NO, Head JF, Kaetzel MA, Dedman JR, Seaton BA. Annexin V forms calcium-dependent trimeric units on phospholipid vesicles. FEBS Lett 1992;314:159–62.
  • Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 1995; 184:39–51.
  • Boersma HH, Kietselaer BL, Stolk LM, Bennaghmouch A, Hofstra L, Narula J, Heidendal GA, Reutelingsperger CP. Past, present, and future of annexin A5: from protein discovery to clinical applications. J Nucl Med 2005;46:2035–50.
  • Lahorte CM, Vanderheyden JL, Steinmetz N, Van de WC, Dierckx RA, Slegers G. Apoptosis-detecting radioligands: current state of the art and future perspectives. Eur J Nucl Med Mol Imaging 2004;31:887–919.
  • Andersen MH, Graversen H, Fedosov SN, Petersen TE, Rasmussen JT. Functional analyses of two cellular binding domains of bovine lactadherin. Biochemistry 2000;39:6200–6.
  • Shi J, Heegaard CW, Rasmussen JT, Gilbert GE. Lactadherin binds selectively to membranes containing phosphatidyl-L-serine and increased curvature. Biochim Biophys Acta 2004;1667:82–90.
  • Tait JF, Gibson D. Phospholipid binding of annexin V: effects of calcium and membrane phosphatidylserine content. Arch Biochem Biophys 1992;298:187–91.
  • Shi J, Pipe SW, Rasmussen JT, Heegaard CW, Gilbert GE. Lactadherin blocks thrombosis and hemostasis in vivo: correlation with platelet phosphatidylserine exposure. J Thromb Haemost 2008;6:1167–74.
  • Ida M, Satoh A, Matsumoto I, Kojima-Aikawa K. Human annexin V binds to sulfatide: contribution to regulation of blood coagulation. J Biochem 2004;135:583–8.
  • Butler JE, Pringnitz DJ, Martens CL, Crouch N. Bovine-associated mucoprotein: I. Distribution among adult and fetal bovine tissues and body fluids. Differentiation 1980; 17:31–40.
  • Ensslin M, Calvete JJ, Thole HH, Sierralta WD, Adermann K, Sanz L, Topfer-Petersen E. Identification by affinity chromatography of boar sperm membrane-associated proteins bound to immobilized porcine zona pellucida. Mapping of the phosphorylethanolamine-binding region of spermadhesin AWN. Biol Chem Hoppe Seyler 1995;376:733–8.
  • Silvestre JS, Thery C, Hamard G, Boddaert J, Aguilar B, Delcayre A, Houbron C, Tamarat R, Blanc-Brude O, Heeneman S, Clergue M, Duriez M, Merval R, Levy B, Tedgui A, Amigorena S, Mallat Z. Lactadherin promotes VEGF-dependent neovascularization. Nat Med 2005;11: 499–506.
  • Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002;417:182–7.
  • Waehrens LN, Rasmussen JT, Heegaard CW, Falborg L. Preparation and in vitro evaluation of Tc-99m-labelled bovine lactadherin as a novel radioligand for apoptosis detection. J Label Compounds Radiopharmaceut 2007;50: 211–7.
  • Hvarregaard J, Andersen MH, Berglund L, Rasmussen JT, Petersen TE. Characterization of glycoprotein PAS-6/7 from membranes of bovine milk fat globules. Eur J Biochem 1996;240:628–36.
  • Verbeke K, Kieffer D, Vanderheyden JL, Reutelingsperger C, Steinmetz N, Green A, Verbruggen A. Optimization of the preparation of 99mTc-labeled hynic-derivatized annexin V for human use. Nucl Med Biol 2003;30:771–8.
  • Blankenberg FG, Vanderheyden JL, Strauss HW, Tait JF. Radiolabeling of HYNIC-annexin V with technetium-99m for in vivo imaging of apoptosis. Nat Protoc 2006;1: 108–10.
  • Fritzberg AR, Whitney WP, Kuni CC, Klingensmith W. Biodistribution and renal excretion of Tc-99M-N,N'-Bis-(Mercaptoacetamido) Ethylenediamine – effect of renal tubular transport inhibitors. Int J Nuclear Med Biol 1982;9:79–82.
  • Altman DG. Practical statistics for medical research. London: Chapman & Hall/CRC; 1991.
  • Kenis H, van GH, Bennaghmouch A, Rinia HA, Frederik P, Narula J, Hofstra L, Reutelingsperger CP. Cell surface-expressed phosphatidylserine and annexin A5 open a novel portal of cell entry. J Biol Chem 2004;279:52623–9.
  • Andersen MH, Berglund L, Petersen TE, Rasmussen JT. Annexin-V binds to the intracellular part of the beta(5) integrin receptor subunit. Biochem Biophys Res Comm 2002; 292:550–7.
  • Dasgupta SK, Guchhait P, Thiagarajan P. Lactadherin binding and phosphatidylserine expression on cell surface-comparison with annexin A5. Transl Res 2006;148:19–25.
  • Shi J, Shi Y, Waehrens LN, Rasmussen JT, Heegaard CW, Gilbert GE. Lactadherin detects early phosphatidylserine exposure on immortalized leukemia cells undergoing programmed cell death. Cytometry A 2006;69:1193–201.
  • Blankenberg FG, Katsikis PD, Tait JF, Davis RE, Naumovski L, Ohtsuki K, Kopiwoda S, Abrams MJ, Darkes M, Robbins RC, Maecker HT, Strauss HW. In vivo detection and imaging of phosphatidylserine expression during programmed cell death. Proc Natl Acad Sci USA 1998;95:6349–54.
  • Blankenberg FG, Katsikis PD, Tait JF, Davis RE, Naumovski L, Ohtsuki K, Kopiwoda S, Abrams MJ, Strauss HW. Imaging of apoptosis (programmed cell death) with 99mTc annexin V. J Nucl Med 1999;40:184–91.
  • Lahorte CM, Van de WC, Bacher K, van den BB, Thierens H, van BS, Slegers G, Dierckx RA. Biodistribution and dosimetry study of 123I-rh-annexin V in mice and humans. Nucl Med Commun 2003;24:871–80.

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