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ORIGINAL ARTICLE

Total and acylated ghrelin in liver cirrhosis: Correlation with clinical and nutritional status

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Pages 252-258 | Received 14 Feb 2010, Accepted 25 Feb 2010, Published online: 06 Apr 2010

References

  • Kondrup J, Müller MJ. Energy and protein requirements of patients with chronic liver disease. J Hepatol 1997;27:239–47.
  • Merli M, Riggio O, Dally L. Does malnutrition affect survival in cirrhosis? Hepatology 1996;23:1041–6.
  • Selberg O, Böttcher J, Tusch G, Pichlmayr R, Henkel E, Müller MJ. Identification of high and low risk patients before liver transplantation: a prospective cohort study of nutritional and metabolic parameters in 150 patients. Hepatology 1997;25:652–7.
  • Greco AV, Mingrone G, Benedetti G, Capristo E, Tataranni PA, Gasbarrini G. Daily energy and substrate metabolism in patients with cirrhosis. Hepatology 1998;27:346–50.
  • Blom WAM, Stafleu A, de Graaf C, Kok FJ, Schaafsma G, Hendriks HF. Ghrelin response to carbohydrate-enriched breakfast is related to insulin. Am J Clin Nutr 2005;81:367–75.
  • Saad MF, Khan A, Sharma A, Michael R, Riad-Gabriel MG, Boyadjian R, Jinagouda SD, Steil GM, Kamdar V. Physiological insulinemia acutely modulates plasma leptin. Diabetes 1998;47:544–9.
  • Tacke F, Brabant G, Kruck E, Horn R, Schöffski P, Hecker H, Manns MP, Trautwein C. Ghrelin in chronic liver disease. J Hepatol 2003;38:447–54.
  • Alvarez P, Isidro L, Garcia-Buela J, Leal-Cerro J, Broglio F, Tassone F, Ghigo E, Dieguez C, Casanueva FF, Cordido F. Marked GH secretion after ghrelin alone or combined with GH releasing hormone (GHRH) in obese patients. Clin Endocrinol 2004;61:250–5.
  • van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004;25:426–57.
  • Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 2001;409:194–8.
  • Shuto Y, Shibasaki T, Otagiri A, Kuriyama H, Ohata H, Tamura H, Kamegai J, Sugihara H, Oikawa S, Wakabayashi I. Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding and adiposity. J Clin Invest 2002;109:1429–36.
  • Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001;86:5992–8.
  • Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin are decreased in human obesity. Diabetes 2001;50:707–9.
  • Otto B, Cuntz U, Fruehauf E, Wawarta R, Folwaczny C, Riepl RL, Heiman ML, Lehnert P, Fichter M, Tschöp M. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol 2001;145:669–73.
  • Ukkola O. Ghrelin and insulin metabolism. Eur J Clin Invest 2003;33:183–5.
  • Marchesini G, Bianchi G, Lucidi P, Villanova N, Zoli M, De Feo P. Plasma ghrelin concentrations, food intake, and anorexia in liver failure. J Clin Endocrinol Metab 2004;89:2136–41.
  • Kalaitzakis E, Bosaeus I, Ohman L, Björnsson E. Altered postprandial glucose, insulin, leptin, and ghrelin in liver cirrhosis: correlations with energy intake and resting energy expenditure. Am J Clin Nutr 2007;85:808–15.
  • Ataseven H, Bahceciogl IH, Kuzu N, Yalniz M, Celebi S, Erensoy A, Ustundag B. The levels of ghrelin, leptin, TNF-alpha, and IL-6 in liver cirrhosis and hepatocellular carcinoma due to HBV and HDV infection. Mediators Inflamm 2006;78380–5.
  • Takahashi H, Kato A, Onodera K, Suzuki K. Fasting plasma ghrelin levels reflect malnutrition state in patients with liver cirrhosis. Hepatol Res 2005:34:117–23.
  • Breidert M, Zimmermann TF, Schneider R, Ehninger G, Brabant G. Ghrelin/Leptin-imbalance in patients with primary biliary cirrhosis. Exp Clin Endocrinol Diabetes 2004;112:123–6.
  • Diz-Lois MT, Garcia-Buela J, Suarez F, Sangiao-Alvarellos S, Vidal O, Cordido F. Fasting and postprandial plasma ghrelin levels are decreased in patients with liver failure previous to liver transplantation. Endocr 2009;35:467–76.
  • Kamath PS, Wiesner RH, Malinchoc M, Kremers W, Therneau TM, Kosberg CL, D’Amico G, Dickson ER, Kim WRA. A model to predict survival in patients with end-stage liver disease. Hepatology 2001;33:464–70.
  • Kushner RF, Schoeller DA. Estimation of total body water by bioelectrical impedance analysis. Am J Clin Nutr 1986;44:417–24.
  • Lautz HU, Selberg O, Körber J, Bürger M, Müller MJ. Protein-calorie malnutrition in liver cirrhosis. Clin Investig 1992;70:478–86.
  • Pirlich M, Schütz T, Spachos T, Ertl S, Weiss ML, Lochs H, Plauth M. Bioelectrical impedance analysis is a useful bedside technique to assess malnutrition in cirrhotic patients with and without ascites. Hepatology 2000;32:1208–15.
  • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412–9.
  • Celinski K, Konturek PC, Slomka M, Cichoz-Lach H, Gonciarz M, Bielanski W, Reiter RJ, Konturek SJ. Altered basal and postprandial plasma melatonin, gastrin, ghrelin, leptin and insulin in patients with liver cirrhosis and portal hypertension without and with oral administration of melatonin or tryptophan. J Pineal Res 2009;46:408–14.
  • Broglio F, Gianotti L, Destefanis S, Fassino S, Abbate Daga G, Mondelli V, Lanfranco F, Gottero C, Gauna C, Hofland L, Van der Lely AJ, Ghigo E. The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state. Clin Endocrinol 2004;60:592–9.
  • Kim MS, Yoon CY, Park KH, Shin CS, Park KS, Kim SY, Cho BY, Lee HK. Changes in ghrelin and ghrelin receptor expression according to feeding status. Neuroreport 2003;14:1317–20.
  • Sato T, Fukue Y, Teranishi H, Yoshida Y, Kojima M. Molecular forms of hypothalamic ghrelin and its regulation by fasting and 2-deoxy-D-glucose administration. Endocrinology 2005;146:2510–6.
  • Teran JC. Nutrition and liver diseases. Curr Gastroenterol Rep 1999;1:335–40.
  • Horvath TL, Diano S, Sotonyi P, Heiman M, Tschop M. Minireview: ghrelin and the regulation of energy balance – a hypothalamic perspective. Endocrinology 2001;142:4163–9.
  • Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, resistin. Clin Chem 2004;50:1511–25.
  • Konturek SJ, Brzozowski T, Konturek PC, Schubert ML, Pawlik WW, Padol S, Bayner J. Brain-Gut and apetite regulating hormones in the control of gastric secretion and mucosal protection. J Physiol Pharmacol 2008;59(Suppl. 2):33–51.
  • Ockenga J, Bischoff SC, Tillmann HL, Rifai K, Widjaja A, Böker KH, Manns MP, Brabant G. Elevated bound leptin correlates with energy expenditure in cirrhotics. Gastroenterology 2000;119(6):1656–62.
  • McCullough AJ, Bugianesi E, Marchesini G, Kalhan SC. Gender-dependent alterations in serum leptin in alcoholic cirrhosis. Gastroenterology 1998;115:947–53.
  • Onodera K, Kato A, Suzuki K. Serum leptin concentrations in liver cirrhosis: relationship to the severity of liver dysfunction and their characteristic diurnal profiles. Hepatology Research 2001;21:205–12.
  • Bolukbas FF, Bolukbas C, Horoz M, Gumus M, Erdogan M, Zeyrek F, Yayla A, Ovunc O. Child-Pugh classification dependent alterations in serum leptin levels among cirrhotic patients: a case controlled study. BMC Gastroenterology 2004;4:23.
  • Wahl DG, Dollet JM, Kreher M, Champigneulle B, Bigard MA, Gaucher P. Relationship of insulin resistance to protein energy malnutrition in patients with alcoholic liver cirrhosis: effect of short-term nutritional support. Alcohol Clin Exp Res 1992;16:971–78.
  • Kwon SY, Kim SS, Kwon OS, Kwon K., Chung MG, Park DK, Kim YS, Koo YS, Kim YK, Choi DJ, Kim JH. Prognostic significance of glycaemic control in patients with HBV and HCV-related cirrhosis and diabetes mellitus. Diab Med 2005;22:1530–5.
  • Abou-Assi S, Vlahcevic ZR. Hepatic encephalopathy. Metabolic consequence of cirrhosis often is reversible. Postgrad Med 2001;109:52–60.
  • Papotti M, Ghé C, Cassoni P, Catapano F, Deghenghi R, Ghigo E, Muccioli G. Growth hormone secretagogue binding sites in peripheral human tissues. J Clin Endocrinol Metab 2000;85:3803–7.
  • Wang Z, Lv J, Zhang R, Zhu Y, Zhu D, Sun Y, Zhu J, Han X. Co-culture with fat cells induces cellular insulin resistance in primary hepatocytes. Biochem Biophysl Res Comm 2006;345:976–83.

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