173
Views
26
CrossRef citations to date
0
Altmetric
Research Article

Association of fetuin-A and cardiac calcification and inflammation levels in hemodialysis patients

, , &
Pages 575-582 | Received 30 May 2010, Accepted 27 Sep 2010, Published online: 21 Oct 2010

References

  • USRDS. Excerpt from the United States Renal Data System 1999. Annual Data Report: Patient mortality and survival in ESRD. Am J Kidney Dis 1999;34:S74–86.
  • London GM. Cardiovascular calcifications in uremic patients: clinical impact on cardiovascular function. J Am Soc Nephrol 2003;14:S305–9.
  • Guérin AP, London GM, Marchais SJ, Metivier F. Arterial stiffening and vascular calcifications in end-stage renal disease. Nephrol Dial Transplant 2000;15:1014–21.
  • Blacher J, Guérin AP, Pannier B. Arterial calcifications, arterial stiffness and cardiovascular risk in end-stage renal disease. Hypertension 2001;38:938–42.
  • Braun J, Oldendorf M, Moshage W. Electron beam computed tomography in evaluation of cardiac calcification in chronic dialysis patients. Am J Kidney Dis 1996;27:394–401.
  • Moe SM, O'Neill KD, Fineberg N. Assessment of vascular calcification in ESRD patients using spiral CT. Nephrol.Dial Transplant 2003;18:1152–8.
  • Floege J, Ketteler M. Vascular calcification in patients with end-stage renal disease. Nephrol Dial Transplant 2004;19:59–66.
  • Cozzolino M, Dusso As, Slatopolsky E. Role of calcium-phosphate product and bone associated proteins on vascular calcification in renal failure. J Am Soc Nephrol 2001;12: 2511–6.
  • Cozzolino M, Brancaccio D, Gallieni M, Slatopolsky E. Pathogenesis of vascular calcification in chronic kidney disease. Kidney Int 2005;68:429–36.
  • Schafer C, Heiss A, Schwarz A. The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J Clin Invest 2003;112:357–66.
  • Keeley KW, Sitarz EE. Identification and quantitation of alpha 2-HS-glycoprotein in the mineralized matrix of calcified plaques of atherosclerotic human aorta. Atherosclerosis 1985;55:63–9.
  • Demetriou M, Binkert C, Sukhu B, Tenenbaum HC, Dennis JW. Fetuin/α2HS glycoprotein is a transforming growth factor-beta type II receptor mimic and cytokine antagonist. J Biol Chem 1996;271:12755–61.
  • Price PA, Lim JE. The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin-mineral complex. J Biol Chem 2003;278: 22144–52.
  • Reynolds JL, Joannides AJ, Skepper JN, McNair R, Schurgers LJ, Proudfoot D, Jahnen-Dechent W, Weissberg PL, Shanahan CM. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 2004;15:2857–67.
  • Ketteler M, Bongartz P, Westenfeld R, Wildberger JE, Mahnken AH, Bohm R, Metzger T, Wanner C, Jahnen-Dechent W, Floege J. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet 2003; 361:827–33.
  • Menon V, Greene T, Wang X. C-reactive protein and albumin as predictors of all cause and cardiovascular mortality in chronic kidney disease. Kidney Int 2005;68:766–72.
  • Honda H, Qureshi AR, Heimburger O. Serum albumin, C-reactive protein, interleukin-6, and fetuin as predictors of malnutrition, cardiovascular disease, and mortality in patients with ESRD. Am J Kidney Dis 2006;47:139–48.
  • Agatston AS, Janowitz WR, Hildner FJ. Quantification of coronary artery calcium using ultra fast computed tomography. J Am Coll Cariol 2002;39:695–701.
  • Schiller NB, Shah PM, Crawford M. Recommendations for quantification of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, committee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358–67.
  • Wong M, Tei C, Shah PM. Sensitivity and specificity of two-dimensional echocardiography in the detection of valvular calcification. Chest 1983;84:423–7.
  • Raggi P, Boulay A, Taber SC. Cardiac calcification in adult hemodialysis patients: a link between end-stage renal disease and cardiovascular disease. J Am Coll Cardiol 2002;39: 695–701.
  • Zhang B, Shi W, He CS, Liang XL, Liu SX, Liang YZ. Low serum fetuin A is a risk factor of coronary artery calcification in patients starting dialysis. Nan Fang Yi Ke Da Xue Xue Bao 2010;30:1002–4.
  • Coen G, Manni M, Agnoli A, Balducci A, Dessi M, De Angelis S, Jankovic L, Mantella D, Morosetti M, Naticchia A, Nofroni I, Romagnoli A, Gallucci MT, Tomassini M, Simonetti G, Splendiani G. Cardiac calcifications: fetuin-A and other risk factors in hemodialysis patients. ASAIO J 2006;52:150–6.
  • Wang AY, Woo J, Lam CW, Wang M, Chan IH, Goa P, Lui SF, Li PK, Sanderson JE. Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients. Nephrol Dial Transplant 2005;20:1676–85.
  • Mehrotra R, Westenfeld R, Christenson P. Serum fetuin-A in nondialyzed patients with diabetic nephropathy: relationship with coronary artery calcification. Kidney Int 2005; 67:1070–7.
  • Mathews ST, Singh GP, Ranalletta M. Improved insulin sensitivity and resistance to weight gain in mice null for the AHSG gene. Diabetes 2002;51:2450–8.
  • Moe SM, Reslerova M, Ketteler M. Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease. Kidney Int 2005;67:2295–304.
  • Lebreton JP, Joisel F, Raoult JP, Lannuzel B, Rogez JP, Humbert G. Serum concentration of human alpha2HS glycoprotein during inflammatory process. Evidence that alpha2HS glycoprotein is a negative acute-phase reactant. J Clin Invest 1979;64:1118–29.
  • Wang H, Zhang M, Soda K, Sama A, Tracey KJ. Fetuin protects the fetus from TNF. Lancet 1997;350:861–2.
  • Ombrellino M, Wang H, Yang H. Fetuin, a negative acute phase protein, attenuates TNF synthesis and the innate inflammatory response to carrageenan. Shock 2001;15: 181–5.
  • Wang AY, Ho SYY, Wang M. Is cardiac valvular calcification a marker of atherosclerosis and arterial calcification in end-stage renal disease patients? Arch Intern Med 2005;165:327–32.
  • Binkert C, Demetriou M, Sukhu B, Szweras M, Tenenbaum HC, Dennis JW. Regulation of osteogenesis by fetuin. J Biol Chem 1999;274:28514–20.
  • Kimmel PL, Phillips TM, Simmens SJ. Immunologic function and survival in hemodialysis patients. Kidney Int 1998;54:236–44.
  • Panichi V, Migliori M, De Pietro S. C- reactive protein and interleukin-6 levels are related to renal function in predialytic chronic renal failure. Nephrology 2002;91:594–600.
  • Plutzky AM. Inflammatory pathways in atherosclerosis and acute coronary syndromes. Am J Cardiol 2001;88:10K–5.
  • Stenvinkel P, Heimburger O, Paultre F. Strong association between malnutrition, inflammation and atherosclerosis in chronic renal failure. Kidney Int 1999;55:1899–911.
  • Cozzolino M, Galassi A, Biondi ML, Turri O, Papagni S, Mongelli N, Civita L, Gallieni M, Brancaccio D. Serum fetuin-A levels link inflammation and cardiovascular calcification in hemodialysis patients. Am J Nephrol 2006;26:423–9.
  • Wang AY, Woo J, Lam CK. Is a single time-point C-reactive protein predictive of outcome in peritoneal dialysis patients? J Am Soc Nephrol 2003;14:1871–9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.