Vitamin D and bone health

References

• Mellanby E. An experimental investigation on rickets. Lancet 1919;1:407–12.
   Google Scholar
• St-Arnaud R, Naja RP. Vitamin D metabolism, cartilage and bone fracture repair. Mol Cell Endocrinol 2011;347: 48–54.
   Google Scholar
• Peacock M. Osteomalacia and rickets. In: Nordin BEC, Need AG, Morris HA, editors. Metabolic Bone and Stone Disease. 3rd ed. London: Churchill Livingstone; 1993. p. 83–118.
   Google Scholar
• Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, Baron R, Demay MB. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 1999;140:4982–7.
   PubMed Web of Science ®Google Scholar
• Aaron JE, Gallagher JC, Nordin BE. Seasonal variation of histological osteomalacia in femoral-neck fractures. Lancet 1974;2:84–5.
   PubMed Web of Science ®Google Scholar
• Lai JK, Lucas RM, Clements MS, Roddam AW, Banks E. Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies. BMC Public Health 2010;10:331.
   Google Scholar
• Lips P, van Ginkel FC, Jongen MJ, Rubertus F, van der Vijgh WJ, Netelenbos JC. Determinants of vitamin D status in patients with hip fracture and in elderly control subjects. Am J Clin Nutr 1987;46:1005–10.
   PubMed Web of Science ®Google Scholar
• Arnala I, Kyrola K, Kroger H, Alhava EM. Analysis of 245 consecutive hip fracture patients with special reference to bone metabolism. Ann Chir Gynaecol 1997;86:343–7.
   Google Scholar
• Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski J. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 2009;169:551–61.
   PubMed Web of Science ®Google Scholar
• Chung M, Lee J, Terasawa T, Lau J, Trikalinos TA. Vitamin D With or Without Calcium Supplementation for Prevention of Cancer and Fractures: An Updated Meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2011;155:827–38.
   PubMed Web of Science ®Google Scholar
• Avenell A, Gillespie WJ, Gillespie LD, O'Connell D. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev 2009:CD000227.
   Google Scholar
• Bischoff-Ferrari HA, Kiel DP, Dawson-Hughes B, Orav JE, Li R, Spiegelman D, Dietrich T, Willett WC. Dietary calcium and serum 25-hydroxyvitamin D status in relation to BMD among U.S. adults. J Bone Miner Res 2009;24: 935–42.
   PubMed Web of Science ®Google Scholar
• Anderson PH, Atkins GJ. The skeleton as an intracrine organ for vitamin D metabolism. Mol Aspects Med 2008;29: 397–406.
   PubMed Web of Science ®Google Scholar
• Suda T, Udagawa N, Nakamura I, Miyaura C, Takahashi N. Modulation of osteoclast differentiation by local factors. Bone 1995;17:87S-91S.
   PubMed Web of Science ®Google Scholar
• Takeda S, Yoshizawa T, Nagai Y, Yamato H, Fukumoto S, Sekine K, Kato S, Matsumoto T, Fujita T. Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: studies using VDR knockout mice. Endocrinology 1999;140: 1005–8.
   PubMed Web of Science ®Google Scholar
• Martin TJ, Seeman E. Bone remodelling: its local regulation and the emergence of bone fragility. Best Pract Res Clin Endocrinol Metab 2008;22:701–22.
   PubMed Web of Science ®Google Scholar
• Owen TA, Aronow MS, Barone LM, Bettencourt B, Stein GS, Lian JB. Pleiotropic effects of vitamin D on osteoblast gene expression are related to the proliferative and differentiated state of the bone cell phenotype: dependency upon basal levels of gene expression, duration of exposure, and bone matrix competency in normal rat osteoblast cultures. Endocrinology 1991;128:1496–504.
   PubMed Web of Science ®Google Scholar
• Atkins GJ, Anderson PH, Findlay DM, Welldon KJ, Vincent C, Zannettino AC, O'Loughlin PD, Morris HA. Metabolism of vitamin D(3) in human osteoblasts: Evidence for autocrine and paracrine activities of 1alpha,25-dihydroxyvitamin D(3). Bone 2007;40:1517–28.
   PubMedGoogle Scholar
• Atkins GJ, Findlay DM, Anderson PH, Morris HA. Target genes: bone proteins. In: Feldman D, Pike JW, Adams JS, editors. Vitamin D, third edition. 3rd edition ed. San Diego: Elsevier Academic Press; 2011. p. 411–24.
   Google Scholar
• Howard GA, Turner RT, Sherrard DJ, Baylink DJ. Human bone cells in culture metabolize 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3. J Biol Chem 1981;256:7738–40.
   PubMed Web of Science ®Google Scholar
• van Driel M, Koedam M, Buurman CJ, Hewison M, Chiba H, Uitterlinden AG, Pols HA, van Leeuwen JP. Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells. Faseb J 2006;20:2417–9.
   PubMed Web of Science ®Google Scholar
• Hendrix I, Anderson P, May B, Morris H. Regulation of gene expression by the CYP27B1 promoter-study of a transgenic mouse model. J Steroid Biochem Mol Biol 2004; 89–90:139–42.
   Google Scholar
• Hendrix I, Anderson PH, Omdahl JL, May BK, Morris HA. Response of the 5′-flanking region of the human 25-hydroxyvitamin D 1{alpha}-hydroxylase gene to physiological stimuli using a transgenic mouse model. J Mol Endocrinol 2005;34:237–45.
   Google Scholar
• Anderson PH, Hendrix I, Sawyer RK, Zarrinkalam R, Manavis J, Sarvestani GT, May BK, Morris HA. Co-expression of CYP27B1 enzyme with the 1.5kb CYP27B1 promoter-luciferase transgene in the mouse. Mol Cell Endocrinol 2008;285:1–9.
   Google Scholar
• Anderson PH, O'Loughlin PD, May BK, Morris HA. Modulation of CYP27B1 and CYP24 mRNA expression in bone is independent of circulating 1,25(OH)2D3 levels. Bone 2005;36:654–62.
   Google Scholar
• Anderson PH, Iida S, Tyson JH, Turner AG, Morris HA. Bone CYP27B1 gene expression is increased with high dietary calcium and in mineralising osteoblasts. J Steroid Biochem Mol Biol 2010;121:71–5.
   Google Scholar
• Boivin G, Mesguich P, Pike JW, Bouillon R, Meunier PJ, Haussler MR, Dubois PM, Morel G. Ultrastructural immunocytochemical localization of endogenous 1,25-dihydroxyvitamin D3 and its receptors in osteoblasts and osteocytes from neonatal mouse and rat calvaria. Bone Miner 1987;3:125–36.
   PubMedGoogle Scholar
• Naja RP, Dardenne O, Arabian A, St Arnaud R. Chondrocyte-specific modulation of Cyp27b1 expression supports a role for local synthesis of 1,25-dihydroxyvitamin D3 in growth plate development. Endocrinology 2009;150:4024–32.
   PubMedGoogle Scholar
• Anderson PH, Atkins GJ, Findlay DM, Oloughlin PD, Welldon K, Vincent C, Morris HA. RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells. J Steroid Biochem Mol Biol 2007;103:601–5.
   Google Scholar
• Tang WJ, Wang LF, Xu XY, Zhou Y, Jin WF, Wang HF, Gao J. Autocrine/paracrine action of vitamin D on FGF23 expression in cultured rat osteoblasts. Calcif Tissue Int 2010;86:404–10.
   Google Scholar
• Kogawa M, Anderson PH, Findlay DM, Morris HA, Atkins GJ. The metabolism of 25-(OH)vitamin D3 by osteoclasts and their precursors regulates the differentiation of osteoclasts. J Steroid Biochem Mol Biol 2010;121: 277–80.
   Google Scholar
• Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ. Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption. Endocrinology 2010;151:4613–25.
   PubMed Web of Science ®Google Scholar
• Atkins GJ, Kostakis P, Pan B, Farrugia A, Gronthos S, Evdokiou A, Harrison K, Findlay DM, Zannettino AC. RANKL expression is related to the differentiation state of human osteoblasts. J Bone Miner Res 2003;18:1088–98.
   Google Scholar
• Parfitt AM, Qiu S, Rao DS. The mineralization index-a new approach to the histomorphometric appraisal of osteomalacia. Bone 2004;35:320–5.
   Google Scholar
• Donohue MM, Demay MB. Rickets in VDR null mice is secondary to decreased apoptosis of hypertrophic chondrocytes. Endocrinology 2002;143:3691–4.
   Google Scholar
• Dardenne O, Prud'Homme J, Hacking SA, Glorieux FH, St-Arnaud R. Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1). Bone 2003;32:332–40.
   Google Scholar
• DeLuca HF, Schnoes HK. Metabolism and mechanism of action of vitamin D. Annu Rev Biochem 1976;45:631–66.
   PubMed Web of Science ®Google Scholar
• Wicks M, Garrett R, Vernon-Roberts B, Fazzalari N. Absence of metabolic bone disease in the proximal femur in patients with fracture of the femoral neck. J Bone Joint Surg Br 1982;64:319–22.
   Google Scholar
• Anderson PH, Sawyer RK, Moore AJ, May BK, O'Loughlin PD, Morris HA. Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model. J Bone Miner Res 2008;23:1789–97.
   Google Scholar
• Morris HA, Lee AM, Sawyer RK, Iida S, O'Loughlin PD, Anderson PH. Increased Bone Cell Vitamin D Activity: The Basis for Synergy between Dietary Calcium and Vitamin D for Bone Health? J Bone Miner Res 2010;25:S131.
   Google Scholar
• Gardiner EM, Baldock PA, Thomas GP, Sims NA, Henderson NK, Hollis B, White CP, Sunn KL, Morrison NA, Walsh WR, Eisman JA. Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage. Faseb J 2000;14: 1908–16.
   Google Scholar
• Morris HA, Turner AG, Sawyer R, O'Loughlin PD, Anderson PH. Increased trabecular bone in the bone-specific CYP27B1 transgenic mouse. Bone 2011;48:S78.
   Google Scholar
• Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001;22: 477–501.
   PubMed Web of Science ®Google Scholar
• Nordin BE, Morris HA. Osteoporosis and vitamin D. J Cell Biochem 1992;49:19–25.
   Google Scholar
• Need AG, Nordin BE. Misconceptions - vitamin D insufficiency causes malabsorption of calcium. Bone 2008;42: 1021–4.
   Google Scholar
• Need AG, O'Loughlin PD, Morris HA, Coates PS, Horowitz M, Nordin BE. Vitamin D metabolites and calcium absorption in severe vitamin D deficiency. J Bone Miner Res 2008;23:1859–63.
   PubMed Web of Science ®Google Scholar
• Morris HA, Morrison GW, Burr M, Thomas DW, Nordin BE. Vitamin D and femoral neck fractures in elderly South Australian women. Med J Aust 1984;140:519–21.
   Google Scholar
• Lidor C, Sagiv P, Amdur B, Gepstein R, Otremski I, Hallel T, Edelstein S. Decrease in bone levels of 1,25-dihydroxyvitamin D in women with subcapital fracture of the femur. Calcif Tissue Int 1993;52:146–8.
   PubMedGoogle Scholar
• Need AG, Horowitz M, Morris HA, Moore R, Nordin C. Seasonal change in osteoid thickness and mineralization lag time in ambulant patients. J Bone Miner Res 2007;22: 757–61.
   Google Scholar
• Parisien M, Silverberg SJ, Shane E, de la Cruz L, Lindsay R, Bilezikian JP, Dempster DW. The histomorphometry of bone in primary hyperparathyroidism: preservation of cancellous bone structure. J Clin Endocrinol Metab 1990;70:930–8.
   PubMed Web of Science ®Google Scholar
• Priemel M, von Domarus C, Klatte TO, Kessler S, Schlie J, Meier S, Proksch N, Pastor F, Netter C, Streichert T, Puschel K, Amling M. Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res 2010;25:305–12.
   PubMed Web of Science ®Google Scholar
• Carlsson A, Lindquist B. Comparison of intestinal and skeletal effects of vitamin D in relation to dosage. Acta Physiol Scand 1955;35:53–5.
   PubMedGoogle Scholar
• Nordin BE, Need AG, Horowitz M, Morris HA, Durbridge TC, Cleghorn DB. Osteoporosis and calcium. Aust N Z J Med 1991;21:275–9.
   Google Scholar
• Horowitz M, Wishart JM, Goh D, Morris HA, Need AG, Nordin BE. Oral calcium suppresses biochemical markers of bone resorption in normal men. Am J Clin Nutr 1994;60:965–8.
   Google Scholar
• Morris HA, O'Loughlin PD, Anderson PH. Experimental evidence for the effects of calcium and vitamin D on bone: A review. Nutrients 2010;2:1026–35.
   Google Scholar