264
Views
1
CrossRef citations to date
0
Altmetric
Research Articles

Automated alarm to detect antigen excess in serum free immunoglobulin light chain kappa and lambda assays

, , &
Pages 575-581 | Received 22 May 2013, Accepted 25 Mar 2014, Published online: 09 Jul 2014

References

  • Murata K, Clark RJ, Lockington KS, Tostrud LJ, Greipp PR, Katzmann JA. Sharply increased serum free light-chain concentrations after treatment for multiple myeloma. Clin Chem 2010;56:16–20.
  • Daval S, Tridon A, Mazeron N, Ristori JM, Evrard B. Risk of antigen excess in serum free light chain measurements. Clin Chem 2007;53:1985–6.
  • Vercammen M, Meirlaen P, Broodtaerts L, Broek IV, Bossuyt X. Effect of sample dilution on serum free light chain concentration by immunonephelometric assay. Clin Chim Acta 2011;412:1798–804.
  • McCudden CR, Voorhees PM, Hammet-Stabler CA. A case of hook effect in the serum free light chain assay using the Olympus AU400e. Clin Biochem 2009:42: 121–4.
  • Bosmann M, Kössler J, Stolz H, Walter U, Knop S, Steigerwald U. Detection of serum free light chains: the problem with antigen excess. Clin Chem Lab Med 2010;48:1419–22.
  • Murng SHK, Follows L, Whitfield P, Snowden JA, Swallow K, Green K, Sargur R, Egner W. Defining the impact of individual sample variability on routine immunoassay of serum free light chains (sFLC) in multiple myeloma. Clin Exp Immunol 2013;171:201–9.
  • Papik K, Molnar B, Fedorcsak P, Schaefer R, Lang F, Sreter L, Feher J, Tulassay Z. Automated prozone effect detection in ferritin homogeneous immunoassays using neural network classifiers. Clin Chem Lab Med 1999; 37:471–6.
  • Al-Mahdili HA, Jones GR. High-dose hook effect in six automated human chorionic gonadotrophin assays. Ann Clin Biochem 2010;47:383–5.
  • Akamatsu S, Tsukazaki H, Inoue K, Nishio Y. Advanced prostate cancer with extremely low prostate-specific antigen value at diagnosis: an example of high dose hook effect. Int J Urol 2006;13:1025–7.
  • Jenner E, Levoguer A, Evans J, Harding S. Serum free light chain immunoassays: a guide to antigen excess detection. Clin Chim Acta 2012;413:949.
  • Te Velthuis H, Knop I, Stam P, van den Broek M, Bos HK, Hol S, Teunissen E, Fischedick KS, Althaus H, Schmidt B, Wagner C, Melsert R. N Latex FLC – new monoclonal high-performance assays for the determination of free light chain kappa and lambda. Clin Chem Lab Med 2011;49:1323–32.
  • Product data sheet for human kappa free kit (for use on the SPAplus). Insert code: SIN 113DS, version 12 May 2011.
  • Product data sheet for human kappa free kit (for use on the Roche Cobas® systems). Insert code: SIN 129Dk, version 1 June 2011.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.