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Original Article

The Titration of Heparin with Protamine

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Pages 284-287 | Received 26 May 1954, Published online: 08 Jul 2009

References

  • Allen J. G., Moulder P. V., Elghammer R. M., Grossmann B. R., McKeen C. L., Sanderson M., Egner W., Crosbie J. M. A protamine titration as an indication of a clotting defect in certain hemorrhagic states. J. Lab. Clin. Med. 1949; 34: 473
  • Chargaff E. Studies on the chemistry of blood coagulation VII. Protamines and blood clotting. J. Biol. Chem. 1938; 125: 671
  • Chargaff E., Olson K. B. Studies on the chemistry of blood coagulation VI. Studies on the action of heparin and other anticoagulants. The influence of protamine on the anticoagulant effect in vivo. J. Biol. Chem. 1938; 122: 153
  • Fischer A. Die Bindung von Heparin an Eiweiß. Biochem. Ztschr. 1935; 278: 133
  • Fischer A., Ast'rup T. Stöchiometrische Bindungs-verhältnisse zwischen Heparin und Gerinnungs-stoff. Biochem. Ztschr. 1935; 278: 326
  • Jaques L. B. The reaction of heparin with proteins and complex bases. Biochem. J. 1943; 37: 189
  • Jaques L. B., Waters E. T. The identity and the origin of the antiocoagulant of anaphylactic shock in the dog. J. Physiol. 1941; 99: 454
  • Ie Roy G. V., Halpern B., Dolkart R. E. An indirect, quantitative method for the estimation of heparin activity in vitro: The heparinprotamine titration test. J. Lab. Clin. Med. 1950; 35: 446
  • Raaschou F., Refn I., Vestergaard L. Om vandige heparinopløsningers protaherede virk-ning efter intramusculâr og subcutan injek-tion. Ugeskr. f. laeger 1954; 116: 281
  • Refn I., Raaschou F. Is sublingual administration of heparin effective?. Nord. med. 1952; 47: 159
  • Ullrich F. W., Cronkite E. P. A method for the titration of heparin-like substances in plasma. Naval Medical Research Institute, Bethesda, Maryland 1947, Project NM 007 039 Report No. 4

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