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Scandinavian Journal of Clinical and Laboratory Investigation Volume 16, 1964 - Issue 4
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Original Article

Administration of Spironolactone as a Source of Error in Determination of 17-Ketosteroids in Urine

J. Lyngrye First Medical University Department, Kommunehospitalet, Århus, the Institute of Hygiene, Århus University, Århus, Denmark; Hormone Department, Statens Seruminstitut, Copenhagen, Denmark
&
S. G. Johnsen First Medical University Department, Kommunehospitalet, Århus, the Institute of Hygiene, Århus University, Århus, Denmark; Hormone Department, Statens Seruminstitut, Copenhagen, Denmark
Pages 427-432 | Received 11 Feb 1964, Published online: 08 Jul 2009

References

  • Allen W. M. A simple method for analyzing complicated absorption curves for use in the colorimetric determination of urinary steroids. J. clin. Endocr 1950; 10: 71
  • Callow N. H., Callow R. K., Emmens C. W. Colorimetric determination of substances containing the grouping -CH2. CO- in urine extracts as an indication of androgen content. Biochem. J 1938; 32: 1312
  • Callow N. H., Callow R. K., Emmens C. W. 17-ketosteroid, androgen and oestrogen excretion in the urine of cases of gonadal or adrenal cortical deficiency. J. Endocr 1940; 2: 88
  • Davidson E. T., Coppage W. S., Island D., Liddle G. W. Effects of steroid-17-spirolac-tones on aldosterone secretion, excretion, and metabolism in man. J. Lab. clin. Med 1961; 58: 505
  • Gochman N., Gantt C. L. A fluorimetric method for the determination of a major spironolactone (Aldactone) metabolite in human plasma. J. Pharmacol, exp. Ther 1962; 135: 312
  • Gochman N. 1962, Personal communication
  • Hamburger C. Normal urinary excretion of neutral 17-ketosteroids with special reference to age and sex variations. Acta endocr 1948; 1: 19
  • Hamburger C. Paavisning af 17-ketosteroider i Urinen. Med saerligt Henblik paa Normaludskillelsen. Nord. Med 1948; 39: 1522
  • Hastrup B. Amylenhydrat og måling af neutrale 17-ketosteroider i urinen. Ibid 1954; 51: 473
  • Johnsen S. G. Fractionation of urinary 17-ketosteroids. I. A simplified method for the chromatographic separation of urinary androgen metabolites. Acta endocr 1956; 21: 127
  • Johnsen S. G. Fractionation of urinary 17-ketosteroids.II. Normal values for men and women at different ages. Ibid 1956; 21: 146
  • Liddle G. W., Bartter F. C. The clinical use of aldosterone antagonists. Thomas, Springfield 1960; 111: 18
  • Lyngbye J. Administration of aldactone as a source of error in determination of fractionated 17-ketosteroids in urine. Preliminary report. Dan. med. Bull 1962; 9: 51
  • Streeten D. H. P., Bartter F. C. The clinical use of aldosterone antagonists. Thomas, Springfield 1960; 111: 86
  • Vestergaard P. Rapid micro-modification of the Zimmermann/Callow procedure for the determination of 17-ketosteroids in urine. Acta endocr 1951; 8: 193
  • Vestergaard P., Claussen B. Hydrolysis of 17-ketosteroid conjugates with a procedure based on simultaneous benzene extraction and acid hydrolysis. Ibid 1962; 35, Suppl 64
  • Zimmermann W. Eine Farbreaktion der Sexual-hormone und ihre Anwendung zur quantitativen colorimetrischen Bestimmung. Hoppe-Seyler's Z. physiol. Chem 1935; 233: 257

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