The Influence of Arterial Hypoxemia upon Labile Phosphates and upon Extracellular and Intracellular Lactate and Pyruvate Concentrations in the Rat Brain

References

• Alexander S. C., Workman R. D., Lambertsen C. J. Hyperthermia, lactic acid infusion, and the composition of arterial blood and cerebrospinal fluid. Amer. J. Physiol. 1962; 202: 1049
   PubMed Web of Science ®Google Scholar
• Chance B., Schoener B. Correlation of oxidation-reduction changes of intracellular reduced pyridine nucleotide and changes in electroencephalogram of the rat in anoxia. Nature 1962; 195: 956
   Google Scholar
• Cohen P. J., Alexander S. C., Smith T. C., Reivich M., Wollman H. Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man. J. appl. Physiol. 1967; 23: 183
   PubMed Web of Science ®Google Scholar
• Gottesfeld Z., Miller A. T. Metabolic response of rat brain to acute hypoxia: influence of polycythemia and hypercapnia. Amer. J. Physiol. 1969; 216: 1374
   PubMedGoogle Scholar
• Granholm L., Lukjanova L., Siesjö B. K. The effect of marked hyperventilation upon tissue levels of NADH, lactate, pyruvate, phosphocreatine and adenosine phosphates of rat brain. Acta physiol. scand. 1969; 77: 179
   Google Scholar
• Gurdjian E. S., Stone W. E., Webster J. E. Cerebral metabolism in hypoxia. Arch. Neurol. Psychiat. (Chic.) 1944; 51: 472
   Google Scholar
• Gurdjian E. S., Webster J. E., Stone W. E. Cerebral constituents in relation to blood gases. Amer. J. Physiol. 1949; 156: 149
   Google Scholar
• Hohorst H. J., Kreuz F. H., Bücher Th. Über Metabolitgehalte und Metabolit-Konzentrationen in der Leber der Ratte. Biochem. Z. 1959; 332: 18
   PubMedGoogle Scholar
• Huckabee W. E. Control of concentration gradients of pyruvate and lactate across cell membranes in blood. J. appl. Physiol. 1956; 9: 163
   PubMed Web of Science ®Google Scholar
• Huckabe W. E., Bunker J. P., Vandam L. D. Effects of Anesthesia on Metabolism and Cellular Functions. Pharmacol. Rev. 1965; 17: 183, 247–252
   Google Scholar
• Kaasik A. E., Nilsson L., Siesjö B. K. The effect of asphyxia upon the lactate, pyruvate and bicarbonate concentrations of brain tissue and cisternal CSF, and upon the tissue concentrations of phosphocreatine and adenine nucleotides in anesthetized rats. Acta physiol. scand. 1970a; 78: 433
   PubMedGoogle Scholar
• Kaasik A. E., Nilsson L., Siesjö B. K. The effect of arterial hypotension upon the lactate, pyruvate and bicarbonate concentrations of brain tissue and cisternal CSF, and upon the tissue concentrations of phosphocreatine and adenine nucleotides in anesthetized rats. Acta physiol. scand. 1970b; 78: 448
   Google Scholar
• Kirsten E., Gerez C., Kirsten R. Eine enzymatische Mikrobestimmung des Ammoniaks, geeignet für Extrakte tierischer Gewebe und Flüssigkeiten. Biochem. Z. 1963; 337: 312
   PubMedGoogle Scholar
• Kjällquist Å., Nardini M., Siesjö B. K. The regulation of extra- and intracellular acid-base parameters in the rat brain during hyper- and hypocapnia. Acta physiol. scand. 1969; 76: 485
   PubMedGoogle Scholar
• Krebs H. A., Veech R. L. Regulation of the redox state of the pyridine nucleotides in rat liver. Pyridine Nucleotide-Dependent Dehydrogenases, H. Sund. Springer Verlag, NY 1970; 413–434
   Google Scholar
• Kuby S. A., Noltmann E. A. ATP-crcatinc transphosphorylase. The Enzymes, P. D. Boyer, H. Lardy, K. Myrbäck. Academic Press. 1962; Vol. 6: 515–603
   Google Scholar
• Laué D. Ein neues Tonometer zur raschen Äquilibrierung von Blut mit verschiedenen Gasdrucken. Pflügers Arch. ges. Physiol. 1951; 254: 142
   PubMedGoogle Scholar
• Leusen I., Lacroix E., Demeester G. Lactate and pyruvate in the brain of rats during changes in acid-base balance. Arch. internat. Physiol. Bioch. 1967; 75: 310
   PubMed Web of Science ®Google Scholar
• Lowry O. H., Passonneau J. V., Hasselberger F. X., Schulz D. W. Effect of ischemia on known substrates and cofactors of the glucolytic pathway in brain. J. biol. Chem. 1964; 239: 18
   PubMed Web of Science ®Google Scholar
• Nilsson L., Siesjö B. K. The effect of hypoxia upon labile substrates and upon acid-base parameters in the brain. Ion Homeostasis of the Brain. Alfred Benzon Symposium III, Munksgaard, Copenhagen. B. K. Siesjö, S. C. Sörensen. 1971, To be published
   Google Scholar
• Pontén U., Siesjö B. K. A method for the determination of the total carbon dioxide content of frozen tissues. Acta physiol. scand. 1964; 60: 297
   PubMedGoogle Scholar
• Pontén U., Siesjö B. K. Gradients of CO2 tension in the brain. Acta physiol. scand. 1966; 67: 129
   PubMedGoogle Scholar
• Schmahl F. W., Betz E., Talke H., Hohorst H. J. Energiereiche Phosphate und Metabolite des Energiestoffwechsels in der Grosshirnrinde der Katze. Biochem. Z. 1965; 342: 518
   PubMedGoogle Scholar
• Schmahl F. W., Betz E., Dettinger E., Hohorst H. J. Energiestoffwechsel der Grosshirnrinde und Elektroencephalogramm bei Sauferstoffmangel. Pflügers Arch. ges. Physiol. 1966; 292: 46
   PubMedGoogle Scholar
• Severinghaus J. W. Blood gas concentrations. Handbook of Physiology, Section 3: Respiration, W. O. Fenn, H. Rahn. American Physiological Society, Washington, D. C. 1965; 1475–1487
   Google Scholar
• Shimojyo S., Scheinberg P., Kogure K., Reinmuth O. M. The effects of graded hypoxia upon transient cerebral blood flow and oxygen consumption. Neurology 1968; 18: 127
   PubMed Web of Science ®Google Scholar
• Siesjö B. K., Zwetnow N. N. The effect of hypovolemic hypotension on extra- and intracellular acid-base parameters and energy metabolites in the rat brain. Acta physiol. scand. 1970; 79: 114
   Google Scholar
• Siesjö B. K., Zwetnow N. N. Effects of increased cerebrospinal fluid pressure upon adenine nucleotides and upon lactate and pyruvate in rat brain tissue. Acta neurol. scand. 1970; 46: 187
   PubMed Web of Science ®Google Scholar
• Siesjö B. K., Messeter K. Factors determining intracellular pH. Ion Homeostasis of the Brain. Alfred Benzon Symposium III, Munksgaard, Copenhagen. B. K. Siesjö, S. C. Sörensen. 1971, To be published
   Google Scholar
• Siesjö B. K., Nilsson L., Rokeach M., Zwetnow N. N. Energy metabolism of the brain at reduced cerebral perfusion pressures and in arterial hypoxemia. Brain Hypoxia, J. B. Brierley, 1971, To be published
   Google Scholar
• Siggaard-Andersen O. Blood acid-base alignment nomogram. Scand. J. clin. Lab. Invest. 1963; 15: 211
   PubMed Web of Science ®Google Scholar
• Thorn W., Scholl H., Pfleiderer G., Mueldener B. Stoffwechselvorgänge im Gehirn bei normaler und herabgesetzer Körpertemperatur unter ischämisher und anoxischer Belastung. J. Neurochem. 1958; 2: 150
   PubMed Web of Science ®Google Scholar
• Wahler B. E., Wollenberger A. Zur Bestimmung des Orthophosphats neben säuremolybdat-labilen Phosphorsäureverbindungen. Biochem. Z. 1958; 329: 508
   PubMedGoogle Scholar
• Williamson D. H., Lund, Patricia, Krebs H. A. The redox state of free nicotinamideadenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem. J. 1967; 103: 514
   PubMed Web of Science ®Google Scholar
• Williamson J. R., Corkey, Barbara E. Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods. Methods in Enzymology, Vol. XIII, Citric Acid Cycle, J. M. Lowenstein. Academic Press. 1969; 434–513
   Google Scholar
• Williamson J. R., Clark J. B., Nicklas W. J., Safer B. Control of glycolysis and oxidative metabolism in tissues. Ion Homeostasis of the Brain. Alfred Benzon Symposium III. Munksgaard, Copenhagen. B. K. Siesjö, S. C. Sörensen. 1971, To be published
   Google Scholar