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Original Article

Evaluation of insulin release and relative peripheral resistance with use of the oral glucose tolerance test: a study in subjects with normoglycaemia, glucose intolerance and non-insulin-dependent diabetes mellitus

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Pages 741-751 | Received 01 Sep 1984, Accepted 10 Apr 1985, Published online: 08 Jul 2009

References

  • Chiles R, Tzagournis M. Excessive serum insulin response to oral glucose in obesity and mild diabetes. Diabetes 1970; 19: 458–64
  • Reaven G, Miller R. Study of the relationship between glucose and insulin responses to an oral glucose load in man. Diabetes 1968; 17: 560–9
  • Reaven G M, Bernstein R, Davis B, Olefsky J M. Nonketotic diabetes mellitus: Insulin deficiency or insulin resistance?. Am J Med 1976; 60: 80–8
  • Seltzer H S, Allen W, Herron A L, Brennan M T. Insulin secretion in response to glycemic stimulus: Relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus. J Clin Invest 1967; 46: 323–34
  • DeFronzo R A, Ferrannini E, Koivisto V. New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus. Am J Med 1983; 74: 52–81
  • DeFronzo R A, Tobin J D, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237(3)E214–23
  • DeFronzo R A, Simonsson D, Ferrannini E. Hepatic and peripheral insulin resistance: A common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1982; 23: 313–9
  • WHO Expert Committee on Diabetes Mellitus. WHO, Geneva 1980, Second Report. Tech Rep Ser 646
  • National Diabetes Data Group. NIH. Classification of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979; 28: 1039–57
  • Wålinder O, Ronquist G, Faber P-J. New spec-trophotometric method for the determination of HbA| compared with a microcolumn method. Clin Chem 1982; 28: 96–9
  • Bergman R N, Phillips L S, Cobelli C. Physiologic evaluation of factors controlling glucose tolerance in man. Measurements of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 1981; 68: 1456–67
  • Delia Corte M, Romano S, Voeghlin M R, Serio M. On a mathematical model for the analysis of the glucose tolerance curve. Diabetes 1970; 19: 445–9
  • Costill D L, Saltin B. Factors limiting gastric emptying during rest and exercise. J Appl Physiol 1974; 37: 679–83
  • Cummins A J. Absorption of glucose and methionine from the human intestine: Influence of the glucose concentration in the blood and in the intestinal lumen. J Clin Invest 1952; 31: 928–37
  • Malmquist J, Lindgärde F, Nordén G. Plasma insulin and C-peptide in normal and glucose intolerant males: the roles of hepatic insulin uptake. Acta Med Scand 1981, Suppl. 656: 19–21
  • Cerasi E, Efendic S, Luft R. Dose-response relation between plasma-insulin and blood glucose levels during oral glucose loads in prediabetic and diabetic subjects. Lancet 1973; I: 794–7
  • Kosaka K, Hagura R, Kuzuya T. Insulin response in equivocal and definite diabetes with special reference to subjects who had mild glucose intolerance but later developed definite diabetes. Diabetes 1977; 26: 944–52
  • Kadowaki T, Miyake Y, Hagura R, Akanuma Y, Kajinuma H, Kuzuya N, Takaku F, Kosaka K. Risk factors for worsening to diabetes in subjects with impaired glucose tolerance. Diabetologia 1984; 26: 44–9
  • Gottesman L, Mandarino L, Gerich J. Estimation and kinetic analysis of insulin-independent glucose uptake in human subjects. Am J Physiol 1983; 244: E632–5
  • Best J D, Taborsky G J, Halter J B, Porte D., Jr. Glucose disposal is not proportional to plasma glucose level in man. Diabetes 1981; 30: 847–50
  • Reaven G M, Ginsberg H, Javorski C, Kimmer-ling G, Olefsky J. Mechanisms of insulin resistance in untreated adult diabetics with fasting hyper-glycemia. Diabetes 1975; 24: 396
  • Felig P, Wahren J W, Hendler R. Influence of maturity-onset diabetes on splanchnic glucose balance after oral glucose ingestion. Diabetes 1978; 27: 121–6
  • Ferrannini E, Wahren J, Felog P, DeFronzo R A. The role of fractional glucose extraction in the regulation of splanchnic glucose metabolism in normal and diabetic man. Metabolism 1980; 29: 28–35
  • DeFronzo R A, Ferrannini E, Hendler R, Wahren J, Felig P. Influence of hyperinsulinemia, hyper-glycemia, and the route of glucose administration on splanchnic glucose exchange. Proc Natl Acad Sci USA 1978; 75: 5173–7
  • Reaven G M. Insulin resistance in noninsulin-dependent diabetes mellitus: Does it exist and can it be measured?. Am J Med 1983; 74: 3–17
  • Greenfield M S, Doberne L, Kraemer F, Tobey T, Reaven G. Assessment of insulin resistance with the insulin suppression test and the euglycemic clamp. Diabetes 1981; 30: 387–92
  • Reaven G M, Miller R G. An attempt to define the nature of chemical diabetes using a multidimensional analysis. Diabetologia 1979; 16: 17–24
  • Olefsky J, Farquhar J W, Reaven G. Relationship between fasting plasma insulin level and resistance to insulin-mediated glucose uptake in normal and diabetic subjects. Diabetes 1973; 22: 507–13

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