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Original Article

Effects of cholic acid, 7β-hydroxy- and 12β-hydroxy-isocholic acid on bile flow, lipid secretion and bile acid synthesis in the rat

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Pages 167-175 | Received 22 Jul 1985, Accepted 21 Oct 1985, Published online: 08 Jul 2009

References

  • Desjeux J F, Erlinger S, Dumont M. Metabolism and influence on bile secretion in the dog of dehydrocholate. Biol Gastroenterol 1973; 6: 9–18
  • Hardison W G. Metabolism of sodium dehydrocholate by the rat liver: its effect on micelle formation in bile. J Lab Clin Med 1971; 77: 811–20
  • Hoffman N E, Sewell R B, Smallwood R A. Bile acid structure and biliary lipid scrction. II. A comparison of three hydroxy and two keto bile acids. Am J Physiol 1978; 234: E637–40
  • O'Máille E RL, Richards T G. The secretory characteristics of dehydrocholate in the dog: comparison with the natural bile salts. J Physiol 1976; 261: 337–57
  • Erlinger S, Dumont M, Berthelat P, Dhumeaux D. Comparison of the choleretic effects of dehydrocholate and glycodeoxycholate in the rabbit. Digestion 1971; 4: 144–5
  • Sewell R B, Hoffman N E, Smallwood R A, Cockbain S. Bile acid structure and bile formation: a comparison of hydroxy and keto bile acids. Am J Physiol 1980; 238: G10–7
  • Danziger R G, Nakagaki M, Hoffman A F, Ljungwe E B. Differing effects of hydroxy‐7‐oxotaurine‐conjugated bile acids on bile flow and biliary lipid secretion in dogs. Am J Physiol 1984; 246: G166–72
  • O'Máille E RL, Kozmary S V, Hofmann A F, Gurantz D. Differing effects of norcholate and cholate on bile flow and biliary lipid secretion in the rat. Am J Physiol 1984; 246: G67–71
  • Roda A, Hofmann A F, Mysels K J. The influence of bile salt structure on self‐association in aqueous solutions. J Biol Chem 1983; 258: 6362–70
  • Pries J M, Gustafson A, Duane W C. Taurocholate is more potent than cholate in suppression of bile salt synthesis in the rat. J Lipid Res 1983; 24: 141–6
  • Samuelsson B. Preparation of ursodeoxycholic acid and 3α,7β,12α trihydroxycholanoic acid. Acta Chem Scand 1960; 14: 17–27
  • Chang F C. Potential bile acid metabolites. 5. 12α‐hydroxy acids by stereoselective reduction. Synthetic Communications 1981; 11: 875–9
  • Bergström S, Rottenberg M, Voltz J. The preparation of some carboxy‐labelled bile acids. Acta Chem Scand 1953; 7: 481–4
  • Duane W C. The intermicellar bile salt concentration in equilibrium with the mixed‐micelles of human bile. Biochim Biophys Acta 1975; 398: 275–86
  • Landin B, Nilsson Å, Johansson B. Biliary and lymphatic lipid and apolipoprotein AI secretion in rats with combined bile and thoracic duct drainage
  • Batta A K, Salen G, Shefer S. Substrate specificity of cholylglycine hydrolase for the hydrolysis of bile acid conjugates. J Biol Chem 1984; 259: 15035–9
  • Gurantz D, Hofmann A F. Influence of bile acid structure on bile flow and biliary lipid secretion in the hamster. Am J Physiol 1984; 247: G736–48
  • Klaassen C D. Comparison of the choloretic properties of bile acids. Eur J Pharm 1973; 23: 270–5
  • Shefer S, Hauser S, Bekersky I, Mosbach E H. Feedback regulation of bile acid biosynthesis in the rat. J Lipid Res 1969; 10: 646–55
  • Davis R A. Regulation of bile acid synthesis by microsomal membrane cholesterol. Enterohepatic circulation of bile acid and sterol metabolism. Falk Symposium no. 42, BerneSwitzerland, 1984
  • Davis R A, Highsmith W E, McNeal M M, Schex‐nayder J ‐C, Kuan J ‐C.W. Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin but not by bile acids. J Biol Chem 1983; 258: 4079–82
  • Nilsell K, Angelin B, Leid B, Einarsson K. Comparative effects of ursodeoxy‐cholic acid and chenodeoxycholic acid on bile acid kinetics and biliary secretion in humans. Gastroenterology 1983; 85: 1248–56
  • Lowe P J, Barnwell S G, Coleman R. Rapid kinetic analysis of the bile‐salt‐dependent secretion of phospholipid, cholesterol and a plasma‐membrane enzyme into bile. Biochem J 1984; 222: 631–7

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