Acetaldehyde adducts of proteins: Diagnostic and pathogenic implications in diseases caused by excessive alcohol consumption

References

• Lieber C S. Biochemical and molecular basis of alcohol-induced injury to liver and other tissues. N Engl J Med 1988; 319: 1639–50
   PubMed Web of Science ®Google Scholar
• Stevens V J, Fantl W J, Newman C B, Sims R V, Cerami A, Peterson C M. Acetaldehyde adducts with hemoglobin. J Clin Invest 1981; 67: 361–9
   PubMed Web of Science ®Google Scholar
• Sorrell M F, Tuma D J. Functional implications of acetaldehyde binding with cell constituents. Ann NY Acad Sci 1987; 492: 51–62
   Google Scholar
• SanGeorge R C, Hoberman H D. Reaction of acetaldehyde with hemoglobin. J Biol Chem 1986; 261: 6811–21
   Google Scholar
• Lin R C, Smith S R, Lumeng L. Detection of a protein-acetaldehyde adduct in the liver of rats fed alcohol chronically. J Clin Invest 1988; 81: 615–9
   PubMed Web of Science ®Google Scholar
• Lin R C, Lumeng L. Further studies on the 37 kD liver protein-acetaldehyde adduct that forms in vivo during chronic ethanol ingestion. Hepatology 1989; 10: 807–14
   Google Scholar
• Smith S L, Jennett R B, Sorrell M F, Tuma D J. Acetaldehyde substoichiometrically inhibits bovine neurotubulin polymerization. J Clin Invest 1989; 84: 337–341
   PubMed Web of Science ®Google Scholar
• Brenner D A, Chojkier M. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. J Biol Chem 1987; 262: 17690–5
   PubMedGoogle Scholar
• Casini A, Cunningham M, Rojkind M, Lieber C S. Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism. Hepatology 1991; 13: 758–65
   PubMed Web of Science ®Google Scholar
• Baraona E, Di Padova C, Tabasco J, Lieber C S. Red blood cells: new modality for acetaldehyde transport from liver to other tissues. Life Sci 1987; 40: 253–8
   Google Scholar
• Israel Y, Hurwitz E, Niemelä O, Arnon R. Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acet-aldehyde-protein adducts. Proc Natl Acad Sci USA 1986; 83: 7923–7
   PubMed Web of Science ®Google Scholar
• Jukkola A, Niemelä O. Covalent binding of acetaldehyde to type III collagen. Biochem Bio-phys Res Commun 1989; 159: 163–9
   Google Scholar
• Niemelä O, Juvonen T, Parkkila S. Immunohistochemical demonstration of acetaldehyde containing epitopes in human liver after ethanol ingestion. J Clin Invest 1991; 87: 1367–74
   PubMed Web of Science ®Google Scholar
• Niemelä O, Israel Y. Hemoglobin-acetaldehyde adducts in human alcohol abusers. Lab Invest 1992; 67: 246–52
   PubMed Web of Science ®Google Scholar
• Sillanaukee P, Seppä K, Koivula T, Israel Y, Niemelä O. Acetaldehyde-modified hemoglobin as a marker of alcohol consumption: comparison of two methods. J Lab Clin Med 1992; 120: 42–7
   PubMed Web of Science ®Google Scholar
• Niemelä O, Blake J, Orrego H. Serum type I collagen propeptide and severity of alcoholic liver disease. Alcohol Clin Exp Res 1992, (in press)
   Google Scholar
• Niemelä O, Risteli L, Sotaniemi E A, Risteli J. Aminoterminal propeptide of type III procollagen in serum in alcoholic liver disease. Gastroenterology 1983; 85: 254–9
   PubMed Web of Science ®Google Scholar
• Niemelä O, Risteli J, Blake J, Risteli L, Compton K V, Orrego H. Markers of fibrogenesis and basement membrane formation in alcoholic liver disease: relation to severity, presence of hepatitis and alcohol intake. Gastroenterology 1990; 98: 1612–9
   PubMed Web of Science ®Google Scholar
• Niemelä O, Risteli L, Sotaniemi E A, Risteli J. Type IV collagen and laminin-related antigens in human serum in alcoholic liver disease. Eur J Clin Invest 1985; 15: 132–7
   PubMed Web of Science ®Google Scholar
• Niemelä O. Radioimmunoassays for type III procollagen aminoterminal peptides in humans. Clin Chem 1985; 31: 1301–4
   PubMed Web of Science ®Google Scholar
• Niemelä O, Risteli L, Parkkinen J, Risteli J. Purification and characterization of the N-terminal propeptide of human type III procollagen. Biochem J 1985; 232: 145–50
   PubMed Web of Science ®Google Scholar
• Niemelä O, Israel Y, Fukunaga T, Mizoi Y, Eriksson C JP. Hemoglobin-acetaldehyde adducts in human volunteers following acute ethanol ingestion. Alcohol Clin Exp Res 1990; 14: 838–41
   PubMedGoogle Scholar
• Niemelä O, Mannermaa R-M, Oikarinen J. Impairment of histone H1 DNA binding by adduct formation with acetaldehyde. Life Sci 1990; 47: 2241–9
   Google Scholar
• Israel Y, Macdonald A, Niemelä O, Zamel D, Shami E, Zywulko M, Klajner F, Borgono C. Hypersensitivity to acetaldehyde-protein adducts. Mol Pharmacol 1992, (in press)
   Google Scholar
• Niemelä O, Halmesmäki E, Ylikorkala O. Hemoglobin-acetaldehyde adducts are elevated in women carrying alcohol-damaged fetuses. Alcohol Clin Exp Res 1991; 15: 1007–10
   PubMedGoogle Scholar
• Niemelä O, Klajner F, Orrego H, Vidins E, Bleodis L M, Israel Y. Antibodies against acetalde-hyde-modified protein epitopes in human alcoholics. Hepatology 1987; 6: 1210–4
   Google Scholar
• Israel Y, Orrego H, Niemelä O. Immune responses to alcohol metabolites. Semin Liver Dis 1988; 8: 81–90
   PubMedGoogle Scholar
• Worrall S, de Jersey J, Shanley B C, Wilce P A. Antibodies against acetaldehyde-modified epitopes: an elevated IgA response in alcoholics. Eur J Clin Invest 1991; 21: 90–5
   PubMedGoogle Scholar
• Sotaniemi E A, Niemelä O, Risteli L, Stenbäck F, Pelkonen R O, Lahtela J, Risteli J. Fibrotic process and drug metabolism in alcoholics. Clin Pharm Ther 1986; 40: 46–55
   Google Scholar
• Niemelä O. Acetaldehyde adducts and excessive alcohol consumption. Alcoholism: A Molecular Perspective. NATO ASI Series,Life Sciences, Plenum press. 1991; 206: 71–5
   Google Scholar