The Transferrin Receptor: Its Diagnostic Value and its Potential as Therapeutic Target

References

• Thorstensen K, Romslo I. The role of transferrin in the mechanism of cellular iron uptake. BiochemJ 1990; 271: 1–10
   PubMed Web of Science ®Google Scholar
• Rao K K, Shapiro D, Mattia E, Bridges K, Klausner R. Effects of alterations in cellular iron on biosynthesis of transferrin receptor in K562 cells. Molecular and Cellular Biology 1985; 5: 595–600
   PubMed Web of Science ®Google Scholar
• Trowbridge I S. Transferrin receptor as a potential therapeutic target. Monoclonal Antibody Therapy Prog Allergy 1988; 45: 121–146
   PubMedGoogle Scholar
• Neckers L M. Regulation of transferrin receptor expression and control of cell growth. Pathobiology 1991; 59: 11–18
   PubMed Web of Science ®Google Scholar
• Kühn L C, Hentze M W. Coordination of cellular iron metabolism by post-transcriptional gene regulation. J Inorg Biochem 1992; 47: 183–195
   PubMed Web of Science ®Google Scholar
• Iacopetta B J, Morgan E H, Yeoh G C.T. Transferrin receptors and iron uptake during erythroid cell development. Biochim Biophys Acta 1982; 687: 204–210
   PubMed Web of Science ®Google Scholar
• Pan B T, Johnstone R. Selective externalization of the transferrin receptor by sheep reticulocytes in vitro. Response to ligands and inhibitors of endocytosis. J Biol Chem 1984; 259: 9776–9782
   PubMed Web of Science ®Google Scholar
• Shih Y J, Baynes R D, Hudson B G, Flowers C H, Skikne B S, Cook J D. Serum transferrin receptor is a truncated form of tissue receptor. J Biol Chem 1990; 265: 19077–19081
   PubMed Web of Science ®Google Scholar
• Huebers H A, Finch C A. The physiology of transferrin and transferrin receptors. Physiological Reviews 1987; 67: 520–582
   PubMed Web of Science ®Google Scholar
• Trowbridge I S, Shackelford D A. Structure and function of transferrin receptors and their relationship to cell growth. Biochem Soc Symp 1986; 51: 117–129
   PubMedGoogle Scholar
• Kohgo Y, Nishisato T, Kondo H, Tsushima N, Niitsu Y, Urushizaki I. Circulating transferrin receptor in human serum. Br J Haematol 1986; 64: 277–281
   PubMed Web of Science ®Google Scholar
• Flowers C H, Skikne B S, Covell A M, Cook J D. The clinical measurement of serum transferrin receptor. J Lab Clin Med 1989; 114: 368–377
   PubMed Web of Science ®Google Scholar
• Huebers H A, Beguin Y, Pootrakul P, Einspahr D, Finch C A. Intact transferrin receptors in plasma and their relation to erythropoiesis. Blood 1990; 75: 102–107
   PubMed Web of Science ®Google Scholar
• Thorstensen K, Egeberg K, Romslo I, DalhOj J, Wiggers P. Variations in serum erythropoietin and transferrin receptor during phlebotomy therapy of hereditary hemochromatosis: A case report. Eur J Haematol 1991; 47: 219–222
   PubMed Web of Science ®Google Scholar
• Kohgo Y, Niitsu Y, Kondo H, Kato J, Tsushima N, Sasaki K, Hirayama M, Numata T, Nishisato T, Urushizaki I. Serum transferrin receptor as a new index of erythropoiesis. Blood 1987; 70: 1955–1958
   PubMed Web of Science ®Google Scholar
• Kohgo Y, Niitsu Y, Nishisato T, Kato J, Kondo H, Sasaki K, Urushizaki I. Quantitation and characterization of serum transferrin receptor in patients with anemias and polycythemias. Jpn J Med 1988; 27: 64–70
   PubMedGoogle Scholar
• Skikne B S, Flowers C H, Cook J D. Serum transferrin receptor: A quantitative measure of tissue iron deficiency. Blood 1990; 75: 1870–1876
   PubMed Web of Science ®Google Scholar
• Ferguson B J, Skikne B S, Simpson K M, Baynes R D, Cook J D. Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J Lab Clin Med 1992; 19: 385–390
   Google Scholar
• Cazzola Mario Beguin Y. New tools for clinical evaluation of erythron function in man. Br J Haematol 1992; 80: 278–284
   PubMed Web of Science ®Google Scholar
• Thorstensen K, Romslo I. Measurement of serum transferrin receptors in screening for hemochromatosis. Clin Chem 1992; 38: 1510
   PubMed Web of Science ®Google Scholar
• Beguin Y, Lipscei G, Thoumsin H, Fillet G. Blunted erythropoietin production and decreased erythropoiesis in early pregnancy. Blood 1991; 78: 89–93
   PubMed Web of Science ®Google Scholar
• Carriaga M T, Skikne B S, Finley B, Cutler B, Cook J D. Serum transferrin receptor for the detection of iron deficiency in pregnancy. Am J Nutr 1991; 54: 1077–1081
   PubMed Web of Science ®Google Scholar
• Trowbridge I S. Immunoassay of serum transferrin receptors: Clinical implications. J Lab Clin Med 1989; 114: 336–337
   PubMed Web of Science ®Google Scholar
• Kayser K, Ernst M, Bubenzer J. Expression of transferrin- and interleukin-2-receptors and HLA-DR in human lung carcinoma. Exp Pathol 1991; 41: 37–43
   PubMedGoogle Scholar
• Panaccio M P, Zalcberg J R, Thompson C H, Leyden M J, Sullivan J R, Lichtenstein M, McKenzie I F.C. Heterogeneity of the human transferrin receptor and use of anti-transferrin receptor antibodies to detect tumors in vivo. Immunol Cell Biol 1987; 65: 461–472
   PubMed Web of Science ®Google Scholar
• Recht L, Torres C O, Smith T W, Raso V, Griffin T W. Transferrin receptor in normal and neoplastic brain tissue: implications for brain-tumor immunotherapy. J Neurosurg 1990; 72: 941–945
   PubMed Web of Science ®Google Scholar
• Prior R, Reifenberg G, Wechsler W. Transferrin receptor expression in tumors of the human nervous system: relation to tumor type,grading and tumor growth fraction. Virchows Archiv A Pathol Anat 1990; 416: 491–496
   Google Scholar
• Kemp J D, Smith K M, Kanner L J, Gomez F, Thorson J A, Naumann P W. Synergistic inhibition of lymphoid tumor growth in vitro by combined treatment with the iron chelator deferoxamine and an immunoglobulin G monoclonal antibody against the transferrin receptor. Blood 1990; 76: 991–995
   PubMed Web of Science ®Google Scholar
• Kemp J D, Thorson J A, Stewart B C, Naumann P W. Inhibition of hematopoietic tumor growth by combined treatment with deferoxamine and IgG monoclonal antibody against the transferrin receptor: evidence for a threshold model of iron deprivation toxicity. Cancer Res 1992; 52: 4144–4148
   PubMed Web of Science ®Google Scholar
• Recht L D, Griffin T W, Raso V, Salimi A R. Potent cytotoxicity of an antihuman transferrin receptor-ricin A-chain immunotoxin on human glioma cells in vitro. Cancer Res 1990; 50: 6696–6700
   PubMed Web of Science ®Google Scholar
• Johnson V G, Wrobel C, Wilson D, Zovickian J, Greenfield L, Oldfield E H, Youle R. Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia. J Neurosurg 1989; 70: 240–248
   PubMed Web of Science ®Google Scholar
• Barabas K, Sizensky J A, Faulk W P. Transferrin conjugates of Adriamycin are cytotoxic without intercalating nuclear DNA. J Biol Chem 1992; 267: 9437–9442
   PubMed Web of Science ®Google Scholar
• Citro G, Perotti D, Cucco C, Agnano I, Sacchi A, Zupi G, Calabretta B. Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxγ-nucleotides. Proc Natl Acad Sci USA 1992; 89: 7031–7035
   PubMed Web of Science ®Google Scholar
• Pardridge W M. Recent developments in peptide drag delivery to the brain. Pharmacology & Toxicology 1992; 71: 3–10
   PubMedGoogle Scholar