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Original Article

Gender difference in red blood cell thiopurine methyltransferase activity

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Pages 747-749 | Received 21 Jan 1993, Accepted 29 May 1993, Published online: 08 Jul 2009

References

  • Lennard L, Lilleyman J S., Van Loon J, Weinshil-Boum R M. Genetic variation in response to 6-mer-captopurine for childhood acute lymphoblastic leukaemia. Lancet 1990; 336: 225–9
  • Weinshilboum R M., Sladek S L. Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J. Hum Genet 1980; 32: 651–62
  • Klemetsdal B, Tollefsen E, Loennechen T, Johnsen K, Utsi E, Gisholt K, Wist E, Aarbakke J. Inter-ethnic difference in thiopurine methyltransferase activity. Clin Pharmacol Ther 1992; 51: 24–31
  • Klemetsdal B, Straume B, Wist E, Aarbakke J. Identification of factors regulating thiopurine methyltransferase activity in a Norwegian population. Eur J Clin Pharmacol 1993; 44: 147–52
  • Szumlanski C L., Honchel R, Scott M C., Weinshilboum R M. Human liver thiopurine methyltransferase pharmacogenetics: Biochemical properties, liver-erythrocyte correlation and presence of isozymes. Pharmacogenetics 1992; 2: 148–59
  • Arias T D., Jorge L F., Barrantes R. Uses and misuses of definitions of genetic polymorphism. A perspective from population pharmacogenetics (letter to the editor). Br J clin Pharmac 1991; 31: 117–8
  • Lilleyman J S., Lennard L, Rees C A., Morgan G, Maddocks J L. Childhood lymphoblastic leukaemia: Sex difference in 6-mercaptopurine utilization. Br J Cancer 1984; 49: 703–7
  • Lennard L, Lilleyman J S. Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia. J Clin Oncol 1989; 7: 1816–23
  • Schmiegelow K. Prognostic significance of methotrexate and 6-mercaptopurine dosage during maintenance chemotherapy for childhood acute lymphoblastic leukemia. Pediatr Hematol Oncol 1991; 8: 301–12
  • Woodson L C., Maus T P., Reiter C, Weinshilboum R M. Rat thiopurine methyltransferase: Regulation by testosterone. J Pharmacol Exp Ther 1981; 218: 734–8
  • Jones C D., Smart C, Titus A, Blyden G, Dorvil M. Nwadike N. Thiopurine methyltransferase activity in a sample population of black subjects in Florida. Clin Pharmacol Ther 1993; 53: 348–53
  • Tinel M. Berson A, Pessayre D, Letteron P, Catto-ni MP, Horsmans Y, Larrey D. Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population. Br J Clin Pharmacol 1991; 32: 729–34
  • Lennard L, Van Loon J A., Lilleyman J S., Weinshilboum R M. Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations. Clin Pharmacol Ther 1987; 41: 18–25
  • Miners J O., Attwood J, Birkett D J. Influence of sex and oral contraceptive steroids on paracetamol me-tabolsim. Br J Clin Pharmacol 1983; 16: 503–9
  • Macleod S M., Giles H G., Bengert B, Liu F F., Sellers E M. Age- and gender-related differences in diazepam pharmocokinetics. J Clin Pharmacol 1979; 19: 15–9
  • Bennett B M., Twiddy D AS, Moffat J A., Armstrong P W., Marks G S. Sex-related difference in the metabolism of isosorbide dinitrate following incubation in human blood. Biochem Pharmacol 1983; 32: 3729–34
  • Skett P. Biochemical basis of sex differences in drug metabolism. Pharmac Ther 1988; 38: 269–304
  • Blondheim S H., Neumann G, Kott E, Ben-Ishai Z. Relationship between ambient temperature and acetylating capacity of human blood. J Appl Physiol 1963; 18: 955–8

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