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Original Article

Plasma homocysteine and thiol compound fractions after oral administration of N-acetylcysteine

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Pages 417-422 | Received 27 Jul 1993, Accepted 08 Apr 1994, Published online: 08 Jul 2009

References

  • Mudd S H, Levy H L, Skovby F. Disorders of trans-sulfuration. The Metabolic Basis of Inherited Disease, 6th edn., C R Scriver, W S Beaudetal, D Valle. McGraw-Hill Book Co, New York 1989; 693–734
  • Brattström L, Hardebo J, Hultberg B. Moderate homocysteinemia–a possible risk factor for arteriosclerotic cerebrovascular disease. Stroke 1984; 15: 1012–16
  • Boers G HJ, Smals A GH, Trijbels F JM, et al. Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease. N Engl J Med 1985; 313: 709–15
  • Kang S S, Wong P WK, Cook H Y, Norusis M, Messer J V. Protein-bound homocysteine; a possible risk factor for coronary artery disease. J Clin Invest 1986; 77: 1482–86
  • Brattström L, Israelsson B, Norrving B, et al. Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease; effects of pyridoxine and folic acid treatment. Atherosclerosis 1990; 81: 51–60
  • Murphy Chutorian D R, Wexman M P, Grieco A J, et al. Methionine intolerance: A possible risk factor for coronary artery disease. J Am Coll Cardiol 1985; 6: 725–34
  • Malinow M R, Kang S S, Taylor L M, et al. Prevalence of hyperhomocysteinemia in patients with peripheral arterial occlusive disease. Circulation 1989; 79: 1180–9
  • Clarke R, Leslie D, Robinson K, et al. Hyperhomocysteinemia: An independent risk factor for vascular disease. N Engl J Med 1991; 324: 1149–55
  • Boman G, Bäcker U, Larsson S, Melander B, Wahlinder L. Oral acetylcysteine reduces exacerbations rates in chronic bronchitis: Report of a trial organised by the Swedish Society for Pulmonary Diseases. Eur J Respir Dis 1983; 64: 405–15
  • Tunek A. Possible mechanisms behind the antiinflammatory effects of N-acetylcysteine: is metabolism essential?. Eur Respir Rev 1992; 2: 35–8
  • Prescott L F, Ballantyne A, Park J, Adreiaenssens P, Proudfoot A T. Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet 1977; 2: 432–4
  • Borgström L, Kågedal B. Dose dependent pharmacokinetics of N-Acetylcysteine after oral dosing to man. Biopharm Drug Disp 1990; 11: 131–6
  • Burgunder J M, Varriale A, Lauterburg B H. The effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration. Eur J Clin Pharmacol 1989; 36: 127–31
  • Andersson A, Isaksson A, Brattström L, Hultberg B. Homocysteine and other thiols determined in plasma by HPLC and thiol-specific postcolumn derivatization. Clin Chem 1993; 39: 1590–7
  • Sjödin K, Nilsson E, Hallberg A, Tunek A. Metabolism of N-acetyl-L-cysteine; some structural requirements for the deacetylation and consequences for the oral bioavailability. Biochem Pharmacol 1989; 38: 3981–5
  • Mansoor M A, Svardal A M, Ueland P M. Determination of in vivo redox status of cysteine, cysteinyl-glycine, homocysteine and glutathione in human plasma. Anal Biochem 1992; 200: 218–29
  • Andersson A, Brattström L, Israelsson B, Isaksson A, Hamfelt A, Hultberg B. Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur J Clin Invest 1992; 22: 79–85
  • Kang S-S, Wong P WK, Curley K. The effect of D-penicillamine on protein-bound homocysteine in homocystinurics. Pediatr Res 1982; 16: 370–2
  • Wiley V C, Dudman N PB, Wilcken D EL. Interrelations between plasma free and protein-bound homocysteine and cysteine in homocystinuria. Metabolism 1988; 162: 191–5
  • Refsum H, Helland S, Ueland M. Radioenzymic determination of homocysteine in plasma and urine. Clin Chem 1985; 31: 624–9
  • Foreman J W, Wald H, Blumberg G, Pepe L M, Segal S. Homocystine uptake in isolated rat renal cortical tubules. Metabolism 1982; 31: 613–18
  • McKeever M P, Weir D G, Molloy A, Scott J M. Betaine-homocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat. Clin Sci 1991; 81: 551–9
  • Mansoor M A, Guttormsen A B, Fiskerstrand T, Refsum H, Ueland P M, Svardal A M. Redox status and protein binding of plasma aminotbiols during the transient hyperhomocysteinemia that follows homocysteine administration. Clin Chem 1993; 39: 980–5

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