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Original Article

How to diagnose cobalamin deficiency

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Pages 61-76 | Published online: 08 Jul 2009

References

  • Gräsbeck R. Soluble and membrane-bound vitamin B12 transport proteins. Vitamin B12, B Zagalak, W Friedrich. Walter de Gruyter & Co, Berlin 1979; 743–65
  • Nexø E, Olesen H. Intrinsic factor, transcobalamin and haptocorrin, D Dolphin. John Wiley & Sons, New-York 1982; Vol. 2: 57–85, B12
  • Shevell M I, Rosenblatt D S. The neurology of cobalamin - review article. Can J Neurol Sci 1992; 19: 472–86
  • Castle W B. The conquest of pernicious anemia. Blood, Pure and Eleoquent, M M Wintrobe. McGraw-Hill, New-York 1980; 283–311
  • Chanarin I. The megaloblastic anaemias. Blackwell Scientific Publications, London 1991
  • Stabler S P, Allen R H, Savage D G, Lindenbaum J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood 1990; 76: 871–81
  • Healton E B, Savage D G, Brust J CM, Garrett T J, Lindenbaum J. Neurologic aspects of cobalamin deficiency. Medicine 1991; 70: 229–45
  • Beck W S. Neuropsychiatric consequences of cobalamin deficiency. Adv Intern Med 1991; 36: 33–56
  • Shorvon S D, Carvey M WP, Chanarin I, Reynolds E H. The neuropsychiatry of megaloblastic anemia. Br Med J 1980; 281: 1036–8
  • Hector M, Burton J. What are the psychiatric manifestations of vitamin B12 deficiency?. J Am Geriatr Soc 1988; 36: 1105–12
  • Lindenbaum J, Rosenberg I H, Wilson P WF, Stabler S P, Allen R H. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994; 60: 2–11
  • Nilsson-Ehle H, Landahl S, Lindstedt G, Netterblad L, Stockbruegger R, Westin J, Ahren C. Low serum cobalamin levels in a population study of 70- and 75-year-old subjects. Gastrointestinal causes and hematological effects. Dig Dis Sci 1989; 34: 716–23
  • Remacha A F, Riera A, Cadafalch J, Gimferrer E. Vitamin B-12 abnormalities in HIV-infected patients. Eur J Haematol 1991; 47: 60–4
  • Jackson I, Doig W B, McDonald G. Pernicious anaemia as a cause of infertility. Lancet 1967; II: 1159–60
  • Gräsbeck R, Solberg H E, Viinikka L. Reference values: A short introduction. St Michel, Finland 1991; 1–7, Nordkem Publications
  • Amos R J, Dawson D W, Fish D I, Leeming R J, Linnell J C. Guidelines on the investigation and diagnosis of cobalamin and folate deficiences. Clin lab Haemat 1994; 16: 101–15
  • Gräsbeck R. Measurement of serum cobalamin. Advances in Thomas Addison's Diseases, H R Bhatt, V HT James, G M Besser, G F Bottazzo, H Keen. Page Bros, Norwich 1994; Vol 2: 313–20
  • Nexø E. Cobalamin Assays. Cobalamin and related binding proteins in clinical nutrition, J L Gueant, J P Nicolas, 1990; 80–94
  • Nexø E, Olesen H. Quantitation of cobalamins in human serum, D Dolphin. John Wiley & Sons, New-York 1982; Vol. 2: 87–104, B12
  • Kolhouse J F, Kondo H, Allen N C, Podell E, Allen R H. Cobalamin analogues are present in human plasma and can mask cobalamin deficiency because current radioisotope dilution assays are not specific for true cobalamin. N Engl J Med 1978; 299: 785–92
  • Cooper B A, Fehedy V, Blanshay P. Recognition of deficiency of vitamin B12 using measurement of serum concentration. J Lab Clin Med 1986; 107: 447–52
  • Gimsing P, Beck W S. Cobalamin analogues in plasma. An in vitro phenomenon?. J Clin Lab Invest 1989; 49(suppl 194)37–40
  • Nexø E, Nexø B. Construction and use of a RIA-gram. J Clin Lab Invest 1989; 49(Suppl 194)27–33
  • Tsalta C D, Meyerhoff M E. Homogeneous Enzyme-Linked assay for vitamin B12. Anal Chem 1987; 59: 837–41
  • van der Weide J, Homan H C, Cozijnsen van Rheenen E, Vivie Kipp Y, Poortman J, Kraaijenhagen R J. Nonisotopic binding assay for measuring vitamin B12 and folate in serum. Clin Chem 1992; 38: 766–68
  • Nexø E. Variation with age of reference values for P-Cobalamin. Scand J Haemat 1983; 30: 430–2
  • Gimsing P, Nexø E. Cobalamin-binding capacity of haptocorrin and transcobalamin: Age-correlated reference intervals and values from patients. Clin Chem 1989; 35: 1447–51
  • Joosten E, Pelemans W, Devos P, Lesaffre E, Criel A, Verhaeghe R. Cobalamin absorption and serum homocysteine and methylmalonic acid in elderly subjects with low serum cobalamin. Eur J Haematol 1993; 51: 25–30
  • Joosten E, van den Berg A, Riezler R, Naurath H J, Lindenbaum J, Stabler S, Allen R H. Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people. Am J Clin Nutr 1993; 58: 468–76
  • Zamorano A F, Arnalich F, Sanchez Casas E, Sicilia A, Solis C, Vazquez J J, Gasalla R. Levels of iron, vitamin B12 and folic acid and their binding proteins during pregnancy. Acta Haematol 1985; 74: 92–6
  • Rosenblatt D S, Cooper B A. Inherited disorders of vitamin B12 utilization. Bioessays 1990; 12: 331–4
  • Herbert V, Fong W, Guile V, Stopler T. Low holotranscobalamin II is the earliest serum marker for subnormal vitamin B12 (cobalamin) absorption in patients with AIDS. Am J Hematol 1990; 34: 132–9
  • Vu T, Amin J, Ramos M, Flener V, Vanyo L, Tisman G. New assay for the rapid determination of plasma holotranscobalamin II levels: Preliminary evaluation in cancer patients. Am J Hematol 1993; 42: 202–11
  • Wickramasinghe S N, Fida S. Correlations between holotranscobalamin II, holo-haptocorrin, and total B12 in serum samples from healthy subjects and patients. J Clin Pathol 1993; 46: 537–9
  • Toft B, Lindgren A, Nexø E. Measurement of TC-cobalamin, a marker of cobalamin deficiency.[Abstract]. Scand J Clin Lab Invest 1994; 54(suppl 218)62
  • Marcell P D, Stabler S P, Podell E R, Allen R H. Quantitation of methylmalonic acid and other dicarboxylic acids in normal serum and urine using capillary gas chromatography-mass spectrometry. Anal Biochem 1985; 150: 58–66
  • Rasmussen K. Solid-phase sample extraction for rapid determination of methylmalonic acid in serum and urine by a stable-isotope-dilution method. Clin Chem 1989; 35: 260–4
  • Rasmussen K, Møller J, Østergaard K, Kristensen M Ø, Jensen J. Methylmalonic acid concentrations in serum of normal subjects: Biological variability and effect of oral L-isoleucine loads before and after intramuscular administration of cobalamin. Clin Chem 1990; 36: 1295–9
  • Rasmussen K, Nathan E. The usefulness of determination of methylmalomic acid in serum or urine for clinical evaluation of cobalamin deficiency is not invalidated by heterozygotes for methylmalonic-acidaemia. J Clin Chem Clin Biochem 1990; 28: 419–21
  • Rasmussen K. Concentrations of methylmalonic acid in serum and urine are not increased in diabetes mellitus [Abstract]. Proceedings, 27th SSIEM Annual Symposium. 1989; 85
  • Hagelskjaer L, Rasmussen K. Methylmalonic acid concentration in serum not affected in hepatic disease. Clin Chem 1992; 38: 493–5
  • Molby L, Rasmussen K, Krogh Jensen M, Pedersen K O. The relationship between clinically confirmed cobalamin deficiency and serum methylmalonic acid. J Int Med 1990; 228: 373–8
  • Rasmussen K, Vyberg B, Pedersen K O, Brøchner-Mortensen J. Methylmalonic acid in renal insufficiency. Evidence of accumulation and implications for diagnosis of cobalamin deficiency. [Letter] Clin Chem 1990; 36: 1523–4
  • Savage D G, Lindenbaum J, Stabler S P, Allen R H. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamine and folate deficiencies. Amer J Med 1994; 96: 239–46
  • Lindenbaum J, Savage D G, Stabler S P, Allen R H. Diagnosis of cobalamin deficiency II: Relative sensitivities of serum cobalamin, methylmalonic acid and total homocysteine concentrations. Amer J Hematol 1990; 34: 99–107
  • Rasmussen K, Moelby L, Jensen M K. Studies on methylmalonic acid in humans. JX Relationship between concentrations in serum and urinary excretion, and the correlation between serum cobalamin and accumulation of methylmalonic acid. Clin Chem 1989; 35: 2277–80
  • Allen R H, Stabler S P, Savage D G, Lindenbaum J. Diagnosis of cobalamin deficiency I: Usefulness of serum methylmalonic acid and total homocysteine concentrations. Amer J Hematol 1990; 34: 90–8
  • Ueland P M, Refsum H, Stabler S, Malinow M R, Andersson A, Allen R H. Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem 1993; 39: 1764–79
  • Vester B, Rasmussen K. High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum. Eur J Clin Chem Clin Biochem 1991; 29: 549–54
  • Stabler S P, Marcell P D, Podell E R, Allen R H. Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry. Anal Biochem 1987; 162: 185–96
  • Stabler S P, Lindenbaum J, Savage D H, Allen R H. Elevation of serum cystathionine levels in patiens with cobalamin and folate deficiency. Blood 1993; 81: 3403–13
  • Andersson A, Brattstrom L, Israelsson B, Hamfelt A, Hultberg B. Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur J Clin Invest 1992; 22: 79–87
  • Andersson A, Hultberg B, Brattstrom L, Isaksson A. Decreased serum homocysteine in pregnancy. Eur J Clin Chem Biochem 1992; 30: 377–9
  • Doscherholmen A, McMahon J, Ripley D. Inhibitory effect of eggs on vitamin B)2 absorption: Description of a simple ovalbumin Co-vitamin B12 absorption test. Br J Haematol 1976; 33: 261–71
  • Doscherholmen A, Silvis S, McMahon J. Dual isotope Schilling test for measuring absorption of food-bound and free vitamin B12 simultaneously. Am J Clin Pathol 1983; 80: 490–5
  • Samloff I M, Varis K, Thamäki T, Simla M, Rotter J I. Serum pepsinogens I and II and gastric acid output, effect of gastritis. Pepsinogens in man. Clinical and genetic advances, J Kreuning, I M Samloff, J I Rotter, A W Eriksson. Alan R Liss, New York 1985; 129–38
  • Borsch K, Axelsson C K, Halgreen H, Damkjaer Nielsen M, Ledin T, Szesci P B. The ratio of pepsinogen A to pepsinogen C: A sensitive test for atrophic gastritis. Scand J Gastroenterol 1989; 24: 870–6
  • Varis K, Ihamaki T, Harkonen M, Samloff I M, Siurala M. Gastric morphology, function and immunology in first-degree relatives of probands with pernicious anaemia and controls. Scand J Gastroenterol 1979; 14: 129–39

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