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Original Article

Plasma β-hexosaminidase isoenzymes a and B exhibit different relations to blood glucose levels in a population of Type 1 diabetic patients

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Pages 723-728 | Received 20 Feb 1995, Accepted 11 Sep 1995, Published online: 08 Jul 2009

References

  • Hultberg B, Isaksson A, Tiderström G. β-Hexosaminidase, leucine aminopeptidase, cystidyl aminopeptidase, hepatic enzymes and bilirubin in serum of chronic alcoholics with acute ethanol ethanolintoxication. Clin Chim Acta 1980; 105: 317–23
  • Hultberg B, Isaksson A, Jansson L. β-Hexosaminidase in serum from patients with cirrhosis and cholestasis. Enzyme 1981; 26: 296–300
  • Hultberg B, Isaksson A. Isoenzyme pattern of serum β-hexosaminidase in liver disease, alcohol intoxication and pregnancy. Enzyme 1983; 30: 166–71
  • Price R C, Dance N. The demonstration of multiple heat stable forms of N-acetyl-β-D-glucosaminidase in normal human serum. Biochim Biophys Acta 1972; 271: 145–53
  • Stirling J L. Separation and characterization of N-acetyl-β-glucosaminidase A and P from maternal serum. Biochim Biophys Acta 1972; 271: 154–62
  • Pampols T, Codina J, Giros M, Sabater J, Gonzales-Sastre F. Tissue differences in the human N-acetyl-β-hexosaminidase isoenzymatic forms. Cell Mol Biol 1980; 26: 187–95
  • Mahuran D, Lowden J H. The subunit and polypeptide structure of hexosaminidases from human placenta. Can J Biochem 1980; 58: 287–94
  • Neufeld E. Natural history and inherited disorders of a lysosomal enzyme, β-hexosaminidase. J Biol Chem 1989; 264: 10927–30
  • Geiger B, Calef E, Arnon R. Biochemical and immunochemical characterization of hexosaminidase P. Biochemistry 1978; 17: 1713–17
  • Isaksson A, Hultberg B. Immunoassay of β-hexosaminidase isoenzymes in serum in patients with raised total activities. Clin Chim Acta 1989; 183: 155–62
  • Bomback F M, Nakagawa S, Kumin S, Nitowsky H M. Altered lysosomal glycohydrolase activities in juvenile diabetes mellitus. Diabetes 1976; 25: 420–7
  • Belfiore F, Napoli E, Lo Vecchio L. Serum N-acetyl-beta-glucosaminidase activity in diabetic patients. Diabetes 1972; 21: 1168–72
  • Pitkänen E, Kyllästinen M, Koivula T, Hormila P. β-N-acetylglucosaminidase and β-glucuronidase activities in insulin-dependent diabetic subjects with retinopathy. Diabetologia 1980; 18: 275–8
  • Whiting P H, Ross I S, Borthwick L. Serum and urine N-acetyl-β-D-glucosaminidase in diabetics on diagnosis and subsequent treatment, and stable insulin dependent diabetics. Clin Chim Acta 1979; 92: 459–63
  • Whiting P H, Ross I S, Borthwick L J. N-acetyl-β-D-glucosaminidase levels and diabetic microangiopathy. Clin Chim Acta 1979; 97: 191–5
  • Poon P YW, Dornan T L, Ellis R B, Turner R C. Increased plasma activities of N-acetyl-β-D-glucosaminidase isoenzymes in human diabetes mellitus. Clin Endocrinol 1979; 11: 625–30
  • Price C P, Foster K J. Serum and urine glucosidase activities in diabetes mellitus. Clin Biochem 1979; 12: 231–3
  • Hanseus K, Hultberg B, Isaksson A. Sjöblad S. Plasma and urinary β-hexosaminidase in juvenile diabetes mellitus. Acta Paediatr Scand 1983; 72: 77–80
  • Poon P YW, Davis T ME, Dornan T L, Turner R C. Plasma N-acetyl-β-D-glucosaminidase activities and glycaemia in diabetes mellitus. Diabetologia 1983; 24: 433–6
  • Skrha J, Perusicova J, Solba P, Stibor V, Pav J. Comparison of N-acetyl-β-glucosaminidase and albuminuria with clinical finding of microangiopathy in type I diabetes mellitus. Clin Chim Acta 1987; 166: 135–41
  • Goi G, Fabi A, Lorenzi R, Lombardo A, Tettamanti G, Burlina A B, et al. Serum enzymes of lysosomal origin as indicators of the metabolic control in diabetes: comparison with glycated hemoglobin and albumin. Acta Diabetol 1986; 23: 117–25
  • Burlina A B, Goi G, Fabi A, Lombardo A, Gaburro D, Tettamanti G. Behaviour of some lysosomal enzymes in the plasma of insulin-dependent diabetic patients during artificial pancreas treatment. Clin Biochem 1987; 20: 423–27
  • Goi G, Lombardo A, Fabi A, Burlina A B, Segalini G, Guagnellini G, et al. Serum enzymes of lysosomal origin as indicators of the metabolic control in non-insulin-dependent diabetics. Acta Diabetol 1987; 24: 331–40
  • Orlacchio A, Maffei C, Beccari T, Lisi P. β-N-acetyl-D-glucosaminidase isoenzymes by chromatofocusing from serum and skin in diabetes. Clin Chim Acta 1984; 141: 127–33
  • Severini G, Alberti L M, Di Girolamo M. N-actyl-β-glucosaminidase isoenzymes in serum and urine of patients with diabetes mellitus. Clin Chem 1988; 34: 2430–2
  • Alhadeff J A, Holzinger R T. Characterization of β-hexosaminidase from liver and sera of diabetic patients and controls. Biochem Med 1982; 27: 214–25
  • Hultberg B, Isaksson A, Nilsson J-å, Lindgärde F. Serum beta-hexosaminidase isoenzymes are related to risk factors for atherosclerosis in a large population of postmenopausal women. Clin Chim Acta 1994; 227: 59–68
  • Hultberg B, Wieslander J. Urinary excretion of β-hexosaminidase in patients with vesico-ureteric reflux. Acta Med Scand 1982; 211: 257–9
  • Isaksson A, Hultberg B, Jonung T. Rat plasma clearance and organ distribution of β-hexosaminidase isoenzymes from human serum. Clin Chem 1992; 38: 1893–8
  • Hultberg B, Isaksson A, Kjellström T. The effects of glucose and insulin on β-hexosaminidase in cultured fibroblasts from diabetic and non-diabetic subjects. Ann Clin Biochem 1985; 22: 133–6
  • Waters P J, Flynn M D, Corral R JM, Pennock C A. Increases in plasma lysosomal enzymes in type 1 (insulin-dependent) diabetes mellitus: relationship to diabetic complications and glycaemic control. Diabetologia 1992; 35: 991–5
  • Hultberg B, Isaksson A, Agardh E, Agardh C-D. The association between plasma β-hexosaminidase and its isoenzyme patterns and retinopathy in type 1 diabetes mellitus. Clin Chim Acta 1991; 196: 177–84

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