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Original Article

Complex intracellular signal transduction regulates tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type-1 (PAI-1) synthesis in cultured human umbilical vein endothelium

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Pages 323-330 | Received 05 Aug 1994, Accepted 01 Feb 1995, Published online: 08 Jul 2009

References

  • Danø K, Andreasen P A, Gröndahl-Hansen J, Kristensen P, Nielsen L S. Plasminogen activators tissue degradation and cancer. Adv Cancer Res 1985; 44: 139–266
  • Pepper M S, Vassali J-D., Montesano R, Orci L. Urokinase type plasminogen activator is induced in migrating capillary EC. J Cell Biol 1987; 105: 2535–41
  • Burnand K G, Stacey M C, Mahmoud M. Plasminogen activators in the re-epithelialising edges on cutan ulcers. Fibrinolysis 1988; 2 Suppl 1: 252
  • Keski-Oja J. Regulation of mRNA for type-1 plasminogen activator inhibitor fibronectin and type-1 procollagen by transforming growth factor-β. J Biol Chem 1988; 263: 3111–15
  • Hekman C M, Luskutoff D J. Kinetic analysis of the interactions between plasminogen activator inhibitor 1 and both urokinase and tissue plasminogen activator. Arch Biochem Biophys 1988; 262: 199–210
  • Kooistra T. The use of cultured human endothelial cells and hepatocytes as in vitro model system to study modulation of endogenous fibrinolysis. Fibrinolysis 1990; 4, Suppl 2: 33–9
  • Tranquille N, Emeis J J. The simultaneous acute release of tissue-type plasminogen activator and von Willebrand factor in the perfused rat hindleg region. Thromb Haemost 1990; 63: 454–8
  • Hajjar K A, Hamel N M, Harpel P C, Nachman R L. Binding of plasminogen activator to cultured human endothelial cells. J Clin Invest 1987; 80: 1712–19
  • Miles L A. Plasminogen receptors: ubiquitous sites for cellular regulation of fibrinolysis. Fibrinolysis 1988; 2: 61–71
  • Diamond S L, Eskin S G, McIntire L V. Fluid flow stimulates tissue plasminogen activator secretion by cultured human endothelial cells. Science 1989; 243: 1438–5
  • Kooistra T, Sprengers E D, Van Hindbergh W H. Rapid inactivation of the plasminogen activator inhibitor upon secretion from cultured human endothelial cells. Biochem J 1986; 239: 497–503
  • Slivka S R, Loskutoff D J. Regulation of type I plasminogen activator inhibitor synthesis by protein kinase C and cAMP in bovine aortic endothelial cells. Biochim Biophys Acta 1991; 1094: 317–22
  • Levin E G, Marotti K R, Santell L. Protein kinase C and the stimulation of tissue plasminogen activator release from human endothelial cells. J Biol Chem 1989; 264: 16030–6
  • Santell L, Levin E G. Cyclic AMP potentiates phorbol ester stimulation of tissue plasminogen activator release and inhibits secretion of plasminogen activator inhibitor-1 from human endothelial cells. J Biol Chem 1988; 263: 16802–8
  • Dichek D, Quertermous T. Thrombin regulation of mRNA levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells. Blood 1989; 74: 222–8
  • Loskutoff D J, Sawdey M, Mimuro J. Type 1 plasminogen activator inhibitor. Progr Haemost Thromb 1989; 9: 87–115
  • Loskutoff D J. Regulation of PAI-1 gene expression. Fibrinolysis 1991; 5: 197–206
  • Maciag T, Cerundolo J, Kelly P R, Forand R. An endothelial cell growth factor from bovine hypothalamus: identification and partial characterization. Proc Natl Acad Sci USA 1979; 76: 5574–8
  • Jaffe E A, Hoyer L W, Nachman R L. Synthesis of antihemophilic factor antigen by cultured human endothelial cells. J Clin Invest 1973; 52: 2757–64
  • Declerch P J, Alessi M-C, Verstreken M, Kruithof EKO, Juhan Vage I. Measurement of plasminogen activator inhibitor-1 in biological fluids with a murine monoclonal antibody-based enzyme immunosorbent assay. Blood 1987; 69: 695–9
  • Eriksson E, Rånby M, Gyzander E, Risberg B. Determination of plasminogen activator inhibitor in plasma using t-PA and a chromogenic single point poly-D-lysine stimulated assay. Thromb Res 1988; 50: 91–101
  • Van Hinsbergh W H, Binnema D, Scheffer M A, Sprenger E D, Kooistra T. Production of plasminogen activators and inhibitors by serially propagated endothelial cells from adult human blood vessels. Arteriosclerosis 1987; 7: 389–400
  • Schramm M, Selinger Z. Message transmission receptor controlled adenylate cyclase systems. Science 1984; 225: 1350–6
  • Limbird L L. Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms. FASEB 1988; 2: 2686–95
  • Keen M, Kelly E, Krane A, Austin A, Wiltshire R, MacDermot J. Cyclic AMP produces desensitization of prostacyclin and adenosine A2 receptors in hybrid cell lines but does not affect Gs function. Biochim Biophys Acta 1992; 1134: 157–63
  • Sibley D R, Lefkowitz R J. Molecular mechanism of receptor desensitization using the betaadrenergic receptor-coupled adenylatecyclase system as a model. Nature 1985; 317: 124–9
  • Brotherton AFA. Induction of prostacyclin biosynthesis is closely associated with increased guanosine 3,5-cyclic monophosphate accumulation in cultured human endothelium. J Clin Invest 1988; 78: 1253–60
  • Furchgott R F, Vanhoutte P M. Endothelium-derived relaxing and contracting factors. FASEB 1989; 3: 2007–18
  • Harrison D G, Bates J. The nitrovasodilators. New ideas about old drugs. Circulation 1993; 878: 1461–1467
  • Lidbury P S, Kornbut R, Vane J R. Sodium nitro-prusside modulates the fibrinolytic system in the rabbit. Br J Pharmacol 1990; 101: 527–30
  • Tranquille N, Emeis J J. The role of cyclic nucleotides in the release of tissue-type plasminogen activator and von Willebrand factor. Thromb Haemost 1993; 69: 259–61
  • Nishizuka Y. Studies and perspectives of protein kinase C. Science 1986; 233: 305–12
  • Francis R B, Neely S. Inhibition of endothelial secretion of tissue-type plasminogen activator and its rapid inhibitor by agent which increase intracellular cyclic AMP. Biochim Biophys Acta 1989; 1012: 207–13
  • Brass L, Hoxle J A, Manning D R. Signaling through G proteins and G protein-coupled receptors during platelet activation. Thromb Haemost 1993; 70: 17–223
  • Obberghen-Schilling E, Pouysségur J. Signal pathways of the thrombin receptor. Thromb Haemost 1993; 70: 163–7
  • Exton J H. Role of calcium and phosphoinositides in the action of certain hormones and neurotransmitters. J Clin Invest 1985; 75: 753–7
  • Yangisawa M, Kurihara H, Kimura S, Tomobe Y. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411–15
  • Eguchi S, Hirata Y, Imai T, Marumo F. Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature. Endocrinology 1993; 132: 524–9
  • Masaki T, Kimura S, Yanagisawa M, Katsutoshi G. Molecular and cellular mechanism of endothelin regulation. Circulation 1991; 84: 1457–68
  • Korbut R. Fibrinolytic activity of endothelin-3. Thromb Res 1989; 55: 797–9
  • Kaij T, Yamamoto C, Sakamoto M, Koizumi F. Endothelin modulation of tissue plasminogen activator release from vascular endothelial cells in culture. Blood Coag Fibrinolysis 1992; 3: 5–10
  • Yamamoto C, Kajit, Sakamoto M, Koizumi F. Effect of endothelin on the release of tissue plasminogen activator and plasminogen activator inhibitor-1 from cultured human umbilical endothelial cells and interaction with thrombin. Thromb Res 1992; 67: 619–24
  • Morrison D C, Lei M G, Kirikae T, Chen T Y. Endotoxin receptors on mammalian cells. Immunobiology 1993; 187: 212–26
  • Nakano M, Saito S, Nokano Y, Yamasu H, Matsuura M. Intracellular protein phosphorylation in murine peritoneal macrophages in response to bacterial lipopolysaccaride (LPS): effect of kinase-inhibitors and LPS-induced tolerance. Immunobiology 1993; 187: 272–82
  • Redl H, Bahrami S, Schlag G, Traber D L. Clinical detection of LPS and animal models of endotoxemia. Immunobiology 1993; 187: 330–45

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