22
Views
10
CrossRef citations to date
0
Altmetric
Original Article

Metabolic cobalamin deficiency in patients with low to low-normal plasma cobalamins

, , , &
Pages 209-215 | Received 18 Jun 1996, Accepted 21 Jan 1997, Published online: 05 Aug 2009

References

  • Rasmussen K, Pedersen K O, Mortensen E S, Mølby L, Jensen M K. Laboratoriediagnostik af cobalaminmangel. Ugeskr Lasger 1992; 154: 326–30
  • Lindenbaum J, Healton E B, Savage D G, Brust J CM, Garret T J, Podell E R, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macro-cytosis. N Engl J Med 1988; 318: 1720–8
  • Lindenbaum J, Savage D G, Stabler S P, Allen R H. Cobalamin deficiency and neuropsychiatric disorders (letter). N Engl J Med 1988; 319: 1734
  • Herbert V. Cobalamin deficiency and neuropsychiatric disorders (letter). N Engl J Med 1988; 319: 1733
  • Norman E J, Denton M D, Martekko O J, Flessa H C. Cobalamin deficiency and neuropsychiatric disorders (letter). N Engl J Med 1988; 319: 1733
  • Gimsing P, Nexø E. Cobalamin-binding capacity of haptocorrin and transcobalamin: age-correlated reference intervals and values from patients. Clin Chem 1989; 35: 1447–51
  • Herbert V. Don't ignore low serum cobalamin (vitamin B12) levels (editorial). Arch Intern Med 1988; 148: 1705–7
  • Nexø E, Hansen M, Rasmussen K, Lindgren A, Gräsbeck R. How to diagnose cobalamin deficiency. Scand J Clin Lab Invest 1994; 54(Suppl 219)61–76
  • Gräsbeck R. Measurement of serum cobalamin. Advances in Thomas Addison's diseases, H R Bhatt, V HT James, G M Besser, G F Bottazzo, H Keen. Page Bros, Norwich 1994; Vol. 2: 313–20
  • Nexø E. Cobalamin assays. Cobalamin and related binding proteins in clinical nutrition, J L Guéant, J P Nicolas, 1990; 80–94
  • Nexø E. Variation with age of reference values for P-cobalamin. Scand J Haematol 1983; 30: 430–2
  • Lindenbaum J, Rosenberg I H, Wilson P W, Stabler S P, Allen R H. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994; 60: 2–11
  • Joosten E, Pelemans W, Devos P, Lesaffre E, Criel A, Verhaeghe R. Cobalamin absorption and serum homocysteine and methylmalonic acid in elderly subjects with low serum cobalamin. Eur J Haematol 1993; 51: 25–30
  • Joosten E, van den Berg A, Reizler R, Naurath H J, Lindenbaum J, Stabler S, et al. Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people. Am J Clin Nutr 1993; 58: 468–76
  • Carmel R. Pernicious anemia, the expected findings of very low serum cobalamin levels, anemia and macrocytosis are often lacking. Arch Intern Med 1988; 148: 1712–4
  • Moelby L, Rasmussen K, Jensen M K, Pedersen K O. The relationship between clinically confirmed cobalamin deficiency and serum methylmalonic acid. J Intern Med 1990; 228: 373–8
  • Stabler S P, Allen R H, Savage D G, Lindenbaum J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood 1990; 76: 871–81
  • Marcell P D, Stabler S P, Podell E R, Allen R H. Quantitation of methylmalonic acid and other dicarboxylic acids in normal serum and urine using capillary gas chromatography-mass spectrometry. Anal Biochem 1985; 150: 58–66
  • Rasmussen K. Solid-phase sample extraction for rapid determination of methylmalonic acid in serum and urine by a stable-isotope-dilution method. Clin Chem 1989; 35: 260–4
  • Rasmussen K, Møller J, Ostergaard K, Kristensen M O, Jensen J. Methylmalonic acid concentrations in serum of normal subjects: biological variability and effect of oral L-isoleucine loads before and after intramuscular administration of cobalamin. Clin Chem 1990; 36: 1295–9
  • Rasmussen K, Vyberg B, Pedersen K O, Brøchner-Mortensen J. Methylmalonic acid in renal insufficiency. Evidence of accumulation and implications for diagnosis of cobalamin deficiency (letter). Clin Chem 1990; 36: 1523–4
  • Moelby L, Rasmussen K, Rasmussen H H. Serum methylmalonic acid in uraemia. Scand J Clin Lab Invest 1992; 52: 351–4
  • Savage D G, Lindenbaum J, Stabler S P, Allen R H. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med 1994; 96: 239–46
  • Lindenbaum J, Savage D G, Stabler S P, Allen R H. Diagnosis of cobalamin deficiency II: Relative sensitivities of serum cobalamin, methylmalonic acid and total homocysteine concentrations. Am J Hematol 1990; 34: 99–107
  • Rasmussen K, Moelby L, Jensen M K. Studies on methylmalonic acid in humans. II Relationship between concentrations in serum and urinary excretion, and the correlation between serum cobalamin and accumulation of methylmalonic acid. Clin Chem 1989; 35: 2277–80
  • Allen R H, Stabler S P, Savage D G, Lindenbaum J. Diagnosis of cobalamin deficiency. I Usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J Hematol 1990; 34: 90–8
  • Altman D G, Gardener M J. Statistics with confidence, M J Gardener, D G Altman, London, Br Med J 1989: 40–1
  • Rasmussen K, Möller J, Lyngbak M, Pedersen A MH, Dybkjar L. Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation. Clin Chem 1996; 42: 630–6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.