28
Views
27
CrossRef citations to date
0
Altmetric
Original Article

A single measurement of biochemical markers of bone turnover has limited utility in the individual person

, , , &
Pages 351-359 | Received 31 Jul 1996, Accepted 01 Apr 1997, Published online: 05 Aug 2009

References

  • Seibel M J, Cosman F, Shen V. Urinary hydroxypyridinium crosslinks of collagen as markers of bone resorption and estrogen efficacy in postmenopausal osteoporosis. J Bone Miner Res 1993; 8: 881–9
  • Reeve J, Pearson J, Mitchell A. Evolution of spinal bone loss and biochemical markers of bone remodelling after menopause in normal women. Calcif Tissue Int 1995; 57: 105–10
  • Mole P A, Walkinshaw M H, Robins S P, Paterson C R. Can urinary pyridinium crosslinks and urinary oestrogens predict bone mass and rate of bone loss after the menopause. Eur J Clin Invest 1992; 22: 767–71
  • Kawana K, Kushida K, Takahashi M. The effect of menopause on biochemical markers and ultrasound densitometry in healthy females. Calcif Tissue Int 1994; 55: 420–5
  • Harris S T, Gertz B J, Genant H K. The effect of short term treatment with alendronate on vertebral density and biochemical markers of bone remodeling in early postmenopausal women. J Clin Endocrin Metab 1993; 76: 1399–406
  • Garnero P, Weichung J S, Gineyts E, Karp D B, Delmas P D. Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrin Metab 1994; 79: 1693–700
  • Adami S, Passed M, Ortolani S. Effects of oral alendronate and intranasal salmon calcitonin on bone mass and biochemical markers of bone turnover in postmenopausal women with osteoporosis. Bone 1995; 17: 383–90
  • Christiansen C, Riis B J, Rødbro P. Prediction of rapid bone loss in postmenopausal women. Lancet 1987; i: 1105–7
  • Hansen M A, Overgaard K, Riis B J, Christiansen C. Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 year study. BMJ 1991; 303: 961–4
  • Keen R W, Hall G M, Nandra D. Early postmenopausal bone loss and biochemical markers. Bone 1995; 16: 108S, Suppl 1
  • Hui S L, Slemanda C W, Johnston C C, Jr. The contribution of bone loss to postmenopausal osteoporosis. Osteoporosis Int 1990; 11: 30–4
  • Falch J A, Sandvik L. Perimenopausal appendicular bone loss: A 10-year prospective study. Bone 1990; 11: 425–8
  • Nordin B EC, Cleghorn D B, Chatterton B E, Morris H A, Need A G. A 5-year longitudinal study of forearm bone mass i 307 postmenopausal women. J Bone Miner Res 1993; 8: 1427–32
  • Jensen J-E B, Sørensen H A, Kollerup G, Jensen L B, Sørensen O H. Biological variation of biochemical bone markers. Scand J Clin Invest 1994; 54: 36–39, Suppl 219
  • Blumsohn R A, Hannon R A, Al-Dehaimi A W, Eastell R. Short-term intraindividual variability of markers of bone turnover in healthy adults. J Bone Miner Res 1994; 9: S153, Suppl 1
  • Vasikaran S D, McCloskey E V, Kahn S, Kanis J A. Intra-individual variation in fasting urinary calcium- and hydroxyproline-creatinine ratios measured in metabolic bone clinic patients as both outpatients and inpatients. Ann Clin Biochem 1994; 31: 272–6
  • Panteghini M, Pagani F. Biological variation in bone-derived biochemical markers in serum. Scand J Clin Lab Invest 1995; 55: 609–16
  • Kollerup G, Thamsborg G, Bhatia H, Sørensen O H. Quantitation of urinary hydroxypyridinium cross-links from collagen by high-performance liquid chromatography. Scand J Clin Lab Invest 1992; 52: 657–62
  • Kivirikko K T, Laitinen O, Prockop D J. Modification of a specific assay for hydroxyproline in urine. Analyt Biochem 1967; 19: 249–55
  • Magid E, Petersen P H, Christensen M. A note on the theory of reference changes. Scand J Clin Invest 1992; 52: 95–101, Suppl 208
  • Harris E K. Effects of intra- and interindividual variation on the appropriate use of normal ranges. Clin Chem 1974; 20: 1535–42
  • Fraser C G, Harris E K. Generation and application of data on biological variation in clinical chemistry. Crit Rev Clin Lab Sci 1989; 27: 409–37
  • Hodsman A B, Fraher L J, Ostbye T, Adachi J D, Steer B M. An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis. J Clin Invest 1993; 91: 1138–48
  • Colwell A, Russell R GG, Eastell R. Factors affecting the assay of urinary 3-hydroxypyridinium crosslinks of collagen as markers of bone resorption. Eur J Clin Invest 1993; 25: 341–9
  • Nielsen H K, Brixen K, Mosekilde L. Diurnal rhythm and 24-h integrated concentrations of serum osteocalcin in normals: Influence of age, sex, season, and smoking habits. Calcif Tissue Int 1990; 47: 284–90
  • Bollen A M, Martin M D, Leroux B G, Eyre D R. Circadian variation in urinary excretion of bone collagen cross-links. J Bone Miner Res 1995; 10: 1885–90
  • Gowans E MS, Fraser C G. Biological variation in analyte concentrations in urine of apparently healthy men and women. Clin Chem 1987; 33: 847–50
  • Price C P, Thompson P W. The role of biochemical tests in the screening and monitoring of osteoporosis. Ann Clin Biochem 1995; 32: 244–60
  • Azria M. The value of biomarkers in detecting alterations in bone metabolism. Calcif Tissue Int 1989; 45: 7–11
  • Altman D G. Practical Statistics for Medical Research. Chapman & Hall 1991; 307
  • Blumsohn A, Eastell R. Prediction of bone loss in postmenopausal women. Eur J Clin Invest 1992; 22: 764–66
  • Hannon R A, Blumsohn A, Colwell A, Peel N FA, Eastell R. Biochemical markers of bone turnover and the prediction of spinal bone loss in older women. J Bone Miner Res 1994; 9: S399, Suppl 1
  • Johnell O, Mellström D, Gause-Nilsson I, Johansson C, Lindstedt G. Can we improve the prediction of fractures. J Bone Miner Res 1994; 9: S402, Suppl 1
  • Falch J A. Can biochemical markers tell us anything about rate of bone loss. Scand J Clin Invest 1994; 54: 40–1, Suppl 219
  • Kleerekoper M, Wilson P S, Simpson P. Within subject variability of biochemical markers of bone remodeling in normal older women. J Bone Miner Res 1994; 9: S394, Suppl 1
  • Black D M. Why elderly women should be screened and treated to prevent osteoporosis. Amer J Med 1995; 98: 67S–75S, Suppl 2A
  • Åkesson K, Ljunghall S, Jonsson B. Assessment of biochemical markers of bone metabolism in relation to the occurrence of fracture: A retrospective and prospective population-based study of women. J Bone Miner Res 1995; 10: 1823–9
  • Lindsay M B. Screening for osteoporosis. Syllabus—46th Postgraduate Assembly Endocrine Society 1994; 212–3

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.