72
Views
6
CrossRef citations to date
0
Altmetric
Letter to the Editor

Variant alleles of the mannose binding lectin 2 gene (MBL2) confer heterozygote advantage within Crohn's families

, , , , , , , , & show all
Pages 1129-1130 | Received 08 Apr 2010, Accepted 08 Apr 2010, Published online: 06 May 2010

References

  • Wallis R. Structural and functional aspects of complement activation by mannose-binding protein. Immunobiology 2002;205:433–45.
  • Eisen DP, Minchinton RM. Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin Infect Dis 2003;37:1496–505.
  • Kruse C, Rosgaard A, Steffensen R, Varming K, Jensenius JC, Christiansen OB. Low serum level of mannan-binding lectin is a determinant for pregnancy outcome in women with recurrent spontaneous abortion. Am J Obstet Gynecol 2002;187:1313–20.
  • Hellemann D, Larsson A, Madsen HO, Bonde J, Jarlov JO, Wiis J, Heterozygosity of mannose-binding lectin (MBL2) genotypes predicts advantage (heterosis) in relation to fatal outcome in intensive care patients. Hum Mol Genet 2007;16:3071–80.
  • Boldt AB, Luty A, Grobusch MP, Dietz K, Dzeing A, Kombila M, Association of a new mannose-binding lectin variant with severe malaria in Gabonese children. Genes Immun 2006;7:393–400.
  • Sebastiani P, Abad MM, Alpargu G, Ramoni MF. Robust transmission/disequilibrium test for incomplete family genotypes. Genetics 2004;168:2329–37.
  • Steffensen R, Thiel S, Varming K, Jersild C, Jensenius JC. Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers. J Immunol Methods 2000;241:33–42.
  • Bernig T, Taylor JG, Foster CB, Staats B, Yeager M, Chanock SJ. Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection. Genes Immun 2004;5:461–76.
  • Imboden M, Swan H, Denjoy I, Van Langen IM, Latinen-Forsblom PJ, Napolitano C, Female predominance and transmission distortion in the long-QT syndrome. N Engl J Med 2006;355:2744–51.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.