Altered sensorimotor responses to esophageal acidification in older adults with GERD

References

• Goh KL. Changing epidemiology of gastroesophageal reflux disease in the Asian-Pacific region: an overview. J Gastroenterol Hepatol 2004;19(Suppl 3):S22–5.
   Google Scholar
• Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006;101:1900–20; quiz 1943.
   Google Scholar
• DeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol 2005;100:190–200.
   PubMed Web of Science ®Google Scholar
• Greenwald DA. Aging, the gastrointestinal tract, and risk of acid-related disease. Am J Med 2004;117(Suppl 5A):8S–13S.
   Google Scholar
• Lee J, Anggiansah A, Anggiansah R, Young A, Wong T, Fox M. Effects of age on the gastroesophageal junction, esophageal motility, and reflux disease. Clin Gastroenterol Hepatol 2007;5:1392–8.
   PubMed Web of Science ®Google Scholar
• Johnson DA, Fennerty MB. Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux disease. Gastroenterology 2004;126:660–4.
   PubMed Web of Science ®Google Scholar
• Collen MJ, Abdulian JD, Chen YK. Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy. Am J Gastroenterol 1995;90:1053–7.
   PubMedGoogle Scholar
• Fass R, Pulliam G, Johnson C, Garewal HS, Sampliner RE. Symptom severity and oesophageal chemosensitivity to acid in older and young patients with gastro-oesophageal reflux. Age Ageing 2000;29:125–30.
   PubMed Web of Science ®Google Scholar
• Rao SS, Mudipalli RS, Mujica VR, Patel RS, Zimmerman B. Effects of gender and age on esophageal biomechanical properties and sensation. Am J Gastroenterol 2003;98:1688–95.
   PubMedGoogle Scholar
• Bontempo I, Piretta L, Corazziari E, Michetti F, Anzini F, Torsoli A. Effects of intraluminal acidification on oesophageal motor activity. Gut 1994;35:884–90.
   PubMedGoogle Scholar
• Orr WC, Chen CL, Sloan S. The role of age and salivation in acid clearance in symptomatic patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2001;15:1385–8.
   PubMedGoogle Scholar
• Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 1999;45:172–80.
   PubMed Web of Science ®Google Scholar
• Fass R, Yalam JM, Camargo L, Johnson C, Garewal HS, Sampliner RE. Increased esophageal chemoreceptor sensitivity to acid in patients after successful reversal of Barrett's esophagus. Dig Dis Sci 1997;42:1853–8.
   PubMedGoogle Scholar
• Velanovich V, Vallance SR, Gusz JR, Tapia FV, Harkabus MA. Quality of life scale for gastroesophageal reflux disease. J Am Coll Surg 1996;183:217–24.
   PubMed Web of Science ®Google Scholar
• Chen CL, Robert JJ, Orr WC. Sleep symptoms and gastroesophageal reflux. J Clin Gastroenterol 2008;42:13–17.
   PubMed Web of Science ®Google Scholar
• Richter JE, Bradley LA, DeMeester TR, Wu WC. Normal 24-hr ambulatory esophageal pH values. Influence of study center, pH electrode, age, and gender. Dig Dis Sci 1992;37:849–56.
   PubMed Web of Science ®Google Scholar
• Mahadeva S, Raman MC, Ford AC, Follows M, Axon AT, Goh KL, Gastro-oesophageal reflux is more prevalent in Western dyspeptics: a prospective comparison of British and South-East Asian patients with dyspepsia. Aliment Pharmacol Ther 2005;21:1483–90.
   PubMed Web of Science ®Google Scholar
• Wu JC, Cheung CM, Wong VW, Sung JJ. Distinct clinical characteristics between patients with nonerosive reflux disease and those with reflux esophagitis. Clin Gastroenterol Hepatol 2007;5:690–5.
   PubMed Web of Science ®Google Scholar
• Lasch H, Castell DO, Castell JA. Evidence for diminished visceral pain with aging: studies using graded intraesophageal balloon distension. Am J Physiol 1997;272:G1–3.
   Google Scholar
• Meciano Filho J, Carvalho VC, de Souza RR. Nerve cell loss in the myenteric plexus of the human esophagus in relation to age: a preliminary investigation. Gerontology 1995;41:18–21.
   PubMedGoogle Scholar
• Wade PR, Cowen T. Neurodegeneration: a key factor in the ageing gut. Neurogastroenterol Motil 2004;16(Suppl 1):19–23.
   PubMedGoogle Scholar
• Moore AR, Clinch D. Underlying mechanisms of impaired visceral pain perception in older people. J Am Geriatr Soc 2004;52:132–6.
   PubMedGoogle Scholar
• Helm JF, Dodds WJ, Hogan WJ. Salivary response to esophageal acid in normal subjects and patients with reflux esophagitis. Gastroenterology 1987;93:1393–7.
   PubMed Web of Science ®Google Scholar
• Phillips RJ, Kieffer EJ, Powley TL. Aging of the myenteric plexus: neuronal loss is specific to cholinergic neurons. Auton Neurosci 2003;106:69–83.
   PubMed Web of Science ®Google Scholar
• Bhalla V, Liu J, Puckett JL, Mittal RK. Symptom hypersensitivity to acid infusion is associated with hypersensitivity of esophageal contractility. Am J Physiol Gastrointest Liver Physiol 2004;287:G65–71.
   Google Scholar
• Achem AC, Achem SR, Stark ME, DeVault KR. Failure of esophageal peristalsis in older patients: association with esophageal acid exposure. Am J Gastroenterol 2003;98:35–9.
   PubMed Web of Science ®Google Scholar
• Ren J, Shaker R, Kusano M, Podvrsan B, Metwally N, Dua KS, Effect of aging on the secondary esophageal peristalsis: presbyesophagus revisited. Am J Physiol 1995;268:G772–9.
   Google Scholar