138
Views
12
CrossRef citations to date
0
Altmetric
Heliobacter Pylori

Association between peroxisome proliferator-activated receptor-γ gene polymorphism (Pro12Ala) and Helicobacter pylori infection in gastric carcinogenesis

, , , &
Pages 1162-1167 | Received 24 Dec 2009, Accepted 01 Jun 2010, Published online: 23 Jun 2010

References

  • Lee DS, Moss SF. Targeting Helicobacter pylori in gastric carcinogenesis. Expert Opin Ther Targets 2007;11:757–69.
  • Vieth M, Stolte M. Elevated risk for gastric adenocarcinoma can be predicted from histomorphology [review]. World J Gastroenterol 2006;12:6109–14.
  • Torres J, Lopez L, Lazcano E, Camorlinga M, Flores L, Munoz O. Trends in Helicobacter pylori infection and gastric cancer in Mexico. Cancer Epidemiol Biomarkers Prev 2005;14:1874–7.
  • Imrie C, Marion FR, Bourke B, Drumm B. Is Helicobacter pylori infection in childhood a risk factor for gastric cancer? Pediatrics 2001;107:373–80.
  • Ando T, Goto Y, Ishiguro K, Maeda O, Watanabe O, Ohmiya N, The interaction of host genetic factors and Helicobacter pylori infection. Inflammopharmacology 2007;15:10–14.
  • Debril MB, Renaud JP, Fajas L, Auwerx J. The pleiotropic functions of peroxisome proliferator-activated receptor gamma. J Mol Med 2001;79:30–47.
  • Auwerx J. Nuclear receptors. I. PPAR-γ in the gastrointestinal tract: gain or pain? Am J Physiol Gastrointest Liver Physiol 2002;282:G581–5.
  • Takahashi N, Okumura T, Motomura W, Fujimoto Y, Kawabata I, Kohgo Y. Activation of PPAR-γ inhibits cell growth and induces apoptosis in human gastric cancer cells. FEBS Lett 1999;455:135–9.
  • Jiang C, Ting AT, Seed B. PPAR-γ agonists inhibits production of monocyte inflammatory cytokines. Nature 1998;391:82–6.
  • Theocharis S, Margeli A, Vielh P, Kouraklis G. Peroxisome proliferator-activated receptor-gamma ligands as cell-cycle modulators. Cancer Treat Rev 2004;30:545–54.
  • Puddu P, Puddu GM, Muscari A. Peroxisome proliferator-activated receptors: are they involved in atherosclerosis progression? Int J Cardiol 2003;90:133–40.
  • Girnun GD, Spiegelman BM. PPAR-γ ligands: taking part in chemoprevention. Gastroenterology 2003;124:564–7.
  • Bardot O, Aldridge TC, Latruffe N, Green S. PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene. Biochem Biophys Res Commun 1993;92:37–45.
  • Osawa E, Nakajima A, Wada K, Ishimine S, Fujisawa N, Kawamori T. Peroxisome proliferator-activated receptor-gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice. Gastroenterology 2003;124:361–7.
  • Tsubouchi Y, Sano H, Kawahito Y, Mukai S, Yamada R, Kohno M. Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. Biochem Biophys Res Commun 2000;270:400–5.
  • Martelli ML, Iuliano R, Le Pera I, Sama I, Monaco C, Cammarota S. Inhibitory effect of peroxisome proliferatoractivated receptor gamma on thyroid carcinoma cell growth. J Clin Endocrinol Metab 2002;87:4728–35.
  • Lu J, Imamura K, Nomura S, Mafune K, Nakajima A, Kadowaki T, Chemopreventive effect of peroxisome proliferator-activated receptor gamma on gastric carcinogenesis in mice. Cancer Res 2005;65:4769–74.
  • Ma XM, Yu H, Huai N. Peroxisome proliferator-activated receptor-gamma is essential in the pathogenesis of gastric carcinoma. World J Gastroenterol 2009;15:3874–83.
  • Swarbrick MM, Chapman CM, McQuillan BM, Hung J, Thompson PL, Beilby JP. A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity. Eur J Endocrinol 2001;144:277–82.
  • Paltoo D, Woodson K, Taylor P, Albanes D, Virtamo J, Tangrea J. Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and risk of prostate cancer among men in a large cancer prevention study. Cancer Lett 2003;191:67–74.
  • Hahn S, Fingerhut A, Khomtsiv U, Khomtsiv L, Tan S, Quadbeck B, The peroxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 2005;62:573–9.
  • Memisoglu A, Hu FB, Hankinson SE, Liu S, Meigs JB, Altshuler DM, Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPAR-gamma gene and type 2 diabetes. Diabetes Care 2003;26:2915–17.
  • Koh WP, Yuan JM, Van Den Berg D, Ingles SA, Yu MC. Peroxisome proliferatoractivated receptor (PPAR) gamma gene polymorphisms and colorectal cancer risk among Chinese in Singapore. Carcinogenesis 2006;27:1797–802.
  • Liao SY, Zeng ZR, Leung WK, Zhou SZ, Chen B, Sung JJ, Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chinese. Aliment Pharmacol Ther 2006;23:289–94.
  • Tahara T, Arisawa T, Shibata T, Nakamura M, Wang F, Maruyama N, Influence of peroxisome proliferator-activated receptor (PPAR) gamma Plo12Ala polymorphism as a shared risk marker for both gastric cancer and impaired fasting glucose (IFG) in Japanese. Dig Dis Sci 2008;53:614–21.
  • Prasad KN, Saxena A, Ghoshal UC, Bhagat MR, Krishnani N. Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease. Ann Oncol 2008;19:1299–303.
  • Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
  • Sugiyama T. Development of gastric cancer associated with Helicobacter pylori infection. Cancer Chemother Pharmacol 2004;54:S12–20.
  • Leung WK, Bai AH, Chan VY, Yu J, Chan MW, To KF. Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. Gut 2004;53:331–8.
  • Gong Z, Xie D, Deng Z, Bostick RM, Muga SJ, Hurley TG, The PPAR {gamma} Pro12Ala polymorphism and risk for incident sporadic colorectal adenomas. Carcinogenesis 2005;26:579–85.
  • Joo YE, Oh WT, Rew JS, Park CS, Cho SK, Kim SJ. Cyclooxygenase-2 expression is associated with well-differentiated and intestinal-type pathway in gastric carcinogenesis. Digestion 2002;66:222–9.
  • Konturek PC, Kania J, Kukharsky V, Raithel M, Ocker M, Rembiasz K, Implication of peroxisome proliferator-activated receptor γ and proinflammatory cytokines in gastric carcinogenesis: link to Helicobacter pylori infection. J Pharmacol Sci 2004;96:134–43.
  • Ricote M, Li AC, Willson TM. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 1998;391:79–82.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.