Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 46, 2011 - Issue 3
Submit an article Journal homepage
117
Views
6
CrossRef citations to date
0
Altmetric
Liver and biliary tract

Low prevalence of hereditary hemochromatosis in multiethnic populations in Northern Norway

Ann R. Broderstad Institute of Community Medicine, University of Tromsø, Norway; Department of Medicine, University Hospital of Northern Norway, Harstad, NorwayCorrespondence[email protected]
,
Tone Smith-Sivertsen Institute of Community Medicine, University of Bergen, Norway
,
Inger Marie Dahl Department of Medicine, University Hospital of Northern Norway, Harstad, Norway
,
Ole Christian Ingebretsen Department of Clinical Chemistry, University Hospital of Northern Norway, Tromsø, Norway
&
Eiliv Lund Institute of Community Medicine, University of Tromsø, Norway
Pages 350-357 | Received 15 Feb 2010, Accepted 18 Sep 2010, Published online: 18 Oct 2010

References

  • Asberg A, Hveem K, Thorstensen K, Ellekjter E, Kannelonning K, Fjosne U, Screening for hemochromatosis: high prevalence and low morbidity in an unselected population of 65,238 persons. Scand J Gastroenterol 2001;36:1108–15.
  • Bell H, Thordal C, Raknerud N, Hansen T, Bosnes V, Halvorsen R, Prevalence of hemochromatosis among first-time and repeat blood donors in Norway. J Hepatol 1997;26:272–9.
  • Distante S, Berg JP, Lande K, Haug E, Bell H. High prevalence of the hemochromatosis-associated Cys282Tyr HFE gene mutation in a healthy Norwegian population in the city of Oslo, and its phenotypic expression. Scand J Gastroenterol 1999;34:529–34.
  • Andersen RV, Tybjaerg-Hansen A, Appleyard M, Birgens H, Nordestgaard BG. Hemochromatosis mutations in the general population: iron overload progression rate. Blood 2004;103:2914–19.
  • Barton JC, Acton RT, Leiendecker-Foster C, Lovato L, Adams PC, McLaren GD, HFE C282Y homozygotes aged 25–29 years at HEIRS Study initial screening. 2007;11:269–75.
  • Olynyk JK, Hagan SE, Cullen DJ, Beilby J, Whittall DE. Evolution of untreated hereditary hemochromatosis in the Busselton population: a 17-year study Mayo Clin Proc 2004;79:309–13.
  • Waalen J, Nordestgaard BG, Beutler E. The penetrance of hereditary hemochromatosis. Best Pract Res Clin Haematol 2005;18:203–20.
  • Beutler E, Felitti V, Gelbart T, Ho N. The effect of HFE genotypes on measurements of iron overload in patients attending a health appraisal clinic. Ann Intern Med 2000;133:329–337.
  • Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med 2005;352:1769–78.
  • Beckman LE, Saha N, Spitsyn V, Van LG, Beckman L. Ethnic differences in the HFE codon 282 (Cys/Tyr) polymorphism. Hum Hered 1997;47:263–7.
  • Smith-Sivertsen T, Lund E, Thomassen Y, Norseth T. Human nickel exposure in an area polluted by nickel refining: the Sor-Varanger study. Arch Environ Health 1997;52:464–71.
  • Jorde R, Haug E, Figenschau Y, Hansen JB. Serum levels of vitamin D and haemostatic factors in healthy subjects: the Tromso study. Acta Haematol 2007;117:91–7.
  • Mangasser-Stephan K, Tag C, Reiser A, Gressner AM. Rapid genotyping of hemochromatosis gene mutations on the LightCycler with fluorescent hybridization probes. Clin Chem 1999;45:1875–8.
  • Bhopal R. Concepts of epidemiology an integrated introduction to the ideas, theories, principles and methods of epidemiology. New York; 2002.
  • Lucotte G, Dieterlen F. A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation? Blood Cells Mol Dis 2003;31:262–7.
  • McLaren CE, Barton JC, Adams PC, Harris EL, Acton RT, Press N, Hemochromatosis and Iron Overload Screening (HEIRS) study design for an evaluation of 100,000 primary care-based adults. Am J Med Sci 2003;325:53–62.
  • Merryweather-Clarke AT, Pointon JJ, Jouanolle AM, Rochette J, Robson KJ. Geography of HFE C282Y and H63D mutations. Genet Test 2000;4:183–98.
  • Pedersen P, Melsen Vedel G, Milman N. Frequencies of the haemochromatosis gene (HFE) variants C282Y, H63D and S65C in 6,020 ethnic Danish men. Ann Hematol 2008;87:735–40.
  • Beutler E, Felitti VJ, Koziol JA, Ho NJ, Gelbart T. Penetrance of 845G – > A (C282Y) HFE hereditary haemochromatosis mutation in the USA. Lancet 2002;359:211–18.
  • Waalen J, Felitti VJ, Gelbart T, Beutler E. Screening for hemochromatosis by measuring ferritin levels: a more effective approach. Blood 2008;111:3373–6.
  • Broderstad AR, Melhus M, Lund E. Iron status in a multiethnic population (age 36–80 yr) in northern Norway: the SAMINOR study. Eur J Haematol 2007;79:447–54.
  • Milman N, Byg KE, Mulvad G, Pedersen HS, Bjerregaard P. Iron status markers in 224 indigenous Greenlanders: influence of age, residence and traditional foods. Eur J Haematol 2001;66:115–25.
  • Knutsen H, Hammerstrøm J. Handlingsplan for hemokromatose. Norsk Selskap for Hematologi 2003. http://www.legeforeningen.no/asset/47362/1/47362_1.doc.
  • Drammeh BS, Schleicher RL, Pfeiffer CM, Jain RB, Zhang M, Nguyen PH. Effects of delayed sample processing and freezing on serum concentrations of selected nutritional indicators. Clin Chem 2008;54:1883–91.
  • Waalen J, Felitti V, Gelbart T, Ho NJ, Beutler E. Penetrance of hemochromatosis. Blood Cells Mol Dis 2002;29:418–32.
  • Saven A, Beutler E. Iron overload after prolonged intramuscular iron therapy. N Engl J Med 1989;321:331–2.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.