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Pancreas

Role of heparin on serum VEGF levels and local VEGF contents in reducing the severity of experimental severe acute pancreatitis in rats

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Pages 237-244 | Received 24 Sep 2011, Accepted 02 Dec 2011, Published online: 03 Jan 2012

References

  • Frossard JL, Steer ML, Pastor CM. Acute pancreatitis. Lancet 2008;371:143–52.
  • Pereda J, Sabater L, Aparisi L, Escobar J, Sandoval J, Vina J, Interaction between cytokines and oxidative stress in acute pancreatitis. Curr Med Chem 2006;13:2775–87.
  • Van Acker GJ, Weiss E, Steer ML, Perides G. Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 2007;292:G1738–46.
  • Hartwig W, Klafs M, Kirschfink M, Hackert T, Schneider L, Gebhard MM, Interaction of complement and leukocytes in severe acute pancreatitis: potential for therapeutic intervention. Am J Physiol Gastrointest Liver Physiol 2006;291:G844–50.
  • Young E. The anti-inflammatory effects of heparin and related compounds. Thromb Res 2008;122:743–52.
  • Wang M, He J, Mei B, Ma X, Huo Z. Therapeutic effects and anti-inflammatory mechanisms of heparin on acute lung injury in rabbits. Acad Emerg Med 2008;15:656–63.
  • Li JP, Vlodavsky I. Heparin, heparan sulfate and heparanase in inflammatory reactions. Thromb Haemost 2009;102:823–8.
  • Salas A, Sans M, Soriano A, Reverter JC, Anderson DC, Pique JM, Heparin attenuates TNF-alpha induced inflammatory response through a CD11b dependent mechanism. Gut 2000;47:88–96.
  • Lever R, Hoult JR, Page CP. The effects of heparin and related molecules upon the adhesion of human polymorphonuclear leucocytes to vascular endothelium in vitro. Br J Pharmacol 2000;129:533–40.
  • Papa A, Danese S, Gasbarrini A, Gasbarrini G. Review article: potential therapeutic applications and mechanisms of action of heparin in inflammatory bowel disease. Aliment Pharmacol Ther 2000;14:1403–9.
  • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669–76.
  • Lucerna M, Zernecke A, de Nooijer R, de Jager SC, Bot I, van der Lans C, Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment. Blood 2007;109:122–9.
  • Ohtani K, Egashira K, Hiasa K, Zhao Q, Kitamoto S, Ishibashi M, Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells. Circulation 2004;110:2444–52.
  • Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S, Ciolkiewicz M. A study on vascular endothelial growth factor and endothelin-1 in patients with extra-articular involvement of rheumatoid arthritis. Clin Rheumatol 2006;25:314–19.
  • Nagashima M, Asano G, Yoshino S. Imbalance in production between vascular endothelial growth factor and endostatin in patients with rheumatoid arthritis. J Rheumatol 2000;27:2339–42.
  • Nolan A, Weiden MD, Thurston G, Gold JA. Vascular endothelial growth factor blockade reduces plasma cytokines in a murine model of polymicrobial sepsis. Inflammation 2004;28:271–8.
  • van der Flier M, van Leeuwen HJ, van Kessel KP, Kimpen JL, Hoepelman AI, Geelen SP. Plasma vascular endothelial growth factor in severe sepsis. Shock 2005;23:35–8.
  • Perkins GD, Roberts J, McAuley DF, Armstrong L, Millar A, Gao F, Regulation of vascular endothelial growth factor bioactivity in patients with acute lung injury. Thorax 2005;60:153–8.
  • Maitre B, Boussat S, Jean D, Gouge M, Brochard L, Housset B, Vascular endothelial growth factor synthesis in the acute phase of experimental and clinical lung injury. Eur Respir J 2001;18:100–6.
  • Hao Q, Wang L, Tang H. Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells. Am J Physiol Cell Physiol 2009;296:C821–7.
  • Fu BM, Shen S. Acute VEGF effect on solute permeability of mammalian microvessels in vivo. Microvasc Res 2004;68:51–62.
  • Goebel S, Huang M, Davis WC, Jennings M, Siahaan TJ, Alexander JS, VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: implications for inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 2006;290:G648–54.
  • Yoo SA, Kwok SK, Kim WU. Proinflammatory role of vascular endothelial growth factor in the pathogenesis of rheumatoid arthritis: prospects for therapeutic intervention. Mediators Inflamm 2008;2008:129873.
  • Boulday G, Haskova Z, Reinders ME, Pal S, Briscoe DM. Vascular endothelial growth factor-induced signaling pathways in endothelial cells that mediate overexpression of the chemokine IFN-gamma-inducible protein of 10 kDa in vitro and in vivo. J Immunol 2006;176:3098–107.
  • Wijelath E, Namekata M, Murray J, Furuyashiki M, Zhang S, Coan D, Multiple mechanisms for exogenous heparin modulation of vascular endothelial growth factor activity. J Cell Biochem 2010;111:461–8.
  • Ashikari-Hada S, Habuchi H, Kariya Y, Kimata K. Heparin regulates vascular endothelial growth factor165-dependent mitogenic activity, tube formation, and its receptor phosphorylation of human endothelial cells. Comparison of the effects of heparin and modified heparins. J Biol Chem 2005;280:31508–15.
  • Norrby K, Nordenhem A. Dalteparin, a low-molecular-weight heparin, promotes angiogenesis mediated by heparin-binding VEGF-A in vivo. APMIS 2010;118:949–57.
  • Aho HJ, Koskensalo SM, Nevalainen TJ. Experimental pancreatitis in the rat. Sodium taurocholate-induced acute haemorrhagic pancreatitis. Scand J Gastroenterol 1980;15:411–16.
  • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351–8.
  • Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969;27:502–22.
  • Chen X, Li SL, Wu T, Liu JD. Proteasome inhibitor ameliorates severe acute pancreatitis and associated lung injury of rats. World J Gastroenterol 2008;14:3249–53.
  • Lever R, Smailbegovic A, Page CP. Locally available heparin modulates inflammatory cell recruitment in a manner independent of anticoagulant activity. Eur J Pharmacol 2010;630:137–44.
  • Reinders ME, Sho M, Izawa A, Wang P, Mukhopadhyay D, Koss KE, Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J Clin Invest 2003;112:1655–65.
  • Zhao Q, Egashira K, Inoue S, Usui M, Kitamoto S, Ni W, Vascular endothelial growth factor is necessary in the development of arteriosclerosis by recruiting/activating monocytes in a rat model of long-term inhibition of nitric oxide synthesis. Circulation 2002;105:1110–15.
  • Kaner RJ, Ladetto JV, Singh R, Fukuda N, Matthay MA, Crystal RG. Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema. Am J Respir Cell Mol Biol 2000;22:657–64.
  • Tsuchihashi S, Ke B, Kaldas F, Flynn E, Busuttil RW, Briscoe DM, Vascular endothelial growth factor antagonist modulates leukocyte trafficking and protects mouse livers against ischemia/reperfusion injury. Am J Pathol 2006;168:695–705.
  • Barleon B, Sozzani S, Zhou D, Weich HA, Mantovani A, Marme D. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 1996;87:3336–43.
  • Ueda T, Takeyama Y, Yasuda T, Matsumura N, Sawa H, Nakajima T, Vascular endothelial growth factor increases in serum and protects against the organ injuries in severe acute pancreatitis. J Surg Res 2006;134:223–30.
  • Presta M, Leali D, Stabile H, Ronca R, Camozzi M, Coco L, Heparin derivatives as angiogenesis inhibitors. Curr Pharm Des 2003;9:553–66.

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