Glucocorticoids in pediatric inflammatory bowel disease

References

• Lehtinen P, Ashorn M, Iltanen S, Jauhola R, Jauhonen P, Kolho KL, Incidence trends of pediatric inflammatory bowel disease in Finland, 1987–2003, a nationwide study. Inflamm Bowel Dis 2011;17:1778–83.
   PubMed Web of Science ®Google Scholar
• Armitage E, Drummond HE, Wilson DC, Ghosh S. Increasing incidence of both juvenile-onset Crohn's disease and ulcerative colitis in Scotland. Eur J Gastroenterol Hepatol 2001;13:1439–47.
   PubMed Web of Science ®Google Scholar
• Benchimol EI, Fortinsky KJ, Gozdyra P, Van den Heuvel M, Van Limbergen J, Griffiths AM. Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis 2011;17:423–39.
   PubMed Web of Science ®Google Scholar
• Truelove SC, Witts LJ. Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J 1955;2:1041–8.
   PubMed Web of Science ®Google Scholar
• Domenech E. Inflammatory bowel disease: current therapeutic options. Digestion 2006;73(Suppl 1):67–76.
   Google Scholar
• Uchida K, Araki T, Toiyama Y, Yoshiyama S, Inoue M, Ikeuchi H, Preoperative steroid-related complications in Japanese pediatric patients with ulcerative colitis. Dis Colon Rectum 2006;49:74–9.
   PubMed Web of Science ®Google Scholar
• Pappa H, Thayu M, Sylvester F, Leonard M, Zemel B, Gordon C. Skeletal health of children and adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2011;53:11–25.
   PubMed Web of Science ®Google Scholar
• Bernstein CN, Fried M, Krabshuis JH, Cohen H, Eliakim R, Fedail S, World Gastroenterology Organization Practice Guidelines for the diagnosis and management of IBD in 2010. Inflamm Bowel Dis 2010;16:112–24.
   PubMed Web of Science ®Google Scholar
• Carter MJ, Lobo AJ, Travis SP. IBD Section, British Society of Gastroenterology. Guidelines for the management of inflammatory bowel disease in adults. Gut 2004;53(Suppl 5):V1–16.
   PubMed Web of Science ®Google Scholar
• Turner D, Walsh CM, Steinhart AH, Griffiths AM. Response to corticosteroids in severe ulcerative colitis: a systematic review of the literature and a meta-regression. Clin Gastroenterol Hepatol 2007;5:103–10.
   PubMed Web of Science ®Google Scholar
• Baron JH, Connell AM, Kanaghinis TG, Lennard-Jones JE, Jones AF. Out-patient treatment of ulcerative colitis. comparison between three doses of oral prednisone. Br Med J 1962;2:441–3.
   PubMedGoogle Scholar
• Rufo PA, Bousvaros A. Current therapy of inflammatory bowel disease in children. Paediatr Drugs 2006;8:279–302.
   PubMedGoogle Scholar
• Sandhu BK, Fell JM, Beattie RM, Mitton SG, Wilson DC, Jenkins H, Guidelines for the management of inflammatory bowel disease in children in the United Kingdom. J Pediatr Gastroenterol Nutr 2010; Epub ahead of print.
   Google Scholar
• Powell-Tuck J, Bown RL, Lennard-Jones JE. A comparison of oral prednisolone given as single or multiple daily doses for active proctocolitis. Scand J Gastroenterol 1978;13:833–7.
   PubMed Web of Science ®Google Scholar
• Markowitz J, Grancher K, Kohn N, Lesser M, Daum F. A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease. Gastroenterology 2000;119:895–902.
   PubMed Web of Science ®Google Scholar
• Escher JC, Taminiau JA, Nieuwenhuis EE, Buller HA, Grand RJ. Treatment of inflammatory bowel disease in childhood: best available evidence. Inflamm Bowel Dis 2003;9:34–58.
   PubMed Web of Science ®Google Scholar
• Wilson D, Thomas A, Croft N, Newby E, Akobeng A, Sawczenko A, Systematic review of the evidence base for the medical treatment of paediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2010; Epub ahead of print.
   Google Scholar
• Hyams J, Markowitz J, Lerer T, Griffiths A, Mack D, Bousvaros A, The natural history of corticosteroid therapy for ulcerative colitis in children. Clin Gastroenterol Hepatol 2006;4:1118–23.
   PubMed Web of Science ®Google Scholar
• Markowitz J, Hyams J, Mack D, Leleiko N, Evans J, Kugathasan S, Corticosteroid therapy in the age of infliximab: acute and 1-year outcomes in newly diagnosed children with Crohn's disease. Clin Gastroenterol Hepatol 2006;4:1124–9.
   PubMed Web of Science ®Google Scholar
• Tung J, Loftus EV Jr, Freese DK, El-Youssef M, Zinsmeister AR, Melton LJ 3rd, A population-based study of the frequency of corticosteroid resistance and dependence in pediatric patients with Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 2006;12:1093–100.
   PubMed Web of Science ®Google Scholar
• Gower-Rousseau C, Dauchet L, Vernier-Massouille G, Tilloy E, Brazier F, Merle V, The natural history of pediatric ulcerative colitis: a population-based cohort study. Am J Gastroenterol 2009;104:2080–8.
   PubMed Web of Science ®Google Scholar
• Jakobsen C, Munkholm P, Paerregaard A, Wewer V. Steroid dependency and pediatric inflammatory bowel disease in the era of immunomodulators-a population-based study. Inflamm Bowel Dis 2011;17:1731–40.
   PubMed Web of Science ®Google Scholar
• Jakobsen C, Bartek J Jr, Wewer V, Vind I, Munkholm P, Groen R, Differences in phenotype and disease course in adult and paediatric inflammatory bowel disease – a population-based study. Aliment Pharmacol Ther 2011;34:1217–24.
   PubMed Web of Science ®Google Scholar
• Langholz E, Munkholm P, Krasilnikoff PA, Binder V. Inflammatory bowel diseases with onset in childhood. Clinical features, morbidity, and mortality in a regional cohort. Scand J Gastroenterol 1997;32:139–47.
   PubMed Web of Science ®Google Scholar
• Turunen P, Ashorn M, Auvinen A, Iltanen S, Huhtala H, Kolho KL. Long-term health outcomes in pediatric inflammatory bowel disease: a population-based study. Inflamm Bowel Dis 2009;15:56–62.
   PubMed Web of Science ®Google Scholar
• Beattie RM, Nicholls SW, Domizio P, Williams CB, Walker-Smith JA. Endoscopic assessment of the colonic response to corticosteroids in children with ulcerative colitis. J Pediatr Gastroenterol Nutr 1996;22:373–9.
   PubMed Web of Science ®Google Scholar
• Sidoroff M, Kolho KL. Glucocorticoid sensitivity in inflammatory bowel disease. Ann Med 2011; Epub ahead of print.
   Google Scholar
• Olivesi A. Normal absorption of oral prednisolone in children with active inflammatory bowel disease, including cases with proximal to distal small bowel involvement. Gastroenterol Clin Biol 1985;9:564–71.
   Google Scholar
• Schwab M, Klotz U. Pharmacokinetic considerations in the treatment of inflammatory bowel disease. Clin Pharmacokinet 2001;40:723–51.
   PubMed Web of Science ®Google Scholar
• Stegk JP, Ebert B, Martin HJ, Maser E. Expression profiles of human 11beta-hydroxysteroid dehydrogenases type 1 and type 2 in inflammatory bowel diseases. Mol Cell Endocrinol 2009;301:104–8.
   PubMed Web of Science ®Google Scholar
• Zbankova S, Bryndova J, Leden P, Kment M, Svec A, Pacha J. 11beta-hydroxysteroid dehydrogenase 1 and 2 expression in colon from patients with ulcerative colitis. J Gastroenterol Hepatol 2007;22:1019–23.
   PubMed Web of Science ®Google Scholar
• Annese V, Valvano MR, Palmieri O, Latiano A, Bossa F, Andriulli A. Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis. World J Gastroenterol 2006;12:3636–44.
   PubMed Web of Science ®Google Scholar
• Shimada T, Hiwatashi N, Yamazaki H, Kinouchi Y, Toyota T. Relationship between glucocorticoid receptor and response to glucocorticoid therapy in ulcerative colitis. Dis Colon Rectum 1997;40:S54–8.
   Google Scholar
• Rogler G, Meinel A, Lingauer A, Michl J, Zietz B, Gross V, Glucocorticoid receptors are down-regulated in inflamed colonic mucosa but not in peripheral blood mononuclear cells from patients with inflammatory bowel disease. Eur J Clin Invest 1999;29:330–6.
   Google Scholar
• Flood L, Lofberg R, Stierna P, Wikstrom AC. Glucocorticoid receptor mRNA in patients with ulcerative colitis: a study of responders and nonresponders to glucocorticosteroid therapy. Inflamm Bowel Dis 2001;7:202–9.
   PubMed Web of Science ®Google Scholar
• Raddatz D, Middel P, Bockemuhl M, Benohr P, Wissmann C, Schworer H, Glucocorticoid receptor expression in inflammatory bowel disease: evidence for a mucosal down-regulation in steroid-unresponsive ulcerative colitis. Aliment Pharmacol Ther 2004;19:47–61.
   PubMed Web of Science ®Google Scholar
• Schottelius A, Wedel S, Weltrich R, Rohde W, Buttgereit F, Schreiber S, Higher expression of glucocorticoid receptor in peripheral mononuclear cells in inflammatory bowel disease. Am J Gastroenterol 2000;95:1994–9.
   PubMed Web of Science ®Google Scholar
• Creed TJ, Lee RW, Newcomb PV, di Mambro AJ, Raju M, Dayan CM. The effects of cytokines on suppression of lymphocyte proliferation by dexamethasone. J Immunol 2009;183:164–71.
   PubMed Web of Science ®Google Scholar
• Smith MA, Marinaki AM, Sanderson JD. Pharmacogenomics in the treatment of inflammatory bowel disease. Pharmacogenomics 2010;11:421–37.
   PubMed Web of Science ®Google Scholar
• Encio IJ, Detera-Wadleigh SD. The genomic structure of the human glucocorticoid receptor. J Biol Chem 1991;266:7182–8.
   PubMed Web of Science ®Google Scholar
• Lu NZ, Cidlowski JA. Glucocorticoid receptor isoforms generate transcription specificity. Trends Cell Biol 2006;16:301–7.
   PubMed Web of Science ®Google Scholar
• Kino T, Su YA, Chrousos GP. Human glucocorticoid receptor isoform beta: recent understanding of its potential implications in physiology and pathophysiology. Cell Mol Life Sci 2009;66:3435–48.
   PubMed Web of Science ®Google Scholar
• Honda M, Orii F, Ayabe T, Imai S, Ashida T, Obara T, Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis. Gastroenterology 2000;118:859–66.
   PubMed Web of Science ®Google Scholar
• Orii F, Ashida T, Nomura M, Maemoto A, Fujiki T, Ayabe T, Quantitative analysis for human glucocorticoid receptor alpha/beta mRNA in IBD. Biochem Biophys Res Commun 2002;296:1286–94.
   PubMed Web of Science ®Google Scholar
• Zhang H, Ouyang Q, Wen ZH, Fiocchi C, Liu WP, Chen DY, Significance of glucocorticoid receptor expression in colonic mucosal cells of patients with ulcerative colitis. World J Gastroenterol 2005;11:1775–8.
   PubMed Web of Science ®Google Scholar
• Towers R, Naftali T, Gabay G, Carlebach M, Klein A, Novis B. High levels of glucocorticoid receptors in patients with active Crohn's disease may predict steroid resistance. Clin Exp Immunol 2005;141:357–62.
   PubMed Web of Science ®Google Scholar
• Fujishima S, Takeda H, Kawata S, Yamakawa M. The relationship between the expression of the glucocorticoid receptor in biopsied colonic mucosa and the glucocorticoid responsiveness of ulcerative colitis patients. Clin Immunol 2009;133:208–17.
   PubMed Web of Science ®Google Scholar
• Hausmann M, Herfarth H, Scholmerich J, Rogler G. Glucocorticoid receptor isoform expression does not predict steroid treatment response in IBD. Gut 2007;56:1328–9.
   PubMed Web of Science ®Google Scholar
• De Iudicibus S, Franca R, Martelossi S, Ventura A, Decorti G. Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease. World J Gastroenterol 2011;17:1095–108.
   PubMed Web of Science ®Google Scholar
• Krupoves A, Mack D, Deslandres C, Seidman E, Amre DK. Variation in the glucocorticoid receptor gene (NR3C1) may be associated with corticosteroid dependency and resistance in children with Crohn's disease. Pharmacogenet Genomics 2011;21:454–60.
   PubMed Web of Science ®Google Scholar
• De Iudicibus S, Stocco G, Martelossi S, Drigo I, Norbedo S, Lionetti P, Association of BclI polymorphism of the glucocorticoid receptor gene locus with response to glucocorticoids in inflammatory bowel disease. Gut 2007;56:1319–20.
   PubMed Web of Science ®Google Scholar
• Schacke H, Docke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 2002;96:23–43.
   PubMed Web of Science ®Google Scholar
• Curtis JR, Westfall AO, Allison J, Bijlsma JW, Freeman A, George V, Population-based assessment of adverse events associated with long-term glucocorticoid use. Arthritis Rheum 2006;55:420–6.
   PubMed Web of Science ®Google Scholar
• Sanderson IR, Udeen S, Davies PS, Savage MO, Walker-Smith JA. Remission induced by an elemental diet in small bowel Crohn's disease. Arch Dis Child 1987;61:123–7.
   Google Scholar
• Thomas AG, Holly JM, Taylor F, Miller V. Insulin like growth factor-I, insulin like growth factor binding protein- I, and insulin in childhood Crohn's disease. Gut 1993;34:944–7.
   PubMed Web of Science ®Google Scholar
• Berni Canani R, Terrin G, Borrelli O, Romano MT, Manguso F, Coruzzo A, Short- and long-term therapeutic efficacy of nutritional therapy and corticosteroids in paediatric Crohn's disease. Dig Liver Dis 2006;38:381–7.
   PubMedGoogle Scholar
• Cowan FJ, Warner JT, Dunstan FD, Evans WD, Gregory JW, Jenkins HR. Inflammatory bowel disease and predisposition to osteopenia. Arch Dis Child 1997;76:325–9.
   PubMed Web of Science ®Google Scholar
• Boot AM, Bouquet J, Krenning EP, de Muinck Keizer-Schrama SM. Bone mineral density and nutritional status in children with chronic inflammatory bowel disease. Gut 1998;42:188–94.
   PubMed Web of Science ®Google Scholar
• Gokhale R, Favus MJ, Karrison T, Sutton MM, Rich B, Kirschner BS. Bone mineral density assessment in children with inflammatory bowel disease. Gastroenterology 1998;114:902–11.
   PubMed Web of Science ®Google Scholar
• Walther F, Fusch C, Radke M, Beckert S, Findeisen A. Osteoporosis in pediatric patients suffering from chronic inflammatory bowel disease with and without steroid treatment. J Pediatr Gastroenterol Nutr 2006;43:42–51.
   PubMed Web of Science ®Google Scholar
• Paganelli M, Albanese C, Borrelli O, Civitelli F, Canitano N, Viola F, Inflammation is the main determinant of low bone mineral density in pediatric inflammatory bowel disease. Inflamm Bowel Dis 2007;13:416–23.
   PubMed Web of Science ®Google Scholar
• Mascarenhas MR, Thayu M. Pediatric inflammatory bowel disease and bone health. Nutr Clin Pract 2010;25:347–52.
   Google Scholar
• Vihinen M, Kolho KL, Ashorn M, Verkasalo M, Raivio T. Bone turnover and metabolism in paediatric patients with inflammatory bowel disease treated with systemic glucocorticoids. Eur J Endocrinol 2008;159:693–8.
   PubMed Web of Science ®Google Scholar
• van Staa TP, Cooper C, Leufkens HG, Bishop N. Children and the risk of fractures caused by oral corticosteroids. J Bone Miner Res 2003;18:913–18.
   PubMed Web of Science ®Google Scholar
• Uchida K, Araki T, Inoue M, Otake K, Yoshiyama S, Koike Y, Poor catch-up growth after proctocolectomy in pediatric patients with ulcerative colitis receiving prolonged steroid therapy. Pediatr Surg Int 2010;26:373–7.
   PubMed Web of Science ®Google Scholar
• Corkins MR, Gohil AD, Fitzgerald JF. The insulin-like growth factor axis in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2003;36:228–34.
   PubMed Web of Science ®Google Scholar
• Cuzzoni E, De Iudicibus S, Bartoli F, Ventura A, Decorti G. Association between BclI polymorphism in the NR3C1 gene and in vitro individual variations in lymphocyte-responses to methylprednisolone. Br J Clin Pharmacol 2012;73:651–5. doi: 10.1111/j.1365–2125.2011.04130.x.
   PubMed Web of Science ®Google Scholar
• Rintamäki H, Salo HM, Vaarala O, Kolho KL. New means to monitor the effect of glucocorticoid therapy in children. World J Gastroenterol 2010;16:1104–9.
   PubMed Web of Science ®Google Scholar
• Rintamäki H, Sipponen T, Salo HM, Vaarala O, Kolho KL. Serum immune-activation potency and response to anti-TNF-α therapy in Crohn's disease. World J Gastroenterol 2010;16:5845–51.
   PubMed Web of Science ®Google Scholar
• De Bosscher K, Haegeman G, Elewaut D. Targeting inflammation using selective glucocorticoid receptor modulators. Curr Opin Pharmacol 2010;10:497–504.
   PubMed Web of Science ®Google Scholar