166
Views
3
CrossRef citations to date
0
Altmetric
Liver and Biliary Tract

Metabolic preconditioning with fructose prior to organ recovery attenuates ischemia-reperfusion injury in the isolated perfused rat liver

&
Pages 218-224 | Received 17 Aug 2012, Accepted 15 Oct 2012, Published online: 27 Dec 2012

References

  • Lemasters JJ, Thurman RG. Reperfusion injury after liver preservation for transplantation. Annu Rev Pharmacol Toxicol 1997;37:327–38.
  • Ploeg RJ, D´Allessandro AM, Knechtle SJ, Stegall MD, Pirsch JD, Hoffmann RM, Risk factors for primary dysfunction after liver transplantation - a multivariate analysis. Transplantation 1993;55:807–13.
  • Schrem H, Till N, Becker T, Bektas H, Manns MP, Strassburg CP, Langzeit-Outcome nach Lebertransplantation. Chirurg 2008;79:121–9.
  • Bilzer M, Gerbes AL. Preservation injury of the liver: mechanisms and novel therapeutic strategies. J Hepatol 2000;32:508–15.
  • De Groot H, Rauen U. Ischemia-reperfusion injury: processes in pathogenetic networks a review. Transplant Proc 2007;39:481–4.
  • Bahde R, Spiegel HU. Hepatic ischemia-reperfusion injury from bench to bedside. Br J Surg 2010;97:1461–75.
  • Miller TB Jr. Cyclic AMP-mediated activation of hepatic glycogenolysis by fructose. Biochim Biophys Acta 1978;540:151–61.
  • Woods HF, Alberti KG. Dangers of intravenous fructose. Lancet 1972;300:1354–7.
  • Frenzel J, Richter J, Eschrich K. Fructose inhibits apoptosis induced by reoxygenation in rat hepatocytes by decreasing reactive oxygen species via stabilization of the glutathione pool. Biochim Biophys Acta 2002;1542:82–94.
  • Gasbarrini A, Borle AB, Farghali H, Francavilla A, Van Thiel D. Fructose protects rat hepatocytes from anoxic injury. J Biol Chem 1992;267:7545–52.
  • Kim JS, Qian T, Lemasters JJ. Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology 2003;124:494–503.
  • Lefebvre V, Goffin I, Buc-Calderon P. Fructose metabolism and cell survival in freshly isolated rat hepatocytes incubated under hypoxic conditions: proposals for potential clinical use. Hepatology 1994;20:1567–76.
  • Zeilinger K, Tonnelier B, Tschesche A, Nehls W, Spatkowski G, Schindler R, Effect of energy substrates on the preservation outcome of hepatocytes and sinusoidal endothelial cells in an experimental hypoxia/reoxygenation model. Transplant Proc 1997;29:403–5.
  • Anundi I, King J, Owen DA, Schneider H, Lemasters JJ, Thurman RG. Fructose prevents hypoxic cell death in liver. Am J Physiol 1987;253:G390–6.
  • Brass CA, Crawford JM, Narciso J, Gollan JL. Hypoxic liver injury and the ameliorating effects of fructose: the "glucose paradox" revisited. Am J Physiol 1992;263:G293–300.
  • Okabe H, Kurosawa K, Hatanaka N, Yoshitake J, Tagawa K. Protection of cellular and mitochondrial functions against anoxic damage by fructose in perfused liver. Biochim Biophys Acta 1991;1098:41–8.
  • Caldwell-Kenkel JC, Currin RT, Coote A, Thurman RG, Lemasters JJ. Reperfusion injury to endothelial cells after cold storage of rat livers: protection by mildly acidic pH and lack of protection by antioxidants. Transpl Int 1995;8:77–85.
  • Gerbes AL, Vollmar AM, Kiemer AK, Bilzer M. The guanylate cyclase-coupled natriuretic peptide receptor: a new target for prevention of cold ischemia-reperfusion damage of the rat liver. Hepatology 1998;28:1309–17.
  • Currin RT, Gores GJ, Thurman RG, Lemasters JJ. Protection by acidotic pH against anoxic cell killing in perfused rat liver: evidence for a pH paradox. FASEB J 1991;5:207–10.
  • Teoh NC, Farrell GC. Hepatic ischemia reperfusion injury: pathogenic mechanisms and basis for hepatoprotection. J Gastroenterol Hepatol 2003;18:891–902.
  • Voet D, Voet JG. editors. Biochemistry. 4th ed. Hoboken: John Wiley & Sons, Inc; 2011.
  • Brand MD, Chien LF, Ainscow EK, Rolfe DF, Porter RK. The causes and functions of mitochondrial proton leak. Biochim Biophys Acta 1994;1187:132–9.
  • Kaplowitz N, Aw TY, Ookhtens M. The regulation of hepatic glutathione. Annu Rev Pharmacol Toxicol 1985;25:715–44.
  • Ballet F, Thurman RG. editors. Perfused liver: clinical and basic applications. London: John Libbey & Company Ltd; 1991.
  • Morales H, Taper H, Buc Calderon P. Thermic transition and glycolytic capacity as critical events in the survival of rat liver slices after overnight cold hypoxic preservation. J Appl Toxicol 1998;18:103–9.
  • Sahebjami H, Scalettar R. Effects of fructose infusion on lactate and uric acid metabolism. Lancet 1971;297:366–9.
  • Evdokimova E, Martos M, Buc Calderon PM. Protective effect of fructose on survival and metabolic capacities of hepatocytes kept overnight under cold hypoxia before normothermic reoxygenation. Food Chem Toxicol 1997;35:669–75.
  • Mayes PA. Intermediary metabolism of fructose. Am J Clin Nutr 1993;58:754S–65S.
  • Hallfrisch J. Metabolic effects of dietary fructose. FASEB J 1990;4:2652–60.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.