278
Views
26
CrossRef citations to date
0
Altmetric
Gastrointestinal Cancer

Characterization of gastrins and their receptor in solid human gastric adenocarcinomas

, , , , &
Pages 688-695 | Received 18 Dec 2012, Accepted 01 Mar 2013, Published online: 02 Apr 2013

References

  • Orlando LA, Lenard L, Orlando RC. Chronic hypergastrinemia: causes and consequences. Dig Dis Sci 2007;52:2482–9.
  • Fossmark R, Qvigstad G, Waldum HL. Gastric cancer: Animal studies on the risk of hypoacidity and hypergastrinemia. World J Gastroenterol 2008;14:1646–51.
  • Burkitt MD, Varro A, Pritchard DM. Importance of gastrin in the pathogenesis and treatment of gastric tumors. World J Gastroenterol 2009;15:1–16.
  • Wang TC, Dangler CA, Chen D, Goldenring JR, Koh T, Raychowdhury R, et al. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology 2000;118:36–47.
  • Cui G, Takaishi S, Ai W, Betz KS, Florholmen J, Koh TJ, et al. Gastrin-induced apoptosis contributes to carcinogenesis in the stomach. Lab Invest 2006;86:1037–51.
  • Watson SA, Durrant LG, Crosbie JD, Morris DL. The in vitro growth response of primary human colorectal and gastric cancer cells to gastrin. Int J Cancer 1989;43:692–6.
  • van Solinge WW, Rehfeld JF. Co-transcription of the gastrin and cholecystokinin genes with selective translation of gastrin mRNA in a human gastric carcinoma cell line. FEBS Lett 1992;309:47–50.
  • Ishizuka J, Martinez J, Townsend CM Jr, Thompson JC. The effect of gastrin on growth of human stomach cancer cells. Ann Surg 1992;215:528–34.
  • Iwase K, Evers BM, Hellmich MR, Guo YS, Higashide S, Kim HJ, et al. Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin. Gastroenterology 1997;113:782–90.
  • Zhou JJ, Chen ML, Zhang QZ, Hu JK, Wang WL. Coexpression of cholecystokinin- B/gastrin receptor and gastrin gene in human gastric tissues and gastric cancer cell line. World J Gastroenterol 2004;10:791–4.
  • Pradeep A, Sharma C, Sathyanarayana P, Albanese C, Fleming JV, Wang TC, et al. Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells. Oncogene 2004;23:3689–99.
  • Subramaniam D, Ramalingam S, May R, Dieckgraefe BK, Berg DE, Pothoulakis C, et al. Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. Gastroenterology 2008;134:1070–82.
  • Rehfeld JF, Bardram L, Hilsted L. Gastrin in human bronchogenic carcinomas: constant expression but variable processing of progastrin. Cancer Res 1989;49:2840–3.
  • van Solinge WW, Nielsen FC, Friis-Hansen L, Falkmer UG, Rehfeld JF. Expression but incomplete maturation of progastrin in colorectal carcinomas. Gastroenterology 1993;104:1099–107.
  • van Solinge WW, Odum L, Rehfeld JF. Ovarian cancers express and process progastrin. Cancer Res 1993;53:1823–8.
  • Goetze JP, Nielsen FC, Burcharth F, Rehfeld JF. Closing the gastrin loop in pancreatic carcinoma: coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma. Cancer 2000;88:2487–94.
  • Rehfeld JF, van Solinge WW. The tumor biology of gastrin and cholecystokinin. Adv Cancer Res 1994;63:295–347.
  • Reubi JC. Targeting CCK receptors in human cancers. Curr Top Med Chem 2007;7:1239–42.
  • Kochman ML, DelValle J, Dickinson CJ, Boland CR. Post-translational processing of gastrin in neoplastic human colonic tissues. Biochem Biophys Res Commun 1992;189:1165–9.
  • Nemeth J, Taylor B, Pauwels S, Varro A, Dockray GJ. Identification of progastrin derived peptides in colorectal carcinoma extracts. Gut 1993;34:90–5.
  • Lee HK, Lee HJ, Hur K, Lee HS, Kim WH, Michaeli D, et al. Growth effect of gastrin on gastric cancer and its clinical implications for gastric cancer surgery. Oncol Rep 2005;14:383–8.
  • Henwood M, Clarke PA, Smith AM, Watson SA. Expression of gastrin in developing gastric adenocarcinoma. Br J Surg 2001;88:564–8.
  • Hur K, Kwak MK, Lee HJ, Park DJ, Lee HK, Lee HS, et al. Expression of gastrin and its receptor in human gastric cancer tissues. J Cancer Res Clin Oncol 2006;132:85–91.
  • Stephens MR, Hopper AN, Lewis WG, Blackshaw G, Edwards P, Osborne B, et al. Prognostic significance of gastrin expression in patients undergoing R0 gastrectomy for adenocarcinoma. Gastric Cancer 2007;10:159–66.
  • Goetze JP, Gore A, Møller CH, Steinbrüchel D, Rehfeld JF, Nielsen LB. Acute myocardial hypoxia increases BNP gene expression. FASEB J 2004;18:1928–30.
  • Rehfeld JF, Stadil F, Rubin B. Production and evaluation of antibodies for the radioimmunoassay of gastrin. Scand J Clin Lab Invest 1972;30:221–32.
  • Stadil F, Rehfeld JF. Determination of gastrin in serum. An evaluation of the reliability of a radioimmunoassay. Scand J Gastroenterol 1973;8:101–12.
  • Rehfeld JF, Gingras ML, Bardram L, Hilsted L, Goetze JP, Poitras P. The Zollinger-Ellison syndrome and mismeasurement of gastrin. Gastroenterology 2011;140:1444–53.
  • Hilsted L, Rehfeld JF. Measurement of precursors for alpha-amidated hormones by radioimmunoassay of glycine-extended peptides after trypsin-carboxypeptidase B cleavage. Anal Biochem 1986;152:119–26.
  • Hilsted L, Rehfeld JF. Alpha-carboxyamidation of antral progastrin. Relation to other post-translational modifications. J Biol Chem 1987;262:16953–7.
  • Hansen TO, Borup R, Marstrand T, Rehfeld JF, Nielsen FC. Cholecystokinin-2 receptor mediated gene expression in neuronal PC12 cells. J Neurochem 2008;104:1450–65.
  • Laabich A, Cooper NG. Regulation of calcium/calmodulin-dependent protein kinase II in the adult rat retina is mediated by ionotropic glutamate receptors. Exp Eye Res 1999;68:703–13.
  • Hannibal J, Georg B, Fahrenkrug J. Melanopsin changes in neonatal albino rat independent of rods and cones. Neuroreport 2007;18:81–5.
  • Rehfeld JF. Accurate measurement of cholecystokinin in plasma. Clin Chem 1998;44:991–1001.
  • Hannibal J, Hundahl C, Fahrenkrug J, Rehfeld JF, Friis-Hansen L. Cholecystokinin (CCK) expressing neurons in the suprachiasmatic nucleus: innervation, light responsiveness and entrainment in CCK-deficient mice. Eur J Neurosci 2010;32:1006–17.
  • Grabowska AM, Watson SA. Role of gastrin peptides in carcinogenesis. Cancer Lett 2007;257:1–15.
  • Blackmore M, Hirst BH. Autocrine stimulation of growth of AR4-2J rat pancreatic tumour cells by gastrin. Br J Cancer 1992;66:32–8.
  • Seva C, Dickinson CJ, Yamada T. Growth-promoting effects of glycine-extended progastrin. Science 1994;265:410–12.
  • Rehfeld JF. Gastrins in serum. Scand J Gastroenterol 1973;8:577–83.
  • Rehfeld JF, Stadil F, Vikelsoe J. Immunoreactive gastrin components in human serum. Gut 1974;15:102–11.
  • Konturek PC, Konturek SJ, Bielanski W, Kania J, Zuchowic Z, Hartwich A, et al. Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients. Dig Dis Sci 2003;48:2005–17.
  • Brett BT, Smith SC, Bouvier CV, Michaeli D, Hochhauser D, Davidson BR, et al. Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer. J Clin Oncol 2002;20:4225–31.
  • Gilliam AD, Watson SA. Emerging biological therapies for pancreatic carcinoma. Eur J Surg Oncol 2002;28:370–8.
  • Ajani JA, Hecht JR, Ho L, Baker J, Oortgiesen M, Eduljee A, et al. An open-label, multinational, multicenter study of G17DT vaccination combined with cisplatin and 5- fluorouracil in patients with untreated, advanced gastric or gastroesophageal cancer: the GC4 study. Cancer 2006;106:1908–16.
  • Rehfeld JF, Goetze JP. Gastrin vaccination against gastrointestinal and pancreatic cancer. Scand J Gastroenterol 2006;41:122–3.
  • Buttar NS, Wang KK. Mechanisms of disease: Carcinogenesis in Barrett's esophagus. Nat Clin Pract Gastroenterol Hepatol 2004;1:106–12.
  • Haigh CR, Attwood SE, Thompson DG, Jankowski JA, Kirton CM, Pritchard DM, et al. Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor. Gastroenterology 2003;124:615–25.
  • Black JW. Reflections on some pilot trials of gastrin receptor blockade in pancreatic cancer. Eur J Cancer 2009;45:360–4.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.