The impact of genetic factors on response to glucocorticoids therapy in IBD

References

• Hench PS, Kendall EC, Slocumb CH, et al. The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Proc Staff Meet Mayo Clin. 1949;24:181–197.
   PubMed Web of Science ®Google Scholar
• Farrell RJ, Kelleher D. Glucocorticoid resistance in inflammatory bowel disease. J Endocrinol. 2003;178:339–346.
   PubMed Web of Science ®Google Scholar
• Nicolaides NC, Galata Z, Kino T, et al. The human glucocorticoid receptor: molecular basis of biologic function. Steroids. 2010;75:1–12.
   PubMed Web of Science ®Google Scholar
• Hearing SD, Norman M, Dayan CM. In vitro measurement of lymphocyte steroid sensitivity: lack of agreement between whole blood culture and separated lymphocyte culture. Immunopharmacol Immunotoxicol. 1999;21:41–53.
   PubMed Web of Science ®Google Scholar
• De Iudicibus S, Franca R, Martelossi S, et al. Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease. World J Gastroenterol. 2011;17:1095–1108.
   PubMed Web of Science ®Google Scholar
• Cuzzoni E, De Iudicibus S, Bartoli F, et al. Association between BclI polymorphism in the NR3C1 gene and in vitro individual variations in lymphocyte responses to methylprednisolone. Br J Clin Pharmacol. 2012;73:651–655.
   PubMed Web of Science ®Google Scholar
• Munkholm P, Langholz E, Davidsen M. Binder VFrequency of glucocorticoid resistance and dependency in Crohn’s disease. Gut. 1994;35:360–362.
   PubMed Web of Science ®Google Scholar
• Tung J, Loftus EV Jr, Freese DK, et al. A population-based study of the frequency of corticosteroid resistance and dependence in pediatric patients with Crohn’s disease and ulcerative colitis. Inflamm Bowel Dis. 2006;12:1093–1100.
   PubMed Web of Science ®Google Scholar
• Van Assche G, Dignass A, Panes J, et al. The second European evidence-based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosis. J Crohns Colitis. 2010;4:7–27.
   PubMed Web of Science ®Google Scholar
• Dignass A, Eliakim R, Magro F, et al. Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 1: definitions and diagnosis. J Crohns Colitis. 2012;6:965–990.
   PubMed Web of Science ®Google Scholar
• Curkovic I, Egbring M, Kullak-Ublick GA. Risks of inflammatory bowel disease treatment with glucocorticosteroids and aminosalicylates. Dig Dis. 2013;31:368–373.
   PubMed Web of Science ®Google Scholar
• Charmandari E, Kino T, Chrousos GP. Primary generalized familial and sporadic glucocorticoid resistance (Chrousos syndrome) and hypersensitivity. Endocr Dev. 2013;24:67–85.
   PubMedGoogle Scholar
• Manenschijn L, van den Akker EL, Lamberts SW, et al. Clinical features associated with glucocorticoid receptor polymorphisms. An overview. Ann N Y Acad Sci. 2009;1179:179–198.
   PubMed Web of Science ®Google Scholar
• Mwinyi J, Wenger C, Eloranta JJ, et al. Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients. World J Gastroenterol. 2010;16:3888–3896.
   PubMed Web of Science ®Google Scholar
• Krupoves A, Mack D, Deslandres C, et al. Variation in the glucocorticoid receptor gene (NR3C1) may be associated with corticosteroid dependency and resistance in children with Crohn’s disease. Pharmacogenet Genomics. 2011;21:454–460.
   PubMed Web of Science ®Google Scholar
• Koper JW, van Rossum EF, van den Akker EL. Glucocorticoid receptor polymorphisms and haplotypes and their expression in health and disease. Steroids. 2014;92:62–73.
   PubMed Web of Science ®Google Scholar
• Chen HL, Li LR. Glucocorticoid receptor gene polymorphisms and glucocorticoid resistance in inflammatory bowel disease: a meta-analysis. Dig Dis Sci. 2012;57:3065–3075.
   PubMed Web of Science ®Google Scholar
• van Rossum EF, Koper JW, van den Beld AW, et al. Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index. Clin Endocrinol. 2003;59:585–592.
   PubMed Web of Science ®Google Scholar
• De Iudicibus S, Stocco G, Martelossi S, et al. Association of BclI polymorphism of the glucocorticoid receptor gene locus with response to glucocorticoids in inflammatory bowel disease. Gut. 2007;56:1319–1320.
   PubMed Web of Science ®Google Scholar
• De Iudicibus S, Stocco G, Martelossi S, et al. Genetic predictors of glucocorticoid response in pediatric patients with inflammatory bowel diseases. J Clin Gastroenterol. 2011;45:1–7.
   PubMed Web of Science ®Google Scholar
• Maltese P, Palma L, Sfara C, et al. Glucocorticoid resistance in Crohn’s disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms. Pharmacogenomics J. 2012;12:432–438.
   PubMed Web of Science ®Google Scholar
• de Lange P, Koper JW, Huizenga NA, et al. Differential hormone-dependent transcriptional activation and repression by naturally occurring human glucocorticoid receptor variants. Mol Endocrinol. 1997;11:1156–1164.
   PubMed Web of Science ®Google Scholar
• Russcher H, Smit P, van den Akker EL, et al. Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression. J Clin Endocrinol Metab. 2005;90:5804–5810.
   PubMed Web of Science ®Google Scholar
• van Rossum EF, Koper JW, Huizenga NA, et al. A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes. 2002;51:3128–3134.
   PubMed Web of Science ®Google Scholar
• van Rossum EF, Feelders RA, van den Beld AW, et al. Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. Am J Med. 2004;117:158–162.
   PubMed Web of Science ®Google Scholar
• Huizenga NA, Koper JW, De Lange P, et al. A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab. 1998;83:144–151.
   PubMed Web of Science ®Google Scholar
• Marti A, Ochoa MC, Sánchez-Villegas A, et al. Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity. BMC Med Genet. 2006;7:50.
   PubMed Web of Science ®Google Scholar
• Westendorp RG, van Heemst D. Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study. Biogerontology. 2006;7:231–238.
   PubMed Web of Science ®Google Scholar
• Cellini E, Castellini G, Ricca V, et al. Glucocorticoid receptor gene polymorphisms in Italian patients with eating disorders and obesity. Psychiatr Genet. 2010;20:282–288.
   PubMed Web of Science ®Google Scholar
• Bamberger CM, Bamberger AM, de Castro M, et al. Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest. 1995;95:2435–2441.
   PubMed Web of Science ®Google Scholar
• Oakley RH, Sar M, Cidlowski JA. The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. J Biol Chem. 1996;271:9550–9559.
   PubMed Web of Science ®Google Scholar
• Leung DY, Hamid Q, Vottero A, et al. J Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta. J Exp Med. 1997;186:1567–1574.
   PubMed Web of Science ®Google Scholar
• Schaaf MJ, Cidlowski JA. The glucocorticoid receptor beta-isoform: a perspective on its relevance in human health and disease. Ernst Schering Res Found Workshop. 2002;40:197–211.
   PubMedGoogle Scholar
• Honda M, Orii F, Ayabe T, et al. Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis. Gastroenterology. 2000;118:859–866.
   PubMed Web of Science ®Google Scholar
• Fujishima S, Takeda H, Kawata S, et al. The relationship between the expression of the glucocorticoid receptor in biopsied colonic mucosa and the glucocorticoid responsiveness of ulcerative colitis patients. Clin Immunol. 2009;133:208–217.
   PubMed Web of Science ®Google Scholar
• Zhang H, Ouyang Q, Wen ZH, et al. Significance of glucocorticoid receptor expression in colonic mucosal cells of patients with ulcerative colitis. World J Gastroenterol. 2005;11:1775–1778.
   PubMed Web of Science ®Google Scholar
• Hausmann M, Herfarth H, Schölmerich J, et al. Glucocorticoid receptor isoform expression does not predict steroid treatment response in IBD. Gut. 2007;56:1328–1329.
   PubMed Web of Science ®Google Scholar
• Bamberger CM, Else T, Bamberger AM, et al. Regulation of the human interleukin-2 gene by the alpha and beta isoforms of the glucocorticoid receptor. Mol Cell Endocrinol. 1997;136:23–28.
   PubMed Web of Science ®Google Scholar
• Orii F, Ashida T, Nomura M, et al. Quantitative analysis for human glucocorticoid receptor alpha/beta mRNA in IBD. Biochem Biophys Res Commun. 2002;296:1286–1294.
   PubMed Web of Science ®Google Scholar
• Bantel H, Domschke W, Schulze-Osthoff K. Molecular mechanisms of glucocorticoid resistance. Gastroenterology. 2000;119:1178–1179.
   PubMed Web of Science ®Google Scholar
• Ma L, Fang M, Liang Y, et al. Low expression of glucocorticoid receptor alpha isoform in adult immune thrombocytopenia correlates with glucocorticoid resistance. Ann Hematol. 2013;92:953–960.
   PubMed Web of Science ®Google Scholar
• Gross KL, Lu NZ, Cidlowski JA. Molecular mechanisms regulating glucocorticoid sensitivity and resistance. Mol Cell Endocrinol. 2009;300:7–16.
   PubMed Web of Science ®Google Scholar
• Pratt WB, Toft DO. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr Rev. 1997;18:306–360.
   PubMed Web of Science ®Google Scholar
• Cheung J, Smith DF. Molecular chaperone interactions with steroid receptors: an update. Mol Endocrinol. 2000;14:939–946.
   PubMed Web of Science ®Google Scholar
• Kojika S, Sugita K, Inukai T, et al. Mechanisms of glucocorticoid resistance in human leukemic cells: implication of abnormal 90 and 70 kDa heat shock proteins. Leukemia. 1996;10:994–999.
   PubMed Web of Science ®Google Scholar
• Tomasello G, Sciumé C, Rappa F, et al. Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy. Cell Physiol Biochem. 2010;25:359–366.
   PubMed Web of Science ®Google Scholar
• Collins CB, Aherne CM, Yeckes A, et al. Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function. Mucosal Immunol. 2013;6:960–971.
   PubMed Web of Science ®Google Scholar
• Tanaka K, Mizushima T. Protective role of HSF1 and HSP70 against gastrointestinal diseases. Int J Hyperthermia. 2009;25:668–676.
   PubMed Web of Science ®Google Scholar
• Chen J, Ren J, Gu G, et al. Crohn’s disease and polymorphism of heat shock protein gene HSP70-2 in the Chinese population. J Gastroenterol Hepatol. 2013;28:814–818.
   PubMed Web of Science ®Google Scholar
• Denny WB, Valentine DL, Reynolds PD, et al. Squirrel Monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding. Endocrinology. 2000;141:4107–4113.
   PubMed Web of Science ®Google Scholar
• Denny WB, Prapapanich V, Smith DF, et al. Structure-function analysis of squirrel monkey FK506-binding protein 51, a potent inhibitor of glucocorticoid receptor activity. Endocrinology. 2005;146:3194–3201.
   PubMed Web of Science ®Google Scholar
• Wochnik GM, Rüegg J, Abel GA, et al. FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. J Biol Chem. 2005;280:4609–4616.
   PubMed Web of Science ®Google Scholar
• Zhang X, Clark AF, Yorio T. FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness. Invest Ophthalmol Vis Sci. 2008;49:1037–1047.
   PubMed Web of Science ®Google Scholar
• Reynolds PD, Ruan Y, Smith DF, et al. Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51. J Clin Endocrinol Metab. 1999;84:663–669.
   PubMed Web of Science ®Google Scholar
• Scammell JG. Steroid resistance in the squirrel monkey: an old subject revisited. Ilar J. 2000;41:19–25.
   PubMedGoogle Scholar
• Riggs DL, Roberts PJ, Chirillo SC, et al. The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo. EMBO J. 2003;22:1158–1167.
   PubMed Web of Science ®Google Scholar
• Westberry JM, Sadosky PW, Hubler TR, et al. Glucocorticoid resistance in squirrel monkeys results from a combination of a transcriptionally incompetent glucocorticoid receptor and overexpression of the glucocorticoid receptor co-chaperone FKBP51. J Steroid Biochem Mol Biol. 2006;100:34–41.
   PubMed Web of Science ®Google Scholar
• Schinkel AH. The physiological function of drug transporting P-glycoproteins. Semin Cancer Biol. 1997;8:161–170.
   PubMed Web of Science ®Google Scholar
• Marzolini C, Paus E, Bucilin T, et al. Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther. 2004;75:13–33.
   PubMed Web of Science ®Google Scholar
• Ueda K, Okamura N, Hirai M, et al. Human P-glycoprotein transports cortisol, aldosteron, and dexamethason, but not progesterone. J Biol Chem. 1992;267:24248–242525.
   PubMed Web of Science ®Google Scholar
• Bourgeois S, Gruol DJ, Newby RF, et al. Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis. Mol Endocrinol. 1993;7:840–851.
   PubMed Web of Science ®Google Scholar
• Higgins CF, Gottesman MM. Is the multidrug transporter a flippase? Trends Biochem Sci. 1992;17:18–21.
   PubMed Web of Science ®Google Scholar
• Kim R, Wilkinson G. Pharmacogenetics of drug transporters. In: Kalow W, Mayer UA, Tyndale RF, editors. Pharmacogenomics. New York: Marcel Dekker, 2001. p. 81–108.
   Google Scholar
• Hoffmeyer S, Burk O, Arnold HP, et al. Functional polymorphism of the human multidrug-resistance gene: multiple sequence variation and correlation of one allele with P-glycoprotein expression acticity in vivo. Proc Natl Acad Sci USA. 2000;97:3473–3478.
   PubMed Web of Science ®Google Scholar
• Gerloff T, Schaefer M, Johne A, et al. MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males. Br J Clin Pharmacol. 2002;54:610–616.
   PubMed Web of Science ®Google Scholar
• Annese V, Latiano A, Rossi L, et al. The polymorphism of multi-drug resistance 1 gene (MDR1) does not influence the pharmacokinetics of dexamethasone loaded into autologous erythrocytes of patients with inflammatory bowel disease. Eur Rev Med Pharmacol Sci. 2006;10:27–31.
   PubMedGoogle Scholar
• Farrell RJ, Murphy A, Long A, et al. High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel diseases patients who fail medical therapy. Gastroenterology. 2000;118:279–288.
   PubMed Web of Science ®Google Scholar
• Cucchiara S, Latiano A, Palmieri O, et al. Polymorphisms of tumor necrosis factor-alpha but not MDR1 influence response to medical therapy in pediatric-onset inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2007;44:171–179.
   PubMed Web of Science ®Google Scholar
• Krupoves A, Mack D, Seidman E, et al. Associations between variants in the ABCB1 (MDR1) gene and corticosteroid dependence in children with Crohn’s disease. Inflamm Bowel Dis. 2011;17:2308–2317.
   PubMed Web of Science ®Google Scholar
• Yang QF, Chen BL, Zhang QS, et al. Contribution of MDR1 gene polymorphisms on IBD predisposition and response to glucocorticoids in IBD in a Chinese population. J Dig Dis. 2015;16:22–30.
   PubMed Web of Science ®Google Scholar
• Pemberton LF, Paschal BM. Mechanisms of receptor-mediated nuclear import and nuclear export. Traffic. 2005;6:187–198.
   PubMed Web of Science ®Google Scholar
• Raby BA, Van Steen K, Lasky-Su J, et al. Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma. Respir Res. 2009;10:67.
   PubMed Web of Science ®Google Scholar
• Sim SC, Ingelman-Sundberg M. The human cytochrome P450 Allele Nomenclature Committee Web site: submission criteria, procedures, and objectives. Methods Mol Biol. 2006;320:183–191.
   PubMedGoogle Scholar
• Kuehl P, Zhang J, Lin Y, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet. 2001;27:383–391.
   PubMed Web of Science ®Google Scholar
• Lamba J, Hebert JM, Schuetz EG, et al. PharmGKB summary: very important pharmacogene information for CYP3A5. Pharmacogenet Genomics. 2012;22:555–558.
   PubMed Web of Science ®Google Scholar
• Hustert E, Haberl M, Burk O, et al. The genetic determinants of the CYP3A5 polymorphism. Pharmacogenetics. 2001;11:773–779.
   PubMedGoogle Scholar
• Wang D, Guo Y, Wrighton SA, et al. Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs. Pharmacogenomics J. 2011;11:274–286.
   PubMed Web of Science ®Google Scholar
• Lamba JK, Lin YS, Schuetz EG, et al. Genetic contribution to variable human CYP3A-mediated metabolism. Adv Drug Deliv Rev. 2002;54:1271–1294.
   PubMed Web of Science ®Google Scholar
• Galon J, Franchimont D, Hiroi N, et al. Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. Faseb J. 2002;16:61–71.
   PubMed Web of Science ®Google Scholar
• Ashwell JD, Vacchio MS, Galon J, et al. Do glucocorticoids participate in thymocyte development? Immunol Today. 2000;21:644–646.
   PubMedGoogle Scholar
• Jahnsen FL, Haye R, Gran E, et al. Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. J Immunol. 1999;163:1545–1551.
   PubMed Web of Science ®Google Scholar
• Pype JL, Dupont LJ, Menten P, et al. Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells. Modulation by corticosteroids and T-helper 2 cytokines. Am J Respir Cell Mol Biol. 1999;21:528–536.
   PubMed Web of Science ®Google Scholar
• Catley M. Dissociated steroids. ScientificWorldJournal. 2007;7:421–430.
   PubMed Web of Science ®Google Scholar
• Ehrchen J, Steinmüller L, Barczyk K, et al. Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes. Blood. 2007;109:1265–1274.
   PubMed Web of Science ®Google Scholar
• Croxtall JD, Choudhury Q, Flower RJ, et al. Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol. 2000;130:289–298.
   PubMed Web of Science ®Google Scholar
• McConkey DJ, Nicotera P, Hartzell P, et al. Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2 + concentration. Arch Biochem Biophys. 1989;269:365–370.
   PubMed Web of Science ®Google Scholar
• Carvalho LA, Bergink V, Sumaski L, et al. Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder. Transl Psychiatry. 2014;4:344.
   PubMed Web of Science ®Google Scholar
• Raddatz D, Toth S, Schwörer H, et al. Glucocorticoid receptor signaling in the intestinal epithelial cell lines IEC-6 and Caco-2: evidence of inhibition by interleukin-1beta. Int J Colorectal Dis. 2001;16:377–383.
   PubMed Web of Science ®Google Scholar
• Franchimont D, Martens H, Hagelstein MT, et al. Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J Clin Endocrinol Metab. 1999;84:2834–2839.
   PubMed Web of Science ®Google Scholar
• Rider CF, King EM, Holden NS, et al. Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. J Pharmacol Exp Ther. 2011;338:860–869.
   PubMed Web of Science ®Google Scholar
• Kam JC, Szefler SJ, Surs W, et al. Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J Immunol. 1993;151:3460–3466.
   PubMed Web of Science ®Google Scholar
• Bantel H, Schmitz ML, Raible A, et al. Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness. FASEB J. 2002;16:1832–1834.
   PubMed Web of Science ®Google Scholar
• Buttgereit F, Saag KG, Cutolo M, et al. The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis. Scand J Rheumatol. 2005;34:14–21.
   PubMed Web of Science ®Google Scholar
• Dejager L, Vandevyver S, Petta I, et al. Dominance of the strongest: inflammatory cytokines versus glucocorticoids. Cytokine Growth Factor Rev. 2014;25:21–33.
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Mechanisms and resistance in glucocorticoid control of inflammation. J Steroid Biochem Mol Biol. 2010;120:76–85.
   PubMed Web of Science ®Google Scholar
• Akira S, Hirano T, Taga T, et al. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J. 1990;4:2860–2867.
   PubMed Web of Science ®Google Scholar
• Engler H, Bailey MT, Engler A, et al. Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen. Psychoneuroendocrinology. 2008;33:108–117.
   PubMed Web of Science ®Google Scholar
• Cerretti DP, Kozlosky CJ, Mosley B, et al. Molecular cloning of the interleukin-1 beta converting enzyme. Science. 1992;256:97–100.
   PubMed Web of Science ®Google Scholar
• Thornberry NA, Bull HG, Calaycay JR, et al. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature. 1992;356:768–774.
   PubMed Web of Science ®Google Scholar
• Van Bogaert T, Vandevyver S, Dejager L, et al. Tumor necrosis factor inhibits glucocorticoid receptor function in mice: a strong signal toward lethal shock. J Biol Chem. 2011;286:26555–26567.
   PubMed Web of Science ®Google Scholar
• Louis E, Peeters M, Franchimont D, et al. Tumour necrosis factor (TNF) gene polymorphism in Crohn’s disease (CD): influence on disease behaviour? Clin Exp Immunol. 2000;119:64–68.
   PubMed Web of Science ®Google Scholar
• Ishiguro Y. Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis. J Gastroenterol. 1999;34:66–74.
   PubMed Web of Science ®Google Scholar
• Griga T, Wilkens C, Wirkus N, et al. A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn’s disease and associated with cumulative steroid doses. Hepatogastroenterology. 2007;54:784–786.
   PubMed Web of Science ®Google Scholar