507
Views
16
CrossRef citations to date
0
Altmetric
Review Article

Does long-term profound inhibition of gastric acid secretion increase the risk of ECL cell-derived tumors in man?

, , , &
Pages 767-773 | Received 18 Nov 2015, Accepted 05 Jan 2016, Published online: 12 Feb 2016

References

  • Ropielski L. β-Imidazolyläthylamin und die organänextrakte. β-Imidazolyläthylamin als mächtiger erreger der magendrüsen. Plügers Archiv. 1920;178:214–236.
  • Hakanson R, Lilja B, Owman C. Cellular localization of histamine and monoamines in the gastric mucosa of man. Histochemie. 1969;18:74–86.
  • Hakanson R, Bottcher G, Ekblad E, et al. Histamine in endocrine cells in the stomach. A survey of several species using a panel of histamine antibodies. Histochemistry. 1986;86:5–17.
  • Barrett P, Hobbs RC, Coates PJ, et al. Endocrine cells of the human gastrointestinal tract have no proliferative capacity. Histochem J. 1995;27:482–486.
  • Ryberg B, Tielemans Y, Axelson J, et al. Gastrin stimulates the self-replication rate of enterochromaffinlike cells in the rat stomach. Effects of omeprazole, ranitidine, and gastrin-17 in intact and antrectomized rats. Gastroenterology. 1990;99:935–942.
  • Peghini PL, Annibale B, Azzoni C, et al. Effect of chronic hypergastrinemia on human enterochromaffin-like cells: insights from patients with sporadic gastrinomas. Gastroenterology. 2002;123:68–85.
  • Rogers LW, Murphy RC. Gastric carcinoid and gastric carcinoma. Morphologic correlates of survival. Am J Surg Pathol. 1979;3:195–202.
  • Wilander E, El-Salhy M, Pitkanen P. Histopathology of gastric carcinoids: a survey of 42 cases. Histopathology. 1984;8:183–193.
  • Havu N. Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion. Digestion. 1986;35:42–55.
  • Poynter D, Pick CR, Harcourt RA, et al. Association of long lasting unsurmountable histamine H2 blockade and gastric carcinoid tumours in the rat. Gut. 1985;26:1284–1295.
  • Waldum HL, Sandvik AK, Brenna E, et al. Gastrin-histamine sequence in the regulation of gastric acid secretion. Gut. 1991;32:698–701.
  • Kleveland PM, Waldum HL, Larsson H. Gastric acid secretion in the totally isolated, vascularly perfused rat stomach. A selective muscarinic-1 agent does, whereas gastrin does not, augment maximal histamine-stimulated acid secretion. Scand J Gastroenterol. 1987;22:705–713.
  • Walsh JH, Richardson CT, Fordtran JS. pH dependence of acid secretion and gastrin release in normal and ulcer subjects. J Clin Invest. 1975;55:462–468.
  • Kopin AS, Lee YM, McBride EW, et al. Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc Natl Acad Sci USA. 1992;89:3605–3609.
  • Waldum HL, Sandvik AK. Gastric functional and trophic receptors for CCK. In: Smith T, editor. Aspects of synaptic transmission. London: Taylor and Francis Ltd; 1993. p. 157–172.
  • Bakke I, Qvigstad G, Sandvik AK, et al. The CCK-2 receptor is located on the ECL cell, but not on the parietal cell. Scand J Gastroenterol. 2001;36:1128–1133.
  • Nakata H, Matsui T, Ito M, et al. Cloning and characterization of gastrin receptor from ECL carcinoid tumor of Mastomys natalensis. Biochem Biophys Res Commun. 1992;187:1151–1157.
  • Sandvik AK, Waldum HL, Kleveland PM, et al. Gastrin produces an immediate and dose-dependent histamine release preceding acid secretion in the totally isolated, vascularly perfused rat stomach. Scand J Gastroenterol. 1987;22:803–808.
  • Blair AJ, 3rd, Feldman M, Barnett C, et al. Detailed comparison of basal and food-stimulated gastric acid secretion rates and serum gastrin concentrations in duodenal ulcer patients and normal subjects. J Clin Invest. 1987;79:582–587.
  • Brenna E, Waldum HL. Trophic effect of gastrin on the enterochromaffin like cells of the rat stomach: establishment of a dose response relationship. Gut. 1992;33:1303–1306.
  • Sjoblom SM, Sipponen P, Karonen SL. Argyrophil cell hyperplasia and carcinoid tumours in oxyntic mucosa of the stomach. Dependence on duration of pernicious anaemia. Eur J Gastroenerol Hepatol. 1991;31:153–157.
  • Oettle AG. Spontaneous carcinoma of the glandular stomach in Rattus (mastomys) natalensis, an African rodent. Br J Cancer. 1957;11:415–433.
  • Soga J, Tazawa K, Kanahara H, et al. Some characteristic features of spontaneous argyrophil cell carcinoids in glandular stomach of Praomys (mastomys) natalensis. GANN Monograph. 1969;8:15–26.
  • Poynter D, Selway SA, Papworth SA, et al. Changes in the gastric mucosa of the mouse associated with long lasting unsurmountable histamine H2 blockade. Gut. 1986;27:1338–1346.
  • Mattsson H, Havu N, Brautigam J, et al. Partial gastric corpectomy results in hypergastrinemia and development of gastric enterochromaffinlike-cell carcinoids in the rat. Gastroenterology. 1991;100:311–319.
  • Safholm C, Havu N, Forssell H, et al. Effect of 7 years' daily oral administration of omeprazole to beagle dogs. Digestion. 1994;55:139–147.
  • Ekman L, Hansson E, Havu N, et al. Toxicological studies on omeprazole. Scand J Gastroenterol Suppl. 1985;108:53–69.
  • Martinsen TC, Benestad SL, Moldal T, et al. Inhibitors of gastric acid secretion increase the risk of prion infection in mice. Scand J Gastroenterol. 2011;46:1418–1422.
  • Hirayama F, Takagi S, Iwao E, et al. Development of poorly differentiated adenocarcinoma and carcinoid due to long-term Helicobacter pylori colonization in Mongolian gerbils. J Gastroenterol. 1999;34:450–454.
  • Waldum HL, Rorvik H, Falkmer S, et al. Neuroendocrine (ECL cell) differentiation of spontaneous gastric carcinomas of cotton rats (Sigmodon hispidus). Lab Anim Sci. 1999;49:241–247.
  • Martinsen TC, Kawase S, Hakanson R, et al. Spontaneous ECL cell carcinomas in cotton rats: natural course and prevention by a gastrin receptor antagonist. Carcinogenesis. 2003;24:1887–1896.
  • Wang TC, Dangler CA, Chen D, et al. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology. 2000;118:36–47.
  • Borch K, Renvall H, Liedberg G. Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia. Gastroenterology. 1985;88:638–648.
  • Solcia E, Capella C, Fiocca R, et al. Gastric argyrophil carcinoidosis in patients with Zollinger-Ellison syndrome due to type 1 multiple endocrine neoplasia. A newly recognized association. Am J Surg Pathol. 1990;14:503–513.
  • Bordi C, D'Adda T, Pilato FP, et al. Carcinoid (ECL cell) tumor of the oxyntic mucosa of the stomach: a hormone-dependent neoplasm? Surgical Pathology. Philiadelphia (PA): Field & Wood; 1988.
  • Cadiot G, Vissuzaine C, Potet F, et al. Fundic argyrophil carcinoid tumor in a patient with sporadic-type Zollinger-Ellison syndrome. Dig Dis Sci. 1995;40:1275–1278.
  • Feurle GE. Argyrophil cell hyperplasia and a carcinoid tumour in the stomach of a patient with sporadic Zollinger-Ellison syndrome. Gut. 1994;35:275–277.
  • Donow C, Pipeleers-Marichal M, Schroder S, et al. Surgical pathology of gastrinoma. Site, size, multicentricity, association with multiple endocrine neoplasia type 1, and malignancy. Cancer. 1991;68:1329–1334.
  • Norton JA, Sugarbaker PH, Doppman JL, et al. Aggressive resection of metastatic disease in selected patients with malignant gastrinoma. Ann Surg. 1986;203:352–359.
  • Calvete O, Reyes J, Zuniga S, et al. Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour. Hum Mol Gen. 2015;24:2914–2922.
  • Modlin IM, Lye KD, Kidd M. A 50-year analysis of 562 gastric carcinoids: small tumor or larger problem? Am J Gastroenterol. 2004;99:23–32.
  • Rindi G, Luinetti O, Cornaggia M, et al. Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study. Gastroenterology. 1993;104:994–1006.
  • Rindi G, Azzoni C, La Rosa S, et al. ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: prognostic evaluation by pathological analysis. Gastroenterology. 1999;116:532–542.
  • Kokkola A, Sjoblom SM, Haapiainen R, et al. The risk of gastric carcinoma and carcinoid tumours in patients with pernicious anaemia. A prospective follow-up study. Scand J Gastroenterol. 1998;33:88–92.
  • Qvigstad G, Falkmer S, Westre B, et al. Clinical and histopathological tumour progression in ECL cell carcinoids (“ECLomas”). APMIS. 1999;107:1085–1092.
  • Waldum HL, Brenna E, Sandvik AK. Relationship of ECL cells and gastric neoplasia. Yale J Biol Med. 1998;71:325–335.
  • Waldum HL, Haugen OA, Isaksen C, et al. Are diffuse gastric carcinomas neuroendocrine tumours? (ECL-omas). Eur J Gastroenterol Hepatol. 1991;3:245–249.
  • Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31–49.
  • Waldum HL, Aase S, Kvetnoi I, et al. Neuroendocrine differentiation in human gastric carcinoma. Cancer. 1998;83:435–444.
  • Qvigstad G, Sandvik AK, Brenna E, et al. Detection of chromogranin A in human gastric adenocarcinomas using a sensitive immunohistochemical technique. Histochem J. 2000;32:551–556.
  • Qvigstad G, Qvigstad T, Westre B, et al. Neuroendocrine differentiation in gastric adenocarcinomas associated with severe hypergastrinemia and/or pernicious anemia. APMIS. 2002;110:132–139.
  • Bakkelund K, Fossmark R, Nordrum I, et al. Signet ring cells in gastric carcinomas are derived from neuroendocrine cells. J Histochem Cytochem. 2006;54:615–621.
  • Sordal O, Qvigstad G, Nordrum IS, et al. The PAS positive material in gastric cancer cells of signet ring type is not mucin. Exp Mol Pathol. 2014;96:274–278.
  • Waldum HL, Qvigstad G. Gastric cancer: the role of neuroendocrine cells. In: Cardinni DC, editor. Research focus on gastric cancer. New York: Novo Science Publishers; 2007. p. 91–102.
  • Lind T, Cederberg C, Ekenved G, et al. Effect of omeprazole–a gastric proton pump inhibitor–on pentagastrin stimulated acid secretion in man. Gut. 1983;24:270–276.
  • Havu N, Mattsson H, Ekman L, et al. Enterochromaffin-like cell carcinoids in the rat gastric mucosa following long-term administration of ranitidine. Digestion. 1990;45:189–195.
  • Smith JT, Gavey C, Nwokolo CU, et al. Tolerance during 8 days of high-dose H2-blockade: placebo-controlled studies of 24-hour acidity and gastrin. Aliment Pharmacol Ther. 1990;4 Suppl 1:47–63.
  • Waldum HL, Arnestad JS, Brenna E, et al. Marked increase in gastric acid secretory capacity after omeprazole treatment. Gut. 1996;39:649–653.
  • Sharma BK, Walt RP, Pounder RE, et al. Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity. Gut. 1984;25:957–964.
  • Vakil N. Review article: esomeprazole, 40 mg once daily, compared with lansoprazole, 30 mg once daily, in healing and symptom resolution of erosive oesophagitis. Aliment Pharmacol Ther. 2003;17:21–23.
  • Hatlebakk JG. Review article: gastric acidity–comparison of esomeprazole with other proton pump inhibitors. Aliment Pharmacol Ther. 2003;17:10–15.
  • Reimer C, Sondergaard B, Hilsted L, et al. Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy. Gastroenterology. 2009;137:80–87. 7 e1.
  • Niklasson A, Lindstrom L, Simren M, et al. Dyspeptic symptom development after discontinuation of a proton pump inhibitor: a double-blind placebo-controlled trial. Am J Gastroenterol. 2010;105:1531–1537.
  • Lamberts R, Creutzfeldt W, Stockmann F, et al. Long-term omeprazole treatment in man: effects on gastric endocrine cell populations. Digestion. 1988;39:126–135.
  • Haga Y, Nakatsura T, Shibata Y, et al. Human gastric carcinoid detected during long-term antiulcer therapy of H2 receptor antagonist and proton pump inhibitor. Dig Dis Sci. 1998;43:253–257.
  • Cavalcoli F, Zilli A, Conte D, et al. Gastric neuorendocrine neoplasms and proton pump inhibitiors (PPI): fact or coincidence. Scand J Gastroenterol. 2015;50:1397–1403.
  • Jianu CS, Fossmark R, Viset T, et al. Gastric carcinoids after long-term use of a proton pump inhibitor. Aliment Pharmacol Ther. 2012;36:644–649.
  • Jianu CS, Lange OJ, Viset T, et al. Gastric neuroendocrine carcinoma after long-term use of proton pump inhibitor. Scand J Gastroenterol. 2012;47:64–67.
  • Kuipers EJ. Proton pump inhibitors and gastric neoplasia. Gut. 2006;55:1217–1221.
  • Berlin RG. Omeprazole. Gastrin and gastric endocrine cell data from clinical studies. Dig Dis Sci. 1991;36:129–136.
  • Commitee. A. Omeprazole magnesium tablets. Wilmington (DE): Astra Zeneca; 2000.
  • Waldum HL, Hauso O, Sordal OF, et al. Gastrin may mediate the carcinogenic effect of Helicobacter pylori infection of the stomach. Dig Dis Sci. 2015;60:1522–1527.
  • Henson DE, Dittus C, Younes M, et al. Differential trends in the intestinal and diffuse types of gastric carcinoma in the United States, 1973–2000: increase in the signet ring cell type. Arch Pathol Lab Med. 2004;128:765–770.
  • Takinami Y, Yuki H, Nishida A, et al. YF476 is a new potent and selective gastrin/cholecystokinin-B receptor antagonist in vitro and in vivo. Aliment Pharmacol Ther. 1997;11:113–120.
  • Fossmark R, Sordal O, Jianu CS, et al. Treatment of gastric carcinoids type 1 with the gastrin receptor antagonist netazepide (YF476) results in regression of tumours and normalisation of serum chromogranin A. Aliment Pharmacol Ther. 2012;36:1067–1075.
  • Karimi P, Islami F, Anandasabapathy S, et al. Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev. 2014;23:700–713.
  • van Blankenstein M, van Vuuren AJ, Looman CW, et al. The prevalence of Helicobacter pylori infection in the Netherlands. Scand J Gastroenterol. 2013;48:794–800.
  • Anderson WF, Camargo MC, Fraumeni JF, Jr, et al. Age-specific trends in incidence of noncardia gastric cancer in US adults. JAMA. 2010;303:1723–1728.
  • Holster IL, Aarts MJ, Tjwa ET, et al. Trend breaks in incidence of non-cardia gastric cancer in the Netherlands. Cancer Epidemiol. 2014;38:9–15.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.