A genetic variant in proximity to the gene LYPLAL1 is associated with lower hunger feelings and increased weight loss following Roux-en-Y gastric bypass surgery

References

• Benoit SC, Hunter TD, Francis DM, et al. Use of bariatric outcomes longitudinal database (BOLD) to study variability in patient success after bariatric surgery. Obes Surg. 2014;24:936–943.
   PubMed Web of Science ®Google Scholar
• Burgmer R, Grigutsch K, Zipfel S, et al. The influence of eating behavior and eating pathology on weight loss after gastric restriction operations. Obes Surg. 2005;15:684–691.
   PubMed Web of Science ®Google Scholar
• Elfhag K, Rössner S, Barkeling B, et al. Sibutramine treatment in obesity: initial eating behaviour in relation to weight loss results and changes in mood. Pharmacol Res. 2005;51:159–163.
   PubMed Web of Science ®Google Scholar
• Bamia C, Orfanos P, Ferrari P, et al. Dietary patterns among older Europeans: the EPIC-Elderly study. Br J Nutr. 2005;94:100–113.
   PubMed Web of Science ®Google Scholar
• Mostad IL, Langaas M, Grill V. Central obesity is associated with lower intake of whole-grain bread and less frequent breakfast and lunch: results from the HUNT study, an adult all-population survey. Appl Physiol Nutr Metab. 2014;39:819–828.
   PubMed Web of Science ®Google Scholar
• Stunkard AJ, Messick S. The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res. 1985;29:71–83.
   PubMed Web of Science ®Google Scholar
• Lindroos AK, Lissner L, Mathiassen ME, et al. Dietary intake in relation to restrained eating, disinhibition, and hunger in obese and nonobese Swedish women. Obes Res. 1997;5:175–182.
   PubMedGoogle Scholar
• French SA, Mitchell NR, Wolfson J, et al. Questionnaire and laboratory measures of eating behavior. Associations with energy intake and BMI in a community sample of working adults. Appetite. 2014;72:50–58.
   PubMed Web of Science ®Google Scholar
• Drapeau V, Provencher V, Lemieux S, et al. Do 6-y changes in eating behaviors predict changes in body weight? Results from the Québec Family Study. Int J Obes Relat Metab Disord. 2003;27:808–814.
   PubMed Web of Science ®Google Scholar
• Gallant AR, Tremblay A, Perusse L, et al. The Three-Factor Eating Questionnaire and BMI in adolescents: results from the Québec family study. Br J Nutr. 2010;104:1074–1079.
   PubMed Web of Science ®Google Scholar
• Thurnheer M, Bisang P, Ernst B, et al. A novel distal very long Roux-en Y gastric bypass (DVLRYGB) as a primary bariatric procedure–complication rates, weight loss, and nutritional/metabolic changes in the first 355 patients. Obes Surg. 2012;22:1427–1436.
   PubMed Web of Science ®Google Scholar
• Coleman KJ, Brookey J. Gender and racial/ethnic background predict weight loss after Roux-en-Y gastric bypass independent of health and lifestyle behaviors. Obes Surg. 2014;24:1729–1736.
   PubMed Web of Science ®Google Scholar
• Heid IM, Jackson AU, Randall JC, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010;42:949–960.
   PubMed Web of Science ®Google Scholar
• Speliotes EK, Willer CJ, Berndt SI, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42:937–948.
   PubMed Web of Science ®Google Scholar
• Jacobsson JA, Schioth HB, Fredriksson R. The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO. Obes Rev. 2012;13:1096–1109.
   PubMed Web of Science ®Google Scholar
• Rask-Andersen M, Jacobsson JA, Moschonis G, et al. The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek children. BMC Med Genet. 2012;13:36. doi: 10.1186/1471-2350-13-36.
   PubMed Web of Science ®Google Scholar
• Dougkas A, Yaqoob P, Givens DI, et al. The impact of obesity-related SNP on appetite and energy intake. Br J Nutr. 2013;110:1151–1156.
   PubMed Web of Science ®Google Scholar
• Llewellyn CH, Trzaskowski M, van Jaarsveld CH, et al. Satiety mechanisms in genetic risk of obesity. JAMA Pediatrics. 2014;168:338–344.
   PubMed Web of Science ®Google Scholar
• Deitel M, Greenstein RJ. Recommendations for reporting weight loss. Obes Surg. 2003;13:159–160.
   PubMed Web of Science ®Google Scholar
• R Core Team. R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2014.
   Google Scholar
• Nettleton JA, Follis JL, Ngwa JS, et al. Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet. 2015;24:4728–4738.
   PubMed Web of Science ®Google Scholar
• Delahanty LM, Pan Q, Jablonski KA, et al. Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. Diabetes Care. 2012;35:363–366.
   PubMed Web of Science ®Google Scholar
• Petereit R, Jonaitis L, Kupcinskas L, et al. Gastrointestinal symptoms and eating behavior among morbidly obese patients undergoing Roux-en-Y gastric bypass. Medicina (Kaunas). 2014;50:118–123.
   PubMed Web of Science ®Google Scholar
• Laurenius A, Larsson I, Bueter M, et al. Changes in eating behaviour and meal pattern following Roux-en-Y gastric bypass. Int J Obes (Lond). 2012;36:348–355.
   PubMed Web of Science ®Google Scholar
• de Lauzon B, Romon M, Deschamps V, et al. The Three-Factor Eating Questionnaire-R18 is able to distinguish among different eating patterns in a general population. J Nutr. 2004;134:2372–2380.
   PubMed Web of Science ®Google Scholar
• Nickel C, Widermann C, Harms D, et al. Patients with extreme obesity: change in mental symptoms three years after gastric banding. Int J Psychiatr Med. 2005;35:109–122.
   PubMed Web of Science ®Google Scholar
• Schindler K, Prager G, Ballaban T, et al. Impact of laparoscopic adjustable gastric banding on plasma ghrelin, eating behaviour and body weight. Eur J Clin Investig. 2004;34:549–554.
   PubMed Web of Science ®Google Scholar
• Sjöström L, Narbro K, Sjostrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357:741–752.
   PubMed Web of Science ®Google Scholar
• Tholin S, Rasmussen F, Tynelius P, et al. Genetic and environmental influences on eating behavior: the Swedish Young Male Twins Study. Am J Clin Nutr. 2005;81:564–569.
   PubMed Web of Science ®Google Scholar
• Gast MT, Tonjes A, Keller M, et al. The role of rs2237781 within GRM8 in eating behavior. Brain Behav. 2013;3:495–502.
   PubMed Web of Science ®Google Scholar
• Steinberg GR, Kemp BE, Watt MJ. Adipocyte triglyceride lipase expression in human obesity. Am J Physiol Endocrinol Metab. 2007;293:E958–E964.
   PubMed Web of Science ®Google Scholar
• Tian L, McClafferty H, Knaus HG, et al. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. J Biol Chem. 2012;287:14718–14725.
   PubMed Web of Science ®Google Scholar
• Rosenbloom KR, Armstrong J, Barber GP, et al. The UCSC Genome Browser database: 2015 update. Nucleic Acids Res. 2015;43:D670–D681.
   PubMed Web of Science ®Google Scholar
• Ghirlando R, Giles K, Gowher H, et al. Chromatin domains, insulators, and the regulation of gene expression. Biochim Biophys Acta. 2012;1819:644–651.
   PubMed Web of Science ®Google Scholar
• Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012;489:391–399.
   PubMed Web of Science ®Google Scholar
• Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell. 2001;104:531–543.
   PubMed Web of Science ®Google Scholar
• Ono T, Nakamura K, Nishijo H, et al. Hypothalamic neuron involvement in integration of reward, aversion, and cue signals. J Neurophysiol. 1986;56:63–79.
   PubMed Web of Science ®Google Scholar
• Haber SN, Knutson B. The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology. 2010;35:4–26.
   PubMed Web of Science ®Google Scholar