Role of COX-2 in nonsteroidal anti-inflammatory drug enteropathy in rodents

References

• Tympner F. Gastroscopic findings after therapy with non-steroid antirheumatic drugs. Z Rheumatol 1981;40:179–81.
   PubMed Web of Science ®Google Scholar
• Langman MJ, Morgan L, Worrall A. Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and haemorrhage. Br Med J (Clin Res Ed) 1985;290:347–9.
   PubMed Web of Science ®Google Scholar
• Vane JR, Bakhle YS, Botting RM. Cyclooxygenases 1 and 2. Annual Review of Pharmacology and Toxicology 1998;38:97–120.
   PubMed Web of Science ®Google Scholar
• Laine L, Connors LG, Reicin A, Hawkey CJ, Burgos-Vargas R, Schnitzer TJ, Yu Q, Bombardier C. Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use. Gastroenterology 2003;124:288–92.
   PubMed Web of Science ®Google Scholar
• Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis B, Day R, Ferraz MB, Hawkey CJ, Hochberg MC, Kvien TK, Schnitzer TJ. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med 2000;343:1520–8.
   PubMed Web of Science ®Google Scholar
• Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, Mahler JF, Lee CA, Goulding EH, Kluckman KD, Kim HS, Smithies O. Prostaglandin-Synthase-1 Gene Disruption in Mice Reduces Arachidonic Acid-Induced Inflammation and Indomethacin-Induced Gastric-Ulceration. Cell 1995;83:483–92.
   PubMed Web of Science ®Google Scholar
• Langenbach R, Loftin C, Lee C, Tiano H. Cyclooxygenase knockout mice: models for elucidating isoform-specific functions. Biochem Pharmacol 1999;58:1237–46.
   PubMed Web of Science ®Google Scholar
• Loftin CD, Tiano HF, Langenbach R. Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2. Prostaglandins Other Lipid Mediat 2002;68-69:177–85.
   PubMed Web of Science ®Google Scholar
• Sigthorsson G, Simpson RJ, Walley M, Anthony A, Foster R, Hotz-Behoftsitz C, Palizban A, Pombo J, Watts J, Morham SG, Bjarnason I. COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice. Gastroenterology 2002;122:1913–23.
   PubMed Web of Science ®Google Scholar
• Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, Jennette JC, Mahler JF, Kluckman KD, Ledford A, Lee CA, Smithies O. Prostaglandin-Synthase-2 Gene Disruption Causes Severe Renal Pathology in the Mouse. Cell 1995;83:473–82.
   PubMed Web of Science ®Google Scholar
• Wallace JL, McKnight W, Reuter BK, Vergnolle N. NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology 2000;119:706–14.
   PubMed Web of Science ®Google Scholar
• Lichtenberger LM, Wang ZM, Romero JJ, Ulloa C, Perez JC, Giraud MN, Barreto JC. Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: insight into the mechanism and reversal of NSAID-induced gastrointestinal injury. Nat Med 1995;1:154–8.
   PubMed Web of Science ®Google Scholar
• Somasundaram S, Rafi S, Hayllar J, Sigthorsson G, Jacob M, Price AB, Macpherson A, Mahmod T, Scott D, Wrigglesworth JM, Bjarnason I. Mitochondrial damage: a possible mechanism of the “topical” phase of NSAID induced injury to the rat intestine. Gut 1997;41:344–53.
   PubMed Web of Science ®Google Scholar
• Somasundaram S, Hayllar H, Rafi S, Wrigglesworth JM, Macpherson AJS, Bjarnason I. The Biochemical Basis of Nonsteroidal Antiinflammatory Drug- Induced Damage to the Gastrointestinal-Tract–a Review and a Hypothesis. Scandinavian Journal of Gastroenterology 1995;30:289–99.
   PubMed Web of Science ®Google Scholar
• Somasundaram S, Rafi S, Jacob M, Sigthorsson G, Mahmud T, Sherwood R, Price AB, Macpherson A, Scott D, Wrigglesworth JM, Bjarnason I. Intestinal tolerability of nitroxybutyl-flurbiprofen in rats Gut 1997;40:608–13.
   PubMed Web of Science ®Google Scholar
• Fournel S, Caldwell J. The metabolic chiral inversion of 2-phenylpropionic acid in rat, mouse and rabbit. Biochem Pharmacol 1986;35:4153–9.
   PubMed Web of Science ®Google Scholar
• Newberry RD, McDonough JS, Stenson WF, Lorenz RG. Spontaneous and continuous cyclooxygenase-2-dependent prostaglandin E2 production by stromal cells in the murine small intestine lamina propria: directing the tone of the intestinal immune response. J Immunol 2001;166:4465–72.
   PubMed Web of Science ®Google Scholar
• Tanaka A, Hase S, Miyazawa T, Ohno R, Takeuchi K. Role of cyclooxygenase (COX)-1 and COX-2 inhibition in nonsteroidal anti-inflammatory drug-induced intestinal damage in rats: relation to various pathogenic events. J Pharmacol Exp Ther 2002;303:1248–54.
   PubMed Web of Science ®Google Scholar
• Brodie DA, Cook PG, Bauer BJ, Dagle GE. Indomethacin-induced intestinal lesions in the rat. Toxicol Appl Pharmacol 1970;17:615–24.
   PubMed Web of Science ®Google Scholar
• Maiden L, Thjodleifsson B, Seigal A, Bjarnason, II, Scott D, Birgisson S, Bjarnason I. Long-term effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective agents on the small bowel: a cross-sectional capsule enteroscopy study. Clin Gastroenterol Hepatol 2007;5:1040–5.
   PubMed Web of Science ®Google Scholar
• Somasundaram S, Sigthorsson G, Simpson RJ, Watts J, Jacob M, Tavares IA, Rafi S, Roseth A, Foster R, Price AB, Wrigglesworth JM, Bjarnason I. Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat. Aliment Pharmacol Ther 2000;14:639–50.
   PubMed Web of Science ®Google Scholar
• Ohno R, Miyazawa T, Hayashi Y, Kanatsu K, Tanaka A, Takeuchi K. Induction of intestinal damage by rofecoxib, the selective COX-2 inhibitor, under inhibition of nitric oxide production in rats. Inflammopharmacology 2002;10:435–48.
   Google Scholar