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Original Article

Inhibitory Effect of the C-Terminal Octapeptide of Oxyntomodulin on Pentagastrin-Stimulated Gastric Acid Secretion in Man

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Pages 1238-1242 | Received 28 Mar 1989, Accepted 26 Jun 1989, Published online: 08 Jul 2009

References

  • Bataille D, Tatemoto K, Gespach C, Jörnvall H, Rosselin G, Mutt V. Isolation of glucagon-37 (bio-active enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Characterization of the peptide. FEBS Lett 1982; 146: 79–86
  • Dubrasquet J M, Bataille D, Gespach C. Oxyntomodulin (glucagon-37 or bioactive enterogluca-gon): a potent inhibitor of pentagastrin-stimulated acid secretion in rat. Biosci Rep 1982; 2: 391–395
  • Jarrousse C, Audousset-Puech M P, Dubrasquet M, Niel H, Martinez J, Bataille D. Oxyntomodulin (glucagon-37) and its C-terrainal octapeptide inhibit gastric secretion. FEBS Lett 1985; 188: 81–84
  • Jarrousse C, Niel H, Audousset-Puech M P, Martinez J, Bataille D. Oxyntomodulin and its C-terminal octapeptide inhibit liquid meal-stimulated acid secretion. Peptides 1986; 7(suppl 1)253–256
  • Schjoldager B, Baldissera F GA, Mortensen P E, Christiansen J, Hoist J J. Oxyntomodulin, a potential hormone from the distal gut. Pharmacokinetics and effects on gastric acid secretion in man. Eur J Clin Invest 1988; 18: 499–503
  • Bataille D, Blache P, Mercier F, et al. Glucagon and related peptides: molecular structure and biological specificity. Ann NY Acad Sci 1988; 527: 168–185
  • Audousset-Puech M P, Jarrousse C, Dubrasquet M, et al. Synthesis of the C-terminal octapeptide of pig oxyntomodulin, Lys-Arg-Asn-Lys-Asn-Asn-Ile-Ala: a potent inhibitor of pentagastrin-induced acid secretion. J Med Chem 1985; 28: 1529–1533
  • Bell G I, Sanchez-Pescador R, Laybourn P J, Najarian R C. Exon duplication and divergence in the human preproglucagon gene. Nature 1983; 304: 368–371
  • Larsson H, Carlsonn E, Mattson H, et al. Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology 1986; 90: 391–399

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