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Original Article

In Vitro Measurement of the pH Gradient and Thickness of the Duodenal Mucus Gel Layer in Rats

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Pages 31-34 | Published online: 08 Jul 2009

References

  • Flemström G, Turnberg L A. Gas-troduodenal defense mechanism. Clin Gastroenterol 1984; 13: 327–354
  • Isenberg J I, Hogan D L, Koss M A, Selling J A. Human duodenal mucosal bicarbonate secretion: evidence for basal secretion and stimulation by hydrochloric acid and a synthetic prostaglandin E1 analogue. Gastroenterology 1986; 91: 370–378
  • Flemström G, Kivilaakso E. Demonstration of a pH gradient at the luminal surface of rat duodenum in vivo and its dependence on mucosal alkaline secretion. Gastroenterology 1983; 84: 787–794
  • Isenberg J I, Selling J A, Hogan D L, Koss M A. Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcers. N Engl J Med 1987; 316: 374–378
  • Kivilaakso E, Flemström G. HCO3- secretion and surface pH gradient in rat duodenum exposed to luminal acid. Scand J Gastroenterol 1984; 19(suppl 92)51–54
  • Matsueda K, Muraoka A, Umeda N, Misaki N, Kawano O, Irino O. A role of gastric mucus-gel thickness and pH gradient on mucosal cytoprotection. Experimental Ulcer 1985; 12: 230–233

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