The Changing Gastrointestinal Side Effect Profile of Non-Steroidal Anti-Inflammatory Drugs: A New Approach for the Prevention of a New Problem

References

• Bjarnason I. Non-steroidal anti-inflammatory drug-induced small intestinal inflammation in man. Recent advances in gastroenterology-?, R Pounder. Churchill Livingstone, Edinburgh 1988; 22–46
   Google Scholar
• Caruso I, Bianchi Porro G. Gastroscopic evaluation of anti-inflammatory agents. Br Med J 1980; 280: 75–78
   PubMed Web of Science ®Google Scholar
• Mellem H, Stave R, Myren J, et al. Symptoms in patients with peptic ulcer and haemetemesis and/or melana related to the use of non-steroidal antiinflammatory drugs. Scand J Gastroenterol 1985; 20: 1246–1248
   PubMed Web of Science ®Google Scholar
• Bianchi Porro G, Pace F, Caruso I. Why are nonsteroidal anti-inflammatory drugs important in peptic ulceration?. Aliment Pharmacol Ther 1987, suppl I: 540S–547
   Google Scholar
• Bartle W R, Gupta A K, Lazor J. Non-steroidal antiinflammatory drugs and gastrointestinal bleeding: a case control study. Arch Intern Med 1986; 146: 2365–2367
   PubMedGoogle Scholar
• du Collins A JA, Toit J. Upper gastrointestinal findings and faecal occult blood in patients with rheumatic diseases taking non steroidal antiinflammatory drugs. Br J Rheumatol 1987; 26: 295–298
   PubMedGoogle Scholar
• Kent T H, Cardeli R M, Stanley F U. Small intestinal ulcers and intestinal flora in rats given indo-methacin. Am J Pathol 1969; 54: 237–245
   PubMed Web of Science ®Google Scholar
• Fang W F, Broughton A, Jacobson E D. Indo-methacin-induced intestinal inflammation. Am J Dig Dis 1977; 22: 749–760
   PubMedGoogle Scholar
• Somogyi A, Kovacs K, Selve H. Jejunal ulcers produced by indomethacin. J Pharm Pharmacol 1969; 21: 121–122
   Web of Science ®Google Scholar
• Satoh H, Guth P H, Grossman M I. Role of bacteria in gastric ulceration produced by indomethacin in the rat: cytoprotective action of antibiotics. Gastroenterology 1983; 84: 483–489
   PubMed Web of Science ®Google Scholar
• Robert A. Effects of prostaglandins on the stomach and intestine. Prostaglandins on the stomach and intestine. Prostaglandins 1971; 6: 523–532
   Google Scholar
• Del Soldato P, Foschi D, Benoni G, Velo P. Early and late phases in the formation by anti-inflammatory drugs of intestinal lesions in rats. Side-effects of antiinflammatory drugs, K D Rain-Sord, G P Velo. MTP Press, Lancaster 1987; 67–81
   Google Scholar
• Bjarnason I, Williams P, So A, et al. Intestinal permeability and inflammation in rheumatoid arthritis: effects of non-steroidal anti-inflammatory drug. Lancet 1984; 2: 1171–1174
   PubMed Web of Science ®Google Scholar
• Bjarnason I, Zanelli G, Smith T, et al. Nonsteroidal anti-inflammatory drug induced intestinal inflammation in humans. Gastroenterology 1987; 93(48)M89
   Google Scholar
• Bjarnason I, Peters T J. Helping the mucosa make sense of macromolecules. Gut 1987; 28: 1057–1061
   PubMed Web of Science ®Google Scholar
• Seagal A W, Isenberg D A, Hajirousou V, et al. Preliminary evidence for gut involvement in the pathogenesis of rheumatoid arthritis?. Br J Rheumatol 1986; 25: 162–166
   PubMedGoogle Scholar
• Rooney P J, Jenkins R T, Smith K M, Coates G. 111Indium-labelled polymorphonuclear leucocyte scans in rheumatoid arthritis-an important clinical cause of false positive results. Br J Rheumatol 1986; 25: 167–170
   PubMedGoogle Scholar
• Svartz N. The treatment of rheumatoid polyarthritis with acid AZO compounds. Rheumatism 1984; 4: 56–60
   Google Scholar
• Svartz N. Sulfasalazine. II. Some notes on the discovery and development of salazopyrin. Am J Gastroenterol 1988; 83: 497–503
   PubMed Web of Science ®Google Scholar
• Mielants H, Vey E M. Nsaid and the leaky gut. Lancet 1985; 1: 218
   PubMedGoogle Scholar
• Mielants M, Veys E M, De Vas M, Cuvelier C. Gut inflammation in the pathogenesis of idiopathic forms of reactive arthritis in the peripheral joint involvement of ankylosing spondylitis. Spondyloarthropathies involvement of the Gut, H Mielants, E M Veys. Excerpta Medica, Amsterdam 1987; 11–22
   Google Scholar
• Bjarnason I, Zanelli G, Prouse P, et al. Blood and protein loss via small intestinal inflammation induced by non-steroidal anti-inflammatory drugs. Lancet 1987; 2: 711–714
   PubMed Web of Science ®Google Scholar
• Lang J, Price A B, Levi A J, et al. Diaphragm disease: pathology of disease of the small intestinal induced by non-steroidal anti-inflammatory drugs. J Clin Pathol 1988; 41: 416–126
   Web of Science ®Google Scholar
• Bjarnason I, Price A B, Zanelli G, et al. Clinico-pathological features of nonsteroidal anti-inflammatory drug-induced small intestinal strictures. Gastroenterology 1988; 94: 1070–1074
   PubMed Web of Science ®Google Scholar
• Cautrot S, Roland D, Barbier J, et al. Acute perforation of colonic diverticula associated with short term indomethacin. Lancet 1978; 2: 1055–1056
   PubMed Web of Science ®Google Scholar
• Schwartz H A. Lower gastrointestinal side effects of non-steroidal anti-inflammatory drugs. J Rheumatol 1981; 8: 952–954
   PubMed Web of Science ®Google Scholar
• Stewart J T, Pennington C R, Pringle R. Antiinflammatory drugs and bowel perforation and haemorrhage. Br Med J 1985; 290: 787–788
   Google Scholar
• Day T K. Intestinal perforation associated with osmotic slow release indomethacin capsules. Br Med J 1983; 287: 1671–1672
   PubMed Web of Science ®Google Scholar
• Debenham G P. Ulcer of the caecum during oxyphenbutazone (tanderil) therapy. Canad Med Ass J 1966; 94: 1982–1184
   Google Scholar
• Charuzi I, Ovnat A, Zirkin H, Peiser J, Sukewik S. Ibuprofen and benign cecal ulcer. J Rheumatol 1985; 12: 188–189
   PubMed Web of Science ®Google Scholar
• Uribe A, Johansson C, Slezak P, Rubio C. Ulcerations of the colon associated with naproxen and acetylsalicylic acid treatment. Gastroint Endosc 1986; 32: 242–244
   PubMed Web of Science ®Google Scholar
• Bravo A J, Lowman R M. Benign ulcer of the sigmoid colon. Radiology 1968; 90: 113–115
   PubMed Web of Science ®Google Scholar
• Shallman R W, Kuehner M, Williams G H, Sajjad S, Sautter R. Benign cecal ulcers. Dis Col Rectum 1985; 28: 732–737
   PubMed Web of Science ®Google Scholar
• Gullikson G W, Sender M, Bass P. Laxative-like effects of non-steroidal anti-inflammatory drugs on intestinal fluid movement and membrane integrity. J Pharmacol Exp Trier 1982; 220: 236–242
   PubMed Web of Science ®Google Scholar
• Langman M JS, Morgan L, Worrall A. Use of antiinflammatory drugs by patients admitted with small or large perforation and haemorrhage. Br Med J 1985; 290: 347–349
   PubMed Web of Science ®Google Scholar
• Woolf D L. Indomethacin suppositories. Br Med J 1965; 1: 1497
   PubMed Web of Science ®Google Scholar
• Berry H, Swinson D, Jones H, Hamilton E BD. Indomethacin and naproxen suppositories in the treatment of rheumatoid arthritis. Ann Rheum Dis 1978; 37: 370–372
   PubMed Web of Science ®Google Scholar
• Wright V, Hopkins R. A note on indomethacin suppositories in rheumatic conditions. Rheumatol Rehab 1979; 18: 186–187
   PubMedGoogle Scholar
• Walls J, Bell D, Schora W. Rectal bleeding and indomethacin. Br J Med 1968; 1: 52
   Google Scholar
• Lanthier P, Detry R, Debongnie J C, Mahieu P, Vanheuverzwyn R. Solitary rectal lesions due to suppositories containing acetylsalicyclic acid and paracetamol. Gastroenterol Clin Biol 1987; 11: 250–253
   PubMedGoogle Scholar
• Dixon J M, Lumsden A B. Anti-inflammatory drugs and bowel perforations and haemorrhage. Br Med J 1985; 290: 788
   Google Scholar
• Hall R, Petty A H, Cobden I, Lendrum R. Enteritis associated with mefenamic acid. Br Med J 1983; 287: 1182
   PubMed Web of Science ®Google Scholar
• Philips M S, Fehilly B, Stewart S, Dronfield M W. Enteritis and colitis associated with mefenamic acid. Br Med J 1983; 287: 1626
   PubMedGoogle Scholar
• Edwards A L, Heagerty A M, Bing R F. Enteritis and colitis associated with mefenamic acid. Br Med J 1983; 287: 1626–1627
   PubMedGoogle Scholar
• Rampton D S, Tapping P J. Enteritis and colitis associated with mefenamic acid. Br Med J 1983; 287: 1627
   Google Scholar
• Williams R, Glazier G. Enteritis and colitis associated with mefenic acid. Br Med J 1983; 287: 1627
   Google Scholar
• Isaacs P ET, Sladen G E, Filpe I. Mefenamic acid enteropathy. J Clin Pathol 1987; 40: 1221–1227
   PubMed Web of Science ®Google Scholar
• Ravi S, Keat A C, Keat E CB. Colitis caused by nonsteroidal anti-inflammatory drugs. Postgrad Med J 1986; 62: 773–776
   PubMed Web of Science ®Google Scholar
• Rampton D S, Sladen G E. Relapse of ulcerative protocolitis during treatment with non-steroidal anti-inflammatory drugs. Postgrad Med J 1981; 57: 297–299
   PubMed Web of Science ®Google Scholar
• Kaufman H J, Taubin H L. Non-steroidal antiinflammatory drugs activate quiescent inflammatory bowel disease. Ann Intern Med 1987; 107: 513–516
   PubMed Web of Science ®Google Scholar
• Rampton D S, McNeil N I, Sarner M. Analgesic ingestion and other factors preceding relapse in ulcerative colitis. Gut 1983; 24: 187–188
   PubMed Web of Science ®Google Scholar
• Bjarnason I, Williams P, Smethurst P, Peters T J, Levi A J. The effect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small bowel. Gut 1986; 27: 1292–1297
   PubMed Web of Science ®Google Scholar
• Bjarnason I, Peters T J, Levi A J. Intestinal permeability: clinical correlates. Dig Dis 1986; 4: 83–92
   PubMedGoogle Scholar
• Bjarnason I, Smethurst P, Fenn C G, et al. Misoprostol reduces indomethacin induced changes in human small intestinal permeability. Dig Dis Sci, in press
   Web of Science ®Google Scholar
• Jenkins R T, Rooney P J, Hunt R H. Increased bowel permeability to 51CrEDTA in controls caused by Naproxen is not prevented by Cytotec. Arthr Rheum 1988; 31(suppl 1)R11
   Google Scholar
• Bjarnason I, Smethurst P, Clarke P, et al. Effect of prostaglandin on indomethacin induced increased intestinal permeability in man. Scand J Gastroenterol 1989, in press
   Google Scholar
• Rainsford K D, Whitehouse M W. Biochemical gastroprotection from acute ulceration induced by aspirin and related drugs. Biochem Pharm 1980; 29: 1281–1289
   PubMed Web of Science ®Google Scholar
• Whitehouse M W, Rainsford-Koechli V, Rainsford K D. Aspirin gastroxicity: protection by various sta-tregems. Side effects of anti-inflammatory analgesic drugs, K D Rainsford, G P Velo. Raven Press, New York 1984; 77–87
   Google Scholar
• Rainsford K D. Prevention of indomethacin-induced gastrointestinal ulceration in rats by glucose-citrate formulations: role of ATP in mucosal defences. Br J Rheumatol 1987, suppl 2: 81
   PubMedGoogle Scholar
• Walker F S, Pritchard M H, Jones G M, Rainsford K D. Inhibition of indomethacin-induced gastrointestinal bleeding, both immediate and persistent, in man by citrate-glucose formulation. Br J Rheumatol 1987, suppl 2: 12
   Google Scholar