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Scandinavian Journal of Gastroenterology Volume 24, 1989 - Issue sup164
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Original Article

Metabolic Fate of Rioprostil in the Rat–in vivo and in Liver Perfusion

H. J. Ahr Institute of Pharmacokinetics, Central Research and Analytical Departments of Bayer AG, Wuppertal and LeverkusenFRG
,
W. Karl Institute of Pharmacokinetics, Central Research and Analytical Departments of Bayer AG, Wuppertal and LeverkusenFRG
,
D. Scherling Institute of Pharmacokinetics, Central Research and Analytical Departments of Bayer AG, Wuppertal and LeverkusenFRG
&
C. Wünsche Institute of Pharmacokinetics, Central Research and Analytical Departments of Bayer AG, Wuppertal and LeverkusenFRG
Pages 52-57 | Published online: 08 Jul 2009

References

  • Shriver A D, Rosenthale M E, Kluender H C, Schut R N, McGuire J L, Hong E. Pharmacology of riop-rostil, a new gastric cytoprotective/antisecretory agent. Arzneim Forsch/Drug Res 1985; 35: 839–843
  • Demol P, Wingender W, Weihrauch T R, Graefe K H. Inhibition of gastric secretion in man by riop-rostil, a new synthetic methyl prostaglandin E. Arzneim Forsch/Drug Res 1985; 35: 861–863
  • Katz L B, Shriver D A, Capetola R J, Genna T, Argentieri D C, Rosenthale M E. Rioprostil prevents gastric lesions induced by nonsteroidal antiinflammatory drugs (NSAIDs) in adjuvant arthritic (AA) rats. Fed Proc 1985; 44: 733
  • Quadros E, Ramsamooj E, Rajapaksa T, Wilson D E. Cytoprotective effects of a prostaglandin E1 (PGE1) analogue: Relationship to mucus synthesis and release in man and the rat. Gastroenterology 1984; 86: 1214
  • De Boer Th J, Backer H J. Diazomethane. Org Synth 1956; 36: 16–19
  • Vane F, Horning M G. Separation and characterization of the prostaglandins by gas chromatography and mass spectrometry. Anal Lett 1969; 2: 357–371
  • Grob K, Grab G. Techniques of capillary gas chromatography. Possibilities of the full utilization of high-performance columns. Part I: Direct sample injection. Chromatographia 1972; 5: 3–12
  • Sies H. The use of perfusion and liver and other organs for the study of microsomal electron-transport and cytochrome P-450 systems. Methods in Enzymology, S Fleischer, L Packer. Academic Press, New York 1978; Vol 52: 48–49
  • Green K. Metabolism of prostaglandin E2 in the rat. Biochemistry 1971; 10: 1072–1086
  • Hamberg M, Samuelsson B. On the metabolism of prostaglandins E1 and E2 in man. J Biol Chem 1971; 246: 6713–6721
  • Ånggård E, Larsson C. The sequence of the early steps in the metabolism of prostaglandin E. Eur J Pharmacol 1971; 14: 66–70

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