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Original Article

Application of Des-γ-Carboxy Prothrombin as a Complementary Tumor Marker with Alpha-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma

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Pages 47-52 | Received 27 Jun 1988, Accepted 31 Aug 1988, Published online: 08 Jul 2009

References

  • Liebman H A, Furie B C, Tong M J, Blanchard R A, Lo K J, Lee S D, Coleman M S, et al. Des-gamma carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma. N Engl J Med 1984; 310: 1427–1431
  • Soulier J P, Lefrere J J. Nouvelle methode de dosage fonctionnel de la de-gamma carboxy prothrombine a I'aide de staphylocoagulase. Presse Med 1985; 14: 2049–2052
  • Soulier J P, Gozin D, Lefrere J J. A new method to assay des-gamma-carboxy prothrombin. Gastroenterology 1986; 91: 1256–1262
  • Okuda H, Obata H, Nakanishi T, Furukawa Hashimoto E. Production of abnormal prothrombin (des-gamma-carboxy prothrombin) by hepatocellular carcinoma. J Hepatol 1987; 4: 357–363
  • Motohara K, Kuroki Y, Kan H, Endo F, Matsuda I. Detection of vitamin K deficiency by the use of an enzyme-linked immunosorbent assay for circulating abnormal prothrombin. Pediatr Res 1985; 19: 354–357
  • Foli A K, Sherlock S, Adinolfi M. Alpha1-feto-protein in patients with disease. Lancet 1969; 2: 1267–1269
  • Okuda K, Kotoda K, Obata H, Hayashi N, Hisamitsu T, Kubo Y, Yakushiji F, et al. Clinical observations during a relatively early stagc of hepatocellular carcinoma, with special reference to serum alpha-fetoprotein levels. Gastroenterology 1975; 69: 226–234
  • Lo K J, Tong M J, Chien M C, Tsai Y T, Liaw Y F, Yang K C, Chian H, et al. The natural course of hepatitis B surface antigen-positive chronic active hepatitis in Taiwan. J Infect Dis 1982; 146: 205–210
  • Okamoto E, Tanaka N, Yamanka N, Toyosaka A. Results of surgical treatments of primary hepatocellular carcinoma: some aspects to improve long-term survival. World J Surg 1984; 8: 360–366
  • Heyward W L, Lanier A P, GcMahon B J, Fitzgerald M A, Kilkenny S, Paprocki T R. Early detection of primary hepatocellular carcinoma among persons infected with hepatitis B virus. JAMA 1985; 254: 3035–3054
  • Shinagawa T, Ohto M, Kimura K, Tsunetomi S, Morita M, Saisho H, Tsuchiya Y, et al. Diagnosis and clinical features of small hepatocellular carcinoma with emphasis on the utility of real-time ultrasonography. A study in 51 patients. Gastroenterology 1984; 86: 495–502
  • Wu J C, Lee S D, Hsiao K J, Wang S S, Chou P, Tsao D, Tsai Y T, et al. Mass screening of primary hepatocellular carcinoma by alpha-fetoprotein in a rural area of Taiwan—A dried blood spot method. Liver 1988; 8: 100–104
  • Bianchi L, De Groote J, Desmet V J, Gedigk P, Korb G, Popper H, Poulsen H, et al. Acute and chronic hepatitis revisited. Lancet 1977; 2: 914–919

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