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Original Article

Effects of Oral S-Adenosyl-l-Methionine on Hepatic Glutathione in Patients with Liver Disease

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Pages 407-415 | Received 20 Jun 1988, Accepted 18 Nov 1988, Published online: 08 Jul 2009

References

  • Lauterburg B H, Mitchell J R. Regulation of hepatic glutathione turnover in rats in vivo and evidence for kinetic homogeneity of the hepatic glutathione pool. J Clin Invest 1981; 67: 1415–1424
  • Meister A. New developments in glutathione metabolism and their potential application in therapy. Hepatology 1984; 4: 739–742
  • Lauterburg B H, Adam J D, Mitchell J R. Hepatic glutathione homeostasis in the rat: efflux accounts for glutathione turnover. Hepatology 1984; 4: 586–590
  • Horowitz J H, Rypins E B, Henderson J M, Heyms-Field S B, Moffitt S D, Bain R P, Chawla R K, et al. Evidence for impairment of transulfuration pathway in cirrhosis. Gastroenterology 1981; 81: 668–675
  • Chawla R K, Lewis F W, Kutner M H, Bate D M, Roy R GB, Rudman D. Plasma cysteine, cystine, and glutathione in cirrhosis. Gastroenterology 1984; 87: 770–776
  • Lauterburg B H, Velez M E. Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut 1988; 29: 1153–1157
  • Poulsen H E, Ranek L, Andreasen P B. The hepatic glutathione content in liver disease. Scand J Clin Lab Invest 1981; 41: 573–576
  • Sieger C P, Bossen K H, Younes M, Mahlke R, Oltmanns D. Glutathione and glutathione-S-trans-ferases in the normal and diseased human liver. Pharmacol Res Commun 1982; 14: 61–72
  • Videla L A, Iturriaga H, Pino M E, Bunout D, Valenzuela A, Ugarte G. Content of hepatic reduced glutathione in chronic alcoholic patients: influence of the length of abstinence and liver necrosis. Clin Sci 1984; 66: 283–290
  • Jewell S A, Di Monte D, Gentile A, Guglielmi A, Altomare E, Albano O. Decreased hepatic glutathione in chronic alcoholic patients. J Hepatol 1986; 3: 1–6
  • Speisky H, Kera Y, Penltila K E, Israel Y, Lindros K O. Depletion of hepatic glutathione by ethanol occurs independently of ethanol metabolism. Alcohol Clin Exp Res 1988; 12: 224–228
  • Duce A M, Ortiz P, Cabrero C, Mato M. S-ade-nosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology 1988; 8: 65–68
  • Cabrero C, Martin Duce Q, Ortiz P, Alemany S, Mato J M. Specific loss of the high-molecular-weight form of S-adenosyl-L-methionine synthetase in human liver cirrhosis. Hepatology 1988; 8: 1530–1534
  • Paredes S R, Geralnik A J, Batlle A M, Conti H A. Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy. Int J Biochem 1985; 17: 625–629
  • Feo F, Pascale R, Garcea R, Daino L, Prisi L, Frassetto S, Ruggiu M E, et al. Effect of the variations of SAMe liver content on fat accumulation and ethanol metabolism in ethanol-intoxicated rats. Toxicol Appl Pharmacol 1986; 83: 331–341
  • Lieber C S, De Cadi I M, Kim C, Lowe N, Sasaki R, Leo M A. S-adenosylmethionine (SAMe) attenuates alcohol-induced mitochondrial injury in the baboon. Hepatology 1988; 8: 1412
  • Marchesini G, Bianchi G P, Lolli R, Zoli M, Pisi E. Effect of S-adenosylmethionine (SAMe) on plasma levels of sulfur-containing amino acids (SCAA) in patients with liver cirrhosis. J Hepatol 1988; 7(suppl 1)S148
  • Vendemiale G, Altomare E, Trizio T, Salerno M T, Carrieri V, Albano O. S-adenosylmethionine administration increases hepatic glutathione in patients with chronic liver disease. J Hepatol 1987; 5(suppl 1)S218
  • Reed D J, Babson J R, Beatty B W, Brodie A E. High performance liquid chromatograph analysis of nanomole levels of glutathione disulfide, and related thiols and disulfides. Anal Biochem 1980; 106: 55–62
  • Lowry O H, Rosebrough R J, Farr A L, Randall R J. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265–275
  • Reed D J, Orrenius S. The role of methionine in glutathione biosynthesis by isolated hepatocytes. Biochem Biophys Res Commun 1977; 77: 1257–1264
  • Shaw S, Lieber C S. Mechanism of increased y-glutamiltrans-peptidase after chronic alcohol consumption. Hepatic microsomal induction rather than dietary imbalance. Subst Alc Actions Misuse 1980; 1: 423–428
  • Lieber C S. Metabolism and metabolic effects of alcohol. Med Clin N Am 1984; 68: 3–31
  • Kinkun G, Lieber C S, Cederbaum A I. Increased microsomal oxidation of ethanol by cytochrome P450 and hydroxyl radical dependent pathways after chronic alcohol consumption. Biochem Pharmacol 1984; 33: 3306–3309
  • Videla L A, Fernandez V, Fernandez N, Valenzuela A. On the mechanism of glutathione depletion induced in the liver by acute ethanol ingestion. Subst Alc Actions Misuse 1981; 2: 153–160
  • Fernandez-Checa J C, Ookhtens M, Kaplowitz N. Effect of chronic ethanol feeding on rat hepatocytic glutathione compartmentation, efflux and response to incubation with ethanol. J Clin Invest 1987; 80: 57–62
  • Speisky H, McDonal A, Giles G, Orrego H, Israel Y. Increased loss and decreased synthesis of hepatic glutathione after acute ethanol administration. Biochem J 1985; 225: 565–572
  • Pascale R, Daino L, Garcea R, Frassetto S, Ruggiu M E, Vannini M G, Cozzolino P, et al. Inhibition by ethanol of rat liver plasma membrane (Na+, K+)ATPase. Protective effect of S-adenosyl-L-methionine, L-methionine and N-acetylcysteine. Toxicol Appl Pharmacol 1988, (in press)
  • Finkelstein J D, Kyle W E, Martin J J, Pick A M. Activation of cystathionine synthetase by adenosylmethionine and adenosylethionine. Biochem Biophys Res Commun 1975; 66: 81–87
  • Zieve L, Dvizaki W M, Zieve F S. Synergism between mercaptans and dimethyl-sulfide in liver cirrhosis before and after ingestion of methionine. J Lab Clin Med 1969; 74: 861
  • Aw T Y, Ookhtens M, Kaplowitz N. Mechanism of inhibition of glutathione efflux by methionine from isolated rat hepatocytes. Am J Physiol 1986; 251: G354–361
  • Lauterburg B H, Smith C V. Stimulation of hepatic efflux and turnover of glutathione by methionine in the rat. Eur J Clin Invest 1986; 16: 494–499
  • Adachi Y, Nanno T, Kanbe A, Inufusa H, Yama-Shita M, Inoue H, Enomoto M, et al. The effects of S-adenosylmethionine on intrahepatic cholestasis. Jpn Arch Int Med 1986; 33: 185–192
  • Frezza M, Di Padova C, the Italian Study Group for SAMe in Liver Disease. Multicenter placebo controlled clinical trial of intravenous and oral S-adenosylmethionine (SAMe) in cholestatic patients with liver disease. Hepatology 1987; 7: 1105
  • Arias I M. Mechanisms and consequences of ion transport in the liver. Progress in liver disease, H Popper, F Schaffner. Grune & Stratton, New York 1986; 145–159
  • Turpini R, Albergati M, Gili C. Macrocytosis in chronic alcoholism: a tentative correction with vitamin B12, 5-rnethyltetrahydrofolate and S-adenosylmethionine. Curr Ther Res 1987; 41: 38–47

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