5-Hydroxytryptamine: New Receptors and Novel Drugs for Gastrointestinal Motor Disorders

References

• Taylor G S, Bywater R AR. Novel autonomic neurotransmitters and intestinal function. Pharmacol Ther 1988; 40: 401–438
   Google Scholar
• Erspamer V. Occurrence of indolealkylamines in nature. Handbook of experimental pharmacology. Springer-Verlag, New York 1966; Vol. XIX: 132–181
   Google Scholar
• Gershon M D, Drakontides A B, Ross L L. Serotinin: synthesis and release from the myenteric plexus of the mouse intestine. Science 1965; 149: 197–199
   PubMed Web of Science ®Google Scholar
• Gershon M D, Mawe G M, Branchek T A. 5-Hydroxytryptamine and enteric neurones. The peripheral actions of 5-hydroxy-tryptamine, J R Fozard. Oxford Medical Publications, Oxford 1989; 247–273
   Google Scholar
• Furness J B, Costa M. The enteric nervous system. Churchill Livingstone, Edinburgh 1987
   Google Scholar
• Verbeuren T J. Synthesis, storage, release and metabolism of 5-hydroxytryptamine in peripheral tissues. The peripheral actions of 5-hydroxytryptamine, J R Fozard. Oxford Medical Publications, Oxford 1989; 1–25
   Google Scholar
• Cohen M L. 5-hydroxytryptamine and non-vascular smooth muscle contraction and relaxation. The peripheral actions of 5-hydroxytryptamine, J R Fozard. Oxford Medical Publications, Oxford 1989; 201–219
   Google Scholar
• Erde S E, Sherman D, Gershon M D. Morphology and serotonergic innervation of physiologically identified cells of the guinea pig's myenteric plexus. J Neurosci 1985; 5: 617–633
   PubMedGoogle Scholar
• Costa M, Furness J B, Llewellyn-Smith I J. Histochemistry of the enteric nervous system. Physiology of the gastrointestinal tract, L R Johnson. Raven Press, New York 1987; 1–40
   Google Scholar
• Gershon M D, Sherman D L. Noradrenergic innervation of serotonergic neurons in the myenteric plexus. J Comp Neurol 1987; 259: 193–210
   PubMed Web of Science ®Google Scholar
• Grønstad K O, DeMagistris L, Dahlström A, et al. The effects of vagal stimulation on endoluminal release of serotonin and substance P into the feline small intestine. Scand J Gastroenterol 1985; 20: 163–169
   PubMed Web of Science ®Google Scholar
• Bülbring E, Crema A. The release of 5-hydroxytryptamine in relation to pressure exerted on the intestinal mucosa. J Physiol (Lond) 1959; 146: 381–407
   Google Scholar
• Bülbring E, Crema A. Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. Br J Pharmacol 1985; 13: 444–457
   Google Scholar
• Gershon M D, Tamir H. Release of endogenous 5-hydroxytryptamine from resting and stimulated enteric neurons. Neuroscience 1981; 6: 2277–2286
   PubMed Web of Science ®Google Scholar
• Wood J D. Physiology of enteric neurons. Physiology of the gastrointestinal tract, L R Johnson. Raven Press, New York 1987; 1–41
   Google Scholar
• Surprenant A. Transmitter mechanisms in the enteric nervous system: an electrophysiological vantage point. Trends in autonomic pharmacology, Kalsner. Urban Schwarzenberg, Baltimore 1985; Vol II: 71–98
   Google Scholar
• North R A, Henderson G, Katayama Y, Johson S M. Electrophysiological evidence for presynaptic inhibition of acetylcholine release by 5-hydroxytryptamine in the enteric nervous system. Neuroscience 1980; 5: 581–586
   PubMedGoogle Scholar
• Fozard J R, Kilbinger H. 8-OHDPAT inhibits transmitter release from guinea-pig enteric cholinergic neurones by activating 5-HT1A receptors. Br J Pharmacol 1985; 86: 601P
   PubMedGoogle Scholar
• Davidson H I, Pilot M A. Doss endogenous neuro-nal 5-hydroxytryptamine influence canine intestinal motility?. J Physiol (Lond) 1986; 376: 49P
   Google Scholar
• Furness J B, Costa M. The nervous release and the action of substances which affect intestinal muscle through neither adrenoceptors nor cholinoreceptors. Phil Trans R Soc Lond [Biol] 1973; 265: 123–133
   PubMed Web of Science ®Google Scholar
• Costa M, Furness J B. The peristaltic reflex: an analysis of the nerve pathways and their pharmacology. Naunyn Schmiedebergs Arch Pharmacol 1976; 294: 47–60
   PubMed Web of Science ®Google Scholar
• Bülbring E, Gershon M D. 5-Hydroxytryptamine participation in the vagal inhibitory innervation of the stomach. J Physiol (Lond) 1967; 192: 823–846
   Google Scholar
• Rattan S, Goyal R K. Evidence of 5-HT participation in vagal inhibitory pathway to opossum LES. Am J Physiol 1978; 234: E273–276
   Google Scholar
• Gershon M D. Serotonergic neurotransmission in the gut. Scand J Gastroenterol 1981; 17: 27–41
   Google Scholar
• Bradley P B, Engel G, Feniuk W, et al. Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuro-pharmacology 1986; 25: 563–576
   Google Scholar
• Humphrey P PA, Richardson B P. 5-HT receptor classification: a current view based on a workshop debate. Serotonin: actions, receptors and pathophysiology, E J Mylecharane, J A Angus, I S de la Lane, P PA Humphrey. Macmillan Press, England 1989; 204–221
   Google Scholar
• Richardson B P, Engel G. The pharmacology and function of 5-HT3 receptors. Trends NeuroPharmacol Sci September, 1986; 424–428
   Google Scholar
• Feniuk W, Humphrey P PA, Watts D. 5-Hydroxy-tryptamine-induced relaxation of isolated mammalian smooth muscle. Eur J Pharmacol 1983; 96: 71–78
   PubMedGoogle Scholar
• Buchheit K H, Engel G, Mutschler E, Richardson B P. Study of the contractile effect of 5-hydroxy-tryptamine (5-HT) in the isolated longitudinal muscle strip from guinea-pig ileum. Evidence for two distinct release mechanisms. Naunyn Schmiedebergs Arch Pharmacol 1985; 329: 36–41
   PubMedGoogle Scholar
• Kilbinger H, Pfeuffer-Friedrich I. Two types of receptors for 5-hydroxytryptamine on the cholinergic nerves of the guinea-pig myenteric plexus. Br J Pharmacol 1985; 85: 529–539
   PubMed Web of Science ®Google Scholar
• Clarke D E, Bond R A, Charlton K G, Blue D R. Pre-synaptic 5-HT receptors mediating inhibition of transmitter release from peripheral cholinergic and noradrenergic nerves. Serotonin: actions, receptors, pathophysiology, E J Mylecharane, J A Angus, I S de la Lande, P PA Humphrey. Macmillan Press Ltd., England 1989; 48–55
   Google Scholar
• Peroutka S J. 5-Hydroxytryptamine receptor subtypes: molecular, biochemical and physiological characterisation. Trends Neurosci 1988; 11: 496–500
   PubMed Web of Science ®Google Scholar
• Peroutka S J, Snyder S H. Multiple serotonin receptors: differential binding of [3H]5-hydroxy-tryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol. Mol Pharmacol 1979; 16: 687–699
   PubMed Web of Science ®Google Scholar
• Hoyer D. 5-Hydroxytryptamine receptors and effector coupling mechanism in peripheral tissues. The peripheral actions of 5-hydroxytryptamine, J R Fozard. Oxford Medical Publications, Oxford 1989; 72–79
   Google Scholar
• Hartig P R. Molecular pharmacology of 5-HT receptors. Trends Pharm Sci 1989; 10: 64–69
   PubMed Web of Science ®Google Scholar
• Fozard J R. The development and early clinical evaluation of selective 5-HT3 receptor antagonists. The peripheral actions of 5-hydroxytryptamine, J R Fozard. Oxford Medical Publications, Oxford 1989; 354–376
   Google Scholar
• Fozard J R. MDL 72222, a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch Pharmacol 1984; 326: 36–44
   PubMed Web of Science ®Google Scholar
• Richardson B P, Engel G, Donatsch P, Stadler P A. Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature 1985; 316: 126–131
   PubMed Web of Science ®Google Scholar
• Brittain R T, Butler A, Coates I H, et al. GR38032F. a novel selective 5-HT, receptor antagonist. Br J Pharmacol 1987; 90: 87P
   Google Scholar
• Fozard J R. Agonists and antagonists of 5-HT, receptors. Cardiovascular pharmacology of 5-hydroxytryptamine: prospective therapeutic applications, P R Saxena, D I Wallis, W Wouters, P Bevan. Kluwer-Academic Publishers, Dordrecht 1989; 101–115
   Google Scholar
• Fozard J R. 5-HT: The enigma variations. Trends Pharmacol Sci 1987; 8: 501–506
   Web of Science ®Google Scholar
• Heuring R E, Peroutka S J. Characterisation of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes. J Neurosci 1987; 7: 894–903
   PubMed Web of Science ®Google Scholar
• Peroutka S J, Switzer J A, Hanisk A. Identification of 5-hydroxytryptamine1D binding sites in human brain membranes. Synapse 1989; 3: 61–66
   PubMedGoogle Scholar
• Leonhardt S, Herrick-Davis K, Titeler M. Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTPbinding protein. J Neurochem 1989; 53: 465–471
   PubMed Web of Science ®Google Scholar
• Mawe G M, Branchek T A, Gershon M D. Peripheral neural serotonin receptors. Identification and characterisation with specific antagonists and agonists. Proc Natl Acad Sci USA 1986; 83: 97–99
   Google Scholar
• Branchek T A, Tamir H, Gershon M D. Location of a peripheral neural 5-HT receptor (5-HT1p) in blood vessels. International symposium on serotonin from cell biology to pharmacology and therapeutics, FlorenceItaly, 1989, 136
   Google Scholar
• Dumuis A, Bouhelal R, Sebben M, Bockaert J. A 5-HT receptor in the central nervous system, positively coupled with adenylate cyclase, is antagonised by ICS 205–930. Eur J Pharmacol 1988; 146: 187–188
   PubMed Web of Science ®Google Scholar
• Dumuis A, Bouhelal R, Sebben M, Cory R, Bockaert J. A non classical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Mol Pharmacol 1988; 34: 880–887
   PubMed Web of Science ®Google Scholar
• Dumuis A, Sebben M, Bockaert J. BRL24924: a potent agonist at a non-classical 5-HT receptor positively coupled with adenylate cyclase in colliculi neurons. Eur J Pharmacol 1988; 162: 381–382
   Google Scholar
• Dumuis A, Sebben M, Bockaert J. The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptors (5-HT4) positively coupled to adenylate cyclase in neurons. Naunyn Schmiedebergs Arch Pharmacol 1989; 340: 403–410
   PubMed Web of Science ®Google Scholar
• Kalkman H O, Engel G, Hoyer D. Inhibition of 5-carboxamidotryptamine-induced relaxation of guinea-pig ileum correlates with [125]LSD binding. Eur J Pharmacol 1986; 129: 139–145
   PubMedGoogle Scholar
• Dainty I A, Eglen R M, McGrath J C, Spedding M. Differences in the relaxant effects of 5-HT, 5-CT and 8-OH-DPAT on rat aorta and guinea pig ileum. Br J Pharmacol 1986; 88: 369P
   PubMedGoogle Scholar
• Clineschmidt B R, Reiss D R, Pettibone D J. Robinson JL. Characterisation of 5-hydroxytryptamine receptors in rat stomach fundus. J Pharmacol Exp Ther 1985; 235: 696–708
   PubMedGoogle Scholar
• Buchheit K H, Engel G, Hagenbach A, Hoyer D, Kalkman H O, Seiler M P. The rat isolated stomach fundus strip, a model for 5-HT1C receptors. Br J Pharmacol 1986; 88: 367P
   Google Scholar
• Leysen J E, Tollenaere J P. Biochemical models for serotonin receptors. Rep Med Chem 1982; 17: 1–10
   Google Scholar
• Engel G, Hoyer D, Kalkman H O, Wick M B. Pharmacological similarity between the 5-HT D-receptor on the guinea pig ileum and the 5-HT2 binding site. Br J Pharmacol 1985; 84: 106P
   Google Scholar
• Butler A, Hill H M, Ireland S J, Jordan C C, Tyers M B. Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors. Br J Pharmacol 1988; 96: 397–412
   Google Scholar
• Sanger G J, Nelson D R. Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL43694 (granisetron). Eur J Pharmacol 1989; 159: 113–124
   PubMed Web of Science ®Google Scholar
• Smith W L, Sancilio L F, Owera-Atepo J B, Naylor R J, Lambert L. Zacopride: a potent 5-HT3 antagonist. J Pharmacol 1988; 40: 301–302
   Google Scholar
• Costall B, Naylor R J, Tyers M B. The psy-chopharmacology of 5-HT3 receptors. Pharmacol Ther, (in press)
   Google Scholar
• Hoyer D, Waeber C, Karpf A, Neijt H, Palacios J M. [3H]ICS 205–930 labels 5-HT3 recognition sites in membranes of cat and rabbit vagus nerve and superior cervical ganglion. Naunyn Schmiedebergs Arch Pharmacol 1989; 340: 396–402
   PubMedGoogle Scholar
• Ireland S J, Tyers M B. Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br J Pharmacol 1987; 90: 229–238
   PubMed Web of Science ®Google Scholar
• Neijt H C, Te Diuts I J, Vijverberg H PM. Pharmacological characterisation of serotonin 5-HT3 receptor-mediated electrical response in cultured mouse neuroblastoma cells. Neuropharmacology 1988; 27: 301–307
   PubMedGoogle Scholar
• Pinkus L, Gordon J, Sarbin N, Barefoot D. Characterisation of (R+, S-) [3H]zacopride binding: inhibition by R+ (AHR4964) and S-(AHR4965) isomers and 5-HT3 antagonists. International symposium on serotonin from cell biology to pharmacology and therapeutics, FlorenceItaly, 1989, 72
   Google Scholar
• Gordon J C, Barefoot D S, Sarbin N S, Pinkus L M. [3H]Zacopride binding to 5-HT3 sites on partially purified rabbit enteric neuronal membrane. J Pharmacol Exp Ther, (in press)
   Google Scholar
• Pinkus L M, Sarbin N S, Barefoot D S, Gordon J C. Association of [3H]zacopride with 5-HT3 binding sites. Eur J Pharmacol, (in press)
   Google Scholar
• Sanger G J, King F D. From metoclopramide to selective gut motility stimulants and 5-HT3 receptor antagonists. Drug Design Deliv 1988; 3: 273–295
   PubMedGoogle Scholar
• Buchheit K H, Costall B, Engel G, Gunning S J, Naylor R J, Richardson B P. 5-Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205–930 in the guinea pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying ‘in vivo’. J Pharm Pharmacol 1985; 37: 669–673
   PubMedGoogle Scholar
• Costall B, Gunning S J, Naylor R J, Tyers M B. The effect of GR38032F, a novel 5-HT3 receptor antagonist on gastric emptying in the guinea pig. Br J Pharmacol 1987; 91: 263–264
   PubMed Web of Science ®Google Scholar
• Gidda J S, Evans D C, Prime P, Schenk K, Cohen M L. Role of 5-HT3 receptor antagonists in gastrointestinal motility [Abstract 867]. Gastroenterology 1989; 95
   PubMedGoogle Scholar
• Buchheit K H, Gamse R, Bertholet A, Büscher H H. Antagonists at serotoninergic 5-HT3 receptors increase gastric emptying of solids and liquids in the rat. International symposium on serotonin from cell biology to pharmacology and therapeutics, FlorenceItaly, 1989, 118
   Google Scholar
• Schiavone A, Micheletti R, Volonte M, Guidier L. Serotonin 5-HT3 receptor antagonists and gastrointestinal motility. International symposium on serotonin from cell biology to pharmacology and therapeutics, FlorenceItaly, 1989, 162
   Google Scholar
• Eeckhout C, Vedder A. 5-HT3 antagonists reverse the cisplatin induced slowing of gastric emptying in fed rats. Gastroenterology 1988; 95: A111
   Google Scholar
• Gamse R, Buchheit K H, Bertholet, Büscher H H. 5-HT3 antagonists increase gastric emptying in the rat. International symposium on serotonin from cell biology to pharmacology and therapeutics, FlorenceItaly, 1989, 118
   Google Scholar
• Sanger G J. Increased gut cholinergic activity and antagonism of 5-hydroxytryptamine M-receptor by BRL24924: potential clinical importance of BRL24924. Br J Pharmacol 1987; 91: 77–87
   PubMed Web of Science ®Google Scholar
• Gunning S J, Bradbury A J, Costall B, Naylor R J. Evidence that 5-hydroxytryptamine may exert both facilitatory and inhibitory control of electrical field stimulation-evoked contractions in longitudinal muscle taken from the body of guinea-pig stomach. J Pharm Pharmacol 1986; 38: 182–187
   PubMedGoogle Scholar
• Gunning S J, Humphrey P PA. Evidence for 5-HT3 receptor mediated release of an inhibitory transmitter in guinea pig isolated ileum. Br J Pharmacol 1987; 90: 359P
   Google Scholar
• Gunning S J, Naylor R J. The effects of 5-hydroxytryptamine on guinea pig stomach muscle in the presence of atropine. Br J Pharmacol 1986; 88: 372P
   Google Scholar
• Bieger D, Ohia S E, Triggle C R. Mast cell mediated relaxations of rat oesophageal smooth muscle-inhibitory effect of 5-HT3 antagonists. International symposium on serotonin from cell biology to pharmacology and therapeutics, FlorenceItaly, 1989, 159
   Google Scholar
• Boeckxstaens G E, Pelckmans P A, Bogers J J, et al. Characterisation of the serotonin receptors in the canine terminal ileum and ileocolonic junction. International symposium on serotonin from cell biology to pharmacology and therapeutics, FlorenceItaly, 1989, 117
   Google Scholar
• North R A. Electrophysiology of the enteric nervous system. Neuroscience 1982; 7: 315–325
   PubMedGoogle Scholar
• Wood J D, Mayer C J. Serotonergic activation of a tonic-type enteric neurones in guinea pig small bowel. J Neurophysiol 1979; 42: 582
   PubMed Web of Science ®Google Scholar
• Johnson S M, Katayama Y, North R A. Multiple actions of 5-hydroxytryptamine on myenteric neurones of the guinea pig ileum. J Physiol (Lond) 1980; 304: 459–470
   Google Scholar
• Netneth P R, Ort C A, Zafirov D H, Wood J D. Interactions between serotonin and cisapride on myenteric neurons. Eur J Pharmacol 1985; 108: 77–83
   PubMedGoogle Scholar
• Derkach V, Surprenant A, North R A. 5-HT, receptors are membrane ion channels. Nature 1989; 339: 706–709
   PubMed Web of Science ®Google Scholar
• Wallis D I. Interaction of 5-hydroxytryptamine with autonomic and sensory neurones. The peripheral actions of 5-hydroxytryptamine, J R Fozard. Oxford Medical Publications, Oxford 1989; 220–246
   Google Scholar
• Takaki M, Branchek T, Tamir H, Gershon M D. Specific antagonism of enteric neural serotonin receptors by dipeptides of 5-hydroxytryptophan: evidence that serotonin is a mediator of slow synaptic excitation in the myenteric plexus. J Neurosci 1985; 5: 1769–1780
   PubMed Web of Science ®Google Scholar
• Nemeth P R, Gullikson G W. Gastrointestinal motility stimulating drugs and 5-HT receptors on myenteric neurons. Eur J Pharmacol 1989; 166: 387–391
   PubMedGoogle Scholar
• Wade P R, Branchek T A, Mawe G M, Gershon M D. Use of stereoisomers of zacopride to distinguish between 5-HT receptor subtypes: an intra-cellular study of myenteric neurons and gastric emptying [Abstract 31]. New York Academy of Sciences. July 10–13th
   Google Scholar
• Sanger G J. Three different ways in which 5-hydroxytryptamine can effect cholinergic activity in guinea-pig isolated ileum. J Pharm Pharmacol 1985; 37: 584–586
   PubMedGoogle Scholar
• Yamaguchi. Effects of 5-hydroxytryptamine on isolated strips of the guinea-pig stomach. Br J Pharmacol 1972; 44: 100–108
   PubMedGoogle Scholar
• Kamikawa Y, Shimo Y. Modulating effects of opioids, purine compounds, 5-hydroxytryptamine and prostaglandin E2 on cholinergic neurotrans-mission in a guinea-pig oesophagus preparation. J Pharm Pharmacol 1982; 34: 794–797
   Google Scholar
• Cohen M L, Schenck K W, Colbert W, Wittauer L. Role of 5-HT2 receptors in serotonin-induced contractions of non vascular smooth muscle. J Pharmacol Exp Ther 1985; 232: 770–774
   PubMedGoogle Scholar
• Fox A J, Morton I KM. Activities of some 5-HT analogues in 5-HT, receptor mediated release of [3H]-Ach in guinea pig ileum. Br J Pharmacol 1989; 96: 53P
   Google Scholar
• Shenker A. Two 5-HT receptors linked to adenylate cyclase in guinea pig hippocampus are discriminated by 5-carboxamidotryptamine and spiperone. Eur J Pharmacol 1985; 109: 427–429
   PubMedGoogle Scholar
• Shenker A, Maayani S, Weinstein H, Green J P. Pharmacological characterisation of two 5-hydroxytryptamine receptors coupled to adenylate cyclase in guinea pig hippocampal membranes. Mol Pharmacol 1987; 31: 357–367
   PubMedGoogle Scholar
• Craig D A, Clarke D E. 5-hydroxytryptamine and cholinergic mechanisms in guinea pig ileum. Br J Pharmacol 1989; 92: 247P
   Google Scholar
• Craig D A, Clarke D E. 5-methoxytryptamine and 2-methyl 5-hydroxytryptamine as discriminative tools for excitatory neuronal receptors (5-HT3 and novel site) in guinea pig ileum. Br J Pharmacol 1990, (in press)
   Google Scholar
• Craig D A, Clarke D E. Pharmacological characterisation of a neuronal receptor for 5-HT in guinea pig ileum with properties similar to the 5-HT4 receptor. J Pharmacol Exp Ther 1990, (in press)
   Google Scholar
• Eglen R M, Swenk S R, Whiting R L. Characterisation of 5-HT receptors modulating the excitatory neuronal activity in guinea pig ileum. Br J Pharmacol 1990, (in press)
   Google Scholar
• Hill J M, Bunce K T, Humphrey P PA. Investigation of the neuronal ‘non-5-HT3’ receptor mediating contraction of guinea-pig ileum. Br J Pharmacol 1990, (in press)
   Google Scholar
• Costall B, Kelly M E, Naylor R J, Tan C CW, Tattersall F D. 5-hydroxytryptamine M-receptor antagonism in the hypothalamus facilitates gastric emptying in the guinea-pig. Neuropharmacology 1986; 25: 1293–1296
   PubMedGoogle Scholar
• Costall B, Gunning S J, Naylor R J. An analysis of the hypothalamic sites at which substituted benzamide drugs act to facilitate gastric emptying in the guinea-pig. Neuropharmacology 1985; 24: 869–875
   PubMedGoogle Scholar
• Schuurkes J AJ, Van Neuten J M. Evidence against a serotonergic mechanism for the motor stimulating properties of cisapride. Gastroenterology 1985; 88: 1577
   Google Scholar
• Dunbar A W, McClelland C M, Sanger G J. BRL24924: a stimulant of gut motility which is also a potent antagonist of the Bezold-Jarisch reflex in anaesthetised rats. Br J Pharmacol 1986; 88: 319P
   Google Scholar
• Schuurkes J AJ, Van Neuten J M, Van Daele P GH, Reyntjens A J, Janssen P AJ. Motor stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J Pharmacol Exp Ther 1985; 234: 775–783
   PubMed Web of Science ®Google Scholar
• Burleigh D E, Trout S J. Evidence against an acetylcholine releasing action of cisapride in the human colon. Br J Clin Pharmacol 1985; 20: 475–478
   PubMedGoogle Scholar
• Masso L, Roberts D J. Comparison of the potencies of clebopride and other substituted benzamide drugs on isolated gastrointestinal tract of the guinea-pig and rat. J Pharm Pharmacol 1980; 32: 727–728
   PubMedGoogle Scholar
• Sanger G J, Wardle K A. 5-hydroxytryptamine and cholinergic function in the gastrointestinal tract. Serotonin from cell biology to pharmacology and therapeutics. FlorenceItaly 1989, (in press)
   Google Scholar
• Cooper S, McClelland C M, McRitchie B, Turner D H. BRL24924: a new and potent gastric motility stimulant. Br J Pharmacol 1986; 88: 383P
   Google Scholar
• McClelland C M. The effect of BRL24924 and metoclopramide on myoelectric activity of the rat small intestine. Br J Pharmacol 1987; 91: 456P
   Google Scholar
• Sanger G J. Activation of a myenteric 5-hydroxy-tryptamine-like receptor by metoclopramide. J Pharm Pharmacol 1987; 39: 449–453
   PubMedGoogle Scholar
• Clarke D E, Craig D A, Fozard J R. The 5-HT4 receptor: naughty, but nice. Trends Pharmacol Sci 1989; 10
   PubMedGoogle Scholar
• Harrington R A, Hamilton C W, Brogden R N, Linkewich J A, Romankiewicz J A, Heel R C. Metoclopramide—an updated review of its pharmacological properties and clinical use. Drugs 1983; 25: 451–494
   PubMed Web of Science ®Google Scholar
• Kris M G, Gralla R J, Clark R A, Tyson L B. Phase II trials of serotonin antagonist GR38032F for the control of vomiting caused by cisplatin. J Natl Cancer Inst 1989; 81: 42–46
   PubMed Web of Science ®Google Scholar
• Gore S, Gilmore I T, Haigh C G, Morris A I. Specific 5-hydroxytryptamine receptor (type 3) antagonist GR38032F slows colonic transit [Abstract A178]. Gastroenterology 1989; 96
   Google Scholar
• Talley N J, Phillips S F, Haddad A, et al. Effect of selective 5-HT3 antagonist (GR38032F) on small intestinal transit and release of gastrointestinal peptides. Dig Dis Sci 1989; 34: 1511–1515
   PubMed Web of Science ®Google Scholar
• Meleagros L, Kreymann B, Ghatel M A, Bloom S R. Mouth-to-caecum transit time in man is reduced by a novel serotonin M-receptor antagonist. Gut 1987; 28: A1373
   Web of Science ®Google Scholar
• Akkermans L MA, Vos A, Hoekstra A. Roelofs JMM, Horrowitz M. Effect of ICS 205–930 (a specific 5-HT3 receptor antagonist) on gastric emptying of a solid meal in normal subjects. Gut 1988; 29: 1249–1252
   PubMed Web of Science ®Google Scholar
• Stacher G, Gaupmann G, Schneider C. et al. Effects of a 5-hydroxytryptamine, receptor antagonist (ICS 205–930) on colonic motor activity in healthy men. Br J Clin Pharmacol 1989; 28: 315–322
   PubMedGoogle Scholar
• Lee K Y, Chey W Y, You C H. Shah AN, Hamilton D. Effect of cisapride on the motility of gut in dogs and colonic transit time in dogs and humans. Gastroenterology 1984; 86: 1157
   Google Scholar
• Bateman D N. The action of cisapride on gastric emptying and the pharmacodynamics and pharmacokinetics of oral diazepam. Eur J Clin Pharmacol 1986; 30: 205–208
   PubMedGoogle Scholar
• Van Wyk M, Sommers DeK, Steyn A GW. Evaluation of gastrointestinal motility using the hydrogen breath test. Br J Clin Pharmacol 1985; 20: 479–481
   PubMedGoogle Scholar
• Edwards C A, Holden S, Brown C, Read N W. Effect of cisapride on the gastrointestinal transit of a solid meal in normal human subjects. Gut 1987; 28: 13–16
   PubMed Web of Science ®Google Scholar
• Reboa G, Arnulfo G, Frascio M, DiSomma L, Pitto G, Berti-Reboli E. Colon motililty and colo-anal reflexes in chronic idiopathic constipation. Effects of a novel enterokinetic agent cisapride. Eur J Clin Pharmacol 1984; 26: 745–748
   PubMedGoogle Scholar
• Horivitz M, Maddern G J, Maddox A, Wishart J. Chatterton BE, Sherman DJC. Effects of cisapride on gastric and esophageal emptying in progressive systemic sclerosis. Gastroenterology 1987; 93: 311–315
   PubMedGoogle Scholar
• Feldman M, Smith H J. Effect of cisapride on gastric emptying of indigestible solids in patients with gastroparesis diabetico rum. Gastroenterology 1987; 92: 171–174
   PubMed Web of Science ®Google Scholar
• Corinaldesi R, Stanghellini V, Raiti C, Salgemini R, Barbara L. Effect of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis. Gut 1987; 28: 300–305
   PubMed Web of Science ®Google Scholar
• Camilleri M, Brown M L, Malagelda J R. Impaired transit of chyme in chronic intestinal pseudoobstruction. Correction by cisapride. Gastroenterology 1986; 91: 619–626
   PubMed Web of Science ®Google Scholar
• Muller-Lissner S A. The Bavarian constipation study group. Treatment of chronic constipation with cisapride and placebo. Gut 1987; 28: 1033–1038
   PubMed Web of Science ®Google Scholar
• Tonini M, Galligan J J, North R A. Effects of cisapride on cholinergic neurotransmission and propulsive motility in the guinea pig ileum. Gastroenterology 1989; 96: 1257–1264
   PubMedGoogle Scholar
• Rapeport W G, Thompson S. Effects of oral BRL24924 on gastric emptying measured by epigastric impedance. Br J Clin Pharmacol 1987; 24: 263P
   Google Scholar
• Staniforth D H, Corbet R. The effect of BRL24924 on upper gastrointestinal tract activity. Br J Clin Pharmacol 1987; 24: 263P–264P
   Google Scholar
• Robertson C S, Ledingham S J, Cooper S M, Evans D F. A double-blind dose ranging study of BRL 24924 and metoclopramide on lower oesophageal sphincter pressure in healthy volunteers. Br J Clin Pharmacol 1989; 28: 323–327
   PubMedGoogle Scholar
• Burke T A, Sanger G J. Regionally selective cholinergic stimulation by BRL 24924 in the human isolated gut. Br J Clin Pharmacol 1988; 26: 261–265
   PubMedGoogle Scholar
• Donowitz M, Tai Y H, Asarkof N. Serotonin (5-HT)-induced ileal secretion: active electrolyte secretion which is calcium dependent [Abstract]. Gastroenterology 1979; 76: 1123
   Google Scholar
• Furman B L, Waton N G. 5-hydroxytryptamine and peripheral secretory mechanisms. The peripheral actions of 5-hydroxytryptamine, J R Fozard. Oxford Medical Publications, Oxford 1989; 274–300
   Google Scholar
• Baird A W, Cuthbert A W. Neuronal involvement in type I hypersensitivity reactions in gut epithelia. Br J Pharmacol 1987; 92: 647–655
   PubMedGoogle Scholar
• Anderson J V, Coupe M O, Morris J A, Hodgson H JF, Bloom S R. Remission of symptoms in carcinoid syndrome with a new 5-hydroxytryptamine M receptor antagonist. Br Med J 1987; 294: 1129
   PubMed Web of Science ®Google Scholar
• Gustafsen J, Lendorf A, Raskov H, Boesby S. Ketanserin versus placebo in carcinoid syndrome. Scand J Gastroenterol 1986; 21: 816–818
   PubMed Web of Science ®Google Scholar
• Jaffe B M. 5-HT in intestinal function. International symposium on serotonin from cell biology to pharmacology and therapeutics, FlorenceItaly, 1989, 115
   Google Scholar
• Costall B, Domeney A M, Naylor R J, Tattersall F D. 5-Hydroxytryptamine M-receptor antagonism to prevent cisplatin-induced emesis. Neurophar-macology 1986; 25: 959–961
   PubMed Web of Science ®Google Scholar
• Miner W D, Sanger G J. Inhibition of cisplatinum-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism. Br J Pharmacol 1986; 88: 497–499
   PubMed Web of Science ®Google Scholar
• Carmichael J, Cantwell B MJ, Edwards C M, et al. A pharmacokinetic study of granisetron (BRL 43694A), a selective 5-HT, receptor antagonist: correlation with anti-emetic response. Cancer Chem Pharmacol 1989; 24: 45–49
   PubMed Web of Science ®Google Scholar
• Andrews P LR, Rapeport W G, Sanger G J. Neuro-pharmacology of emesis induced by anti-cancer therapy. Trends Pharmacol Sci 1988; 9: 334–341
   PubMed Web of Science ®Google Scholar
• Alphin R S, Proakis A G, Leonard C A, Smith W L, Dannenburg W N, Kinnier W J. Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility. Dig Dis Sci 1986; 31: 524–529
   PubMedGoogle Scholar