10
Views
13
CrossRef citations to date
0
Altmetric
Original Article

Stress Bleeding Prophylaxis with Sucralfate: Pathophysiologic Basis and Clinical Use

Pages 22-33 | Published online: 08 Jul 2009

References

  • Skillman J J, Gould S A, Chung R SK, Silen W. The gastric mucosal barrier: clinical and experimental studies in critically ill and normal man and in the rabbit. Ann Surg 1970; 172: 564–584
  • van den Berg B, van Blankenstein M. The prevention of stress-induced upper gastrointestinal bleeding by ranitidine in critically ill patients. The clinical use of ranitidine, JJ Misiewicz, KG Wormsley. Medicine Publishing Foundation, Oxford 1982; 263–268
  • van den Berg B, van Blankenstein M. Prevention of stress-induced upper gastrointestinal bleeding by cimetidine in patients on assisted ventilation. Digestion 1985; 31: 1–8
  • Cheadle W G, Vitale G C, Mackie C R, Cuschieri A. Prophylactic postoperative nasogastric decompression. A prospective study of its requirement and the influence of cimetidine in 200 patients. Ann Surg 1985; 202: 36
  • Groll A, Simon J B, Wigle R D, Taguchi K, Todd R J, Depew WT. Cimetidine prophylaxis for gastrointestinal bleeding in an intensive care unit. Gut 1986; 27: 135–140
  • Zinner M J, Zuidema G D, Smith P L, Mignosa M. The prevention of upper gastrointestinal tract bleeding in patients in an intensive care unit. Surg Gynecol Obstet 1981; 153: 214–220
  • Hase T, Anderson P R, Mehlmann P. Significance of gastric secretory changes in pathogenesis of stress ulcers. Dig Dis 1975; 20: 339–443
  • Kamada T, Fusamoto H, Kawano S, et al. Gastrointestinal bleeding following head injury: a clinical study of 433 cases. J Trauma 1977; 17: 44–47
  • Stannard V A, Hutchinson A, Morris D L, Byrne A. Gastric exocrine ‘failure' in critically ill patients: incidence and associated features. Br Med J 1988; 296: 155–156
  • Alphin R S, Vokac V A, Gregory R L, Bolton P M, Tawes JW. Role of intragastric pressure, pH and pepsin in gastric ulceration in the rat. Gastroenterology 1977; 73: 495–500
  • Schumpelick V, Grossner D. Erste klinische Erfah-rungen mit Cholestyramin zur StreBulkusprophy-laxe. MMW 1977; 119: 1329–1332
  • Rees W DW. Mucus-bicarbonate barrier–shield or sieve. Gut 1987; 28: 1553–1556
  • Fiddian-Green R G, McGough E, Pittenger G, Rothman E. Predictive value of intramural pH and other risk factors for massive bleeding from stress ulceration. Gastroenterology 1983; 85: 613
  • Kivilaakso E. Prostaglandin cytoprotection during hemorrhagic shock induced gastric stress lesions. Gastroenterol Clin Biol 1985; 9: 122
  • Watanabe Y, Kudo T, Sakakibara N. The preventive and therapeutic effects of vagotomy for stress ulcer–experimental studies on the aspects of gastric submucosal blood flow and ulcer index. Jpn J Surg 1988; 18: 447–454
  • Kivilaakso E. High plasma HC03 protects gastric mucosa against acute ulceration in the rat. Gastroenterology 1981; 81: 921
  • Menguy R, Desbaillets L, Masters YF. Mechanism of stress ulcer: influence of hypvovolemia shock on energy metabolism in the gastric mucosa. Gastroenterology 1974; 66: 46–55
  • Derrida S, Nury B, Slama R, et al. Occult gastrointestinal bleeding in high-risk intensive care unit patients receiving antacid prophylaxis: frequency and significance. Crit Care Med 1989; 17: 122–125
  • Bighley L D, Giesing D. Mechanism of action: studies of sucralfate. Duodenal ulcer, gastric ulcer. Sucralfate: a new therapeutic concept Urban and Schwarzenberg, WF Caspary, Baltimore 1981; 39
  • Mann NS. Bile-induced acute erosive gastritis. Its prevention by antacid, cholestyramine, and prostaglandin E2. Dig Dis 1976; 21: 89–92
  • Graham D Y, Sackman J W, Giesing D H, Runser DJ. In vitro adsorption of bile salts and aspirin to sucralfate. Dig Dis Sci 1984; 29: 402–406
  • Hui W M, Chen B W, Lam S K, Ng M MT, Cho Ch Luk CT. Sucralfate increases gastric mucosal blood flow in rats. 5th International Sucralfate Symposium Abstract Book. 1989; 16
  • Guslandi M. Sucralfate and gastric bicarbonate. Pharmacology 1985; 31: 298–300
  • Konturek S J, Kwiecien N, Hebzda Z, Olesky J. Stimulation of gastric alkaline secretion by gastro-protective drugs in man. Z Gastroenterol 1988; 26: 27–30, suppl 1
  • Guslandi M, Ballarin M, Cambielli M, Tittobello A. Stimulation of mucus output: a further mode of action of sucralfate [Abstract]. Gastroenterology 1983; 84: 1177
  • Quadros E, Ramsamooj E, Wilson DE. Role of mucus and prostaglandins in the gastric mucosal protective actions of sucralfate against ethanol-induced injury in the rat. Am J Med 1987; 83: 19–23
  • Shea-Donohue T, Steel L, Montcalm E, Dubois A. Gastric protection by sucralfate. Gastroenterology 1986; 91: 660–666
  • Slomiany B L, Slomiany LA. Effect of sucralfate on the viscosity of gastric mucus and the permeability of hydrogen ion. Digestion 1986; 33: 146–151
  • Tarnawski A, Hollander D, Krause W J, Zipser R D, Stachura J, Gergely H. Does sucralfate affect the normal gastric mucosa?. Gastroenterology 1986; 90: 893–905
  • Konturek S J, Brzozowski T, Bielanski W, War-Zecha Z, Drozdowicz D. Epidermal growth factor in the gastroprotective and ulcer-healing actions of sucralfate in rats. Am J Med 1989; 86: 32–37
  • Borrero E, Bank S, Margolis I, Schulman N, Char-Davoyne R. Comparison of antacid and sucralfate in the prevention of gastrointestinal bleeding in patients who are crtically ill. Am J Med 1985; 79: 62–64
  • Borrero E, Ciervo J, Chang JB. Antacid vs sucralfate in preventing acute gastrointestinal tract bleeding in abdominal aortic surgery. Arch Surg 1986; 121: 810–812
  • Bresalier R S, Grendell J H, Cello J P, Meyer AA. Sucralfate suspension vs titrated antacid for the prevention of acute stress-related gastrointestinal hemorrhage in critically ill patients. Am J Med 1987; 83: 110–116
  • Cannon L A, Heiselman D, Gardner W, Jones W. Prophylaxis of upper gastrointestinal tract bleeding in mechanically ventilated patients. A randomized study comparing the efficacy of sucralfate, cime-tidine, and antacids. Arch Intern Med 1987; 147: 2101–2106
  • Driks M R, Craven D E, Celli B R, et al. Nosocomial pneumonia in intubated patients randomized to sucralfate versus antacids and/or histamine type 2 blockers: the role of gastric colonization. N Engl J Med 1987; 317: 1376–1382
  • Israsena S, Anantapanpong S, Kladcharoen N, Chayanand D, Limthongkul S. Sucralfate versus antacid in the prevention of stress ulcer bleeding on mechanical ventilation. J Med Assoc Thai 1987; 70: 678–683
  • Mundinger G H, Hays A, Alio M, Lamy P, Kitler M E, Zuidema G. Effect of meciadanol and sucralfate as compared with antacid titration regimen on prevention of acute gastrointestinal hemorrhage in postoperative intensive care patients. Surg Forum 1985; 121–123
  • Tryba M, Zevounou F, Török M, Zenz M. Prevention of acute stress bleeding with sucralfate, antacids or cimetidine. A controlled study with pirenzepine as a basic medication. Am J Med 1985; 79: 55–61
  • Tryba M. The risk of acute stress bleeding and nosocomial pneumonia in ventilated ICU-patients: sucralfate vs antacids. Am J Med 1987; 83: 117–124
  • Laggner A N, Lenz K, Graninger W, et al. Stress-ulcusprophylaxe auf einer intemen Intensivstation: Sucralfat versus Ranitidin. Anaesthesist 1988; 37: 704–710
  • Vogelaer D. Studies on the prevention of stress bleeding with sucralfate. Prevention of stress bleeding in critically ill patients– a new concept, M Tryba. Thieme Medical Publishers, New York 1988; 50–54
  • Breucha G, Daschner F, Eckart J, et al. Inter-disziplinäres Gespräch: Streŝblutungsprophylaxe. Chirurgische Gastroenterologie mid interdis-ziplinären Gesprächen. TM-Verlag, Hameln 1988; 105–117
  • Daschncr F, Kappstein I, Engels I. Antibakterielle Aktivität von Sucralfat in künstlichem Magensaft. Intensivmed 1987; 24: 163–166
  • Shenep J L, Kalwinski D K, Hutson P R, et al. Efficacy of oral sucralfate suspension in prevention and treatment of chemotherapy-induced mucositis. J Pediatr 1988; 113: 758–763
  • Tryba M, Mantey-Stiers F. Antibacterial activity of sucralfate in human gastric juice. Am J Med 1987; 83: 125–127
  • Atherton S T, White DJ. Stomach as source of bacteria colonizing respiratory tract during artificial ventilation. Lancet 1978; 2: 968–969
  • Du Moulin G C, Paterson D G, Hedley-White J, Lisbon A. Aspiration of gastric bacteria in antacid-treated patients: a frequent cause of postoperative colonisation of the airway. Lancet 1982; 1: 242–245
  • Ibanez J, Penafiel A, Raurich J M, Marse P, Pater-Nostro J C, Mata F. Gastroesophageal reflux and aspiration of gastric contents during nasogastric feeding, the effect of posture [Abstract]. Intensive Care Med 1988; 14: 296, suppl 2
  • Nachtkamp J, Bares R, Winkeltau G, et al. Keim-besiedlung des Magens unter medicamentöser Streŝulcusprophylaxe–Ursache von broncho-pul-monalen Infektionen bei Beatmungspatienten?. Z Gastroenterol 1988; 26: 493
  • Marshall J C, Christou N V, Horn R, Meakins JL. The microbiology of multiple organ failure. The proximal gastrointestinal tract as an occult reservoir of pathogens. Arch Surg 1988; 123: 309–315
  • Craven D E, Kunches L M, Kilinsky V, Lichtenberg D A, Make B J, McCabe WR. Risk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation. Am Rev Resp Dis 1986; 133: 792–796
  • Tryba M. Prevention of stress bleeding with ranitidine or pirenzepine and the risk of pneumonia. J Clin Anaesth 1988; 1: 12–20
  • Anderson W. Esophageal medication bezoar in a patient receiving enteral feedings and sucralfate. Am J Gastroenterol 1989; 84: 205–206

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.